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| 1 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 2 | Objective criteria may assist in distinguishing necrotizing fasciitis from nonnecrotizing soft tissue infection显示文摘 | Wall DB de Virgilio C Black S | 2000 | Am J Surg2000，179，1： | 1 |
| 3 | Tracheal and main bronchial disruptions after blunt chest trauma:Presentation and Management显示文摘 | Baumgartner F Sheppard B de Virgilio C | 1990 | Ann Thorac Surg1990，50，： | 1 |
| 4 | Gastric adenocarcinoma in patients 40 years of age or younger显示文摘 | Theuer CP de Virgilio C Keese G | 1996 | Am J Surg1996，172，5： | 1 |
| 5 | The role of trehalose synthesis for the acquisition of thermotolerance in yeast-Ⅱ physiological concentrations of trehalose increase the thermal stability of proteins in vitro显示文摘 | Hottiger T De Virgilio C Hall M N | 1994 | European Journal of Biochemistry1994，219，12： | 1 |
| 6 | Paucisymptomatic pneumonia due to Rothia mucilaginosa: case report and literature review显示文摘 | Fusconi M Conti C De Virgilio A | 2009 | Infez Med2009，17，2： | 1 |
| 7 | Fibrin glue inhibits intra-abdominal adhesion formation显示文摘 | de Virgilio C Dubrow T Sheppard BB | | 0，，10： | 1 |
| 8 | Tracheal and main bronchial clisruptions after blunt chest truma: presentation and management 显示文摘 | BAUMGARTNER F SHEPPARD B de VIRGILIO C | 1990 | Ann Thorac Surg1990，50，4： | 1 |
| 9 | Fibrin glue reduces the severity of intra-abdominal adhesions in a rat model显示文摘 | Elbassir M Hidalgo A | 1999 | Am J Surg1999，178，6： | 1 |
| 10 | Gastric adenocarcinoma in patients 40 year of age and younger显示文摘 | Theuer CP de Virgilio C Keese G | 1996 | Am J Surg1996，172，4： | 1 |
| 11 | Detection of intern αIIbβ3 clustering in living cells 显示文摘 | Buensuceso C de Virgilio M Shattil SJ | 2003 | JBiol Chem2003，278，15： | 1 |
| 12 | Gastric adenocarcinoma in patients 40 years of age or younger显示文摘 | Theuer CP de Virgilio C keese G | 1996 | Am J Surg1996，172，5： | 1 |
| 13 | Plication as primary treatment of steal syndrome in arteriovenous fistulas 显示文摘 | Yaghoubian A de Virgilio C | 2009 | Ann Vase Surg2009，23，1： | 1 |
| 14 | Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast显示文摘 | Cvrckova F De Virgilio C Manser E | 1995 | Genes Dev1995，9，15： | 1 |
| 15 | Fibrin glue inhibits intra-abdominal adhesion formation显示文摘 | De Virgilio C Dubuow T Sheppurd B | 1990 | Arch Surg1990，125，： | 1 |
| 16 | Candida sepsis in surgical patients显示文摘 | Eubanks PJ de Virgilio C Klein S | 1993 | Am J Surg1993，166，3： | 1 |
| 17 | Endovascular abdominalaortic aneurysm repair with general versus local anesthesia;A com-parision of cardiopulmonary morbidity and mortality rates显示文摘 | De Virgilio C Romem L Donayre C et a1 | 2002 | VascSurg2002，36，： | 1 |
| 18 | Laryngeal electromyography and prognosis of unilateral vocal fold paralysis--a long-term prospective study 显示文摘 | WANG C C CHANG M H DE VIRGILIO A | 2015 | Laryngoscope2015，125，4： | 1 |
| 19 | Candida sepsis in surgical patients显示文摘 | Eubanks P J de Virgilio C Klein S | 1993 | Am J Surg1993，166，6： | 1 |
| 20 | Disruption of TPS2, the gene encoding the 100-kDa subunit of the tre- halose-6-phosphate synthase/phosphatase eomplex in Saecharomyces cerevisiae,causes accumulation of treha- lose-6-phosphate and loss of trehalose-6-phosphate phosphatase activity 显示文摘 | De Virgilio C Barekert N Bell W | 1993 | European Journal of Biochem- istry/FEBS1993，212，2： | 1 |
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