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| 1 | Favorable lifestyle before diagnosis associated with lower risk of screen-detected advanced colorectal neoplasia显示文摘AIM: To investigate the association between adherence to health recommendations and detection of advanced colorectal neoplasia(ACN) in colorectal cancer(CRC) screening.METHODS: A total of 14832 women and men were invited to CRC screening, 6959 in the fecal immunochemical test arm and 7873 in the flexible sigmoidoscopy arm. These were also sent a self-reported lifestyle questionnaire to be completed prior to their first CRC screening. A lifestyle score was created to reflect current adherence to healthy behaviors in regard to smoking, body mass index, physical activity, alcohol consumption and food consumption, and ranged from zero(poorest) to six(best). Odds ratios(ORs) and 95%CIs were calculated using multivariable logistic regression to evaluate the association between the single lifestyle variables and the lifestyle score and the probability of detecting ACN.RESULTS: In all 6315 women and men completed the lifestyle questionnaire, 3323(53%) in the FIT arm and 2992(47%) in the FS arm. This was 89% of those who participated in screening. ACN was diagnosed in 311(5%) participants of which 25(8%) were diagnosed with CRC. For individuals with a lifestyle score of two, three, four, and five-six, the ORs(95%CI) for the probability of ACN detection were 0.82(0.45-1.16), 0.43(0.28-0.73), 0.41(0.23-0.64), and 0.41(0.22-0.73), respectively compared to individuals with a lifestyle score of zero-one. Of the single lifestyle factors, adherence to non-smoking and moderate alcohol intake were associated with a decreased probability of ACN detection compared to being a smoker or having a high alcohol intake 0.53(0.42-0.68) and 0.63(0.43-0.93) respectively.CONCLUSION: Adopted healthy behaviors were inversely associated with the probability of ACN detection. Lifestyle assessment might be useful for risk stratification in CRC screening. | Markus D Knudsen Thomas de Lange Edoardo Botteri Dung-Hong Nguyen Helge Evensen Chloé B Steen Geir Hoff Tomm Bernklev Anette Hjartaker Paula Berstad | 2016 | World Journal of Gastroenterology2016，22，27： | 3 |
| 2 | Heterogeneous nucleating in the crystallization of polyolefins:Part 2 Kinetics of crystallization of nucleated polyolefins显示文摘 | Binsbergen F L De Lange B G M | 1970 | Polymer1970，11，6： | 2 |
| 3 | Real ileal protein and amino acid digestibilities in feedsruffs for growing pigs as determined with the 15N-isotope dilution technique显示文摘 | de Lange C F M Souffrant W B Sauer W C | 1990 | J Anim Sci1990，68，： | 1 |
| 4 | TRF2 protects human telomeres from end-to-end fusion 显示文摘 | VAN STEENSEL B SMOGORZEWSKA A DE LANGE T | 1998 | Cell1998，92，3： | 1 |
| 5 | Organic materials for reversible optical data storage 显示文摘 | Fefinga B L Jager W F de Lange B | 1993 | Tetrahedron1993，49，37： | 1 |
| 6 | Significance of endogenous gut nitrogen losses in the nutrition of growing pigs:a review显示文摘 | Nyachoti C M de Lange C F M McBride B W | 1997 | Canada Animal Science1997，77，： | 1 |
| 7 | Control of telomere length by the human telomeric protein TRF1显示文摘 | van Steensel B de Lange T | | 0，，6618： | 1 |
| 8 | Effects of hydroxyapatite particles on periodontal ligamentfibroblast-like cell behavior显示文摘 | ALLIOT-LICHT B De LANGE G L GREGOIRE M | 1997 | J Periodontol1997，68，2： | 1 |
| 9 | Invited review:Amino acid bioavailability and digestibility in pig feed ingredients:Terminology and application显示文摘 | Stein HH Sève B Fuller MF Moughan PJ de Lange CFM | | 0，，： | 1 |
| 10 | Significance of endogenous gut nitrogen losses in the nutrition of growing pigs:a review显示文摘 | Nyachoti C M de Lange C F M McBride B W | 1997 | Can J Anim Sci1997，77，1： | 1 |
| 11 | The effect of protein status of the pig on the recovery and amino acid composition of endogenous protein in digesta collected from the distal ileum显示文摘 | De Lange C F M Sauer W C Souffrant W B | 1989 | J Anim Sci1989，67，： | 1 |
| 12 | The effect of limited rewarming and postoperative hypothermia on cognitive function in a rat cardiopulmonary bypass model显示文摘 | DE LANGE F JONES W L MACKENSEN G B | | 0，，03： | 1 |
| 13 | Control of the telomere length by human telomeric protein TRF1显示文摘 | van Steensel B de Lange T | 1997 | Nature1997，385，： | 1 |
| 14 | Control of telomere length by the human telomeric protein TRFI显示文摘 | van Steensel B de Lange T | 1997 | Nature1997，385，： | 1 |
| 15 | Control of telomere length by the human telomeric protein TRF1 显示文摘 | VAN STEENSEL B DE LANGE T | 1997 | Nature1997，385，6618： | 1 |
| 16 | A piglet model for detection of hypoxic-ischemic brain injury with magnetic resonance imaging显示文摘 | Munkeby B H De Lange C Emblem K E | 2008 | Acta Radiol2008，49，9： | 1 |
| 17 | Organic materials for reversible optical datastorage显示文摘 | Feringa B L Jager W F de Lange B | 1993 | Tetrahedron1993，49，37： | 1 |
| 18 | Syno-vial inflammati - on, immune cells and their cytokines in osteoarthri- tis : a review显示文摘 | de Lange - Brokaar B J Ioan- Faesinay A van Osch GJ | 2012 | Osteoarthritis Cartilage2012，20，： | 1 |
| 19 | Effects d car diopulmonary bypass on neurocognitive performance and cyto- kine release in old and diabetic rats 显示文摘 | de Lange F Dieleman JM Jungwirth B | 2007 | Br J Anaesth2007，99，2： | 1 |
| 20 | Morbidity and mortality related to non-hepatic surgery in Patients with liver cirrhosis;A systematic review显示文摘 | De Goede B Klitise PJ Lange JF | 2012 | Best Prac Res Clin Gastreenterol2012，26，1： | 1 |
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