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| 1 | Gut-microbiome-brain axis:the crosstalk between the vagus nerve,alpha-synuclein and the brain in Parkinson's disease显示文摘This critical review of the literature shows that there is a close link between the microbiome,the gut,and the brain in Parkinson's disease.The vagus nerve,the main component of the parasympathetic nervous system,is involved in the regulation of immune response,digestion,heart rate,and control of mood.It can detect microbiota metabolites through its afferents,transferring this gut information to the central nervous system.Preclinical and clinical studies have shown the important role played by the gut microbiome and gut-related factors in disease development and progression,as well as treatment responses.These findings suggest that the gut microbiome may be a valuable target for new therapeutic strategies for Parkinson's disease.More studies are needed to better understand the underlying biology and how this axis can be modulated for the patient's benefit. | Júlio César Claudino dos Santos Leandro Freitas Oliveira Felipe Micelli Noleto Camilla Teixeira Pinheiro Gusmão Gerly Anne de Castro Brito Glauce Socorro de Barros Viana | 2023 | Neural Regeneration Research2023，18，12： | 2 |
| 2 | Reduction of ethyl benzoylacetate and selective protection of 2- (3-hydroxy-1- phenylpropyl) -4-methylphenol: A new and facile synthesis of tolterodine 显示文摘 | De Castro KA Ko J Park D | 2007 | Org Process Res Dev2007，11，5： | 1 |
| 3 | Sequential (step-by-step) detection, identification and quantitation of extra virgin olive oil adulterationby chemometric treatment of chromatographic profiles 显示文摘 | F Priego Capot J Ruiz Jira6nez M D Luque de Castro | 2007 | Anal Bioanal Chem2007，388，： | 1 |
| 4 | Ultrasound-assisted dynamic extraction of valuable compounds from aromatic plants and flowers as compared with steam distillation and superheated liquid extraction显示文摘 | Roldan-Gutierrez J M Ruiz-Jimenez J Luque de Castro M D | 2008 | Talanta2008，75，5： | 1 |
| 5 | Epigenetic modifications: basic mechanisms and role in cardiovascular disease 显示文摘 | Handy DE Castro R Loscalzo J | 2011 | Circulation2011，123，19： | 1 |
| 6 | Business and so- cial reputation: Exploring the concept and main Dimen- sions of corporate reputation 显示文摘 | De Castro G M Lopez J E N Sdez P L | 2006 | Journal of Business Ethics2006，63，4： | 1 |
| 7 | Correlation between symptom fatigue and muscular fatigue in multiple sclerosis显示文摘 | Iriarte J de Castro P | 1998 | Eur J Neurol1998，5，6： | 1 |
| 8 | The Construction of a Boolean Competitive Neural Network Using Ideas from Immunology显示文摘 | Von Zuben F J De Deus J G A | 2003 | Neurocomputing2003，50，： | 1 |
| 9 | Pneumococcal antimicro-bial resistance:therapeutic strategy and management in community-acquired pneumonia显示文摘 | Aspa J Rajas O de Castro F R | 2008 | Expert Opin Pharmacother2008，9，2： | 1 |
| 10 | PROSITE,aprotein domain database for functional characterization and anno-tation显示文摘 | S IGRIST C J A CERUTTI L de CASTRO E | 2010 | Nucleic Acids Research2010，38，1： | 1 |
| 11 | Immune and neural network models: theoretical and empirical comparisons 显示文摘 | de CASTRO L N van ZUBEN F J | 2001 | International Journal of Computational Intelligence and Applications2001，1，3： | 1 |
| 12 | Wind park reduced-order model using singular perturbations theory显示文摘 | Castro Rui M G Ferreira de Jesus J M | 1996 | IEEE Trans on Energy Conversion1996，11，4： | 1 |
| 13 | Sequential(step-by-step) detection,identification and quantization of extra virgin olive oil adulteration by chemo metric treatment of chromatographic profiles显示文摘 | CAPOTE F P JIMINEZ J R LUQUE de CASTRO M D | 2007 | Analytical and Bioanalytical Chemistry2007，338，8： | 1 |
| 14 | Gerontogenes mediate health and longevity in nematodes through increasing resis-tance to environmental toxins and sa'essors显示文摘 | Johnson T Cypser J De Castro E | 2000 | Exp Gerontol2000，35，6： | 1 |
| 15 | Mutational analysis reveals a complex interplay of peptide binding and multiple biologi- cal features of HLA-B27显示文摘 | Galocha B Lopez de Castro J A | 2010 | J Biol Chem2010，285，39： | 1 |
| 16 | PI3K/Akt signalling pathway and cancer显示文摘 | Fresno Vara JA Casado E de Castro J | 2004 | Cancer Treat Rev2004，30，2： | 1 |
| 17 | Learning and Optimization Using the Clonal Selection Principle显示文摘 | De Castro L N Von Zuben F J | 2002 | IEEE Trans on Evolutionary Computation2002，6，3： | 1 |
| 18 | Learning and optimization using the clonal selection principle 显示文摘 | DE CASTRO L N VON ZUBEN F J | 2002 | IEEE Trans Evolutionary Computation Special Issue on Artificial Immune Systems2002，6，3： | 1 |
| 19 | Ultrasoundassisted soxhlet extraction:an expeditive approach for solid sample treatment Application to the extraction of total fat from oleaginous seeds显示文摘 | Luque-garcia J L Luque de Castro M D | 2004 | J Chromatogr A2004，1034，3： | 1 |
| 20 | Interpretation of chloride profiles from concrete exposed to tropical marine environments显示文摘 | CASTRO P DE RINCON O T PAZINI E J | 2001 | Cement and Concrete Research2001，31，4： | 1 |
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