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| 1 | Host pathogen interactions in Helicobacter pylori related gastric cancer显示文摘Helicobacter pylori (H. pylori), discovered in 1982, is a microaerophilic, spiral-shaped gram-negative bacterium that is able to colonize the human stomach. Nearly half of the world's population is infected by this pathogen. Its ability to induce gastritis, peptic ulcers, gastric cancer and mucosa-associated lymphoid tissue lymphoma has been confirmed. The susceptibility of an individual to these clinical outcomes is multifactorial and depends on H. pylori virulence, environmental factors, the genetic susceptibility of the host and the reactivity of the host immune system. Despite the host immune response, H. pylori infection can be difficult to eradicate. H. pylori is categorized as a group?Ⅰ?carcinogen since this bacterium is responsible for the highest rate of cancerrelated deaths worldwide. Early detection of cancer can be lifesaving. The 5-year survival rate for gastric cancer patients diagnosed in the early stages is nearly 90%. Gastric cancer is asymptomatic in the early stages but always progresses over time and begins to cause symptoms when untreated. In 97% of stomach cancer cases, cancer cells metastasize to other organs. H. pylori infection is responsible for nearly 60% of the intestinaltype gastric cancer cases but also influences the development of diffuse gastric cancer. The host genetic susceptibility depends on polymorphisms of genes involved in H. pylori-related inflammation and the cytokine response of gastric epithelial and immune cells. H. pylori strains differ in their ability to induce a deleterious inflammatory response. H. pylori-driven cytokines accelerate the inflammatory response and promote malignancy. Chronic H. pylori infection induces genetic instability in gastric epithelial cells and affects the DNA damage repair systems. Therefore, H. pylori infection should always be considered a pro-cancerous factor. | Magdalena Chmiela Zuzanna Karwowska Weronika Gonciarz Bujana Allushi Pawel Staczek | 2017 | World Journal of Gastroenterology2017，23，9： | 37 |
| 2 | Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis显示文摘Acute pancreatitis (AP) is an inflammatory disorder of pancreatic tissue initiated in injured acinar cells. Severe AP remains a significant challenge due to the lack of effective treatment. The widely-accepted autodigestion theory of AP is now facing challenges, since inhibiting protease activation has negligible effectiveness for AP treatment despite numerous efforts. Furthermore, accumulating evidence supports a new concept that malfunction of a self-protective mechanism, the unfolded protein response(UPR), is the driving force behind the pathogenesis of AP. The UPR is induced by endoplasmic reticulum(ER) stress, a disturbance frequently found in acinar cells, to prevent the aggravation of ER stress that can otherwise lead to cell injury. In addition, the UPR's signaling pathways control NFκB activation and autophagy flux, and these dysregulations cause acinar cell inflammatory injury in AP, but with poorly understood mechanisms. We therefore summarize the protective role of the UPR in AP, propose mechanistic models of how inadequate UPR could promote NFκB's pro-inflammatory activity and impair autophagy's protective function in acinar cells, and discuss its relevance to current AP treatment. We hope that insight provided in this review will help facilitate the research and management of AP. | Kaylene Barrera Albert Stanek Kei Okochi Zuzanna Niewiadomska Cathy Mueller Peiqi Ou Devon John Antonio E Alfonso Scott Tenner Chongmin Huan | 2018 | World Journal of Gastrointestinal Pathophysiology2018，9，2： | 9 |
| 3 | Enzymatic Degradation of Poly(butylenesuccinate)/Thermoplastic Starch Blend显示文摘The degradation of thermoplastic starch blend in the presence of commerciala-amylase and unpurified amylase of microbial origin was investigated.The blends consisting of thermoplastic starch and poly(butylene succinate)have potential use in packaging applications thus,it is essential to establish susceptibility to degradation.Molar mass loss,gravimetric weight loss,and molecular structure were evaluated.The changes in the surface were observed with scanning electron microscopy.It was confirmed that there was a significant difference in gravimetric weight loss between the blends degraded in two different solutions.Unpurified enzymes of microbial origin,produced by Rhizopus oryzae cultures decomposed analyzed materials more efficiently than purified commercial ones.Moreover,it was proved that in applied conditions,the molar mass of PBS fraction did not change significantly. | Anna Kundys Justyna Ostrowska Urszula Chojnacka Zuzanna Grodzka Aleksandra Lange Magdalena Paluch | 2018 | Journal of Renewable Materials2018，6，6： | 2 |
| 4 | Control of ionic transport through gated single conical nanopores显示文摘 | Eric B. Kalman Olivier Sudre Ivan Vlassiouk Zuzanna S. Siwy | 2009 | Analytical and Bioanalytical Chemistry2009，，2： | 1 |
| 5 | Subjective and Objective Knowledge as Determinants of Organic Vegetables Consumption 显示文摘 | Zuzanna P Joris A Wim V | 2010 | Food Quality and Preference2010，21，6： | 1 |
| 6 | Interferon-γ–Stimulated Genes, but Not USP18, Are Expressed in Livers of Patients With Acute Hepatitis C显示文摘 | Michael T. Dill Zuzanna Makowska Francois H.T. Duong Franzisca Merkofer Magdalena Filipowicz Thomas F. Baumert Luigi Tornillo Luigi Terracciano Markus H. Heim | 2012 | Gastroenterology2012，，3： | 1 |
| 7 | Liposomes as delivery systems for antibiotics 显示文摘 | ZUZANNA DRULIS-KAWA AGATA DOROTKIEWICZ-JACH | 2010 | Int J Pharm2010，387，12： | 1 |
| 8 | Disruption of the Arabidopsis cir- cadian clock is responsible for extensive variation in the cold-responsive tran- scriptome显示文摘 | Zuzanna B Carmen E Armin S et ai | 2008 | Plant Physiology2008，147，1： | 1 |
| 9 | European consumers'use of and trust in information sources about fish 显示文摘 | Zuzanna P Verbeke W Joachim S | 2007 | Food Quality and Preference2007，18，： | 1 |
| 10 | Particle size of unsweetened azuki paste as related to cultivar and cooking time显示文摘 | Byung-Kee Balk Beata Klamczynska Zuzanna Czuchajowska | 1998 | Journal of Food Science1998，63，2： | 1 |
| 11 | Paste particle and bean size as related to sweetened adzuki paste quality显示文摘 | Byung-Kee B Zuzanna C | 1999 | Cereal Chem1999，76，1： | 1 |
| 12 | Grouping of ammunition types by means of frequencies of occurrence of GSR显示文摘 | Zuzanna Brozek-Mucha Grzegorz Zadora | | 0，，： | 1 |
| 13 | Con-sumer perception versus scientific evidence about health ben-efits and safety risks from fish consumption显示文摘 | Wim Verbeke Isabelle Sioen Zuzanna Pieniak | | 0，，04： | 1 |
| 14 | Evaluation of the possibility of differentiation between various types of ammunition by means of GSR examination with SEM-EDX method显示文摘 | Agnieszka Jankowicz Zuzanna Brozek-Mucha | | 0，，： | 1 |
| 15 | Role and contribution of starch and protein contents and quality to texture profile analysis of oriental noodles 显示文摘 | Byung- kee Baik Zuzanna Czuchajowska Yeshajahu Pomeranz | 1994 | Cereal Chemistry1994，71，4： | 1 |
| 16 | Etiopathogenesis of Recurrent Aphthous Stomatitis and the Role of Immunologic Aspects:Literature Review显示文摘 | Zuzanna S'lebioda El zbieta Szponar Anna Kowalska | 2014 | Archivum Immunologiaeet Therapiae Experimentalis2014，62，20： | 1 |
| 17 | Liposomes as delivery systems for antibiotics 显示文摘 | ZUZANNA D K AGATA D J | 2010 | International Journal of Pharmaceutics2010，387，12： | 1 |
| 18 | Consumer interest in fish information and |abelling: exploratory insights显示文摘 | Zuzanna Pieniak Wim Verbeke Joachim Scholderer | 2007 | Journal of International Food & Agribusiness Marketing2007，19，23： | 1 |
| 19 | Heated Humidiffied High-Flow Nasal Cannula Therpy:Yet Another Way to Deliver Continuous Positive Airway Pressure显示文摘 | Zuzanna J Kubicka Joseph Limauro | 2008 | Pediatyics2008，121，： | 1 |
| 20 | European consumers’useof and trust in information sources about fish 显示文摘 | Zuzanna P Verbeke W Joachim S | 2007 | Food Quality andPreference2007，18，： | 1 |
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