|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Recent Advances in Space-Deployable Structures in China显示文摘Deployable space structure technology is an approach used in building spacecraft,especially when realizing deployment and folding functions.Once in orbit,the structures are released from the fairing,deployed,and positioned.With the development of communication,remote-sensing,and navigation satellites,space-deployable structures have become cutting-edge research topics in space science and technology.This paper summarizes the current research status and development trend of spacedeployable structures in China,including large space mesh antennas,space solar arrays,and deployable structures and mechanisms for deep-space exploration.Critical technologies of space-deployable structures are addressed from the perspectives of deployable mechanisms,cable-membrane form-finding,dynamic analysis,reliable environmental adaptability analysis,and validation.Finally,future technology developments and trends are elucidated in the fields of mesh antennas,solar arrays,deployable mechanisms,and on-orbit adjustment,assembly,and construction. | Xiaofei Ma Tuanjie Li Jingya Ma Zhiyi Wang Chuang Shi Shikun Zheng Qifeng Cui Xiao Li Fan Liu Hongwei Guo Liwu Liu Zuowei Wang Yang Li | 2022 | Engineering2022，，10： | 6 |
| 2 | Pharmacokinetics and radiation dosimetry of ^(99m)Tc-3PRGD_2 in healthy individuals:A pilot study显示文摘99mTc-3PRGD2 is a new SPECT radiotracer for several tumor imaging with high uptake where integrinαvβ3 is highly expressed.This pilot study was to assess the safety,biodistribution and radiation dosimetry of 9,mTc-3PRGD2 in healthy volunteers.The 10 healthy male volunteers were injected with 99mTc-3PRGD2(786.7±55.8 MBq,19.1-24.2 mCi).Baseline measurements of vital signs,laboratory safety tests and 12-lead electrocardiogram were recorded before and after injection.Blood and urine samples were collected and radiation counts were obtained at various time points.Whole-body scans and ROIs of identified organs were used for visual analysis and estimating the radiation dosimetry.No adverse reactions were found during the study.99mTc-3PRGD2 exhibited a rapid clearance from the blood with less than 45%of the initial dosage at 10 min after injection and gradual increasing radioactivity in urine with(52.9±6)%of original dose at 1440 min.The whole-body imaging showed high radioactive accumulation in bladder.And the highest 99mTc-3PRGD2 uptake was found in the kidneys(3.50×10-2 mSv/MBq).The 99mTc-3PRGD2 exhibited good pharmacokinetic properties and little radiation burden.This study showed that 99mTc-3PRGD2 would be a safe and attractive SPECT agent in clinic applications. | CHENG Guanghui GAO Shi JI Tiefeng MA Qingjie JIA Bing CHEN Zuowei WANG Qing | 2012 | Nuclear Science and Techniques2012，23，6： | 5 |
| 3 | ^(99m)Tc-3P_4 -RGD_2 radiotracers for SPECT/CT of esophageal tumor显示文摘In recent years,several RGD(Arg-Gly-Asp)-based radiotracers have already been successfully tested in human for the visualization of integrin αvβ3,demonstrating its feasibility in tumor diagnosis.In this paper,we evaluated the 99mTc-3P4-RGD2 single photon emission computed tomography/computerized tomography(SPECT/CT)in patients suffering from space occupying disease of esophagus.40 patients(34 males and 6 female;mean age: 58.3 years) with a suspected space occupying lesion of esophagus were included,thus finally obtaining their definite pathologic diagnosis(malignant,n=32;benign,n=8).All patients underwent endoscopic,barium esophagography and SPECT/CT imaging preoperatively.The chest SPECT was performed at 4 h after administration of99mTc-3P4-RGD2 with a dose of 939±118 MBq.The diagnosis precision,sensitivity and specificity among these methods were compared.The relationship between radioactive uptake and clinical pathological stage of esophageal carcinoma was discussed by calculating the tumor to normal esophagus(T/N).Meanwhile,the integrin αvβ3 expression was assessed immunohistochemically in postoperative esophageal tissues.31 patients were diagnosed as esophageal carcinoma;and 1,leiomyosarcoma;and 6.leimyoma;and 2,esophageal tuberculosis.The accuracy,sensitivity and specificity of barium esophagography,endoscopic and SPECT/CT imaging are 92.5/93.8/87.5%,97.5/96.9/100%,and 90/90.6/87.5%,respectively.Abnormal accumulation of radiotracer in 29 malignant lesions is observed.The SPECT/CT imaging displayed the region of radioactive uptake and lesions matched extremely with the T/N ratio from 1.31 to 2.79(mean 2.04).A case with pulmonary metastases and a case with mediastinal lymph node metastases were found which were missed by barium esophagography and endoscopic.The99mTc-3P4-RGD2 uptake of the esophageal carcinoma masses had no relevance to the tumor pathologic classification(P>0.05).There was a significant positive correlation between T/N ratio and positive cell percentage of integrin αvβ3(r=0.976),demonstrating the certain clinical potential in the diagnosis of esophageal carcinoma. | GAO Shi MA Qingjie WEN Qiang JIA Bing LIU Zhaofei CHEN Zuowei ZHANG Haishan LI Dandan | 2013 | Nuclear Science and Techniques2013，24，4： | 3 |
| 4 | IL1RN promotes osteoblastic differentiation via interacting with ITGB3 in osteoporosis显示文摘The occurrence and progress of osteoporosis(OP)are partially caused by impaired osteoblast differentiation.Interleukin-I receptor antagonist(IL1RN)is an immune modulatory molecule that commonly functions by means of competing the binding site of IL-1R with IL-1.Although it was recently reported that IL1RN is involved in osteoblast differentiation,the role of IL1RN in osteogenesis remains unclear.In this work,we first investigated the expression pattern of IL1RN in ovariectomy mice and in vitro osteogenic induction of MC3T3-E1 and C3H10T1/2 cells.To verify the exact role of IL1RN in osteoblast differentiation,we established IL1RN-downregulated/upregulated cell lines.The results indicated that IL1RN was constantly expressed in MC3T3-E1 and C3H10T1/2 cells.Interestingly,an increase of IL1RN expression in osteoblasts occurred when osteoblasts were cultured in osteogenic medium(OM).As expected,silencing of IL1RN attenuated the osteogenic effect of OM,while IL1RN overexpression increased the osteogenic staining and promoted the expression of osteogenic markers,including alkaline phosphatase,osterix,and osteocalcin.In addition to evaluating the function of IL1RN in osteoblasts,we also investigated the molecular mechanism of the role of IL1RN in osteoblasts.We found that IL1RN interacts with integrinβ3 to activateβ-catenin signaling,which finally regulates osteoblast differentiation.Taken together,this study provides the framework that IL1RN,as a novel regulator of osteogenesis,may be a potential therapeutic target for the treatment of OP. | Zehua Zou Ruixuan Liu Yiwen Wang Yufei Xing Zuowei Shi Kaifu Wang Daming Dong | 2021 | Acta Biochimica et Biophysica Sinica2021，53，3： | 3 |
| 5 | Wave-Breaking Features of Blocking over Central Siberia and Its Impacts on the Precipitation Trend over Southeastern Lake Baikal显示文摘Precipitation over southeastern Lake Baikal features a significant decreasing trend in July and August over 1979–2018 and is closely related to blocking occurrence over central Siberia(45°–70°N,75°–115°E).This study investigates the formation and maintenance of anticyclonic and cyclonic wave-breaking(AWB and CWB)blocking events and their climate impacts on precipitation in the southeastern Lake Baikal area.Both AWB and CWB blocking events are characterized by a cold trough deepening from the sub-Arctic region and a ridge amplifying toward its north over central Siberia,as well as an evident Rossby wave train over midlatitude Eurasia.For AWB blocking events,the ridge and trough pair tilts clockwise and the wave train exhibits a zonal distribution.In contrast,ridge and trough pair associated with CWB blocking events leans anticlockwise with larger-scale,meridional,and more anisotropic signatures.Moreover,the incoming Rossby wave energy associated with CWB blocking events is more evident than for AWB blocking events.Therefore,CWB blocking events are more persistent.AWB blocking events produce more extensive and persistent precipitation over the southeastern Lake Baikal area than CWB blocking events,in which moderate above-normal rainfall is seen in the decaying periods of blockings.A significant decreasing trend is found in terms of AWB blocking occurrence over central Siberia,which may contribute to the downward trend of precipitation over southeastern Lake Baikal. | Dorina CHYI Zuowei XIE Ning SHI Pinwen GUO Huijun WANG | 2020 | Advances in Atmospheric Sciences2020，37，1： | 2 |
| 6 | Co-transplantation of macaque autologous Schwann cells and human embryonic nerve stem cells in treatment of macaque Parkinson's disease显示文摘Objective:To investigate the therapeutic effects of co-transplantation with Schwann cells(SCs) and human embryonic nerve stem cells(NSCs) on macaque Parkinson’s disease(PD).Methods: Macaque autologous SCs and human embryonic NSCs were adopled for the treatment of macaque PD.Results:Six months after transplantation,positron emission computerized tomography showed that 18F-FP-β-CIT was significantly concentrated in the injured striatum in the cotransplanted group.Immunohistoehemieal staining of transplanted area tissue showed migration of tyrosine hydroxylase positive cells from the transplant area to the surrounding area was significantly increased in the co-transplanted group.Conclusions:Co-transplantation of SCs and NSCs could effectively cure PD in macaques.SCs harvested from the autologous peripheral nerves can avoid rejection and the ethics problems,so it is expected to be applied clinically. | Ying Xia Chengchuan Jiang Zuowei Cao Keshan Shi Yang Wang | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，1： | 1 |
| 7 | A Sim-ple Hybrid Wire-wireless Fiber Laser Sensor by DirectlyPhotonic Generation of Beat Signal显示文摘 | Shengchun Liu Liang Gao Zuowei Yin Yuechun Shi Liang Zhang Xiangfei Chen and Jianchun Cheng | 2011 | Applied Optics2011，50，12： | 1 |
| 8 | A pilot study on ^(99m)Tc-3PRGD2 scintigraphy in diagnosis of brain glioma显示文摘The 99mTc-3PRGD2 targeted SPECT/CT scanning was of significance in detecting differentiated glioma.In this work,the diagnostic value of 99mTc-3PRGD2 scintigraphy in brain glioma was evaluated by the ten clinically verified brain glioma patients after obtaining informed consent.The patients first accepted X-ray imaging to localize the detecting regions before administrating with 99mTc-3PRGD2 at a mean radioactivity of 849±115 MBq via single intravenous bolus injection 2 h prior to SPECT/CT imaging.Tumor samples for detectingαvβ3 were collected by surgical operations two weeks after the scintigraphy.The results of CT and SPECT scanning were merged and compared.The correlation between tumor occupation(T/N ratio) andαvβ3 expression level were analyzed.The T/N ratios in brain glioma were proportionally correlated to av(33 positive cell percentage(R2=0.9253,p<0.05).This study primarily evaluated the clinical application of 99mTc-3PRGD2 SPECT scintigraphy on brain glioma.The more pathological types and detecting strategies covering a large amount of samples would aid to clarify the potentials. | GAO Shi MA Qingjie CUI Qu LIU Lin ZHOU Xueyan JIA Bing CHEN Zuowei ZHANG Haishan | 2013 | Nuclear Science and Techniques2013，24，2： | 1 |
| 9 | ^(131)I-chTNT-mediated radioimmunotherapy for non-uptaking ^(131)I pulmonary metastases from differentiated thyroid carcinoma显示文摘In this paper,the safety and efficacy of 131I-labeled mouse/human chimeric monoclonal antibody(131I-chTNT)-mediated radioimmunotherapy are evaluated because the patients have non-uptaking 131I pulmonary metastases from differentiated thyroid carcinoma(DTC).The 16 patients were injected intravenously by 29.6±3.7MBq·kg–1 using 131I-chTNT.The chest computer tomography was performed before treatment,as well as 28 and 70days after treatment.Responses and safety were assessed during the treatment.The results show that the 131I-chTNT infusion was well tolerated with the 12.5%complete response,18.8%partial response,25.0%progressive disease,and the 43.8%stable disease,indicating that most treatment-related adverse effects are mild transient and reversible.The131I-chTNT is promising for patients with non-uptaking the 131I pulmonary metastases from DTC. | GAO Shi JI Tiefeng WEN Qiang CHEN Bin MA Qingjie CHEN Zuowei LIU Lin | 2013 | Nuclear Science and Techniques2013，24，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员