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| 1 | N^6-Methyladenosine modification: a novel pharmacological target for anti-cancer drug development显示文摘N6-Methyladenosine(m6 A) modification is the most pervasive modification of human mRNA molecules. It is reversible via regulation of m6 A modification methyltransferase, demethylase and proteins that preferentially recognize m6 A modification as 'writers', 'erasers' and 'readers', respectively. Altered expression levels of the m6 A modification key regulators substantially affect their function, leading to significant phenotype changes in the cell and organism. Recent studies have proved that the m6 A modification plays significant roles in regulation of metabolism, stem cell self-renewal, and metastasis in a variety of human cancers. In this review, we describe the potential roles of m6 A modification in human cancers and summarize their underlying molecular mechanisms. Moreover, we will highlight potential therapeutic approaches by targeting the key m6 A modification regulators for cancer drug development.& 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license(http://gffzzeb6f7f563f66445dhbcvx5p56n5w96o9v.ffgz.tsg.suse.edu.cn/licenses/by-nc-nd/4.0/). | Yi Niu Arabella Wan Ziyou Lin Xiongbin Lu Guohui Wan | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 5 |
| 2 | Coastal wetlands in Lianyungang,Jiangsu Province,China:probably the most important site globally for the Asian Dowitcher(Limnodromus semipalmatus)显示文摘Background:Despite an increasing number of surveys and a growing interest in birdwatching,the population and distribution of Asian Dowitcher(Limnodromus semipalmatus),a species endemic to the East Asian-Australasian and Central Asian Flyways,remains poorly understood,and published information about the species is largely outdated.In boreal spring 2019,over 22,432 Asian Dowitchers were recorded in a coastal wetland at Lianyungang,Jiangsu Prov-ince,China,constituting 97.5%of its estimated global population.Methods:In 2019 and 2020,we conducted field surveys at Lianyungang to determine the numbers of Asian Dow-itchers using the area during both southward and northward migrations.We also assessed the distribution and abun-dance of Asian Dowitchers elsewhere along the China coast by searching literature and consulting expert opinion.Results:The coastal wetlands of Lianyungang are the most important stopover site for Asian Dowitchers during both northward and southward migrations;they supported over 90%of the estimated global population during north-ward migration in two consecutive years(May 2019 and 2020).This area also supported at least 15.83%and 28.42%(or 30.74%and 53.51%using modelled estimates)of the global population during southward migration in 2019 and 2020 respectively.Coastal wetlands in the west and north of Bohai Bay also have been important stopover sites for the species since the 1990s.Although comprehensive,long-term monitoring data are lacking,available evidence sug-gests that the population of the species may have declined.Conclusions:The high concentration of Asian Dowitchers at Lianyungang during migration means the species is highly susceptible to human disturbances and natural stochastic events.The coastal wetlands of Lianyungang should be protected and potentially qualify for inclusion in China’s forthcoming nomination for World Heritage listing of Migratory Bird Sanctuaries along the Coast of Yellow Sea-Bohai Gulf of China(Phase II)in 2023.Additional research is needed to understand Asian Dowitchers’distribution and ecology,as well as why such a high proportion of their population rely on the Lianyungang coast. | Ziyou Yang Jing Li Yongxiang Han Chris J.Hassell Kar-Sin Katherine Leung David S.Melville Yat-tung Yu Lin Zhang Chi-Yeung Choi | 2021 | Avian Research2021，12，3： | 1 |
| 3 | LncRP11-675F6.3 responds to rapamycin treatment and reduces triglyceride accumulation via interacting with HK1 in hepatocytes by regulating autophagy and VLDL-related proteins显示文摘Long noncoding RNAs(lncRNAs)have been widely proven to be involved in liver lipid homeostasis.Herein,we identify an upregulated lncRNA named lncRP11-675F6.3 in response to rapamycin treatment using a microarray in HepG2 cells.Knockdown of lncRP11-675F6.3 leads to a significant reduction in apolipoprotein 100(ApoB100),microsomal triglyceride transfer protein(MTTP),ApoE and ApoC3 with increased cellular triglyceride level and autophagy.Furthermore,we find that ApoB100 is obviously colocalized with GFP-LC3 in autophagosomes when lncRP11-675F6.3 is knocked down,indicating that elevated triglyceride accumulation likely related to autophagy induces the degradation of ApoB100 and impairs very low-density lipoprotein(VLDL)assembly.We then identify and validate that hexokinase 1(HK1)acts as the binding protein of lncRP11-675F6.3 and mediates triglyceride regulation and cell autophagy.More importantly,we find that lncRP11-675F6.3 and HK1 attenuate high fat diet induced nonalcoholic fatty liver disease(NAFLD)by regulating VLDL-related proteins and autophagy.In conclusion,this study reveals that lncRP11-675F6.3 is potentially involved in the downstream of mTOR signaling pathway and the regulatory network of hepatic triglyceride metabolism in cooperation with its interacting protein HK1,which may provide a new target for fatty liver disorder treatment. | Lingling Wang Xiaojuan Fang Ziyou Yang Xueling Li Mengdi Cheng Liang Cheng Ganglin Wang Wei Li Lin Liu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，10： | 0 |
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