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| 1 | Curative effect of acupuncture on quality of life in patient with depression: a clinical randomized single-blind placebo-controlled study显示文摘OBJECTIVE:To evaluate the effect of acupuncture on the quality of life in patients with depression by clinical randomized single-blind placebo-controlled study.METHODS:one hundred and sixty-three cases of depression according with the inclusion criteria were randomly divided into a group of acupuncture dredging liver and regulating flow of theosophy(group 1),a group of acupoint shallow stab(group 2)and a group of non-acupoint shallow stab(group 3)at 1∶1∶1 ratio,and treated with acu-puncture,moxibustion,and intradermal embedding of needle,twice a week,for a total of 12 weeks.Scale of Quality of Life(SF-36)was used to measure the scores at four different time points and evaluate the effect of acupuncture on the quality of life of the patients with depression.RESULTS:At each time point after treatment,in scores of the 8 items,physical function,physical role,bodily pain,general physical condition,energy,social function,emotional function and mental health there were statistically significant differences among the 3 groups(P<0.0125).CONCLUSION:Acupuncture can effectively improve the quality of life of patients with depression. | Fan Ling Fu Wenbin Chen Zhao Xu Nenggui Liu Jianhua LǚAiping Li Ziping Su Shengyong Wu Taixiang Ou Aihua | 2016 | Journal of Traditional Chinese Medicine2016，36，2： | 12 |
| 2 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 3 | Smart Substation Integration Technology and Its Application in Distribution Power Grid显示文摘At present,smart substations use the IEC61850 standard based on the architectural framework of three layers and two networks to realize information digitization and advanced applications.Although the smart substation offers many improvements in design,equipment manufacturing,and construction,the intelligent devices used in smart substations are costly,and are also difficult to maintain since they are dispersed within a single unit.Functionality optimization and device integration,thus,have become important issues in smart substation development.This paper presents an integrated solution and implementation process for a smart substation system.In the process layer,an integrated intelligence component is developed that functions both as an intelligent terminal and a merging unit.In the bay layer,an integrated station-area protection measurement and control master device is designed to achieve such functions as protection,monitoring,control,fault recorder,and power quality monitoring.Finally,in the station control layer,an integrated information platform is established to bring together various system functions and to promote interactive sharing.Integration technology improves the economy and practicality of the smart substation,especially in a distribution power grid. | Qipeng Song Wanxing Sheng Lingfeng Kou Dongbo Zhao Ziping Wu Hengfu Fang Xiaolong Zhao | 2016 | CSEE Journal of Power and Energy Systems2016，2，4： | 6 |
| 4 | Synthesis and Characterization of Sphere-like Pt Nanoparticles Supported on DWCNT/WO_3 Nanorods with Electrocatalytic Activity显示文摘Tungsten oxide(WO3) nanorods, which were used to load platinum(Pt) nanoparticles, were investigated. H2WO4 nanorods with diameters from 10 to 50 nm were obtained when tungsten precursor was added into homogenous double-walled carbon nanotubes(DWCNT) and ethylene glycol(EG) solution.Nanosized rod-like WO3 were achieved after calcination of the DWCNT/H2WO4 composite. Sphere-like Pt nanoparticles were loaded on the surface of the nanorods by EG in-situ reduction. Pt particles were isolated by DWCNT/WO3 nanorods and secondary accumulation could be prevented when Pt particles appeared in the DWCNT/WO3 nanorod/EG dispersion solution. Therefore, Pt nanoparticles with mean diameters of 2–6 nm could be obtained. Pt-deposited on DWCNT/WO3 nanorods exhibited high electrochemical activity, which could facilitate the low-cost mass production of Pt catalyst. | Yanhong Yin Chun'an Ma Ziping Wu Man Zhao Litao Chen Youqun Chu | 2015 | Journal of Materials Science & Technology2015，31，9： | 4 |
| 5 | Survival difference between EGFR Del19 and L858R mutant advanced non-small cell lung cancer patients receiving gefitinib:a propensity score matching analysis显示文摘Objective: Although superior clinical benefits of epidermal growth factor receptor(EGFR) tyrosine kinase inhibitors(TKIs) in the treatment of advanced non-small-cell lung cancer(NSCLC) had been reported,the survival difference between exon 19 deletion(Del19) and exon 21 Leu858 Arg substitution(L858 R) remains controversial.The purpose of this study is to investigate the differences in progression-free survival(PFS) and overall survival(OS) between different EGFR mutant subtypes among advanced NSCLC patients receiving gefitinib.Methods: There were 204 advanced NSCLC patients with EGFR mutations treated with gefitinib were enrolled in this retrospective cohort study.Patients were divided into the EGFR Del19 group and the L858 R mutated group according to their mutant subtype.Propensity score matching(PSM) was conducted by using a nearest-neighbor algorithm(1:1) to adjust for demographical and clinical covariates.Survival curves were constructed with the Kaplan-Meier method and compared by using the log-rank test.Results: The PFS in Del19 group was similar to that in the L858 R group [before PSM 8.6 vs.7.2 months,P=0.072; after PSM 7.3 vs.7.2 months,P=0.155].No differences were detected in OS between the L858 R and the Del19 group(before PSM 17.8 vs.13.1 months,P=0.253; after PSM 16.9 vs.13.1 months,P=0.339).The Del19 group was significantly younger compared with the L858 R mutation group in age(P=0.015).Conclusions: No significant difference was found in the PFS or OS between the Del19 and L858 R mutant NSCLC patients receiving gefitinib.The age gap might contribute to the survival differences between Del19 and L858 R groups.PSM is of important value to the elimination of potential bias. | Minglei Zhuo Qiwen Zheng Jun Zhao Meina Wu Tongtong An Yuyan Wang Jianjie Li Shuhang Wang Jia Zhong Xue Yang Hanxiao Chen Bo Jia Zhi Dong Emei Gao JingjingWang Ziping Wang | 2017 | Chinese Journal of Cancer Research2017，29，6： | 4 |
| 6 | Self-attention transfer networks for speech emotion recognition显示文摘Background A crucial element of human-machine interaction,the automatic detection of emotional states from human speech has long been regarded as a challenging task for machine learning models.One vital challenge in speech emotion recognition(SER)is learning robust and discriminative representations from speech.Although machine learning methods have been widely applied in SER research,the inadequate amount of available annotated data has become a bottleneck impeding the extended application of such techniques(e.g.,deep neural networks).To address this issue,we present a deep learning method that combines knowledge transfer and self-attention for SER tasks.Herein,we apply the log-Mel spectrogram with deltas and delta-deltas as inputs.Moreover,given that emotions are time dependent,we apply temporal convolutional neural networks to model the variations in emotions.We further introduce an attention transfer mechanism,which is based on a self-attention algorithm to learn long-term dependencies.The self-attention transfer network(SATN)in our proposed approach takes advantage of attention transfer to learn attention from speech recognition,followed by transferring this knowledge into SER.An evaluation built on Interactive Emotional Dyadic Motion Capture(IEMOCAP)dataset demonstrates the effectiveness of the proposed model. | Ziping ZHAO Keru Wang Zhongtian BAO Zixing ZHANG Nicholas CUMMINS Shihuang SUN Haishuai WANG Jianhua TAO Björn WSCHULLER | 2021 | Virtual Reality & Intelligent Hardware2021，3，1： | 3 |
| 7 | N-Doped Carbon Nanofibers Encapsulating CoO@Co_(9)S_(8) Nanoparticles:Preparation from S-Rich Co_(32) Coordination Cluster Precursors by Electrospinning and Application for Superior Li-ion Storage显示文摘Thiacalixarene-supported Co_(32) nanoclusters encapsulated in polyacrylonitrile nanofibers(Co_(32)@PAN-NFs)by electrospinning have been utilized as precursors to fabricate N-doped CoO@Co_(9)S_(8) carbon nanofibers(CoO@Co_(9)S_(8)@CNFs)for superior Li-ion storage.The S-rich Co_(32) clusters capped by organic sheets afforded the well dispersed cobalt oxide/sulfide nanoparticles embedded in carbon nanofiber composites by direct calcination.The N-doped CoO@Co_(9)S_(8)@CNFs nanocomposites have been utilized as anode materials for lithium ion battery with the reversible capabilities being of 1051.8,967.6,894.7,782.7,669.5 and 525.4 mA·h/g at 0.1,0.2,0.5,1,2 and 3 A/g,respectively.The CoO@Co_(9)S_(8)@CNFs also showed a relatively high stable capacity of 551.7 mA·h/g at the current density of 1 A/g after 200 cycles of rate experiments.The as-obtained N-doped CoO@Co_(9)S_(8)@CNFs nanocomposites exhibited superior reversible capacity,rate performance,Coulomb efficiency(74.5%vs.63.9%)and cyclic stability comparing with the CoO@Co_(9)S_(8)@C derived from simple annealing of Co_(32) templates. | YANG Siran AI Feixue LI Ziping ZHAO Guiyan BI Yanfeng | 2022 | Chemical Research in Chinese Universities2022，38，2： | 1 |
| 8 | Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first-line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, randomized, open-label, parallel controlled clinical study显示文摘Background:Lipusu is the first commercialized liposomal formulation of pacli-taxel and has demonstrated promising efficacy against locally advanced lung squamous cell carcinoma(LSCC)in a small-scale study.Here,we conducted a multicenter,randomized,phase 3 study to compare the efficacy and safety of cis-platin plus Lipusu(LP)versus cisplatin plus gemcitabine(GP)as first-line treat-ment in locally advanced or metastatic LSCC.Methods:Patients enrolled were aged between 18 to 75 years,had locally advanced(clinical stage IIIB,ineligible for concurrent chemoradiation or surgery)or metastatic(Stage IV)LSCC,had no previous systemic chemother-apy and at least one measurable lesion as per the Response Evaluation Criteria in Solid Tumors(version 1.1)before administration of the trial drug.The primary endpoint was progression-free survival(PFS).The secondary endpoints included objective response rate(ORR),disease control rate(DCR),overall survival(OS),and safety profiles.To explore the possible predictive value of plasma cytokines for LP treatment,plasma samples were collected from the LP group at baseline and first efficacy evaluation time and were then subjected to analysis by 45-Plex ProcartaPlex Panel 1 to detect the presence of 45 cytokines using the Luminex xMAP technology.The correlation between treatment outcomes and dynamic changes in the levels of cytokines were evaluated in preliminary analyses.Results:The median duration of follow-up was 15.4 months.237 patients in the LP group and 253 patients in the GP group were included in the per protocol set(PPS).In the PPS,the median PFS was 5.2 months versus 5.5 months in the LP and GP group(hazard rtio[HR]:1.03,P=0.742)respectively.The median OS was 14.6 months versus 12.5 months in the LP and GP group(HR:0.83,P=0.215).The ORR(41.8%versus 45.9%,P=0.412)and DCR(90.3%versus 88.1%,P=0.443)were also similar between the LP and GP group.A significantly lower proportion of patients in the LP group experienced adverse events(AEs)leading to treatment interruptions(10.9%versus 26.4%,P<0.001)or treatment termination(14.3%versus 23.1%,P=0.011).The analysis of cytokine levels in the LP group showed that low baseline levels of 27 cytokines were associated with an increased ORR,and 15 cytokines were associated with improved PFS,with 14 cytokines,including TNF-a,IFN-y,IL-6,and IL-8,demonstrating an overlapping trend.Conclusion:The LP regimen demonstrated similar PFS,OS,ORR and DCR as the GP regimen for patients with locally advanced or metastatic LSCC but had more favorable toxicity profiles.The study also identified a spectrum of different cytokines that could be potentially associated with the clinical benefit in patients who received the LP regimen. | Jie Zhang Yueyin Pan Qin Shi Guojun Zhang Liyan Jiang Xiaorong Dong Kangsheng Gu Huijuan Wang Xiaochun Zhang Nong Yang Yuping Li Jianping Xiong Tienan Yi Min Peng Yong Song Yun Fan Jiuwei Cui Gongyan Chen Wei Tan Aimin Zang Qisen Guo Guangqiang Zhao Ziping Wang Jianxing He Wenxiu Yao Xiaohong Wu Kai Chen Xiaohua Hu Chunhong Hu Lu Yue Da Jiang Guangfa Wang Junfeng Liu Guohua Yu Junling Li Jianling Bai Wenmin Xie Weihong Zhao Lihong Wu Caicun Zhou | 2022 | Cancer Communications2022，42，1： | 1 |
| 9 | Terahertz metalens of hyper-dispersion显示文摘Chromatic optical lenses have promising applications in three-dimensional imaging, which allows fast spectral tomography without mechanical moving parts. The scanning range of current chromatic optical lenses is limited by their dispersion ability. The recent development in metasurfaces provides ideal blocks for optical wavefront manipulation and dispersion engineering of artificial materials at sub-wavelength scales. Hyper-dispersive metalenses can be realized by utilizing dispersive meta-atoms, which have enhanced dispersion compared to regular diffractive lenses. This is critical for increasing the imaging depth of fast spectral tomography. In this work, a hyper-dispersive metalens is realized with a chromatic dispersion 1.76 times greater than that of a regular diffractive metalens in the THz frequency range of 2.40–2.61 THz by simultaneously controlling the frequencydependent phase, group delay(GD), and GD dispersion of the metalens. This approach can also be extended to other optical spectra and improve the performance of spectral tomography. | Fen Zhao Ziping Li Sheng Li Xuemei Dai Yi Zhou Xiaoyu Liao JCCao Gaofeng Liang Zhengguo Shang Zhihai Zhang Zhongquan Wen Hua Li Gang Chen | 2022 | Photonics Research2022，10，4： | 1 |
| 10 | Highly sensitive piezoresistive and thermally responsive fibrous networks from the in situ growth of PEDOT on MWCNT-decorated electrospun PU fibers for pressure and temperature sensing显示文摘Flexible electronics have demonstrated various strategies to enhance the sensory ability for tactile perception and wearable physiological monitoring.Fibrous microstructures have attracted much interest because of their excellent mechanical properties and fabricability.Herein,a structurally robust fibrous mat was first fabricated by electrospinning,followed by a sequential process of functionalization utilizing ultrasonication treatment and in situ polymerization growth.Electrospun polyurethane(PU)microfibers were anchored with multi-walled carbon nanotubes(MWCNTs)to form conductive paths along each fiber by a scalable ultrasonic cavitation treatment in an MWCNT suspension.After,a layer of poly(3,4-ethylene dioxythiophene)(PEDOT)was grown on the surface of PU fibers decorated with MWCNTs to enhance the conductive conjunctions of MWCNTs.Due to the superior electromechanical behaviors and mechanical reinforcement of PEDOT,the PEDOT/MWCNT@PU mat-based device exhibits a wide working range(0–70 kPa),high sensitivity(1.6 kPa−1),and good mechanical robustness(over 18,000 cycles).The PEDOT/MWCNT@PU mat-based sensor also demonstrates a good linear response to different temperature variations because of the thermoelectricity of the PEDOT/MWCNT composite.This novel strategy for the fabrication of multifunctional fibrous mats provides a promising opportunity for future applications for high-performance wearable devices. | Yunyun Luo Libo Zhao Guoxi Luo Linxi Dong Yong Xia Min Li Ziping Li Kaifei Wang Ryutaro Maeda Zhuangde Jiang | 2023 | Microsystems & Nanoengineering2023，9，5： | 0 |
| 11 | Associations of genome-wide structural variations with phenotypic differences in cross-bred Eurasian pigs显示文摘Background During approximately 10,000 years of domestication and selection,a large number of structural variations(SVs)have emerged in the genome of pig breeds,profoundly influencing their phenotypes and the ability to adapt to the local environment.SVs(≥50 bp)are widely distributed in the genome,mainly in the form of insertion(INS),mobile element insertion(MEI),deletion(DEL),duplication(DUP),inversion(INV),and translocation(TRA).While studies have investigated the SVs in pig genomes,genome-wide association studies(GWAS)-based on SVs have been rarely conducted.Results Here,we obtained a high-quality SV map containing 123,151 SVs from 15 Large White and 15 Min pigs through integrating the power of several SV tools,with 53.95%of the SVs being reported for the first time.These high-quality SVs were used to recover the population genetic structure,confirming the accuracy of genotyping.Potential functional SV loci were then identified based on positional effects and breed stratification.Finally,GWAS were performed for 36 traits by genotyping the screened potential causal loci in the F2 population according to their corresponding genomic positions.We identified a large number of loci involved in 8 carcass traits and 6 skeletal traits on chromosome 7,with FKBP5 containing the most significant SV locus for almost all traits.In addition,we found several significant loci in intramuscular fat,abdominal circumference,heart weight,and liver weight,etc.Conclusions We constructed a high-quality SV map using high-coverage sequencing data and then analyzed them by performing GWAS for 25 carcass traits,7 skeletal traits,and 4 meat quality traits to determine that SVs may affect body size between European and Chinese pig breeds. | Wencheng Zong Jinbu Wang Runze Zhao Naiqi Niu Yanfang Su Ziping Hu Xin Liu Xinhua Hou Ligang Wang Lixian Wang Longchao Zhang | 2024 | Journal of Animal Science and Biotechnology2024，15，1： | 0 |
| 12 | Single-pulse Emission Variation of Two Pulsars Discovered by FAST显示文摘We investigate the single-pulse emission variations of two pulsars,PSRs J0211+4235 and J0553+4111,observed with the Five-hundred-meter Aperture Spherical radio Telescope at the 1.25 GHz central frequency.The observation sessions span from 2020 December to 2021 July,with 21 and 22 observations for them respectively.The integrated pulse profile of PSR J0211+4235 shows that there is a weak pulse component following the main component,and PSR J0553+4111 displays a bimodal profile with a bridge component in the middle.PSR J0211+4235 presents significant nulling phenomenon with nulling duration lasting from 2 to 115 pulses and burst duration lasting from 2 to 113 pulses.The NF of each observation is determined to be 45%-55%.No emission greater than threeσis found in the mean integrated profile of all nulling pulses.In most cases,the pulse energy changes abruptly during the transition from null to burst,while in the transition from burst to null there are two trends:abrupt and gradual.We find that the nulling phenomenon of PSR J0211+4235 is periodic by the Fourier transform of the null and burst state.In addition,the single-pulse modulation characteristics of these two pulsars are investigated,and the distributions of modulation index,LRFS and 2DFS are analyzed with PSRSALSA.The left peak of PSR J0553+4111 has intensity modulation.Finally,the polarization properties of these two pulsars are obtained through polarization calibration,and their characteristics are analyzed.The possible physical mechanisms of these phenomena are discussed. | Ziping Guo Zhigang Wen Jianping Yuan Feifei Kou Qingdong Wu Na Wang Weiwei Zhu Di Li Mengyao Xue Pei Wang Chenchen Miao De Zhao Yue Hu Wenming Yan Jiarui Niu Rukiye Rejep Zhipeng Huang | 2023 | Research in Astronomy and Astrophysics2023，23，7： | 0 |
| 13 | Frustration recognition from speech during game interaction using wide residual networks显示文摘Background Although frustration is a common emotional reaction while playing games,an excessive level of frustration can negatively impact a user's experience,discouraging them from further game interactions.The automatic detection of frustration can enable the development of adaptive systems that can adapt a game to a user's specific needs through real-time difficulty adjustment,thereby optimizing the player's experience and guaranteeing game success.To this end,we present a speech-based approach for the automatic detection of frustration during game interactions,a specific task that remains under explored in research.Method The experiments were performed on the Multimodal Game Frustration Database(MGFD),an audiovisual dataset-collected within the Wizard-of-Oz framework-that is specially tailored to investigate verbal and facial expressions of frustration during game interactions.We explored the performance of a variety of acoustic feature sets,including Mel-Spectrograms,Mel Frequency Cepstral Coefficients(MFCCs),and the low-dimensional knowledge-based acoustic feature set eGeMAPS.Because of the continual improvements in speech recognition tasks achieved by the use of convolutional neural networks(CNNs),unlike the MGFD baseline,which is based on the Long Short Term Memory(LSTM)architecture and Support Vector Machine(SVM)classifier-in the present work,we consider typical CNNs,including ResNet,VGG,and AlexNet.Furthermore,given the unresolved debate on the suitability of shallow and deep networks,we also examine the performance of two of the latest deep CNNs:WideResNet and EfficientNet.Results Our best result,achieved with WideResNet and Mel-Spectrogram features,increases the system performance from 58.8%unweighted average recall(UAR)to 93.1%UAR for speech-based automatic frustration recognition. | Meishu SONG Adria MALLOL-RAGOLTA Emilia PARADA-CABALEIRO Zijiang YANG Shuo LIU Zhao REN Ziping ZHAO Björn WSCHULLER | 2021 | Virtual Reality & Intelligent Hardware2021，3，1： | 0 |
| 14 | Study on Sustainable Development Capability of Shandong Province显示文摘Based on the indicator system of Sustainable Development (SD), Shandong Province was select- ed as an example for assessment with AHP method and the standard year was 1978. The conclusion was that Shandong Province’ s ability of SD was be- ing strengthened step by step, and there were also some restrictive factors, and according to the basic conditions of Shandong Province, countermeasures and strategy of SD were put forward. | Ren Ziping Luo Qishan Wang Yanchun Deng Hongbing Zhao Jingzhu | 2005 | Science Foundation in China2005，13，2： | 0 |
| 15 | A Research and Analysis Method of Open Source Threat Intelligence Data显示文摘As the form of cyber threats becomes more complex,which leads to a widespread concern about how to promote network security active defense system by using the exploding cyber threat intelligence.Basing on the content analysis method,introduces the precision,recall rate and timely rate on the basis of the change of time dimension,and analyzes the threat intelligence provider from three aspects.The validity of this method is verified by the test of massive source of threat data,which improves the efficiency of CIF analysis and makes it easy to analyze and extract the threat intelligence information quickly. | Ruyue Liu Ziping Zhao Chengjun Sun Xiaoyu Yang Xiaoli Gong Jin Zhang | 2017 | 国际计算机前沿大会会议论文集2017，，1： | 0 |
| 16 | Increased Soluble Epoxide Hydrolase Activity Positively Correlates with Mortality in Heart Failure Patients with Preserved Ejection Fraction:Evidence from Metabolomics显示文摘Epoxyeicosatrienoic acids(EETs)have pleiotropic endogenous cardiovascular protective effects and can be hydrolyzed to the corresponding dihydroxyeicosatrienoic acids by soluble epoxide hydrolase(sEH).Heart failure with preserved ejection fraction(HFpEF)has shown an increased prevalence and worse prognosis over the decades.However,the role of sEH activ-ity in HFpEF remains unclear.We enrolled 500 patients with HFpEF and 500 healthy controls between February 2010 and March 2016.Eight types of sEH-related eicosanoids were measured according to target metabolomics,and their correlation with clinical endpoints was also analyzed.The primary endpoint was cardiac mortality,and the secondary endpoint was a composite of cardiac events,including heart failure(HF)readmission,cardiogenic hospitalization,and all-cause mortal-ity.Furthermore,the effect of sEH inhibitors on cardiac diastolic function in HFpEF was investigated in vivo and in vitro.Patients with HFpEF showed significantly enhanced EET degradation by the sEH enzyme compared with healthy controls.More importantly,sEH activity was positively correlated with cardiac mortality in patients with HFpEF,especially in older patients with arrhythmia.A consistent result was obtained in the multiple adjusted models.Decreased sEH activity by the sEH inhibitor showed a significant effective effect on the improvement of cardiac diastolic function by ameliorating lipid disorders in cardiomyocytes of HFpEF mouse model.This study demonstrated that increased sEH activity was associated with cardiac mortality in patients with HFpEF and suggested that sEH inhibition could be a promising therapeutic strategy to improve diastolic cardiac function.Clinical trial identifier:NCT03461107(https://clini caltr ials.gov). | Liyuan Peng Ziping Song Chengcheng Zhao Kudusi Abuduwufuer Yanwen Wang Zheng Wen Li Ni Chenze Li Ying Yu Yi Zhu Hualiang Jiang Jinshan Shen Xiangrui Jiang Chen Chen Xu Zhang Dao Wen Wang | 2023 | Phenomics2023，3，1： | 0 |
| 17 | Si-based InGaAs photodetectors on heterogeneous integrated substrate显示文摘In this paper,InGaAs p-i-n photodetectors(PDs)on an InP/SiO2/Si(InPOI)substrate fabricated by ion-slicing technology are demonstrated and compared with the identical device on a commercial InP substrate.The quality of epitaxial layers on the InPOI substrate is similar to that on the InP substrate.The photo responsivities of both devices measured at 1.55μm are comparable,which are about 0.808-0.828 A W^(-1).Although the dark current of PD on the InPOI substrate is twice as high as that of PD on the InP substrate at 300 K,the peak detectivities of both PDs are comparable.In general,the overall performance of the InPOI-based PD is comparable to the InP-based PD,demonstrating that the ion-slicing technology is a promising route to enable the highquality Si-based InP platform for the full photonic integration on a Si substrate. | Chaodan Chi Jiajie Lin Xingyou Chen Chengli Wang Ziping Li Liping Zhang Zhanglong Fu Xiaomeng Zhao Hua Li Tiangui You Li Yue Jiaxiang Zhang Niefeng Sun Peng Gao Robert Kudrawiec Shumin Wang Xin Ou | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，6： | 0 |
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