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| 1 | Validation of the Nanjing Criteria for Diagnosing Pyrrolizidine Alkaloids-induced Hepatic Sinusoidal Obstruction Syndrome显示文摘Background and Aims:Hepatic sinusoidal obstruction syndrome(HSOS)is caused by toxic injury to sinusoidal endothelial cells in the liver.The intake of pyrrolizidine alkaloids(PAs)in some Chinese herbal remedies/plants remains the major etiology for HSOS in China.Recently,new diagnostic criteria for PA-induced HSOS(i.e.PA-HSOS)have been developed;however,the efficacy has not been clinically validated.This study aimed to assess the performance of the Nanjing criteria for PA-HSOS.Methods:Data obtained from consecutive patients in multiple hospitals,which included 86 PA-HSOS patients and 327 patients with other liver diseases,were retrospectively analyzed.Then,the diagnostic performance of the Nanjing criteria and simplified Nanjing criteria were evaluated and validated.The study is registered in www.chictr.org.cn(ID:ChiCTR1900020784).Results:The Nanjing criteria have a sensitivity and specificity of 95.35%and 100%,respectively,while the simplified Nanjing criteria have a sensitivity and specificity of 96.51%and 96.33%,respectively,for the diagnosis of PA-HSOS.Notably,a proportion of patients with Budd-Chiari syndrome(11/49)was misdiagnosed as PA-HSOS on the basis of the simplified Nanjing criteria,and this was mainly due to the overlapping features in the enhanced computed tomography/magnetic resonance imaging examinations.Furthermore,most of these patients(10/11)had occlusion or thrombosis of the hepatic vein,and communicating vessels in the liver were found in 8/11 patients,which were absent in PA-HSOS patients.Conclusions:The Nanjing criteria and simplified Nanjing criteria exhibit excellent performance in diagnosing PA-HSOS.Thus,both could be valuable diagnostic tools in clinical practice. | Wei Zhang Lu Liu Ming Zhang Feng Zhang Chunyan Peng Bin Zhang Jun Chen Lin Li Jian He Jiangqiang Xiao Yanhong Feng Xunjiang Wang Aizhen Xiong Li Yang Xiaoping Zou Yuecheng Yu Yuzheng Zhuge | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 4 |
| 2 | Proton pump inhibitor pantoprazole abrogates adriamycin-resistant gastric cancer cell invasiveness via suppression of Akt/GSK-β/β-catenin signaling and epithelial–mesenchymal transition显示文摘 | Bin Zhang Yan Yang Xiaoting Shi Wanyu Liao Min Chen Alfred Sze-Lok Cheng Hongli Yan Cheng Fang Shu Zhang Guifang Xu Shanshan Shen Shuling Huang Guangxia Chen Ying Lv Tingsheng Ling Xiaoqi Zhang Lei Wang Yuzheng Zhuge Xiaoping Zou | 2014 | Cancer Letters2014，，： | 2 |
| 3 | Expression of a Bacillus subtilis pectate lyase gene in Pichia pastoris显示文摘 | Zhuge Bin Du Guo Cheng Shen Wei | | 0，，01： | 1 |
| 4 | Expression of a Bacillus subtilis pectate lyase gene in Pichia pastoris显示文摘 | Bin Zhuge Guo-Cheng Du Wei Shen Jian Zhuge Jian Chen | 2007 | Biochemical Engineering Journal2007，，1： | 1 |
| 5 | Efficient algorithms for dynamic update of shortest path tree in networking显示文摘 | Bin Xiao Qingfeng Zhuge Edwin H-M Sha | 2004 | Journal of Computers and Their Applications2004，11，1： | 1 |
| 6 | Minimum Dynamic Update for Shortest Path Tree Construction显示文摘 | Xiao Bin ZhuGe Qingfeng | 2001 | IEEE CNF2001，25，1： | 1 |
| 7 | Analysis and implementation of an open programmable router based on forwarding and control elements separation 显示文摘 | Wang Weiming Dong Ligang Zhuge Bin | 2008 | Journal of computing science and technology2008，23，5： | 1 |
| 8 | Resource Scheduling Algorithm and Ecnomic Model in ForCES Networks显示文摘Resource scheduling algorithm for ForCES(Forwarding and Control Element Separation) networks need to meet the flexibility,programmability and scalability of node resources.DBC(Deadline Budget Constrain) algorithm relies on users select cost or time priority,then scheduling to meet the requirements of users.However,this priority strategy of users is relatively simple,and cannot adapt to dynamic change of resources,it is inevitable to reduce the QoS.In order to improve QoS,we refer to the economic model and resource scheduling model of cloud computing,use SAL(Service Level Agreement) as pricing strategy,on the basis of DBC algorithm,propose an DABP(Deadline And Budget Priority based on DBC) algorithm for ForCES networks,DABP combines both budget and time priority to scheduling.In simulation and test,we compare the task finish time and cost of DABP algorithm with DP(Deadline Priority) algorithm and BP(Budget Priority) algorithm,the analysis results show that DABP algorithm make the task complete with less cost within deadline,benifical to load balancing of ForCES networks. | ZHUGE Bin DENG Li DAI Guowei WAN Lei WANG Weiming LAN Julong | 2014 | China Communications2014，11，3： | 0 |
| 9 | Histidine enhances carbamazepine action against seizures and improves spatial memory deficits induced by chronic transauricular kindling in rats显示文摘 | Qing Li Chun -Lei Jin Zheng - Bin Zhuge Li - Xia Yang Zhong Chen | 2005 | 中国药理通讯2005，22，4： | 0 |
| 10 | Bioinformatics Analysis and Identification of Key Candidate Genes Associated with Nephrotoxicity Induced by Cobalt显示文摘Cobalt(Co)is a silver-gray,high-intensity,widely distributed metal element that exists in cobalt compounds,and its common valences are bivalence(Co2+)and trivalence(Co3+)[1].The main routes of Co-exposure are occupational and environmental exposures.The human body can be exposed to high concentrations of Co2+through inhalation of contaminated air,consumption of contaminated food and water,or ingestion of Co-containing supplements[2]. | WANG Rui ZHANG Ding ZHUGE Rui Jian XUE Qian HE Chang Hao MA Wen Xuan SHEN Zhu Bin GUO Li | 2023 | Biomedical and Environmental Sciences2023，36，2： | 0 |
| 11 | Improved pinene production in a recombinant yeast by fusion linker optimization and chaperon coexpression显示文摘Pinene is an active natural monoterpene from plants and has important applications in favorings,fragrances,and pesticides.Especially,pinene dimers are regarded as renewable fuels with high density.However,the microbial pinene production was limited by the low activity pinene synthase.In this study,the pinene synthase activity was improved by fusion linker optimization and chaperon coexpression.To construct the pinene pathway in Saccharomyces cerevisiae,YPL062W gene was deleted to increase the MVA pathway precursor acetyl-CoA.Truncated 3-hydroxyl-3-methylglutaryl-CoA reductase(tHMG1),isopentenyl-diphosphate isomerase(IDI1),and farnesyl diphosphate synthase mutant(ERG20F96W−N127W)were then integrated to improve the GPP pool.Pinene synthase tPt1 was expressed in the constructed engineered yeast,and the titer of pinene reached 0.166 mg/L.GPP is the direct precursor of pinene,ERG20ww and tPt1 were fused by diferent linkers and orders to improve the accessibility of GPP.Pinene titer reached 9.94 mg/L by fusion these proteins in the order of ERG20ww and tPt1 and with a fexible linker(G)8.After that,several chaperons were coexpressed and the chaperon Sil1p improved the pinene titer to 10.2 mg/L with a yield of 1.63 mg/L·OD600.The results presented here provide novel information on the applications of protein fusion and protein chaperons in microbial pinene production. | Quanlu Ren Yaxi He Xinyao Lu Hong Zong Bin Zhuge | 2022 | Systems Microbiology and Biomanufacturing2022，2，1： | 0 |
| 12 | Research and Implementation of the SDN Resources Transaction Process Based on Trust Mechanism显示文摘SDN network as new network architecture,can address a range of issues of the current internet effectively,this paper in the view of SDN network resources' allocation,for decreasing resources waste and achieving a reasonable distribution of SDN resources,come up with a suitable resource price negotiation algorithm based on trust mechanism in SDN network environment.According to the characteristics of the trust mechanism,simulating on the unit utility and equivalent price of SDN network resources in three aspects(remove individual malicious nodes,remove most malicious nodes and remove all malicious nodes),through the above simulation,combined trust mechanism with MCDAM algorithm,can form a weighing system which pricing and trust comprehensive competitive,so that the whole SDN trading environment become safer and more stable.So trust mechanism as the patch of SDN pricing negotiation algorithm.Finally,propose the planned trading model based on trust mechanism as a management method of SDN trading. | ZHUGE Bin PENG Dan BU Xiaobo WANG Weiming | 2016 | China Communications2016，13，S1： | 0 |
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