|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3显示文摘AIM: To investigate the inhibitory role and the underlying mechanisms of sorafenib on signal transducer and activator of transcription 3 (STAT3) activity in hepatocellular carcinoma (HCC).METHODS: Human and rat HCC cell lines were treated with sorafenib. Proliferation and STAT3 dephosphorylation were assessed. Potential molecular mechanisms of STAT3 pathway inhibition by sorafenib were evaluated. In vivo antitumor action and STAT3 inhibition were investigated in an immunocompetent orthotopic rat HCC model.RESULTS: Sorafenib decreased STAT3 phosphorylationat the tyrosine and serine residues (Y705 and S727), but did not affect Janus kinase 2 (JAK2) and phosphatase shatterproof 2 (SHP2), which is associated with growth inhibition in HCC cells. Dephosphorylation of S727 was associated with attenuated extracellular signal-regulated kinase (ERK) phosphorylation, similar to the effects of a mitogen-activated protein kinase (MEK) inhibitor U0126, suggesting that sorafenib induced S727 dephosphorylation by inhibiting MEK/ERK signaling. Meanwhile, sorafenib could also inhibit Akt phosphorylation, and both the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 and Akt knockdown resulted in Y705 dephosphorylation, indicating that Y705 dephosphorylation by sorafenib was mediated by inhibiting the PI3K/Akt pathway. Finally, in the rat HCC model, sorafenib signifi cantly inhibited STAT3 activity, reducing tumor growth and metastasis.CONCLUSION: Sorafenib inhibits growth and metastasis of HCC in part by blocking the MEK/ERK/STAT3 and PI3K/Akt/STAT3 signaling pathways, but independent of JAK2 and SHP2 activation. | Fang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian ZhouFang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian Zhou, Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Shanghai 200032, China Author contributions: Gu FM, Li QL and Gao Q contributed equally to this work Gu FM and Li QL performed the experi- ments and interpretation of the data and statistical analysis Zhou J and Gao Q contributed to the conception and design of the study Gu FM, Gao Q, Li QL and Zhou J wrote the manuscript Jiang JH, Huang XY, Pan JF and Fan J made substantial contri- bution to the design and conception of the study and interpreta- tion of data all authors read and approved the f inal manuscript. | 2011 | World Journal of Gastroenterology2011，17，34： | 18 |
| 3 | Leber's hereditary optic neuropathy is associated with the mitochondrial ND4 G11696A mutation in five Chinese families显示文摘 | Zhou XT Wei QP Yang L Tong Y Zhao FX Lu CJ Qian YP Sun YH Lu F Qu J Guan MX | 2006 | 中国生物学文摘2006，20，4： | 18 |
| 4 | Rapid nongenomic inhibitory effects of glucocorticoids on phagocytosis and superoxide anion production by macrophages显示文摘 | Long F Wang YX Liu L Zhou J Cui RY Jiang CL | 2005 | 第二军医大学学报2005，26，10： | 14 |
| 5 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 6 | 柑桔黄龙病的鉴定和柯赫氏定理(英文)显示文摘黄龙(梢)病被认为是世界柑橘生产上的毁灭性病害已超过一个世纪,但该病害的病原学至今还没有清晰地建立起来。根据16S rRNA基因序列分析,一组被称为'Candidatus Liberibacter species'的难培养细菌被认为与黄龙病相关。然而,要确定'Ca.Liberibacter spp.'是黄龙病病原的柯赫氏定理并没有真正完成。令我们担忧的是,近年来有些文献频频指出'Ca.Liberibacter spp.'是黄龙病的病原,其实该细菌与柑橘寄主的直接病理反应还没有完全确定。我们建议,在黄龙病病原学清楚之前,文献报道在这方面需要有准确的阐述。 | Chen J Deng X Civerolo E L Lee R F Jones J B Zhou C Hartung J S Manjunath K L Brlansky R H | 2011 | 植物病理学报2011，41，2： | 10 |
| 7 | Effects of iptakalim on extracellular glutamate and dopamine levels in the striatum of unilateral 6-hydroxydopamine-lesioned rats: a microdialysis study显示文摘 | Yang J Hu LF Liu X Zhou F Ding JH Hu G | 2006 | 中国生物学文摘2006，20，10： | 3 |
| 8 | Effects of U50,488H on transient outward and ultra-rapid delayed rectifier K+ currents in young human atrial myocytes显示文摘 | Xiao G S Zhou J J Cheung Y F | 2003 | Eur J Pharmacol2003，473，： | 2 |
| 9 | Texture feature based on local fourier transform显示文摘 | Zhou F F Shi J Q | 2001 | IEEE International Conference on ImageProcessing2001，17，2： | 2 |
| 10 | Magnetic texture in Fe nanowire array显示文摘 | Wang J B Zhou X Z Liu Q F | 2004 | Nanotecnology2004，15，： | 2 |
| 11 | Decreased hepatic ischemia-reperfusion injury by manganese-porphyrin complexes 显示文摘 | Wu T J Khoo NH Zhou F | 2007 | Free Radic Res2007，41，2： | 1 |
| 12 | High-temperature oxidation of Fe-Cr alloys in wet oxygen显示文摘 | Shen J N Zhou L J Li T F | 1997 | Oxidation of Metals1997，48，： | 1 |
| 13 | Dissipation of oxytetracycline in soils under different redox conditions显示文摘 | YANG J F YING G G ZHOU L J | 2009 | Environl Poll2009，157，10： | 1 |
| 14 | Simulation of swirling combustion and NO formation using a USM turbulence-chemistry model显示文摘 | Zhou L Wang F Zhang J | 2003 | Fuel2003，82，13： | 1 |
| 15 | Trace Elemental and PGE Geochemical Constraints of Mesozoic and Cenozoic Peridotitic Xenoliths on Lithospheric Evolution of the North China Craton显示文摘 | Zheng J P Sun M Zhou M F | 2005 | Geochimica et Cosmoehimica Acta2005，69，13： | 1 |
| 16 | Comprehensive understanding on the formation of highly ordered mesoporous tungsten oxides by X-ray diffraction and Raman spectroscopy显示文摘 | Zhou L Ren Q J Zhou X F | 2008 | Microporous and MesoporousMaterials2008，109，13： | 1 |
| 17 | Study on an antiwear and extreme pressure additive of surface coated LaF3 nanoparticles in liquid paraffin显示文摘 | Zhou J F Wu Z S Zhang Z J | 2001 | Wear2001，249，： | 1 |
| 18 | Carbon dioxide and nitrous oxide fluxes in corn grown under two tillage systems in Southwestern Quebec显示文摘 | Almaraz J J Mabood F Zhou X M | 2009 | Soil Science Society of America Journal2009，73，1： | 1 |
| 19 | Anodic dissolution of spongy titanium in ethanol solution for preparation of nano-sized Tio2 powder显示文摘 | Zhou X F Chu D B Lin C J | 2002 | Electrochim Acta2002，47，： | 1 |
| 20 | Study on an antiwear and extreme pressure additive of surface coated LaF3 nanoparticles in liquid paraffin显示文摘 | Zhou J F Wu Z S Zhang Z J | 2001 | Wear2001，249，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员