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| 1 | Emodin alleviates cardiac fibrosis by suppressing activation of cardiac fibroblasts via upregulating metastasis associated protein 3显示文摘Excess activation of cardiac fibroblasts inevitably induces cardiac fibrosis. Emodin has been used as a natural medicine against several chronic diseases. The objective of this study is to determine the effects of emodin on cardiac fibrosis and the underlying molecular mechanisms. Intragastric administration of emodin markedly decreased left ventricular wall thickness in a mouse model of pathological cardiac hypertrophy with excess fibrosis induced by transaortic constriction(TAC) and suppressed activation of cardiac fibroblasts induced by angiotensin II(AngII). Emodin upregulated expression of metastasis associated protein 3(MTA3) and restored the MTA3 expression in the setting of cardiac fibrosis. Moreover, overexpression of MTA3 promoted cardiac fibrosis;in contrast, silence of MTA3 abrogated the inhibitory effect of emodin on fibroblast activation. Our findings unraveled the potential of emodin to alleviate cardiac fibrosis via upregulating MTA3 and highlight the regulatory role of MTA3 in the development of cardiac fibrosis. | Dan Xiao Yue Zhang Rui Wang Yujie Fu Tong Zhou Hongtao Diao Zhixia Wang Yuan Lin Zhange Li Lin Wen Xujuan Kang Philipp Kopylov Dmitri Shchekochikhin Yong Zhang Baofeng Yang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 11 |
| 2 | Effects of Forest Type and Urbanization on Carbon Storage of Urban Forests in Changchun, Northeast China显示文摘Rapid urbanization has led to dramatic changes in urban forest structures and functions, and consequently affects carbon(C) storage in cities. In this study, field surveys were combined with high resolution images to investigate the variability of C storage of urban forests in Changchun, Northeast China. The main objectives of this study were to quantify the C storage of urban forests in Changchun City, Northeast China and understand the effects of forest type and urbanization on C storage of urban forests. The results showed that the mean C density and the total C storage of urban forests in Changchun were 4.41 kg/m2 and 4.74 × 108 kg, respectively. There were significant differences in C density among urban forest types. Landscape and relaxation forest(LF) had the highest C density with 5.41 kg/m2, while production and management forest(PF) had the lowest C density with 1.46 kg/m2. These differences demonstrate that urban forest type is an important factor needed to be considered when the C storage is accurately estimated. Further findings revealed significant differences in different gradients of urbanization, and the mean C density decreased from the first ring(6.99 kg/m2) to the fourth ring(2.87 kg/m2). The total C storage increased from the first ring to the third ring. These results indicate that C storage by urban forests will be significantly changed during the process of urbanization. The results can provide insights for decision-makers and urban planners to better understand the effects of forest type and urbanization on C storage of urban forests in Changchun, and make better management plans for urban forests. | ZHANG Dan ZHENG Haifeng REN Zhibin ZHAI Chang SHEN Guoqiang MAO Zhixia WANG Peijiang HE Xingyuan | 2015 | Chinese Geographical Science2015，25，2： | 9 |
| 3 | Effects of Urbanization,Soil Property and Vegetation Configuration on Soil Infiltration of Urban Forest in Changchun,Northeast China显示文摘Urban forest soil infiltration, affected by various factors, is closely related with surface runoff. This paper studied the effect of urban forest types, vegetation configuration and soil properties on soil infiltration. In our study, 191 typical plots were sampled in Changchun City, China to investigate the soil infiltration characteristics of urban forest and its influencing factors. Our results showed that the steady infiltration rates of urban forest soil were highly variable. High variations in the final infiltration rates were observed for different vegetation patterns and compaction degrees. Trees with shrubs and grasses had the highest infiltration rate and trees with bare land had the lowest infiltration rate. In addition, our results showed that the soil infiltration rate decreased with an increase in the bulk density and with a reduction in the soil organic matter content and non-capillary porosity. The soil infiltration rate also had significantly positive relationships with the total porosity and saturated soil water content. Urban soil compaction contributed to low soil infiltration rates. To increase the infiltration rate and water storage volume of urban forest soil, proper techniques to minimize and mitigate soil compaction should be used. These findings can provide useful information for urban planners about how to maximize the water volume of urban forest soil and decrease urban instantaneous flooding. | WANG Peijiang ZHENG Haifeng REN Zhibin ZHANG Dan ZHAI Chang MAO Zhixia TANG Ze HE Xingyuan | 2018 | Chinese Geographical Science2018，28，3： | 7 |
| 4 | High-mobility group box 1 protein is involved in the protective effect of Saquinavir on ventilation-induced lung injury in mice显示文摘 | Xin Wang Renlingzi Zhang Yao Tong Xibing Ding Shuqing Jin Xiang Zhao Jiaying Zong Zhixia Chen Timothy R. Billiar Quan Li | 2017 | Acta Biochimica et Biophysica Sinica2017，49，10： | 5 |
| 5 | Transcriptome Profiling Reveals Auxin and Cytokinin Regulating Somatic Embryogenesis in Different Sister Lines of Cotton Cultivar CCRI24显示文摘在在棉花(Gossypium hirsutum L.) 位于体的 embryogenesis (SE ) 下面的分子的机制上得到一个更宽广的看法,棉花 transcriptome 动力学的全球分析用 RNA-Seq 在在不同姐妹线的 SE 期间被执行。204349 unigenes 的一个总数被 214977462 Illumina 的汇编读的 de novo 检测。量的反向的 transcriptionpolymerase 链反应(qRT-PCR ) 大小断然与几乎所有测试基因的 RNA-Seq 结果被相关(R2=0.841,关联在 0.01 水平是重要的) 。不同植物激素(植物生长素和细胞激动素) 在媒介和在在不同姐妹线的二个阶段的这二植物激素的内长的内容变化的集中比率在棉花 SE 期间建议了植物生长素和细胞激动素的角色。根据植物激素相关的基因的全球基因规定,从所有差别的众多的基因表示了抄本涉及植物生长素和细胞激动素生合成和信号 transduction 小径。差别的分析表示了涉及揭示的这些小径的基因在在二根姐妹线之间的基因类型和丰富的实质的变化。隔离,克隆并且在棉花 SE 期间揭示了显著起来表示或下面表示的基因是的 silencing/overexpressing 重要。而且,植物生长素和细胞激动素与对方或另外的因素遗体一起在 SE,而是潜在的串音起一个主要作用不清楚。 | Zhenzhen Xu Chaojun Zhang Xueyan Zhang Chuanliang Liu Zhixia Wu Zuoren Yang Kehai Zhou Xiaojie Yang Fuguang Li | 2013 | Journal of Integrative Plant Biology2013，55，7： | 5 |
| 6 | Effects of Nitrogen Concentration on Microstructure and Antibacterial Property of Copper-Bearing Austenite Stainless Steels显示文摘Austenite antibacterial stainless steels have been found to have wide applications in hospitals and food indus- tries.In recent years epsilon copper precipitation in antibacterial stainless steels has obtained much research interest due to its antibacterial action.The objective of this study was to determine the effects of nitro- gen concentration on the precipitation of epsilon copper and antibacterial property.Two kinds of austenite antibacterial stainless steels containing copper and different nitrogen concentration(0.02 and 0.08 wt pct,re- spectively)were prepared and the microstructures were characterized by a combination of electron microscopy and thermodynamic analysis.A mathematical expression was deduced to predict the effect of nitrogen con- centration on the activity coefficient of copper,In(f_(Cu)/f_(cu)~0=0.53524+4.11x_N-0.48x_N^2.Higher nitrogen was found to increase the free energy difference of copper concentration distribution between precipitation phase and austenite matrix,stimulate the aggregation of copper atoms from austenite,increase the precipitation amount and consequently enhance the antibacterial property of steel. | Zhixia ZHANG Laizhu JIANG Gang LIN Zhou XU | 2008 | Journal of Materials Science & Technology2008，24，5： | 4 |
| 7 | Ag-containing austenitic antibacterial stainless steel显示文摘Ag-containing austenitic antibacterial stainless steel was produced by adding Ag-Cu intermediate alloy of different compositions during the melting process.After the Ag-containing austenitic antibacterial stainless steel's microstructure,mechanical properties and corrosion resistance were analyzed,conclusions that the antibacterial Ag- enriched phase distributed uniformly in the steel,and Ag-containing austenitic stainless steel had a good antibacterial property in addition to the properties of normal austenitic stainless steel were obtained. | Lin Gang Zhang Zhixia Shen Jicheng | 2008 | Baosteel Technical Research2008，2，1： | 3 |
| 8 | Comprehensive Assessment of Urbanization Coordination:A Case Study of Jiangxi Province, China显示文摘In order to make assessment on urbanization coordination, we developed a comprehensive model by integrating entropy weight method(EWM), coupling degree model(CDM), coupling coordination degree model(CCDM), multi-index grading method(MIGM) and Remote Sensing & Geographic Information System(RS & GIS) technology. Then we applied this integrated model to a case study in Jiangxi Province, China. Our study finds that: 1) EWM, CDM and CCDM can evaluate the temporal dynamic of urbanization. Urbanization process of Jiangxi Province can be divided into three periods, the stable development period(1990–2001), the accelerated development period(2002–2009) and the rapid development period(2010–2015). Coordinated development of urbanization in Jiangxi Province can be divided into two phases, an increasingly coordinated phase(1990–2003) and an increasingly incongruous phase(2003–2015). The state transition was due to low development rate of population urbanization. 2) RS & GIS technology is an effective tool for detecting urban growth. Urban construction land area of Jiangxi Province increased from 615.8 km^2 in 1990 to 2896.8 km^2 in2015, and the per capita urban construction land area(PCUCLA) reached 122.9 m^2, with the maximum value of 343 m^2 in Gongqingcheng City. 3) MIGM and RS & GIS technology can analyze spatial difference of urbanization. There is a significant spatial difference in socioeconomic development at county scale, with the maximum value six times the minimum value for both PCUCLA and per capita GDP in 2015. Population urbanization lag and excessive land use are the main reasons for uncoordinated urbanization. There were 15 counties with a lag in demographic urbanization and 33 counties where PCUCLA exceeded the national standard in 2015, among which 20 exceeded the national standard of PCUCLA by 50%(≥165 m^2). Since there are significant spatio-temporal differences in urbanization, it is necessary to carry out a comprehensive assessment to facilitate differential urbanization strategy making. | LI Shu YING Zhixia ZHANG Huan GE Gang LIU Qijing | 2019 | Chinese Geographical Science2019，29，3： | 3 |
| 9 | Surface segregation of copper in antibacterial ferritic stainless steel显示文摘By using auger electron spectroscopy(AES)and diffusion theory to analyze the surface segregation of copper in antibacterial ferritic stainless steel,establishing a diffusion model,and calculating the activation energy of diffusion of the copper in ferrite,the affect of surface segregation on the antibacterial capabilities were researched.The results show that the concentration of the copper surface at 973 K and 1 073 K could be expressed asln (X_(Cu)~s)/(X_(Cu)~b)=k_0 ((Dt)^(1/2))/d((-ΔH_r^(Cu)+ΔH_r^(iron)+ΔH_s^(Cu))/(3RT)),with the parameters relating to the concentration of the diffusion layer,the coefficient of diffusion,the length of diffusion,the latent heat of evaporation and the latent heat of fusion.The activation energy of diffusion of copper in ferrite is approximately 221.688 kJ/mol.The antibacterial property of the steel is improved as the surface segregation of the copper is increased.At 1073 K for 60 min,the concentration of the surface copper is over three times higher than the basic concentration.The antibacterial property of the stainless steel can reach approximately 99.9%. | Zhang Zhixia Lin Gang Jiang Laizhu | 2008 | Baosteel Technical Research2008，2，2： | 2 |
| 10 | Grain Yield, Quality and 2-Acetyl-1-Pyrroline of Fragrant Rice in Response to Different Planting Seasons in South China显示文摘Climate conditions is an important factor affected the fragrant rice growth and development.In order to study the effects of different planting seasons on fragrant rice performance in South China,present study was conducted with three planting seasons(early season(April to July),middle season(June to September)and late season(August to November))and three fragrant rice cultivars,‘Basmati-385’,‘Meixiangzhan-2’and‘Xiangyaxiangzhan’.The results showed that the highest grain yield and grain 2-acetyl-1-pyrroline(2-AP,key component of fragrant rice aroma)content were both recorded in late season treatment while the fragrant rice in middle season treatment produced the lowest grain yield,grain filling percentage,1000-grain weight and gain 2-AP content.The highest contents of precursors(proline,pyrroline-5-carboxylic acid and 1-pyrro-line)which related to 2-AP biosynthesis were recorded in late season treatment compared with early season treatment and middle season treatment.The highest activities of enzymes(proline dehydrogenase,pyrroline-5-carboxylic acid synthetase and ornithine transaminase)which involved in 2-AP biosynthesis were also observed in late season treatment.Moreover,the fragrant rice cultivars in late season possessed the lowest chalk rice rate,chalkiness as well as the highest brown rice rate,head rice and protein content.Thus,the optimal season for fragrant rice production in South China is the late season. | Leilei Kong Haowen Luo Zhaowen Mo Shenggang Pan Zhixia Liu Qiang Zhang Song Bai Xiangru Tang | 2020 | Phyton-International Journal of Experimental Botany2020，89，3： | 2 |
| 11 | Precipitation of Epsilon Copper in Ferrite Antibacterial Stainless Steel显示文摘The precipitation of epsilon copper at 1023 K ageing in ferrite antibacterial stainless steel was investigated by a combination of electron microscopy and micro-Vickers hardness measurement.The results show that epsilon copper precipitation occurs within 90 s.Complex multilayer structure confirmed as twins and stacking faults on{111}_(ε_Cu) planes was observed in the precipitates.The precipitates grow by the lengthwise enlargement of a set of parallel layers,having[111]_(ε-Cu) and[112]_(ε-Cu) preferred growth orientations.The volume fraction of precipitates f formed within 120 min can be predicted by a modified Avrami equation(In 1/(1-f)=kt+b). Simultaneously,substituent atom clusters with a size of 5-10 nm was found to occur in the solution and cause matrix strain.The precipitate morphology and distribution on the surface of ferrite antibacterial stainless steel are associated with surface crystallographic orientation of the matrix.The precipitates are predominantly located within the ferrite grains of<110>orientation.The precipitates located on{111}_(α-Fe) surface planes have sphere or ellipse shape. | Zhixia ZHANG Gang LIN Zhou XU | 2008 | Journal of Materials Science & Technology2008，24，5： | 2 |
| 12 | Pilot production of u-PA with porous microcarrier cell culture显示文摘 | Xianwen Hu Chengzu Xiao Zicai Huang Zhixia Guo Zhengguang Zhang Zuohu Li | 2000 | Cytotechnology (-)2000，，1： | 1 |
| 13 | Fault line Detection in Neutral Point in Effectively Grounding Power System Based on Phase-Locked loop显示文摘 | Zhang Zhixia Liu Xiaopiao | 2014 | IET Generation Transmission & Distribution2014，8，2： | 1 |
| 14 | Dextran-grafted-PNIPAAm as an artificial chaperone for protein refolding显示文摘 | Diannan Lu Zhixia Liu Minlian Zhang Xiaogong Wang Zheng Liu | 2005 | Biochemical Engineering Journal2005，，3： | 1 |
| 15 | A new type-γ'/γ''coprecipitation behavior and its evolution mechanism in wrought Ni-based ATI 718Plus superalloy显示文摘In the precipitation-hardened Ni-based superalloy,typified by ATI 718 Plus,the nano-scaleγandγphase in duplet or triple coprecipitate morphology can provide superior high-temperature strength.Thus,it is of great sense to study the evolution ofγ’/γ’’coprecipitate during long term service at elevated temperature.In this study,the new-typeγ’/γ’’coprecipitates with a sandwich or compact configuration were found firstly in wrought ATI 718 Plus superalloy during long term thermal exposure at 705℃.These co-structure of theγ’/γ’’precipitates evidently inhibit the coarsening ofγ’phase.The increase of thermal exposure time evidently leads to the increase of the volume fraction ofγ’/γ’’coprecipitate and transformation of sandwich-typeγ’/γ’’coprecipitate to compact-typeγ’/γ’’coprecipitate,which is characterized asγphase precipitate at several faces of theγphase.The main evolution mechanism ofγ’/γ’’coprecipitates is element segregation,especially the composition variations of Al+Ti and Nb and their ratio of Al+Ti/Nb.In addition,the interfacial energy betweenγ’’phase andγmatrix also plays a key role on theγ’/γ’’coprecipitates evolution.The calculated results show that the longer thermal exposure time leads to the higher interfacial energy,which is beneficial for nucleation and precipitation ofγ’’phase on the faces ofγ’phase. | Qianying Guo Zongqing Ma Zhixia Qiao Chong Li Teng Zhang Jun Li Chenxi Liu Yongchang Liu | 2022 | Journal of Materials Science & Technology2022，，24： | 1 |
| 16 | A fluorometric method for the discrimination of harmful algal bloom species developed by wavelet analysis显示文摘 | Fang Zhang Rongguo Su Liang Wang Minghong Cai Zhixia Zheng | 2009 | Joumal of Experimen- tal Marine Biology and Ecology2009，368，01： | 1 |
| 17 | Trace metal sin traditional chinese medicine:a preliminary study using ICP-MS metal determination and Sa speciation显示文摘 | Wang xiaoru Zhang Zhixia Sun Dahai | 1999 | Atomic Spectroscopy1999，20，3： | 1 |
| 18 | Application of a Newly Built Semi-submersible Vessel for Transportation of a Tension Leg Platform显示文摘紧张腿站台(TLP ) 的交通组织因为长距离总是与一个重半运输容器的使用被联系了。这类容器的要求总是是特殊的,并且他们的可获得性是有限的。为华南海深海的工程的未来发展准备,中国近海油工程公司最近造了重电梯运输 vessel-Hai 杨实你 278。这个半能沉入水中的容器有 42 米的 50k DWT,和呼吸的一个排水量能力。理解容器适用性并且在未来为使用准备它深海的工程正在成为逼近的需要。这份报纸考察与 TLP 交通联系的当前的关键问题并且在装载外面和交通期间执行设计 TLP 的详细分析。新建 COOEC 交通容器 HYSY 278 被使用在华南在 Qingdao 从 COOEC 制造院子弄干 TLP 结构的运输到一块油地海。全部进程从制造院子,从容器,在长距离上的 TLP 的干燥运输,并且平台的最后的卸载卸载和平台的漂浮上的 landsite 包括了 TLP 结构的装载外面。水动力学和结构分析被执行评估运输容器和 TLP 结构的行为。特殊注意对与这个新容器的使用联系的批评区域被给予,与任何潜在的限制一起。结果证明 HYSY 278 能有效地被用于与合适的安排和准备得好的操作搬运结构。过程和细节根据学习结果被介绍。特殊注意也从分析基于结果被给未来使用的讨论。 | Dagang Zhang WeiyingSun Zhixia Fan | 2012 | Journal of Marine Science and Application2012，11，3： | 1 |
| 19 | The mechanism of PNIPAAm-assisted refolding of lysozyme denatured by urea 显示文摘 | Lu Diannan Liu Zhixia Zhang Minlian | 2005 | Bichemical Engineering Journal2005，24，： | 1 |
| 20 | Fault line detection in neutral point in effectively grounding power system based on phase-locked loop显示文摘 | Zhang Zhixia Liu Xiao Piao Zailin | 2014 | IET Generation Transmission Distribution2014，8，2： | 1 |
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