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| 1 | Inflammatory Cytokines and Alzheimer's Disease: A Review from the Perspective of Genetic Polymorphisms显示文摘Neuroinflammatory processes are a central feature of Alzheimer's disease(AD) in which microglia are over-activated, resulting in the increased production of proinflammatory cytokines. Moreover, deficiencies in the antiinflammatory system may also contribute to neuroinflammation. Recently, advanced methods for the analysis of genetic polymorphisms have further supported the relationship between neuroinflammatory factors and AD risk because a series of polymorphisms in inflammation-related genes have been shown to be associated with AD. In this review, we summarize the polymorphisms of both pro- and anti-inflammatory cytokines related to AD, primarily interleukin-1(IL-1), IL-6, tumor necrosis factor alpha, IL-4, IL-10, and transforming growth factor beta, as well as their functional activity in AD pathology. Exploration of the relationship between inflammatory cytokine polymorphisms and AD risk may facilitate our understanding of AD pathogenesis and contribute to improved treatment strategies. | Fan Su Feng Bai Zhijun Zhang | 2016 | Neuroscience Bulletin2016，32，5： | 22 |
| 2 | Study on the HPHT synthetic diamond crystal from Fe-C(H) system and its significance显示文摘Investigations of crystal habit, micro-topographic imaging, micro-composition and micro-structural analysis of HPHT synthetic diamonds from the Fe-C(H) system indicate that most of them have an oc-tahedral habit. The crystals grow mainly layer-to-layer from center to periphery. HPHT synthetic dia-mond is smaller in size than natural diamond because it only goes through nucleation and growth in the early stage. In the middle and late stages, due to the coalescence of diamond grains related to dif-ferences of surface energy, the growth of HPHT synthetic diamond is limited. The active energy (E) of transforming single nitrogen into a nitrogen-pair is lowered and the time of transforming single nitro-gen into a nitrogen-pair is shortened because of the existence of hydrogen. Therefore, aggregate ni-trogen (A-centers) may exist in synthetic diamond from HPHT and explosive detonation processes. It needs further discussion on a worldwide view that the time of natural diamond formation extracted from nitrogen aggregation is some hundred million years. Consideration of the way in which surface energy influences the growth of diamond can help to understand some of the remaining issues (e.g. growth mechanism, etc.) in the HPHT synthetic process and effectively explain the formation of natural diamond in terms of HPHT thermodynamic theory. Especially, it is important to pay more attention to the influence of hydrogen on surface energy in that hydrogen may be a 'bridge' for explaining the formation of HPHT synthetic and natural diamond. | YANG ZhiJun LI HongZhong PENG MingSheng CHEN Jun LIN Feng SU YuWei | 2008 | Chinese Science Bulletin2008，53，1： | 15 |
| 3 | YAGG:Ce transparent ceramics with high luminous efficiency for solid-state lighting application显示文摘A series of Y2.985Al5–xGaxO12:0.015Ce(YAGG:Ce,x=0,1,2,3,4,5)transparent ceramics were prepared via a solid-state reaction method.Two-step sintering technique was proved to be an effective approach to prepare functional ceramics with high Ga concentration,and Y3Ga5O12(YGG)transparent ceramic was successfully prepared for the first time.According to the variation of Al/Ga ratio,regulation of band structure and luminescence properties of YAGG:Ce transparent ceramics were effectively investigated.When Ga substitutes Al sites,the tetrahedral site is more favorable compared to the octahedral site for Ga to occupy according to the first-principle calculation.A continuous blue shift of the emission from 565 to 515 nm was achieved as Ga was gradually introduced into Y3Al5O12:Ce matrix.High quality green light was obtained by coupling the YAGG:Ce ceramics with commercial blue InGaN chips.Transparent luminescence ceramics accomplished in this work can be quite prospective for high power LED application. | Hui HUA Shaowei FENG Zhongyu OUYANG Hezhu SHAO Haiming QIN Hui DING Qiping DU Zhijun ZHANG Jun JIANG Haochuan JIANG | 2019 | Journal of Advanced Ceramics2019，8，3： | 13 |
| 4 | The intrinsic mechanism of corrosion resistance for FCC high entropy alloys显示文摘The concept of high entropy alloys(HEAs) or multi-principal component alloys has inspired a great progress of physical metallurgy along with several unusual phenomena. The high corrosion resistance of HEAs was frequently mentioned but without convincing explanations. In this paper, the intrinsic mechanism of corrosion resistance in FCC HEAs was revealed by designing equal atomic alloys with single solid solution phase. The results showed that the Cr element in FCC HEAs played the dominant role in the corrosion resistance rather than the simple structure from high entropy effect or uniform element distribution. | shang xuliang wang zhijun he feng wang jincheng li junjie yu jiakang | 2018 | Science China(Technological Sciences)2018，61，2： | 11 |
| 5 | Formation law and criterion of nebulous macroscopic segregation in ZL205A alloy castings显示文摘The appearance of macroscopic segregation in ZL205A alloy castings bears a super resemblance to theappearance of shrinkage porosity, and the chemical composition of the segregation is Al2Cu whose microstructure isin the form of dentrite or skeleton crystal. According to the characteristic of nebulous segregation, the formationprocess could be divided into two steps by the eutectic temperature of Al2Cu. Then a criterion for each of the twosteps is brought forward on the basis of the shrinkage porosity criterion of low pressure casting. | Li Yusheng Zhai Hu Feng Zhijun Qu Xuahui | 2008 | China Foundry2008，5，1： | 11 |
| 6 | Stability of coal pillar in gob-side entry driving under unstable overlying strata and its coupling support control technique显示文摘Considering the situation that it is difficult to control the stability of narrow coal pillar in gob-side entry driving under unstable overlying strata, the finite difference numerical simulation method was adopted to analyze the inner stress distribution and its evolution regularity, as well as the deformation characteristics of narrow coal pillar in gob-side entry driving, in the whole process from entry driving of last working face to the present working face mining. A new method of narrow coal pillar control based on the triune coupling support technique (TCST), which includes that high-strength prestressed thread steel bolt is used to strain the coal on the goaf side, and that short bolt to control the integrity of global displacement zone in coal pillar on the entry side, and that long grouting cable to fix anchor point to constrain the bed separation between global displacement zone and fixed zone, is thereby generated and applied to the field production. The result indicates that after entry excavating along the gob under unstable overlying strata, the supporting structure left on the gob side of narrow coal pillar is basically invalid to maintain the coal-pillar stability, and the large deformation of the pillar on the gob side is evident. Except for the significant dynamic pressure appearing in the coal mining of last working face and overlying strata stabilizing process, the stress variation inside the coal pillar in other stages are rather steady, however, the stress expansion is obvious and the coal pillar continues to deform. Once the gob-side entry driving is completed, a global displacement zone on the entry side appears in the shallow part of the pillar, whereas, a relatively steady fixed zone staying almost still in gob-side entry driving and present working face mining is found in the deep part of the pillar. The application of TCST can not only avoid the failure of pillar supporting structure, but exert the supporting capacity of the bolting structure left in the pillar of last sublevel entry, thus to jointly maintain the stability of coal pillar. | Yuan Zhang Zhijun Wan Fuchen Li Changbing Zhou Bo Zhang Feng Guo Chengtan Zhu | 2013 | International Journal of Mining Science and Technology2013，23，2： | 8 |
| 7 | Altered functional connectivity networks of hippocampal subregions in remitted late-onset depression:a longitudinal resting-state study显示文摘在迟了生活的消沉(LLD ) 的海马趾的畸形的地区性的特性在以前的研究被表明了。在这研究,我们寻求了检验功能的连接(FC ) 在汇寄的迟了发作的消沉(rLOD ) 的海马趾的分区的模式, LLD 的一种特殊子类型。十四个 rLOD 病人和 18 健康控制象功能的磁性的回声成像在基线并且在 21 月后续扫描的休息状态一样经历了临床、认知的评估。每马头鱼尾的怪兽被划分成三部分,角 ammonis (CA ) ,有牙齿的回转,和 subicular 建筑群,然后六个基于种子的海马趾的分区网络被建立。六个网络的纵的变化直接随着时间的过去在 rLOD 和控制组之间被比较。从基线到后续,在左 CA 的连接给更大的衰落看到双边的以后的 cingulate cortex/precuneus (PCC/PCUN ) ,但是出现的 rLOD 组与正面的外皮(双边的中间的前额的 cortex/anterior cingulate 外皮和增补马达区域) 增加了恰好海马趾的分区网络的连接。进一步的关联词分析表明在在左 CA 和 PCC/PCUN 之间的 FC 的纵的变化断然在标志位形式测试与纵的变化被相关( r = 0.624 , P = 0.017 )并且位跨度测试( r = 0.545 , P = 0.044 )在 rLOD 组得分。这些结果可以提供卓见进在 rLOD 病人位于认知机能障碍下面的 neurobiological 机制。 | Zan Wang Yonggui Yuan Feng Bai Hao Shu Jiayong You Lingjiang Li Zhijun Zhang | 2015 | Neuroscience Bulletin2015，31，1： | 4 |
| 8 | Four-year dynamic observation and study on standardized management of elderly patients with type 2 diabetes in Beijing Yongding Road Community显示文摘Purpose:This study aimed to understand the joint standard of blood glucose,blood li-pids,and blood pressure in elderly patients>60 years of age with type 2 diabetes in the Beijing Yongding Road Community.Methods:One hundred ninety-two elderly patients>60 years of age who were diagnosed with type 2 diabetes in Yongding Road Community served as the investigation subjects,under-went standard management,and the dynamic changes in blood glucose,blood lipids,and blood pressure were monitored for 48 months.Results:At the end of the observation period,the standard rates of fasting blood glucose and postprandial blood glucose were 72.55%and 80.00%,respectively,which were increased compared with 55.73%and 56.08%at baseline(P<0.01).The standard rate of HbA1c was 59.81%,which was increased compared with 53.44%at baseline(P>0.05).The standard rates of TG and LDL-C were 76.71%and 60.38%,respectively,which were increased compared with 54.69%and 34.74%at base-line,and the standard rate of HDL-C was 13.64%,which was decreased compared with 40.10%at baseline(P<0.01).The standard rate of BP was 58.33%,which was increased compared with 38.54%at baseline(P<0.01).The optimal control rate of blood glucose for 48 months(the standard times of the total measurement times in 48 months≥75%)was higher;the fasting blood glucose was 52.17%,the 2-h postprandial blood glucose was 60.22%,and the HbA1c was 46.45%.The optimal control rate of blood lipids was lower;LDL-C was 17.49%and HDL-C was 13.59%.The optimal control rate of BP was 9.13%.At the end of the observation period,the levels of fasting blood glucose and postprandial blood glucose were decreased by 0.7 mmol/L and 1.48 mmol/L,respectively,compared with the base-line(P<0.01).The level of HbA1c was decreased by 0.18%compared with the baseline(P<0.05).The levels of LDL-C and HDL-C were decreased by 0.4 mmol/L and 0.23 mmol/L,respectively,compared with the baseline(P<0.01).The levels of SBP and DBP were decreased by 4 mmHg compared with the baseline(P<0.01).At the end of the observation period,the joint standard rate of the three indices of HbA1c,LDL-C,and BP was 24.72%,which was increased compared with 6.25%at baseline(P<0.01).Conclusion:Standardized management of elderly patients with diabetes in the Community can improve the joint standard rate of blood glucose,blood lipids,and blood pressure.The op-timal control rate and joint standard rate are the important indices for evaluating the quality of diabetes management. | Yue Li Dongyun Shen Wei Zhang Yimin Wang Hongmei Li Jie Geng Liying Yang Zhijun Xiao Yan Liu Zhigang Feng Linying Cao Yan Jin Lixia Shi | 2014 | Family Medicine and Community Health2014，2，2： | 4 |
| 9 | The liver transcriptome of two full-sibling Songliao black pigs with extreme differences in backfat thickness显示文摘Background:Fatness traits in animals are important for their growth,meat quality,reproductive performance,and immunity.The liver is the principal organ of the regulation of lipid metabolism,and this study used massive parallelized high-throughput sequencing technologies to determine the porcine liver tissue transcriptome architecture of two full-sibling Songliao black pigs harboring extremely different phenotypes of backfat thickness.Results:The total number of reads produced for each sample was in the region of 53 million,and 8,226 novel transcripts were detected.Approximately 92 genes were differentially regulated in the liver tissue,while 31 spliced transcripts and 33 primary transcripts showed significantly differential expression between pigs with higher and lower backfat thickness.Genes that were differentially expressed were involved in the metabolism of various substances,small molecule biochemistry,and molecular transport.Conclusions:Genes involved in the regulation of lipids could play an important role in lipid and fatty acid metabolism in the liver.These results could help us understand how liver metabolism affects the backfat thickness of pigs. | Kai Xing Feng Zhu Liwei Zhai Huijie Liu Zhijun Wang Zhuocheng Hou Chuduan Wang | 2015 | Journal of Animal Science and Biotechnology2015，6，1： | 3 |
| 10 | Effect of herb-partitioned moxibustion on dopamine levels and dopamine receptor 1 expression in the colon and central nervous system in rats with Crohn’s disease显示文摘OBJECTIVE:To observe the effect of herb-partitioned moxibustion at the Tianshu (ST 25) and Qihai (CV 6) acupoints in rats with Crohn's disease,and explore the underlying mechanism from dopamine (DA) and dopamine receptor 1 (D1 R) in the colon,spinal dorsal horn and hypothalamus.METHODS:The rats were randomly divided into the normal,model (CD),herb-partitioned moxibustion (Mox) and mesalazine (Mesa) groups.Damage in the colons was scored and observed by hematoxylin and eosin staining.DA and D1R protein expression in the colonic mucosa were detected by immunohistochemistry.The concentrations of DA and D1R in the spinal dorsal horn and hypothalamus were measured by enzyme-linked immunosorbent assay,and D1R mRNA expression was evaluated by quantitative real-time polymerase chain reaction.RESULTS:In the colon,compared with the normal group,DA,D1 R protein expressions and D1 R mRNA expression were significantly higher in the model group,while decreased in the Mox group and the Mesa group.In the spinal dorsal horn and hypothalamus,compared with the normal group,the concentrations of DA and D1 R,and the D1R mRNA expressions were significantly higher in the model group,and decreased in the Mox group and the Mesa group.CONCLUSION:Herb-partitioned moxibustion at the Tianshu (ST 25) and Qihai (CV 6) acupoints relieved ulceration in CD rats,the underlying mechanism maybe relative with the regulation of DA and D1R in the colon,spinal dorsal horn and hypothalamus by moxibustion. | Lu Yuan Zheng Handan Lü Tingting Ma Zhe Wu Huangan Xu Manwen Weng Zhijun Feng Hui Zhang Fang Ding Guanghong Wu Luyi Liu Huirong | 2019 | Journal of Traditional Chinese Medicine2019，39，3： | 3 |
| 11 | Experimental study on multi-point autoignition characteristics and influence factors of diesel spray in a controllable active thermo-atmosphere显示文摘Auto-ignition characteristics of high-pressure diesel spray in the controllable active thermo-atmos-phere (CATA) were studied with a high-speed camera video system. Multi-point autoignition phe-nomenon of diesel spray in the CATA was observed and the influence factors of the autoignition were analyzed. The stabilization mechanisms of the spray flame in different coflow temperatures were also discussed. The stabilization of the flames was controlled by different factors: autoignition phenomenon in low coflow temperature and flame spread in high coflow temperature. The test results also show that the autoignition delay depends strongly on the coflow temperature and has nonlinear relationship with the temperature. Autoignition delay decreases by almost 10 ms from 16.9 to 7.1 ms when the coflow temperature increases from 996 to 1048 K and only 4 ms from 1048 to 1101 K. The injection parameters in terms of nozzle diameter, injection pressure and pump speed, have some effects on autoignition delay while these effects depend on the coflow temperature. The significant effect lies in low coflow temperature. The injection parameters influence the autoignition delay because it can shorten the physical delay by improving the spray quality and enlarging the spray angle or penetration rate to im-prove mixture quality. | DENG Jun WU ZhiJun HUANG ChengJie FENG Wei LI LiGuang | 2007 | Chinese Science Bulletin2007，52，2： | 2 |
| 12 | Characterization and origin of charcoalified foxtail millet(Setaria italica) from the Chenyuan Site of the Western Zhou Dynasty in Shangluo, SE Shaanxi, China显示文摘In this paper, we discuss charcoalified foxtail millet grains dated to the middle to late Western Zhou Dynasty and collected from the Chenyuan archeological site in Shangluo, in China's southeastern Shaanxi Province. We assigned these specimens to the species Setaria italica based on the following characteristics: an obtuse chalazal apex with missing stigmatic remains; an undulant seed surface composed of rectangular cells with undulate anticlinal walls; an elongated and deeply depressed embryo extending to almost the full seed length; and spherical starch grains. We suggest that the spread of foxtail millet from its original northern distribution center to the southern slopes of the Qinling Mountains could be attributed to: its prominence across Zhou crop systems; the latter area's arid or subarid climate; and the migration south of Zhou people fleeing severe conflict between their nation and northern nomads. | FENG GuangPing LU HuaYu ZHAO JianCheng YANG YaChang LI ChengSen ZHAO ZhiJun YUAN ShunQuan BAO Yan ZHONG Bei | 2013 | 科学通报2013，58，S1： | 2 |
| 13 | High mobility group-box 3 overexpression is associated with poor prognosis of resected gastric adenocarcinoma显示文摘AIM:To elucidate high mobility group-box 3(HMGB3) protein expression in gastric adenocarcinoma,its potential prognostic relevance,and possible mechanism of action.METHODS:Ninety-two patients with gastric adenocarcinomas surgically removed entered the study.HMGB3 expression was determined by immunohistochemistry through a tissue microarray procedure.The clinicopathologic characteristics of all patients were recorded,and regular follow-up was made for all patients.The inter-relationship of HMGB3 expression with histological and clinical factors was analyzed using nonparametric tests.Survival analysis was carried out by Kaplan-Meier(log-rank) and multivariate Cox(Forward LR) analyses between the group with overexpression of HMGB3 and the group with low or no HMGB3 ex-pression to determine the prognosis value of HMGB3 expression on overall survival.Further,HMGB3 expression was knocked down by small hairpin RNAs(shRNAs) in the human gastric cancer cell line BGC823 to observe its influence on cell biological characteristics.The MTT method was utilized to detect gastric cancer cell proliferation changes,and cell cycle distribution was analyzed by flow cytometry.RESULTS:Among 92 patients with gastric adenocarcinomas surgically removed in this study,high HMGB3 protein expression was detected in the gastric adenocarcinoma tissues vs peritumoral tissues(P < 0.001).Further correlation analysis with patients' clinical and histology variables revealed that HMGB3 overexpression was obviously associated with extensive wall penetration(P = 0.005),a positive nodal status(P = 0.004),and advanced tumor-node-metastasis(TNM) stage(P = 0.001).But there was no correlation between HMGB3 overexpression and the age and gender of the patient,tumor localization or histologic grade.Statistical Kaplan-Meier survival analysis disclosed significant differences in overall survival between the HMGB3 overexpression group and the HMGB3 no or low expression group(P = 0.006).The expected overall survival time was 31.00 ± 3.773 mo(95%CI = 23.605-38.395) for patients with HMGB3 overexpression and 49.074 ± 3.648 mo(95%CI = 41.925-57.311) for patients with HMGB3 no and low-level expression.Additionally,older age(P = 0.040),extensive wall penetration(P = 0.008),positive lymph node metastasis(P = 0.005),and advanced TNM tumor stage(P = 0.007) showed negative correlation with overall survival.Multivariate Cox regression analysis indicated that HMGB3 overexpression was an independent variable with respect to age,gender,histologic grade,extent of wall penetration,lymph nodal metastasis,and TNM stage for patients with resectable gastric adenocarcinomas with poor prognosis(hazard ratio = 2.791,95%CI = 1.233-6.319,P = 0.019).In the gene function study,after HMGB3 was knocked down in the gastric cell line BGC823 by shRNA,the cell proliferation rate was reduced at 24 h,48 h and 72 h.Compared to BGC823 shRNA-negative control(NC) cells,the cell proliferation rate in cells that had HMGB3 shRNA transfected was significantly decreased(P < 0.01).Finally,cell cycle analysis by FACS showed that BGC823 cells that had HMGB3 knocked down were blocked in G1/G0 phase.The percentage of cells in G1/G0 phase in BGC823 cells with shRNA-NC and with shRNA-HMGB3 was 46.84% ± 1.7%,and 73.03% ± 3.51% respectively(P = 0.001),whereas G2/M cells percentage decreased from 26.51% ± 0.83% to 17.8% ± 2.26%.CONCLUSION:HMGB3 is likely to be a useful prognostic marker involved in gastric cancer disease onset and progression by regulating the cell cycle. | Hua-Rong Tang Xian-Qin Luo Gang Xu Yan Wang ZhiJun Feng Hui Xu Ya-Wei Shi Qin Zhang Li-Guang Wu Chun-Quan Xue Cheng-Wei Wang Chao-Yang Wu | 2012 | World Journal of Gastroenterology2012，18，48： | 2 |
| 14 | Tailoring nanoprecipitates for ultra-strong high-entropy alloys via machine learning and prestrain aging显示文摘The multi-principal-component concept of high-entropy alloys(HEAs) generates numerous new alloys.Among them,nanoscale precipitated HEAs have achieved superior mechanical properties and shown the potentials for structural applications.However,it is still a great challe nge to find the optimal alloy within the numerous candidates.Up to now,the reported nanoprecipitated HEAs are mainly designed by a trialand-error approach with the aid of phase diagram calculations,limiting the development of structural HEAs.In the current work,a novel method is proposed to accelerate the development of ultra-strong nanoprecipitated HEAs.With the guidance of physical metallurgy,the volume fraction of the required nanoprecipitates is designed from a machine learning of big data with thermodynamic foundation while the morphology of precipitates is kinetically tailored by prestrain aging.As a proof-of-principle study,an HEA with superior strength and ductility has been designed and systematically investigated.The newly developed γ’-strengthened HEA exhibits 1.31 GPa yield strength,1.65 GPa ultimate tensile strength,and 15% tensile elongation.Atom probe tomography and transmission electron microscope characterizations reveal the well-controlled high γ’ volume fraction(52%) and refined precipitate size(19 nm).The refinement of nanoprecipitates originates from the accelerated nucleation of the γ’ phase by prestrain aging.A deeper understanding of the excellent mechanical properties is illustrated from the aspect of strengthening mecha nisms.Finally,the versatility of the current design strategy to other precipitation-hardened alloys is discussed. | Tao Zheng Xiaobing Hu Feng He Qjngfeng Wu Bin Han Chen Da Junjie Li Zhijun Wang Jincheng Wang Ji-jung Kai Zhenhai Xia C.T.Liu | 2021 | Journal of Materials Science & Technology2021，，10： | 2 |
| 15 | Design Fe-based Eutectic Medium-Entropy Alloys Fe_2NiCrNb_x显示文摘High-entropy alloys have attracted broad research interests due to their unique and intriguing mechanical properties. As a category of high-entropy alloys, eutectic high-entropy alloys combine the advantages of eutectic and high-entropy alloys, with excellent mechanical properties and casting properties. Some eutectic high-entropy alloys have been developed and shown exciting properties. In this paper, based on the physical metallurgy of eutectic high-entropy alloy, medium-entropy alloy Fe_(2)NiCrNb_(x) was designed. The as-cast alloy is composed of FCC and Laves phases, Nb element promotes the formation of primary Laves phase, and the hardness of the alloy increases with the increase in Nb element. Among the four alloys, the eutectic chemical composition at eutectic point is Fe_(2)NiCrNb_(0.34);the alloy has a good strength and plastic balance. The ultimate comprehensive strength is 2267 MPa, and the fracture strain is 30.8%. The experiment data and analyses identified the eutectic points and the excellent mechanical behavior. Moreover, the expensive Co element was replaced by Fe element. This cheap medium-entropy alloy has promising prospect in the consideration of the cost performance ratio. | Jiafen Song Zishu Chai Jian Zheng Qingfeng Wu Feng He Zenan Yang Junjie Li Jincheng Wang Haiou Yang Zhijun Wang | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，8： | 2 |
| 16 | Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants. | Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang | 2022 | Virologica Sinica2022，37，5： | 2 |
| 17 | Role of mitochondrial NADH kinase and NADPH supply in the respiratory chain activity of Saccharomyces cerevisiae显示文摘在 Saccharomyces cerevisiae, mitochondrial 菸碱腺嘌 dinucleotide 氢化物 kinase Pos5p 为许多必要细胞的小径被要求,最重要地呼吸。Pos5p 猛烈紧张 pos5 在非沸腾的媒介糟糕成长。在这呼吸缺乏和到供应菸碱腺嘌 dinucleotide 磷酸盐(NADPH ) 的房间的能力之间的一种潜在的关系被分析 pos5 和二 NADP+ 特定的脱氢酶异种的呼吸的链活动检验, idp1 和 zwf1。所有 pos5 的呼吸的链建筑群展出了差的相对活动 <26% 在中间木头的阶段并且 62% 在静止阶段。idp1 和 zwf1 的呼吸的链活动层次也 pos5 象那些一样在静止阶段,不是要用体力地在中间木头的阶段,和 73%81% 和 67%88% 归结为 22%37% 和 28%84% 。展出的双异种 idp1pos5 甚至降低活动 <20% 与 pos5 在中间木头的阶段,而是 zwf1pos5 显示出类似的活动。补充紧张 POS5/pos5 更高展出了 1.05- 到 3 褶层活动比 pos5。这些数据证明 Pos5p 贡献呼吸的链建筑群活动的维护,与另外的 NADPH 来源一起,例如 Idp1p 和 Zwf1p,做更小的贡献。这些贡献是部分与到供应 NADPH 的房间的能力有关,特别在线粒体。 | Feng Shi Zhijun Li Mingdi Sun Yongfu Li | 2011 | Acta Biochimica et Biophysica Sinica2011，43，12： | 2 |
| 18 | DTI for the assessment of disease stage in patients with glomerulonephritis-correlation with renal histology显示文摘 | Qiang Feng Zhijun Ma Jianlin Wu Wei Fang | 2015 | European Radiology2015，25，1： | 1 |
| 19 | An experimental study on processing performance of rotary ultrasonic drilling of K9 glass 显示文摘 | ZHANG Chenglong FENG Pingfa WU Zhijun | 2011 | Advanced Materials Research2011，，： | 1 |
| 20 | A novel TiO_2 with a large amount of bulk intrinsic defects-Visible-light-responded photocatalytic activity induced by foreign trap显示文摘A novel TiO2 (anatase) containing a large amount of single electron trapped oxygen vacancies (SETOV) was prepared by dehydration of titanic acid nanotubes. This novel TiO2 contains high concentration intrinsic defects in bulk structure, while its surface still remains the stoichiometric structure to protect them. And this novel TiO2 itself has the visible light absorption without any doping, so we call it as the third generation of TiO2 . However, it is regretted that this novel TiO2 (A) only has photocatalytic activity under UV light irradiation, and was inactive for the visible light. The true reasons for this phenomenon were investigated by the transient IR absorption and photoluminescence spectra. Through constructing the foreign electron traps (PdO, PtO2 ), the photocatalytic oxidation of propylene under visible light irradiation was successfully achieved. The removal yield of propylene (C3H6 ) reached 7.6% and 28% on 2 wt.% PtO2 /novel TiO2 and 2 wt.% PdO/novel TiO2 , respectively. By comparison with the noble metal electron traps (Pt, Pd), we found that the effective foreign electron traps need to satisfy two conditions: (1) its work function should situate in the range of Eg(TiO2 ); (2) O2 adsorbes on it undissociatively. This work opens up a new route for the investiga- tion of solar-energy-available TiO2 . | LI QiuYe ZHANG JiWei JIN ZhenSheng FENG CaiXia ZHANG JingWei WU ZhiShen ZHANG ZhiJun | 2013 | Chinese Science Bulletin2013，58，14： | 1 |
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