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| 1 | Clinical efficacy of 0.1% pranoprofen in treatment of dry eye patients:a multicenter, randomized, controlled clinical trial显示文摘 | Chen Jingyao Dong Fei Chen Wei Sun Xuguang Deng Yingping Hong Jing Zhang Mingchang Yang Wenzhao Liu Zuguo Xie Lixin | 2014 | Chinese Medical Journal2014，，13： | 18 |
| 2 | Visible light-induced N-doped TiO_2 nanoparticles for the degradation of microcystin-LR显示文摘N-doped nano-crystalline TiO2 powders have been synthesized by the sol-gel method.The shape and crystal structure of the resulting N-doped TiO2 were investigated by X-ray Photoelectron Spectroscopy (XPS),X-ray spectroscopy (XRD),Transmission Electron Microscopy (TEM) and UV-vis reflection spectrum.The results showed that doping TiO2 with nitrogen can lower its band gap and apparently shift its optical response to the visible region.Under the visible light (λ> 420 nm) irradiation,the MC-LR was degraded by the synthesized N-TiO2 nano-material.The variation of MC-LR amount and its intermediates were detected by high performance liquid chromatography (HPLC) and LC-MS,respectively.The mineralization of MC-LR was determined by total organic carbon (TOC) analysis.Simultaneously,transient oxidative species generated during photocatalysis were tracked by electron spin resonance (ESR) and Peroxidase method.All these results indicated that visible-light excited N-TiO2 can activate molecular oxygen and thereby achieve degradation of MC-LR completely within 14 h.The removal of 59% of TOC was achieved after 20 h irradiation.The major oxidative species in the system were hydroxyl radical (·OH) and H2O2.13 Kinds of intermediates were primarily identified in the process.Based on these results,a reasonable conclusion was drawn for the degradation of MC-LR wherein its four positions are easy to be attacked by the photo-generated OH radical followed by the hydrolyzation of peptides. | YANG Jing,CHEN DengXia,DENG AnPing,FANG YanFen,LUO GuangFu,LI DeJiang,LI RuiPing & HUANG YingPing Alan G.MacDiarmid Research Institute of Renewable Energy,China Three Gorges University,Yichang 443000,China | 2010 | Science China Chemistry2010，53，8： | 12 |
| 3 | A-DA′D-A non-fullerene acceptors for high-performance organic solar cells显示文摘Since the world-record power conversion efficiency of 15.7%was achieved for organic solar cells(OSCs)in 2019,the newly developed non-fullerene acceptor(NFA)Y6 with an A-DA′D-A structure(A denotes an electron-accepting moiety,D denotes an electron-donating moiety)has attracted increasing attention.Subsequently,many new A-DA′D-A NFAs have been designed and synthesized,and the A-DA′D-A NFAs have played a significant role in the development of high-performance non-fullerene organic solar cells(NF-OSCs).Compared with the classical A-D-A-type acceptors,A-DA′D-A NFAs contain an electrondeficient core(such as benzothiadiazole(BT),benzotriazole(BTA),quinoxaline(Qx),or their derivatives)in the ladder-type fused rings to fine-tune the energy levels,broaden light absorption and achieve higher electron mobility of the NFAs.This review emphasizes the recent progress on these emerging A-DA′D-A(including Y-series)NFAs.The synthetic methods of DA′D-fused rings are introduced.The relationships between the chemical structure of the A-DA′D-A NFAs and the photovoltaic performance of the corresponding OSCs are summarized and discussed.Finally,issues and prospects for further improving photovoltaic performance of the OSCs are also proposed. | Qingya Wei Wei Liu Mario Leclerc Jun Yuan Honggang Chen Yingping Zou | 2020 | Science China Chemistry2020，63，10： | 7 |
| 4 | Recent progress in organic solar cells(PartⅠmaterial science)显示文摘During past several years,the photovoltaic performances of organic solar cells(OSCs)have achieved rapid progress with power conversion efficiencies(PCEs)over 18%,demonstrating a great practical application prospect.The development of material science including conjugated polymer donors,oligomer-like organic molecule donors,fused and nonfused ring acceptors,polymer acceptors,single-component organic solar cells and water/alcohol soluble interface materials are the key research topics in OSC field.Herein,the recent progress of these aspects is systematically summarized.Meanwhile,the current problems and future development are also discussed. | Yahui Liu Bowen Liu Chang-Qi Ma Fei Huang Guitao Feng Hongzheng Chen Jianhui Hou Lingpeng Yan Qingya Wei Qun Luo Qinye Bao Wei Ma Wei Liu Weiwei Li Xiangjian Wan Xiaotian Hu Yanchun Han Yaowen Li Yinhua Zhou Yingping Zou Yiwang Chen Yongfang Li Yongsheng Chen Zheng Tang Zhicheng Hu Zhi-Guo Zhang Zhishan Bo | 2022 | Science China Chemistry2022，65，2： | 5 |
| 5 | Green and efficient degradation of cefoperazone sodium by Bi_(4)O_(5)Br_(2) leading to the production of non-toxic products:Performance and degradation pathway显示文摘Photocatalytic process represents a promising approach to overcome the pollution challenge associated with the antibiotics-containing wastewater.This study provides a green,efficient and novel approach to remove cephalosporins,particularly cefoperazone sodium(CFP).Bi_(4)O_(5)Br_(2) was chosen for the first time to systematically study its degradation for CFP,including the analysis of material structure,degradation performance,the structure and toxicity of the transformation products,etc.The degradation rate results indicated that Bi_(4)O_(5)Br_(2) had an excellent catalytic activity leading to 78%CFP removal compared with the pure BiOBr(38%)within 120 min of visible light irradiation.In addition,the Bi_(4)O_(5)Br_(2) presents high stability and good organic carbon removal efficiency.The effects of the solution p H(3.12-8.75)on catalytic activity revealed that CFP was mainly photocatalyzed under acidic conditions and hydrolyzed under alkaline conditions.Combined with active species and degradation product identification,the photocatalytic degradation pathways of CFP by Bi_(4)O_(5)Br_(2) was proposed,including hydrolysis,oxidation,reduction and decarboxylation.Most importantly,the identified products were all hydrolysis rather than oxidation byproducts transformed from the intermediate ofβ-lactam bond cleavage in CFP molecule,quite different from the mostly previous studies.Furthermore,the final products were demonstrated to be less toxic through the toxicity analysis.Overall,this study illustrates the detailed mechanism of CFP degradation by Bi_(4)O_(5)Br_(2) and confirms Bi_(4)O_(5)Br_(2) to be a promising material for the photodegradation of CFP. | Yingying Chen Ruiping Li Yan Gu Hailin Tian Yingping Huang Junsong Chen Yanfen Fang Changying Yang | 2021 | Journal of Environmental Sciences2021，33，2： | 4 |
| 6 | Recent progress in organic solar cells(PartⅡdevice engineering)显示文摘1 Introduction Organic solar cells(OSCs)belong to a multidisciplinary field composed of chemistry,materials science,physics,engineering,etc.For a better reviewing of this field,we briefly divide the research field of OSCs into two parts:material science and device engineering.In our previous review,the material science part of OSCs,including conjugated polymer donors and acceptors,small molecular donors and acceptors. | Yahui Liu Bowen Liu Chang-Qi Ma Fei Huang Guitao Feng Hongzheng Chen Jianhui Hou Lingpeng Yan Qingya Wei Qun Luo Qinye Bao Wei Ma Wei Liu Weiwei Li Xiangjian Wan Xiaotian Hu Yanchun Han Yaowen Li Yinhua Zhou Yingping Zou Yiwang Chen Yuqiang Liu Lei Meng Yongfang Li Yongsheng Chen Zheng Tang Zhicheng Hu Zhi-Guo Zhang Zhishan Bo | 2022 | Science China Chemistry2022，65，8： | 3 |
| 7 | 20(R)-ginsenoside Rg3,a product of high-efficiency thermal deglycosylation of ginsenoside Rd,exerts protective effects against scrotal heat-induced spermatogenic damage in mice显示文摘Heat stress(HS)reaction can lead to serious physiological dysfunction associated with cardiovascular and various organ diseases.Ginsenoside Rg3(G-Rg3)is a representative component of ginseng rare saponin and can protect against multiple organs,also used as functional food to adjust the balance of the human body,but the therapeutic effect and molecular mechanism of G-Rg3 on male diseases under HS are underexplored.The aim of the present study,G-Rg3 was prepared through the efficient conversion of ginsenoside Rd and investigate the contribution of G-Rg3 to testicular injury induced exposure to HS.All mice were divided into four groups as follows:normal group,HS group,and HS+G-Rg3(5 and 10 mg/kg)groups.G-Rg3 was administered orally for 14 days,then exposed to a single scrotal heat treatment(43°C,18min)on the 7th day.After HS treatment,the morphology of testis and epididymis changes,and caused a significant loss of multinucleated giant cells,desquamation of germ cells in destructive seminiferous tubules,and degenerative Leydig cells,further destroying the production of sperm.After administration G-Rg3(5 and 10 mg/kg/day)for 2 weeks,the spermatogenic-related indexes of testosterone levels and superoxide dismutase(SOD)activity,glutathione(GSH)content significantly(p<0.01)increase compared with the HS group.Moreover,G-Rg3 treatment effectively ameliorated the production of malondialdehyde(MDA)(p<0.05 or p<0.01).Importantly,G-Rg3 exhibited the protective potential against HS-induced injury not only suppressing the protein levels of heme oxygenase-1(HO-1),hypoxia-inducible factor-1α(HIF-1α),and heat shock protein 70(HSP70)but also modulating the Bcl-2 family(p<0.01 or p<0.001)and activation of mitogen-activated protein kinase(MAPK)signaling pathways(p<0.01).For most of the parameters tested,the HS+G-Rg3(10 mg/kg)group exhibited potent effects compared with those exhibited by the low dose(5 mg/kg)group.In conclusion,the present study demonstrated that G-Rg3 exerted protective effects against HS-induced testicular dysfunction via inhibiting the MAPK-mediated oxidative stress and apoptosis in mice. | WEI LIU ZI WANG JING LENG HENG WEI SHEN REN XIAOJIE GONG CHEN CHEN YINGPING WANG RUI ZHANG WEI LI | 2020 | BIOCELL2020，44，4： | 2 |
| 8 | High efficiency ternary organic solar cells enabled by compatible dual-donor strategy with planar conjugated structures显示文摘Ternary organic solar cells(OSCs) have received extensive attention for improving the power conversion efficiency(PCE) of organic photovoltaics(OPVs). In this work, a novel donor material(ECTBD) consisting of benzodithiophene(BDT) central electron donor unit was developed and synthesized. The small molecular donor has the same central unit as PM6. The addition of ECTBD into PM6:Y6 system could improve the morphology of active blend layer. In addition, ECTBD showed good morphologically compatibility when blending with PM6:Y6 host, resulting in the improvement of fill factor and current density. As a result, the ternary devices based on PM6:ECTBD:Y6 ternary system achieved a highest PCE of 16.51% with fill factor of 76.24%, which was much higher than that of the binary devices(15.7%). Overall, this work provided an effective strategy to fabricate highly efficient ternary organic solar cells through design of the novel small molecular donor as the third component. | Sanhui Chen Tingting Yan Billy Fanady Wei Song Jinfeng Ge Qiang Wei Ruixiang Peng Guohui Chen Yingping Zou Ziyi Ge | 2020 | Science China Chemistry2020，63，7： | 2 |
| 9 | Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants. | Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang | 2022 | Virologica Sinica2022，37，5： | 2 |
| 10 | Electro-catalytic degradation of sulfisoxazole by using graphene anode显示文摘Graphite and graphene electrodes were prepared by using pure graphite as precursor. The electrode materials were characterized by a scanning electron microscope(SEM), X-ray diffraction(XRD) and cyclic voltammetry(CV) measurements. The electro-catalytic activity for degradation of sulfisoxazole(SIZ) was investigated by using prepared graphene or graphite anode. The results showed that the degradation of SIZ was much more rapid on the graphene than that on the graphite electrode. Moreover, the graphene electrode exhibited good stability and recyclability. The analysis on the intermediate products and the measurement of active species during the SIZ degradation demonstrated that indirect oxidation is the dominant mechanism, involving the electro-catalytic generation of OH and O_2^- as the main active oxygen species. This study implies that graphene is a promising potential electrode material for long-term application to electro-catalytic degradation of organic pollutants. | Yanyan Wang Shuan Liu Ruiping Li Yingping Huang Chuncheng Chen | 2016 | Journal of Environmental Sciences2016，28，5： | 2 |
| 11 | Screening of Benzoic Acid Biodegradation Strains显示文摘Three strains BQ,BJ,and BS utilizing benzoic acid as the sole carbon source were achieved from Yichang City,Hubei Province,China,through selective enrichment and domestication.Both BQ and BJ were primarily identified as Acinetobacter.spp while BS was Geotrichum.spp.After three domestications,the removal rates of BQ,BJ,and BS to chemical oxygen demand(COD) value of benzoic acid were 62.41%,94.44%,and 43.34%,respectively.The strains were mixed cultured,and the degradation rates of strains to benzoic acid at different temperature,pH and benzoic acid concentration were determined.The results show that the optimum degradation conditions about strains were pH 7.0,temperature 30 ℃,and aerobic with 1 500 mg/L of concentration of benzoic acid.In this condition,the COD removal rate of strains to benzoic acid reached 84.93%. | WANG Shulian,ZHANG Liping,WANG Xiaoxing,CHEN Dengxia,LI Xiaocong,HUANG Yingping Alan G.MacDiarmid Research Institute of Renewable Energy,China Three Gorges University,Yichang 443002,Hubei,China | 2010 | Wuhan University Journal of Natural Sciences2010，15，6： | 2 |
| 12 | Spatialand temporal variability of drought in the arid region ofChina and its relationships to teleconnection indices显示文摘 | Wan Huaijung Chen Yaning Pan Yingping | 2015 | Journal of Hydrology2015，523，： | 1 |
| 13 | Decoupling engineering of formamidinium–cesium perovskites for efficient photovoltaics显示文摘Although pure formamidinium iodide perovskite(FAPbI3)possesses an optimal gap for photovoltaics,their poor phase stability limits the long-term operational stability of the devices.A promising approach to enhance their phase stability is to incorporate cesium into FAPbI3.However,state-of-the-art formamidinium–cesium(FA–Cs)iodide perovskites demonstrate much worse efficiency compared with FAPbI3,limited by the different crystallization dynamics of formamidinium and cesium,which result in poor composition homogeneity and high trap densities.We develop a novel strategy of crystallization decoupling processes of formamidinium and cesium via a sequential cesium incorporation approach.As such,we obtain highly reproducible,highly efficient and stable solar cells based on FA_(1–x)Cs_(x)PbI_(3)(x=0.05–0.16)films with uniform composition distribution in the nanoscale and low defect densities.We also revealed a new stabilization mechanism for Cs doping to stabilize FAPbI3,i.e.the incorporation of Cs into FAPbI3 significantly reduces the electron–phonon coupling strength to suppress ionic migration,thereby improving the stability of FA–Cs-based devices. | Haoran Chen Yong Wang Yingping Fan Yuetian Chen Yanfeng Miao Zhixiao Qin Xingtao Wang Xiaomin Liu Kaicheng Zhu Feng Gao Yixin Zhao | 2022 | National Science Review2022，9，10： | 1 |
| 14 | Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains显示文摘The production capability of a fermentation process is predominately determined by individual strains,which ultimately affected ultimately by interactions between the scale-dependent flow field developed within bioreactors and the physiological response of these strains.Interpreting these complicated interactions is key for better understanding the scale-up of the fermentation process.We review these two aspects and address progress in strategies for scaling up fermentation processes.A perspective on how to incorporate the multiomics big data into the scale-up strategy is presented to improve the design and operation of industrial fermentation processes. | Jianye Xia Guan Wang Meng Fan Min Chen Zeyu Wang Yingping Zhuang | 2021 | Chinese Journal of Chemical Engineering2021，34，2： | 1 |
| 15 | Medium optimization for meilingmycin production by Streptomyces nanchangensis using response surface methodology显示文摘 | ZHUANG Yingping CHEN Bin CHU Ju | 2006 | Process Biochemistry2006，41，2： | 1 |
| 16 | Understanding energetic disorder in electron-deficient-core-based non-fullerene solar cells显示文摘Recent advances in material design for organic solar cells(OSCs)are primarily focused on developing near-infrared nonfullerene acceptors,typically A-DA′D-A type acceptors(where A abbreviates an electron-withdrawing moiety and D,an electron-donor moiety),to achieve high external quantum efficiency while maintaining low voltage loss.However,the charge transport is still constrained by unfavorable molecular conformations,resulting in high energetic disorder and limiting the device performance.Here,a facile design strategy is reported by introducing the'wing'(alkyl chains)at the terminal of the DA′D central core of the A-DA′D-A type acceptor to achieve a favorable and ordered molecular orientation and therefore facilitate charge carrier transport.Benefitting from the reduced disorder,the electron mobilities could be significantly enhanced for the'wing'-containing molecules.By carefully changing the length of alkyl chains,the mobility of acceptor has been tuned to match with that of donor,leading to a minimized charge imbalance factor and a high fill factor(FF).We further provide useful design strategies for highly efficient OSCs with high FF. | Jun Yuan Chujun Zhang Honggang Chen Can Zhu Sin Hang Cheung Beibei Qiu Fangfang Cai Qingya Wei Wei Liu Hang Yin Rui Zhang Jidong Zhang Ye Liu Huotian Zhang Weifang Liu Hongjian Peng Junliang Yang Lei Meng Feng Gao Shukong So Yongfang Li Yingping Zou | 2020 | Science China Chemistry2020，63，8： | 1 |
| 17 | Synthesis and biological evaluation of dimeric RGD peptide-paclitaxel conjugate as a model for integrin-targeted drug delivery显示文摘 | Chen Xiaoyuan Plasencia Carmen Hou Yingping | 2005 | Journal of Medical Chemistry2005，48，4： | 1 |
| 18 | MicroPET imaging of brain tumor angiogenesis with 18F-labeled PEGylated RGD peptide显示文摘 | Xiaoyuan Chen Ryan Park Yingping Hou Vazgen Khankaldyyan Ignacio Gonzales-Gomez Michel Tohme James R. Bading Walter E. Laug Peter S. Conti | 2004 | European Journal of Nuclear Medicine and Molecular Imaging2004，，8： | 1 |
| 19 | How can photoreceptor cells breathe in the retina? Neuroglobin may be the answer显示文摘Dear Editor, The retina is one of the highest oxygen-consuming tissues in the body because the visual process in the | Xin Wei Yingping Deng Xuyang Liu Lin Wang Xiaoming Chen | 2010 | Neural Regeneration Research2010，5，9： | 1 |
| 20 | Fluorine-doped BiVO_(4) photocatalyst: Preferential cleavage of C−N bond for green degradation of glyphosate显示文摘With increasing concerns on the environment and human health,the degradation of glyphosate through the formation of less toxic intermediates is of great importance.Among the developed methods for the degradation of glyphosate,photodegradation is a clean and efficient strategy.In this work,we report a new photocatalyst by doping F ion on BiVO_(4) that can efficiently degrade glyphosate and reduce the toxic emissions of aminomethylphosphonic acid(AMPA)through the selective(P)−C−Ncleavage in comparison of BiVO_(4) catalyst.The results demonstrate that the best suppression of AMPA formation was achieved by the catalyst of 0.3F@BiVO_(4) at pH=9(AMPA formation below10%).In situ attenuated total reflectance Fourier transforms infrared(ATR-FTIR)spectroscopy indicates that the adsorption sites of glyphosate on BiVO_(4) and 0.3F@BiVO_(4) are altered due to the difference in electrostatic interactions.Such an absorption alteration leads to the preferential cleavage of the C−Nbond on the N−C−P skeleton,thereby inhibiting the formation of toxic AMPA.These results improve our understanding of the photodegradation process of glyphosate catalyzed by BiVO_(4)-based catalysts and pave a safe way for abiotic degradation of glyphosate. | Yunlong Chen Yingping Huang Hailin Tian Liqun Ye Ruiping Li Chuncheng Chen Zhongxu Dai Di Huang | 2023 | Journal of Environmental Sciences2023，，5： | 0 |
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