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| 1 | Efficacy of Chinese herbal medicine for lumbar disc herniation: a systematic review of randomized controlled trials显示文摘OBJECTIVE: This is a review of the effects of Chinese herbal medicine(CHM) used alone to treat lumbar disc herniation(LDH). METHORDS: A literature search of the following electronic databases from their inception to February 2013 was conducted: Chinese Biomedical databases, Chinese National Knowledge Infrastructure, Wanfang Database, China Science and Technology Journal Database, Cochrane Library, Web of Science, MEDLINE, and EMBASE. Randomized controlled trials where CHM had been used to treat LDH were selected. Data extraction, quality assessment, and data analysis were carried out by two independent reviewers. RESULTS: Of the 2415 studies identified, eight with complete data on 1146 patients were selected. The methodological quality was poor in all trials. Five studies reported that CHM was better than Western Medicine [OR=2.81, 95% CI(1.27, 6.18); OR=3.34, 95% CI(1.92, 5.79); OR=2.22, 95% CI(1.08, 4.57); OR= 6.67, 95% CI(1.34, 33.28); and OR=1.94, 95% CI(1.23, 3.06)]. Two studies reported that the clinical outcome was better in CHM groups than in physiotherapy and placebo groups, [OR=3.02, 95% CI(1.08, 8.46); and OR=2.67, 95% CI(1.26, 5.64), respectively], whereas one study reported no difference between CHM and physiotherapy groups. One study reported that CHM resulted in higher Japanese Orthopedic Association scores [MD=7.78, 95% CI(6.67, 8.89)] than in a control group and another that participants treated with CHM had lower Visual Analogue Scale scores [MD=﹣0.72, 95% CI( ﹣0.86, ﹣0.58)] than those in a control group. Three studies reported that the adverse effects of CHM and Western Medicine did not differ significantly [OR=0.10, 95% CI(0.01, 1.85); OR=0.19, 95% CI(0.01, 4.07); and OR=0.07, 95% CI(0.00, 1.32)]. CONCLUSION: CHM may be more effective than other interventions for LDH; however, methodological weaknesses in the studies assessed in this review prevent a definitive conclusion. More high-quality large-scale studies are required to clarify this matter. | Yi Luo Jian Huang Lin Xu Weikang Zhao Jie Hao Zhenming Hu | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 15 |
| 2 | Isolation via enrichment and characterization of ten polymorphic microsatellite loci in the cuttlefish, Sepiella maindroni de Rochebruns显示文摘Ten novel polymorphic microsatellite loci were developed using an enrichment and colony hybridization protocol and characterized for the cuttlefish,Sepiella maindroni.Polymorphism was explored by using 30 individuals from the coastal waters of Zhanjiang,Guangdong province,China,in December 2007.The number of alleles ranged from 5 to 13.The ranges of observed and expected heterozygosity were from 0.578 9 to 1.000 0 and 0.682 8 to 0.925 7,respectively,and the average polymorphic information content (P IC) was 0.778 5.These microsatellite loci will certainly facilitate the detection of the genetic variation and population structure of S.maindroni. | WU Changwen CHI Changfeng HE Guangyuan LU Zhenming XU Meiying | 2010 | Acta Oceanologica Sinica2010，29，6： | 6 |
| 3 | Estimated biomass carbon in thinned Cunninghamia lanceolate plantations at different stand-ages显示文摘Chinese fir(Cunninghamia lanceolate[Lamb.]Hook.)is a fast-growing species which is not only important as a timber-supplier,but also as an available sink for carbon(C)storage in biomass.Stand age and density are two critical factors that can determine tree C sequestration as interrelated drivers through natural self-thinning.C.lanceolate were planted using 1-year-old bare-root seedlings at the initial density of 1800 stems ha^(-1)in a 15-ha montane area of Hunan Province,China in 1987.The plantation was thinned twice 10 and 20 years after planting to leave trees of437.5±26.6,675.0±155.2 and 895.8±60.1 stems ha^(-1)as low,medium,and high densities,respectively.Tree height and diameter at breast height(DBH)were measured every2 years beginning from 23 years(2009)to 31 years(2018)after establishment,timber volume(TV)and biomass C were estimated accordingly.We did not find any interactive effect of age and density on any variables except for height.Both TV and biomass C increased with stand age or decreased in higher densities.The allometric heightDBH relationship can be fitted by an exponential risingto-maximum model with higher maximum value over time.The decline of biomass C along density fit with the inverse first-order polynomial model which indicated that at least1300-1500 stems ha^(-1)may be needed to maximize TV and biomass C for a longer term over 20 years.Therefore,to control the density to a reasonable level,over 1300 stems ha^(-1)in a rotation over 20 years old will be practical for tree biomass C in Chinese fir plantations. | Xie Zhang Zhenming Wu Zhongkun Xu Liang Xu Qingqian Xu Jianzhong Lin | 2021 | Journal of Forestry Research2021，32，4： | 5 |
| 4 | High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors显示文摘A new coronavirus(SARS-CoV-2)has been identified as the etiologic agent for the COVID-19 outbreak.Currently,effective treatment options remain very limited for this disease;therefore,there is an urgent need to identify new anti-COVID-19 agents.In this study,we screened over 6,000 compounds that included approved drugs,drug candidates in clinical trials,and pharmacologically active compounds to identify leads that target the SARS-CoV-2 papain-like protease(PLpro).Together with main protease(Mpro),PLpro is responsible for processing the viral replicase polyprotein into functional units.There-fore,it is an attractive target for antiviral drug develop-ment.Here we discovered four compounds,YM155,cryptotanshinone,tanshinone I and GRL0617 that inhibit SARS-CoV-2 PLpro with IC50 values ranging from 1.39 to 5.63 pmol/L.These compounds also exhibit strong antiviral activities in cell-based assays.YM155,an anti-cancer drug candidate in clinical trials,has the most potent antiviral activity with an EC50 value of 170 nmol/L.In addition,we have determined the crystal structures of this enzyme and its complex with YM155,revealing a unique binding mode.YM155 simultaneously targets three'hot'spots on PLpro,including the substrate-binding pocket,the interferon stimulating gene product 15(ISG15)binding site and zinc finger motif.Our results demonstrate the efficacy of this screening and repur-posing strategy,which has led to the discovery of new drug leads with clinical potential for COVID-19 treatments. | Yao Zhao Xiaoyu Du Yinkai Duan Xiaoyan Pan Yifang Sun Tian You Lin Han Zhenming Jin Weijuan Shang Jing Yu Hangtian Guo Qianying Liu Yan Wu Chao Peng Jun Wang Chenghao Zhu Xiuna Yang Kailin Yang Ying Lei Luke W.Guddat Wenqing Xu Gengfu Xiao Lei Sun Leike Zhang Zihe Rao Haitao Yang | 2021 | Protein & Cell2021，12，11： | 4 |
| 5 | Highly Dispersed Cobalt Nanoparticles Embedded in Nitrogen-Doped Graphitized Carbon for Fast and Durable Potassium Storage显示文摘Potassium-ion batteries(KIBs)have great potential for applications in large-scale energy storage devices.However,the larger radius of K+leads to sluggish kinetics and inferior cycling performance,severely restricting its practical applicability.Herein,we propose a rational strategy involving a Prussian blue analogue-derived graphitized carbon anode with fast and durable potassium storage capability,which is constructed by encapsulating cobalt nanoparticles in nitrogen-doped graphitized carbon(Co-NC).Both experimental and theoretical results show that N-doping effectively promotes the uniform dispersion of cobalt nanoparticles in the carbon matrix through Co-N bonds.Moreover,the cobalt nanoparticles and strong Co-N bonds synergistically form a threedimensional conductive network,increase the number of adsorption sites,and reduce the diffusion energy barrier,thereby facilitating the adsorption and the diffusion kinetics.These multiple effects lead to enhanced reversible capacities of 305 and 208.6 mAh g^−1 after 100 and 300 cycles at 0.05 and 0.1 A g^−1,respectively,demonstrating the applicability of the Co-NC anode for KIBs. | Xiaodong Shi Zhenming Xu Cheng Han Runze Shi Xianwen Wu Bingan Lu Jiang Zhou Shuquan Liang | 2021 | Nano-Micro Letters2021，13，2： | 4 |
| 6 | Two-stage ADMM-based distributed optimal reactive power control method for wind farms considering wake effects显示文摘Since the connection of small-scale wind farms to distribution networks,power grid voltage stability has been reduced with increasing wind penetration in recent years,owing to the variable reactive power consumption of wind generators.In this study,a two-stage reactive power optimization method based on the alternating direction method of multipliers(ADMM)algorithm is proposed for achieving optimal reactive power dispatch in wind farm-integrated distribution systems.Unlike existing optimal reactive power control methods,the proposed method enables distributed reactive power flow optimization with a two-stage optimization structure.Furthermore,under the partition concept,the consensus protocol is not needed to solve the optimization problems.In this method,the influence of the wake effect of each wind turbine is also considered in the control design.Simulation results for a mid-voltage distribution system based on MATLAB verified the effectiveness of the proposed method. | Zhenming Li Zhao Xu Yawen Xie Donglian Qi Jianliang Zhang | 2021 | Global Energy Interconnection2021，4，3： | 3 |
| 7 | Local heat transfer measurements on a rotating flat blade model with a single film hole显示文摘An experimental study was performed to measure the heat transfer coeffcient distributions on a flat blade model under rotating oper-ating conditions. A steady-state thermochromic liquid crystal technique was employed to measure the surface temperature, and all the signals from the rotating reference frame were collected by the telemetering instrument via a wireless connection. Both air and CO2 were used as coolant. Results show that the rotational effect has a significant influence on the heat transfer coeffcient distributions. The pro-files of hg/h0, which is the ratio of heat transfer coeffcient with film cooling to that without film cooling, deffect towards the high-radius locations on both the pressure surface and suction surface as the rotation number (Rt) increases, and the deffective tendency is more evident on the suction surface. The variations in mainstream Reynolds number (ReD) and blowing ratio (M) present different distribu-tions of hg/h0 on the pressure and suction surfaces, respectively. Furthermore, the coolant used for CO2 injection is prone to result in lower heat transfer coeffcients. | Guoqiang Xu, Bin Yang*, Zhi Tao, Zhenming Zhao, Hongwei Wu National Key Laboratory on Aero-Engines, School of Jet Propulsion, Beihang University, Beijing 100083, China | 2009 | Progress in Natural Science:Materials International2009，19，3： | 3 |
| 8 | Electromagnetic Filtration of Primary Fe-Rich Phases from Al-Si Alloy Melt显示文摘Electromagnetic filtration of primary Fe-rich phases (complex compound of AlFeSiMn) from Al-Si alloy melt containing 1.2 wt pct Fe have been studied by theoretical analysis and on a self-designed electromagnetic filtration equipment. The principle of the electromagnetic filtration is that the EMF (electromagnetic force) scarcely acts on the primary Fe-rich phases having low electric conductivity, which are then moved in the direction opposite to that of the EMF. Experimental results show that the primary Fe-rich phases are separated from Al-Si alloy melt and are collected in the filter while the melt is in horizontal flow. The removal efficiency of the primary iron-phases (77) calculated is less as the greatest flow velocity of the melt (UM) and the height of the filter (2h) are larger, while it becomes larger as EMF, operating distance of electromagnetic force (cr) and particle size (dv) become larger. It has been confirmed that the primary iron-phases larger than 20 jim can be removed efficiently by theoretical analysis and experiments. This new technique is high efficient and available for continuously flowing melts as compared with natural settling and filtration methods, which offer a possibility for recycling high quality aluminum alloys. | Zhenming XU, Tianxiao LI, Da SHU and Yaohe ZHOU School of Materials Science and Engineering, Shanghai Jiaotong University, Shanghai 200030, China E-mail: zmxu@mail1.sjtu.edu.cn | 2001 | Journal of Materials Science & Technology2001，17，3： | 3 |
| 9 | A Surfactant-stable Bacillus pumilus K9 α-Keratinase and Its Potential Application in Detergent Industry显示文摘 | GONG Jinsong WANG Yue ZHANG Dandan LI Heng ZHANG Xiaomei ZHANG Rongxian LU Zhenming XU Zhenghong SHI Jinsong | 2015 | Chemical Research in Chinese Universities2015，31，1： | 3 |
| 10 | Crystallization Growth of Single Crystal Cu by Continuous Casting显示文摘Crystallization growth of single-crystal Cu by continuous casting has been investigated using self- designed horizontal continuous casting equipment and XRD. Experimental results showed that the crystallization plane of (311), (220) and (111) were eliminated sequentially in evolutionary process. The final growth plane of crystal was (200), the direction of crystallization was [100], the growwth direction of both sides of the rod inclined to axis, and the degree of deviation of direction [100] from the crystal axis was less than 10? In order to produce high quality single crystal, the solid-liquid interface morphology must be smooth, even be planar. | Zhenming XU and Jianguo LI (School of Materials Science and Engineering, Shanghai Jiaotong University, Shanghai 200030, China) Hengzhi FU (State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi’an 710072, China) | 2000 | Journal of Materials Science & Technology2000，16，3： | 2 |
| 11 | Comparative mitochondrial genome analysis of Varunidae and its phylogenetic implications显示文摘Complete mitochondrial genomes(mitogenomes)can indicate phylogenetic relationships,as well as useful information for gene rearrangement mechanisms and molecular evolution.Currently,the phylogenetic location of the genus Varuna(Brachyura:Varunidae)has not been well resolved mainly because of limited representatives(only two extant species).Here,we determined a new mitogenome of this genus(Varuna litterata)and added the published mitogenomes to reconstruct the phylogeny of Varunidae.The 16368-bp mitogenome contains the entire set of 37 genes and a putative control region.The characteristics of this newly sequenced mitogenome were described and compared with the other 15 Varunidae mitogenomes.All 16 analyzed mitogenomes have identical gene order and similar molecular features.The sliding window and genetic distance analyses demonstrate highly variable nucleotide diversity,with comparatively low variability of COI and COII,and high variability of ND6.The nonsynonymous/synonymous substitution rates(dN/dS ratio)analysis shows that all 13 PCGs are under purifying selection and ATP8 gene evolves under the least selective pressure.Twelve tRNA genes,two rRNAs,one PCG,and the putative control region are found to be rearranged with respect to the pancrustacean ground pattern gene order.Tandem duplication/random loss model is adopted to explain the large-scale gene rearrangement events occurring in Varunidae mitogenomes.Phylogenetic analyses show that all Varunidae species are placed into one group,and form a sister clade with Macrophthalmidae.Nevertheless,the phylogenetic relationships within Varunidae are not completely consistent based on the two different datasets used in this study.These findings will contribute to a better understanding of gene rearrangement and molecular evolution in Varunidae mitogenomes,as well as provide insights into the phylogenetic studies of Brachyura. | Ying Zhang Li Gong Xinting Lu Zengliang Miao Lihua Jiang Bingjian Liu Liqin Liu Pengfei Li Xu Zhang Zhenming Lü | 2022 | Acta Oceanologica Sinica2022，41，6： | 2 |
| 12 | Application of glass-nonmetals of waste printed circuit boards to produce phenolic moulding compound显示文摘 | Jie Guo Qunli Rao Zhenming Xu | 2007 | Journal of Hazardous Materials2007，，1： | 2 |
| 13 | S100A8 mediates the activation of P65/HLA-B/S100A8/BCL-2/Caspase-9 (-3) pathway in laryngeal carcinogenesis显示文摘S100 calcium binding protein A8 (S100A8),a possible novel member of NF-kappa B signal pathway in laryngeal squamous cell carcinoma (LSCC),interacts with human leukocyte antigen B (HLA-B) which carries an NF-kappa B binding site within the enhancer A. The objective of this study was to explore the molecular mechanism of S100A8 in laryngeal carcinogenesis. RT-PCR,Western blotting and immuno-histochemistry staining were applied to evaluate the expression levels of IKKα,P65,REL-B,S100A8,APAF-1 and BCL-2 genes. The signal transduction passway in which S100A8 might participate was explored by RNA interference. Flow cytometry,TUNEL assay and cell invasion in vitro were used to detect the biological behavior of Hep2 cells induced by S100A8 gene. Our results showed that high expression of S100A8 was related to tumorigenesis in LSCC and negatively correlated with the degree of differentiation,indicating that S100A8 gene could inhibit apoptosis and promote metastasis in LSCC. Additionally,the suppression of S100A8 by RNA interference down-regulated BCL-2 but not APAF-1,P65 and IKKα,while,the suppression of P65 could significantly down-regulate the expression of S100A8 gene. In conclusion,S100A8 plays an important role in P65/HLA-B/S100A8/BCL-2/Caspase-9 (-3) pathway in laryngeal carcinoma. | HUANG DaiFa FU WeiNeng GUO Yan XU ZhenMing SUN XingHe SUN KaiLai | 2008 | Chinese Science Bulletin2008，53，13： | 2 |
| 14 | On semantics of L-valued first-order logic L 显示文摘 | Xu Yang Liu Jun Song Zhenming | 2000 | International Journal of General Systems2000，29，1： | 1 |
| 15 | An environmental friendly recovery production line of waste toner cartridges显示文摘 | Ruan Jujun Li Jia Xu Zhenming | 2011 | Journal of Hazardous Materials2011，185，23： | 1 |
| 16 | Metformin reverses multidrug resistance in human hepatocellular carcinomaBel?7402/5?fluorouracil cells显示文摘 | Sunbin Ling Yu Tian Haiquan Zhang Kaiqi Jia Tingting Feng Deguang Sun Zhenming Gao Fei Xu Zhaoyuan Hou Yan Li Liming Wang | 2014 | Molecular Medicine Reports2014，，6： | 1 |
| 17 | Recycling of non-metallic fractions from waste printed circuit boards: a review显示文摘 | GUO Jiuyong GUO Jie XU Zhenming | 2009 | Journal of Hazardous Materials2009，168，23： | 1 |
| 18 | A facile approach for synthesis of high-stable CdS nanoparticles显示文摘CdS nanoparticles with prolonged sta- bility against photo-oxidation have been successfully synthesized in aqueous solution using 2-mercapto- succinic acid (MSA) as stabilizer at room temperature The growth progress of particles is found to be af- fected with changing Cd2+ concentration. Whether the thiol group in MSA could be dissociated plays an important role on the effective passivation of CdS nanoparticles. | LI Cheng CHEN Xiao SUI Zhenming WANG Luyan XU Limei HAO Jingcheng | 2006 | Chinese Science Bulletin2006，51，10： | 1 |
| 19 | A Two-phase Method of Approximate String Match显示文摘 | WANG Yi XU Yang XU Zhenming | 2004 | Systems Man and Cybernetics2004，4，12： | 1 |
| 20 | Performance and thermal behavior of wood plastic composite produced by nonmetals of pulverized waste printed circuit boards显示文摘 | Jie Guo Yinen Tang Zhenming Xu | 2010 | Journal of Hazardous Materials2010，，1： | 1 |
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