3篇
您的检索式：作者名="Zhenlu Chong"
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| 1 | E3 ligase FBXW7 aggravates TMPD-induced systemic lupus erythematosus by promoting cell apoptosis显示文摘Systemic lupus erythematosus(SLE)is a systemic autoimmune disease,and the pathogenesis of SLE has not been fully elucidated.The E3 ubiquitin ligase FBXW7 has been well characterized in cancer as a tumor suppressor that can promote the ubiquitination and subsequent degradation of various oncoproteins;however,the potential role of FBXW7 in autoimmune diseases is unclear.In the present study,we identified that FBXW7 is a crucial exacerbating factor for SLE development and progression in a mouse model induced by 2,6,10,14-tetramethylpentadecane(TMPD).Myeloid cell-specific FBXW7-deficient(Lysm+FBXW7f/f)C57BL/6 mice showed decreased immune complex accumulation,glomerulonephritis,glomerular mesangial cell proliferation,and basemembrane thickness in the kidney.Lysm+FBXW7f/f mice produced fewer anti-Sm/RNP and anti-ANA autoantibodies and showed a decreased MHC II expression in B cells.In Lysm+FBXW7f/f mice,we observed that cell apoptosis was reduced and that fewer CD11b+Ly6Chi inflammatory monocytes were recruited to the peritoneal cavity.Consistently,diffuse pulmonary hemorrhage(DPH)was also decreased in Lysm+FBXW7f/f mice.Mechanistically,we clarified that FBXW7 promoted TMPD-induced cell apoptosis by catalyzing MCL1 degradation through K48-linked ubiquitination.Our work revealed that FBXW7 expression in myeloid cells played a crucial role in TMPD-induced SLE progression in mice,which may provide novel ideas and theoretical support for understanding the pathogenesis of SLE. | Zhenlu Chong Chunjing Bao Jia He Tianxiao Chen Lijia Zhong Gaopeng Li Huanle Li Lutong Fang Yinjing Song Guoxiang Fu Xuyan Yang Lihua Lai Yang Liu Qingqing Wang | 2018 | Cellular & Molecular Immunology2018，15，12： | 2 |
| 2 | Identification and in vitro culture of Spermatogonial Stem Cells (SSCs) in Prepubertal Buffaloes显示文摘 | Xue Yu Hasan Riaz Ping Dong Zhenlu Chong Xuan Luo Aixin Liang Liguo Yang | 2014 | Theriogenology2014，，： | 1 |
| 3 | A bound on the distance between Loop subdivision surface and its control mesh显示文摘By means of direct analysis of the connection between Loop subdivision surface and its control mesh and the computation of the basis functions,we obtain a bound on the distance between Loop subdivision surface patch and its control mesh.The bound can be used to compute the numbers of subdivision for a given tolerance.Finally,two examples are listed in this paper to demonstrate the applications of the bound. | Zhang Yuhua Zhao Chong Cui Zhenlu Zeng Xiaoming | 2012 | Computer Aided Drafting,Design and Manufacturing2012，22，1： | 0 |
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