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| 1 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 2 | Major controlling factors and predictions for cadmium transfer from the soil into spinach plants显示文摘 | Zhenfei Liang Qiong Ding Dongpu Wei Jumei Li Shibao Chen Yibing Ma | 2013 | Ecotoxicology and Environmental Safety2013，，： | 1 |
| 3 | Numerical Simulation of Charging Performance of Combined Sensible-Latent Heat Storage System with a Macro-Encapsulation Method显示文摘In recent years,heat storage system combining sensible and latent heat materials has received more and more attentions.In this paper,we proposed the hybrid configuration with a macro-encapsulation,and analyzed its charging performance with different influencing factors by CFD simulation.In the case,the sensible heat storage materials are magnesia brick or HT concrete and the phase change materials(PCMs)are mixed molten salts.Firstly,we analyzed the heat transfer characteristics of the hybrid configuration in charging process.Then,we analyzed the effect of heating power on charging performance.The maximum temperature of the heating surface shall not exceed 500℃as the constraint condition,the heat storage capacity increases at first and then decreases with the heating power.Then,we compared the charging performance of different solid structure and the hybrid configurations.Whether magnesia brick or HT concrete,the charging performance of the solid structure is better than that of the hybrid configuration,because the thermal conductivity of the molten salt is significantly lower than that of the two sensible heat storage materials.Then,we compared the charging performance of different molten salts.The hybrid configuration with lower melting point molten salt has better performance because of more intensity natural convection.Finally,we analyzed the charging performance of the hybrid configuration used the composite phase change material(CPCM)with high thermal conductivity and specific heat.From the result,the charging performance increases by 22.5%compared with the solid structure.These results indicate that the hybrid configuration with the macro-encapsulation method is a potential form of thermal energy storage,but it needs to be further optimized. | WANG Wei PAN Zhenfei LEI Biao WU Yuting WANG Jingfu MA Chongfang | 2023 | Journal of Thermal Science2023，32，6： | 0 |
| 4 | Numerical investigation on dynamic characteristics of flow field in cyclone separators with different dust hopper structures显示文摘The dynamic characteristics of flow field in cyclone separators with different dust hopper structures were studied by coupling Reynolds Stress Model(RSM)and Lagrangian Particle Tracking(LPT)methods.The characteristic frequencies of cylinder section,cone section and dust hopper were calculated as f_(1)=53 Hz,f_(2)=65 Hz,and f_(3)=8 Hz by using Fast Fourier Transform(FFT)method,respectively.Based on the effects of f3 on the motion of vortex,the separated space was divided into none affected region,weakly affected region,and strongly affected region.The characteristic frequency of dust hopper increased with the decrease of dust hopper diameter,while it was independent of the height.The dust hopper with d=1.5D(model D3)and h=1.5D(model H3)can significantly decrease the effect of back-mixing on the motion of inner vortex,which is beneficial to improve the efficiency of cyclone separator. | Liyun Zhu Sen Wang Yi Ru Jianzhu Wang Pengju Yang Anjun Li Zhenfei Ma Zhenbo Wang | 2023 | Particuology2023，，11： | 0 |
| 5 | A Review of Metal Silicides for Lithium-Ion Battery Anode Application显示文摘Lithium batteries(LIBs) with low capacity graphite anode(~372 mAh g-1) cannot meet the ever-growing demand for new energy electric vehicles and renewable energy storage.It is essential to replace graphite anode with higher capacity anode materials for high-energy density LIBs.Silicon(Si) is well known to be a possible alternative for graphite anode due to its highest capacity(~4200 mAh g-1).Unfortunately,large volume change during lithiation and delithiation has prevented the Si anode from being commercialized.Metal silicides are a promising type of anode materials which can improve cycling stability via the accommodation of volume change by dispersing Si in the metal inactive/active matrix,while maintain greater capacity than graphite.Here,we present a classification of Si alloying with metals in periodic table of elements,review the available literature on metal silicide anodes to outline the progress in improving and understanding the electrochemical performance of various metal silicides,analyze the challenges that remain in using metal silicides,and offer perspectives regarding their future research and development as anode materials for commercial LIBs application. | Bo Ding Zhenfei Cai Zishan Ahsan Yangzhou Ma Shihong Zhang Guangsheng Song Changzhou Yuan Weidong Yang Cuie Wen | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，3： | 0 |
| 6 | Enhanced stability and electrochemical properties of lanthanum and cerium co-modified LiVOPO_(4) cathode materials for Li-ion batteries显示文摘A facile and efficient ball-milling assisted sol-gel synthesis route was developed to prepare triclinic e-LiVOPO_(4)(LVOP)material with lanthanum(La)and cerium(Ce)modification individually as well as simultaneously.An LVOP/LaPO_(4)/CePO_(4)composite cathode material was successfully synthesized and results show that La and Ce co-modification noticeably improves the electrochemical performance by enhancing the high voltage capacity upon cycling,which indicates contributions from the good ionic conductors LaPO_(4)and CePO_(4).The simultaneous La and Ce modification improves the high voltage performance significantly with an increase of 50%in high voltage capacity after 20 cycles compared to pure LVOP.It also shows stabilized cycling perfo rmance with 91%capacity rete ntion after 50 cycles at 0.1 C rate,along with high-rate capability with a capacity of 83.1 mAh/g compared to the pristine sample showing the capacity of 51.6 mAh/g at a high rate of 5C.This can be attributed to the good conductivity of LaPO_(4)and CePO_(4).In addition,the LVOP/LaPO_(4)/CePO_(4)composite and the pristine LVOP give a charge transfer resistance of-105 and-212Ω,respectively,showing much lower impedance due to a combination of La and Ce addition. | Zishan Ahsan Zhenfei Cai Shuai Wang Haichuan Wang Yangzhou Ma Guangsheng Song Shihong Zhang Weidong Yang Muhammad Imran Cuie Wen | 2023 | Journal of Rare Earths2023，41，10： | 0 |
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