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| 1 | Effect of Phosphorus Grain Boundaries Segregation and Precipitations on Mechanical Properties for Ti-IF Steel after Recrystallization Annealing显示文摘The cold-rolled(75% reduction ratio) Ti-IF(interstitial-free) steels of 1 mm thickness were recrystallized by annealing at 810°C for different times.The microstructure,mechanical properties and phosphorus segregation at grain boundary were investigated by means of optical microscopy(OM),tensile testing and field emission transmission electron microscopy(FE-TEM).It was observed that recrystallization was completed after annealing at 810°C for 180 s.The yield strength and tensile strength decreased as annealing time increased.The FE-TEM observation showed that after the annealing treatment,the grain boundary was broadened and the dislocations with higher density of phosphorus atoms and phosphide at grain boundaries became evident.The amount of phosphorus segregated at grain boundaries increased with annealing time. | Xinli Song Zexi Yuan Juan Jia Di Wang Pinghe Li Zhaojun Deng | 2010 | Journal of Materials Science & Technology2010，26，9： | 2 |
| 2 | Coordinated transcription of ANRIL and P16 genes is silenced by P16 DNA methylation显示文摘Objective: To investigate the relationship between the transcription of ANRIL, P15, P14 and P16 at the same locus and the regulation mechanism of ANRIL.Methods: Publicly available database of Cancer Cell Line Encyclopedia(CCLE) was used in bioinformatic analyses. Methylation of Cp G islands was detected by denaturing high performance liquid chromatography(DHPLC). Gene transcript levels were determined using quantitative real-time polymerase chain reaction(q RTPCR) assays. An engineered P16-specific transcription factor and DNA methyltransferase were used to induce P16-specific DNA demethylation and methylation.Results: The expression level of ANRIL was positively and significantly correlated with that of P16 but not with that of P15 in the CCLE database. This was confirmed in human cell lines and patient colon tissue samples. In addition, ANRIL was significantly upregulated in colon cancer tissues. Transcription of ANRIL and P16 was observed only in cell lines in which the P16 alleles were unmethylated and not in cell lines with fully methylated P16 alleles.Notably, P16-specific methylation significantly decreased transcription of P16 and ANRIL in BGC823 and GES1 cells. In contrast, P16-specific demethylation re-activated transcription of ANRIL and P16 in H1299 cells(P<0.001).Alteration of ANRIL expression was not induced by P16 expression changes.Conclusions: ANRIL and P16 are coordinately transcribed in human cells and regulated by the methylation status of the P16 Cp G islands around the transcription start site. | Ying Gan Wanru Ma Xiuhong Wang Juanli Qiao Baozhen Zhang Chenghua Cui Zhaojun Liu Dajun Deng | 2018 | Chinese Journal of Cancer Research2018，30，1： | 2 |
| 3 | Extensive evolution analysis of the global chikungunya virus strains revealed the origination of CHIKV epidemics in Pakistan in 2016显示文摘Chikungunya virus(CHIKV) is a mosquito-borne virus that causes epidemics widely in the world especially in the tropical and subtropical regions. Phylogenetic analysis has found that the CHIKV lineages were associated with the spatial and temporal distributions, which were related to the virus adaption to the major mosquito species and their distributions. In this study, we reported the complete genome sequences of eight CHIKV isolates from the outbreak in Pakistan last year. Then we reviewed the evolutionary history using extensive phylogenetic analysis, analyzed lineagespecific substitutions in viral proteins, and characterized the spreading pathway of CHIKV strains including the Pakistani strains. The results showed that the Pakistani stains belonged to the ECSA.IOL sub-lineage and derived from India. The genetic properties of the Pakistani strains including the adaptive substitution to vectors were further characterized, and the potential risks from the occurrence of CHIKV infection in Pakistan were discussed. These results provided better understanding of CHIKV evolution and transmission in the world and revealed the possible origination of the CHIKV outbreak and epidemic in Pakistan, which would promote the disease prevention and control in the identified countries and territories with the history of CHIKV infections as well as new regions with potential risk of CHIKV outbreaks. | Junming Shi Zhengyuan Su Zhaojun Fan Jun Wang Siqing Liu Bo Zhang Hongping Wei Shoukat Jehan Nadia Jamil Shu Shen Fei Deng | 2017 | Virologica Sinica2017，32，6： | 2 |
| 4 | Microstructures and Mechanical Properties of Nb-Ti Bearing Hot-rolled TRIP Steels显示文摘有高粘性和保留的奥氏体的适当体积百分比的 Nb-Ti 热转动的帮助旅行的钢在实验基于好铁酸盐谷物被开发了。测试,结果证明铌趋于与更少的 降水,和铌钛在矩阵处于答案状态存在能被猛抛处于良好的竟技状态( Nb , Ti ) C 或( Nb , Ti )( C , N ),它在增加收益力量起一个重要作用(从 495 MPa 到 610 MPa )。而且,保留的奥氏体在在张力的变丑期间由转变改进粘性进马氏体上有积极效果。 | Yu CHEN Guoyi TANG Haoyang TIAN Feipeng LI Yu ZHANG Lihui WANG Zhaojun DENG Dexing LUO | 2006 | Journal of Materials Science & Technology2006，22，6： | 2 |
| 5 | A measurement method for magnetic property of the non- oriented silicon steels 显示文摘 | Shunbing ZHOU Dajun FENG Zhaojun DENG | 2013 | Advanced Materials Research2013，，602604： | 1 |
| 6 | Regulatory considerations for animal studies of biomaterial products显示文摘Animal studies play a vital role in validating the concept,feasibility,safety,performance and efficacy of biomaterials products during their bench-to-clinic translation.This article aims to share regulatory considerations for animal studies of biomaterial products.After briefly emphasizing the importance of animal studies,issues of animal studies during biomaterial products’translation are discussed.Animal studies with unclear purposes,flawed design and poor reporting quality could significantly reduce the translation efficiency and create regulatory challenges.Regulatory perspectives on the purpose,principle,quality and regulatory science of animal studies are also presented.Animal studies should have clear purposes,follow principles of 3R+DQ(replacement,reduction,refinement,design and quality)and execute under an efficiently operating quality management system.With the advancement of regulatory science,National Medical Products Administration of China has been developing a series of standards and guidance documents on animal studies of medical devices.Case studies of making decisions on whether to conduct animal studies are provided in the end with drug-eluting stents as examples.In summary,animal studies of biomaterial products should pay close attention to the rationale,design and quality in order to achieve their purposes. | Maobo Cheng Wenbo Liu Jiazhen Zhang Song Zhang Zhaojun Guo Lu Liu Jiaxin Tian Xiangmei Zhang Jin Cheng Yinghui Liu Gang Deng Guobiao Gao Lei Sun | 2022 | Bioactive Materials2022，7，5： | 1 |
| 7 | Epigenetic alterations as cancer diagnostic,prognostic,and predictive biomarkers显示文摘 | Deng Dajun Liu Zhaojun Du Yantao | 2010 | Adv Genet2010，71，： | 1 |
| 8 | Hunan geological disaster emergency survey system 显示文摘 | XU Zhaojun DENG Jiqiu | 2013 | JDCTA2013，7，6： | 1 |
| 9 | Characteristic of Near-surface Microstructure and Its Effects on the Torsion Performance of Cold Drawn Pearlitic Steel Wires for Bridge Cables显示文摘The characteristic of near-surface microstructure and its effects on the torsion performance of cold-drawn pearlitic steel wires for bridge cables were investigated by focused ion beam-scanning electron microscope,transmission electron microscopy and differential scanning calorimetry.The samples with similar tensile strength before and after hot-dip galvanizing process are,respectively,characterized as delaminated and non-delaminated in torsion test which indicates that the tensile strength is independent of the toughness value(i e,reduction area and torsion ability).It is interesting to find that there exists submicron granular ferrite on near-surface of the wires,which can be attributed to dislocation rearrangement and sub-grains rotation during cold drawing and hot-dip galvanizing process.And their distribution can suggest homogeneousness of deformation degree to a certain extent:the closer to the surface of their distribution,the more homogeneous deformation of the wires.There is a close relationship between the thermal stability of the cementite layer and distribution of granular ferrite:differential scanning calorimetry(DSC)analysis shows that the sample is accompanied by submicron granular ferrite which is located closer to the surface has higher thermal stability under galvanizing temperature(450°C).A new mechanism of the torsion delamination of pearlitic steel wires is discussed in terms of the thermal stability of the cementite layer and distribution of granular ferrite. | 张帆 MAO Xinping 鲍思前 ZHAO Gang ZHAO Sixin DENG Zhaojun HE Meng HUANG Fangyu QU Xi | 2022 | Journal of Wuhan University of Technology(Materials Science)2022，37，5： | 0 |
| 10 | Analysis of inclusions and precipitates in tough weld metal of X80 steel显示文摘Submerged arc welding(SAW) and gas metal arc welding(GMAW) experiments of Nb-bearing X80 steel were conducted with high-toughness wires.The inclusions in weld metals were analyzed in terms of their types and sizes.In GMAW,the inclusions are primarily Ti, Ca, Si, Al, and Mg compounds with no Nb and are generally less than 0.8 μm in size, whereas, in SAW weld, the inclusions are larger, mostly approximately 2-5 μm in size, and are cored with Ca and Ti, exhibiting obvious oxidation metallurgical features.The SAW joint was hot-deformed, and Nb-bearing nano precipitates were newly found in the weld metal through transmission electron microscopy, and Nb-free core-shell inclusion was found through scanning electron microscopy.The inclusions and precipitates were dispersed in or on the boundaries of acicular ferrite, contributing to acicular ferrite nucleation and grain refinement. | HUANG Zhijun DENG Zhaojun | 2021 | Baosteel Technical Research2021，15，4： | 0 |
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