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| 1 | Increasing trend of prevalence of infertility in Beijing显示文摘 | Zhang Hongxia Wang Shuyu Zhang Songwen Wang Tao Deng Xiaohong | 2014 | Chinese Medical Journal2014，，4： | 16 |
| 2 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 7 |
| 3 | POLYMORPH CONTROL OF ANTIMONY WHITE(Sb_2O_3) PREPARED BY HYDROMETALLURGY METHOD显示文摘POLYMORPHCONTROLOFANTIMONYWHITE(Sb2O3)PREPAREDBYHYDROMETALLURGYMETHOD①ZhangDuomo,XiaoSongwen,ChoTongraeLiuZhihong,GeRongde,C... | Zhang Duomo, Xiao Songwen, Cho Tongrae * Liu Zhihong, Ge Rongde, Chen Huiguang, Guo Xueyi Department of Nonferrous Metallurgy, Central South University of Technology, Changsha 410083 * College of Engineering, Chung Nam National University, South Ko | 1997 | 中国有色金属学会会刊:英文版1997，7，4： | 4 |
| 4 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
| 5 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
| 6 | SIRT1 deacetylates and positively regulates the nuclear receptor LXR显示文摘 | Xiaoling li Songwen Zhang Leonard Guarente | 2007 | Molecular Cell2007，28，1： | 1 |
| 7 | Association between polymorphisms of DNA repair genes and survival of advanced NSCLC patients treated with platinum-based chemotherapy显示文摘 | Shengxiang Ren Songwen Zhou Fengyin Wu Ling Zhang Xuefei Li Jie Zhang Jianfang Xu Meijun Lv Jie Zhang Caicun Zhou | 2011 | Lung Cancer2011，，1： | 1 |
| 8 | Over-expression of #-1,4-galactosyltransferase Ⅰ, Ⅱ, and Ⅴ in human astrocytoma显示文摘 | Xiaoyu Zhu Songwen Zhang | 2001 | Journal of Cancer Research and Clinical Oncology2001，127，： | 1 |
| 9 | A novel PI3K inhibitor XH30 suppresses orthotopic glioblastoma and brain metastasis in mice models显示文摘Glioblastoma is carcinogenesis of glial cells in central nervous system and has the highest incidence among primary brain tumors.Brain metastasis,such as breast cancer and lung cancer,also leads to high mortality.The available medicines are limited due to blood-brain barrier.Abnormal activation of phosphatidylinositol 3-kinases(PI3 K)signaling pathway is prevalent in glioblastoma and metastatic tumors.Here,we characterized a 2-amino-4-methylquinazoline derivative XH30 as a potent PI3 K inhibitor with excellent anti-tumor activity against human glioblastoma.XH30 significantly repressed the proliferation of various brain cancer cells and decreased the phosphorylation of key proteins of PI3 K signaling pathway,induced cell cycle arrest in G1 phase as well.Additionally,XH30 inhibited the migration of glioma cells and blocked the activation of PI3 K pathway by interleukin-17 A(IL-17 A),which increased the migration of U87 MG.Oral administration of XH30 significantly suppressed the tumor growth in both subcutaneous and orthotopic tumor models.XH30 also repressed tumor growth in brain metastasis models of lung cancers.Moreover,XH30 reduced IL-17 A and its receptor IL-17 RA in vivo.These results indicate that XH30 might be a potential therapeutic drug candidate for glioblastoma migration and brain metastasis. | Ming Ji Dongjie Wang Songwen Lin Chunyang Wang Ling Li Zhihui Zhang Jing Jin Deyu Wu Yi Dong Heng Xu Duo Lu Xiaoguang Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 1 |
| 10 | Distribution of human papillomavirus genotype and cervical neoplasia among women with abnormal cytology in Beijing, China显示文摘 | Ren Hou Caiyan Xu Songwen Zhang Minghui Wu Weiyuan Zhang | 2012 | International Journal of Gynecology and Obstetrics2012，，3： | 1 |
| 11 | SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXB 显示文摘 | Xiaoling Li Songwen Zhang Gil Blander | 2007 | Mol Cell2007，28，1： | 1 |
| 12 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
| 13 | SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR显示文摘 | Xiaoling Li Songwen Zhang Gil Blander Jeanette G. Tse Monty Krieger Leonard Guarente | 2007 | Molecular Cell2007，，1： | 1 |
| 14 | Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis显示文摘 | Songwen Zhang Juan Wang Qiangyuan Liu Douglas C. Harnish | 2009 | Journal of Hepatology2009，，2： | 1 |
| 15 | Domestication of marine microalga Nannochloropsis oceanica to freshwater medium and the physiological responses显示文摘Marine microalga Nannochloropsis oceanica LAMB0001 were domesticated (~730 generations,~two days each) to adapt freshwater BG11 medium. A number of freshwater medium adapted colony-derived strains were obtained. The strains were verified phylogenetically to be N. oceanica LAMB0001 based on the 18S ribosomal RNA gene. Freshwater-medium adapted strain (FA1) grew faster in the BG11 medium prepared with freshwater than wild-type N. oceanica grew in f/2 medium prepared with seawater. We assumed that (1) the expression patterns of the genes that expressed differentially between FA1 and the wild-type N. oceanica exposing to the BG11 medium (WT-F) have been reprogrammed;(2) the physiological processes in which these genes involved have been modified;and (3) a Gene Ontology (GO) term or a KEGG pathway enriched by DEGs between FA1 and WT-F has been up- or down-regulated if it was enriched simultaneously by up- or down-regulated DEGs between FA1 and WT-F, respectively. Under these assumptions, we found that FA1 reprogrammed the expression patterns of a set of genes that involved in cell adhesion, membrane and membrane integrity, material transportation, cell movement, and cellular signaling network. These changes in cellular functions and metabolic pathways indicate that the microalga modified its gene expression pattern in a wide function range and at a high regulation rank in order to adapt to the freshwater medium. It is feasible to domesticate marine microalgae to a freshwater habitat, which may aid to modify their cultivation performances. | GUO Li LIANG Sijie ZHANG Zhongyi LIU Hang WANG Songwen YANG Guanpin | 2019 | Journal of Oceanology and Limnology2019，37，4： | 0 |
| 16 | Attention-based efficient robot grasp detection network显示文摘To balance the inference speed and detection accuracy of a grasp detection algorithm,which are both important for robot grasping tasks,we propose an encoder–decoder structured pixel-level grasp detection neural network named the attention-based efficient robot grasp detection network(AE-GDN).Three spatial attention modules are introduced in the encoder stages to enhance the detailed information,and three channel attention modules are introduced in the decoder stages to extract more semantic information.Several lightweight and efficient DenseBlocks are used to connect the encoder and decoder paths to improve the feature modeling capability of AE-GDN.A high intersection over union(IoU)value between the predicted grasp rectangle and the ground truth does not necessarily mean a high-quality grasp configuration,but might cause a collision.This is because traditional IoU loss calculation methods treat the center part of the predicted rectangle as having the same importance as the area around the grippers.We design a new IoU loss calculation method based on an hourglass box matching mechanism,which will create good correspondence between high IoUs and high-quality grasp configurations.AEGDN achieves the accuracy of 98.9%and 96.6%on the Cornell and Jacquard datasets,respectively.The inference speed reaches 43.5 frames per second with only about 1.2×10^(6)parameters.The proposed AE-GDN has also been deployed on a practical robotic arm grasping system and performs grasping well.Codes are available at http://gffzz188fe103f8f1460as09b5cq5po56p6qcv.ffgz.tsg.suse.edu.cn/robvincen/robot_gradet. | Xiaofei QIN Wenkai HU Chen XIAO Changxiang HE Songwen PEI Xuedian ZHANG | 2023 | Frontiers of Information Technology & Electronic Engineering2023，24，10： | 0 |
| 17 | Research on the effects of CD137 signaling on the function of CD3^-CD56^+NK cells显示文摘Objective:To investigate the effects of CD137 signaling on the regulation of CD3-CD56+NK cells function. Methods: CD3-CD56+NK cells were treated with CD137 mAb or mouse IgG1 isotype control to study the effects of CD137 signaling on the function of CD3-CD56+NK cells. Cytotoxicity was measured by LDH activity in the supernatants of cell cultures; NKG2D and LFA-1 expression on CD3-CD56+NK cells were analyzed by flow cytometry. Results: CD137 was expressed on activated CD3-CD56+NK cells. The CD137 mAb enhanced the ability of CD3-CD56+NK cells to kill lung cancer cells(A549);Further studies revealed that the expression of NKG2D and LFA-1 was significantly increased in activated cells,and blockade of NKG2D and LFA-1 dramatically attenuated CD3-CD56+NK cytolysis of A549 cancer cells. Conclusion: CD137 signaling increases the ability of CD3-CD56+NK cells to kill cancer cells via up-regulating the expression of NKG2D and LFA-1. | Yu Zhang Songwen Ju Yongqian Shu | 2009 | Journal of Nanjing Medical University2009，23，1： | 0 |
| 18 | The brassinosteroid signaling component SlBZR1 promotes tomato fruit ripening and carotenoid accumulation显示文摘The plant hormone ethylene is essential for climacteric fruit ripening, although it is unclear how other phytohormones and their interactions with ethylene might affect fruit ripening. Here, we explored how brassinosteroids(BRs) regulate fruit ripening in tomato(Solanum lycopersicum) and how they interact with ethylene. Exogenous BR treatment and increased endogenous BR contents in tomato plants overexpressing the BR biosynthetic gene SlCYP90B3promoted ethylene production and fruit ripening.Genetic analysis indicated that the BR signaling regulators Brassinazole-resistant1(SlBZR1) and BRI1-EMS-suppressor1(SlBES1) act redundantly in fruit softening. Knocking out Sl BZR1 inhibited ripening through transcriptome reprogramming at the onset of ripening. Combined transcriptome deep sequencing and chromatin immunoprecipitation followed by sequencing identified 73 Sl BZR1-repressed targets and 203 Sl BZR1-induced targets involving major ripening-related genes, suggesting that Sl BZR1 positively regulates tomato fruit ripening.Sl BZR1 directly targeted several ethylene and carotenoid biosynthetic genes to contribute to the ethylene burst and carotenoid accumulation to ensure normal ripening and quality formation. Furthermore,knock-out of Brassinosteroid-insensitive2(Sl BIN2),a negative regulator of BR signaling upstream of Sl BZR1, promoted fruit ripening and carotenoid accumulation. Taken together, our results highlight the role of Sl BZR1 as a master regulator of tomato fruit ripening with potential for tomato quality improvement and carotenoid biofortification. | Fanliang Meng Haoran Liu Songshen Hu Chengguo Jia Min Zhang Songwen Li Yuanyuan Li Jiayao Lin Yue Jian Mengyu Wang Zhiyong Shao Yuanyu Mao Lihong Liu Qiaomei Wang | 2023 | Journal of Integrative Plant Biology2023，65，7： | 0 |
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