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| 1 | A novel m6A reader Prrc2a controls oligodendroglial specification and myelination显示文摘While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2A), which controls oligodendrocyte specification and myelination. Nestin-Cre-mediated knockout of Prrc2a induces significant hypomyelination, decreased lifespan, as well as locomotive and cognitive defects in a mouse model. Further analyses reveal that Prrc2a is involved in oligodendrocyte progenitor cells (OPCs) proliferation and oligodendrocyte fate determination. Accordingly, oligodendroglial-lineage specific deletion of Prrc2a causes a similar phenotype of Nestin-Cre-mediated deletion. Combining transcriptome-wide RNA-seq, m6A-RIP-seq and Prrc2a RIP-seq analysis, we find that Olig2 is a critical downstream target gene of Prrc2a in oligodendrocyte development. Furthermore, Prrc2a stabilizes Olig2 mRNA through binding to a consensus GGACU motif in the Olig2 CDS (coding sequence) in an m6A-dependent manner. Interestingly, we also find that the m6A demethylase, Fto, erases the m6A modification of Olig2 mRNA and promotes its degradation. Together, our results indicate that Prrc2a plays an important role in oligodendrocyte specification through functioning as a novel m6A reader. These findings suggest a new avenue for the development of therapeutic strategies for hypomyelination-related neurological diseases. | Rong Wu Ang Li Baofa Sun Jian-Guang Sun Jinhua Zhang Ting Zhang Yusheng Chen Yujie Xiao Yuhao Gao Qingyang Zhang Jun Ma Xin Yang Yajin Liao Wei-Yi Lai Xiaolong Qi Shukun Wang Yousheng Shu Hai-Lin Wang Fengchao Wang Yun-Gui Yang Zengqiang Yuan | 2019 | Cell Research2019，29，1： | 32 |
| 2 | Active disturbance rejection control on first-order plant显示文摘Conventional PI control encounters some problems when dealing with large lag process in the presence of parameter uncertainties.For the typical first-order process,an observerbased linear active disturbance rejection control(LADRC) scheme is presented to cope with the difficulties,and a reduced-order observer scheme is proposed further.Some quantitative dynamic results with regard to non-overshoot characteristics are obtained.Finally,the performance boundaries of LADRC and PI control are explicitly compared with each other,which shows that the former is more superior in most cases. | Ruiguang Yang Mingwei Sun Zengqiang Chen | 2011 | Journal of Systems Engineering and Electronics2011，22，1： | 20 |
| 3 | Epidemic spreading behavior in local-world evolving networks显示文摘The susceptible-infected-susceptible(SIS)epidemic model is presented which can be used to study the epidemic spreading behavior in the local-world evolving network model.Local-world evolving model displays a transition from the exponential network to the scale-free network with respect to the connectivity distribution.From theoretical analyses and numerical simulations,we find that the epidemic spreading behavior on local-world networks also takes on some kind of transitional behaviors.The transitional behavior is further ver-ified by comparing the spreading behavior of local-world network with that of random and scale-free networks.Some feasible control strategies are also proposed to keep from the epidemic spreading on networks. | Chengyi Xia Zhongxin Liu Zengqiang Chen Shiwen Sun Zhuzhi Yuan | 2008 | Progress in Natural Science:Materials International2008，18，6： | 17 |
| 4 | EVENT-TRIGGERED AVERAGE-CONSENSUS OF MULTI-AGENT SYSTEMS WITH WEIGHTED AND DIRECT TOPOLOGY显示文摘这份报纸与直接、加权的拓扑学调查多代理人系统的平均一致的问题。被触发事件的控制法律被采用以便减少自从代理人可以是在许多真实系统的资源有限,更新的单个控制的频率。事件被触发的分离时间片刻被扳机功能关于某个测量错误决定。一个集中的平均一致的协议与固定相互作用拓扑学,稳定性和哪个也被分析的影响因素为网络首先被建议。为有可变拓扑学的网络的扳机函数的设计也被讨论。然后,结果被扩大到分散的对应物,代理人在要求仅仅他们的邻居的信息。数字例子也是如果表明理论结果的有效性。 | Zhongxin LIU Zengqiang CHEN Zhuzhi YUAN | 2012 | Journal of Systems Science & Complexity2012，25，5： | 15 |
| 5 | Mitochondrial calcium uniporter protein MCU is involved in oxidative stress-induced cell death显示文摘Mitochondrial 钙 uniporter (MCU ) 是在在真核细胞的房间的 mitochondrial 的保存 Ca 2+ transporter。然而,在氧化导致压力的房间死亡的 MCU 蛋白质的角色仍然保持不清楚。这里,我们证明宫外地表示的 MCU 是在局部性的 mitochondrial HeLa 和主要小脑的小粒神经原(CGN ) 。内长的 MCU 减少 mitochondrial Ca 2+ 举起追随者组织安刺激击倒并且稀释氧化应力在 HeLa 房间和 CGN 导致的房间死亡。我们也发现 MCU 与 VDAC1 交往并且调停在 CGN 的 VDAC1 导致 overexpression 的房间死亡。这发现证明那 MCU-VDAC1 建筑群调整 mitochondrial Ca 2+ 举起和氧化导致压力的 apoptosis,它可能表示为氧化应力的治疗学的目标联系了疾病。 | Yajin Liao Yumin Hao Hong Chen Qing He Zengqiang Yuan Jinbo Cheng | 2015 | Protein & Cell2015，6，6： | 12 |
| 6 | Semi-tensor product approach to controllability and stabilizability of finite automata显示文摘Using semi-tensor product of matrices, the controllability and stabilizability of finite automata are investigated. By expressing the states, inputs, and outputs in vector forms, the transition and output functions are represented in matrix forms.Based on this algebraic description, a necessary and sufficient condition is proposed for checking whether a state is controllable to another one. By this condition, an algorithm is established to find all the control sequences of an arbitrary length. Moreover, the stabilizability of finite automata is considered, and a necessary and sufficient condition is presented to examine whether some states can be stabilized. Finally, the study of illustrative examples verifies the correctness of the presented results/algorithms. | Yongyi Yan Zengqiang Chen Zhongxin Liu | 2015 | Journal of Systems Engineering and Electronics2015，26，1： | 12 |
| 7 | Modeling and analysis of colored petri net based on the semi-tensor product of matrices显示文摘This paper applies the model petri net method based on the semi-tensor product of matrices to colored petri net. Firstly, we establish the marking evolution equation for colored petri net by using the semitensor product of matrices. Then we define the concept of controllability and the control-marking adjacency matrix for colored petri net. Based on the marking evolution equation and control-marking adjacency matrix, we give the necessary and sufficient condition of reachability and controllability for colored petri net. The algorithm to verify the reachability of colored petri net is given, and we analyze the computational complexity of the algorithm. Finally, an example is given to illustrate the effectiveness of the proposed theory. The significance of the paper lies in the application of the model petri net method based on the semitensor product of matrices to colored petri net. This is a convenient way of verifying whether one marking is reachable from another one as well as finding all firing sequences between any two reachable markings.Additionally, the method lays the foundations for the analysis of other properties of colored petri net. | Jiantao ZHAO Zengqiang CHEN Zhongxin LIU | 2018 | Science China(Information Sciences)2018，61，1： | 12 |
| 8 | Mechanism of rock burst caused by fracture of key strata during irregular working face mining and its prevention methods显示文摘To study the occurrence mechanism of rock burst during mining the irregular working face,the study took irregular panel 7447 near fault tectonic as an engineering background.The spatial fracture characteristic of overlying strata was analyzed by Winkler elastic foundation beam theory.Furthermore,the influence law of panel width to suspended width and limit breaking span of key strata were also analyzed by thin plate theory.Through micro-seismic monitoring,theoretical analysis,numerical simulation and working resistance of support of field measurement,this study investigated the fracture characteristic of overlying strata and mechanism of rock burst in irregular working face.The results show that the fracture characteristic of overlying strata shows a spatial trapezoid structure,with the main roof being as an undersurface.The fracture form changes from vertical‘‘O-X'type to transverse‘‘O-X'type with the increase of trapezoidal height.From the narrow mining face to the wide mining face,the suspended width of key strata is greater than its limit breaking width,and a strong dynamic load is produced by the fracture of key strata.The numerical simulation and micro-seismic monitoring results show that the initial fracture position of key strata is close to tailgate 7447.Also there is a high static load caused by fault tectonic.The dynamic and static combined load induce rock burst.Accordingly,a cooperative control technology was proposed,which can weaken dynamic load by hard roof directional hydraulic fracture and enhance surrounding rock by supporting system. | Zengqiang Yang Chang Liu Hengzhong Zhu Fuxing Xie Linming Dou Jianhang Chen | 2019 | International Journal of Mining Science and Technology2019，29，6： | 12 |
| 9 | Dynamic spreading behavior of homogeneous and heterogeneous networks显示文摘传播在上的 dynsmic 流行病的详细调查同类并且 heteiogeneous 网络被执行。在基本流行模型的分析以后,同质、异构的网络上的 susceptible-infected-susceptible (SIS ) 模型被建立,并且在网络的这二种不同类型的感染的个人的密度的动态进化理论上被分析。它显示对 piopagate 更容易的那异构的网络 sre 因为流行病和领先的传播行为被在起始的爆发的指数的增加支配。感染在同类的上比那在异构的网络上是快得多的大规模模拟显示。它意味着网络拓扑学能在发生在复杂网络上的流行病上有重要效果。根据理论分析和数字模拟介绍的流行爆发 sre 的某抑制 sfrategies。 | XIA Chengyi LIU Zhongxin CHEN Zengqiang YUAN Zhuzhi | 2007 | Progress in Natural Science:Materials International2007，17，3： | 11 |
| 10 | Solving type-2 fuzzy relation equations via semi-tensor product of matrices显示文摘The problem of solving type-2 fuzzy relation equations is investigated. In order to apply semi-tensor product of matrices,a new matrix analysis method and tool, to solve type-2 fuzzy relation equations, a type-2 fuzzy relation is decomposed into two parts as principal sub-matrices and secondary sub-matrices; an r-ary symmetrical-valued type-2 fuzzy relation model and its corresponding symmetrical-valued type-2 fuzzy relation equation model are established. Then, two algorithms are developed for solving type-2 fuzzy relation equations, one of which gives a theoretical description for general type-2 fuzzy relation equations;the other one can find all the solutions to the symmetrical-valued ones. The results can improve designing type-2 fuzzy controllers,because it provides knowledge to search the optimal solutions or to find the reason if there is no solution. Finally some numerical examples verify the correctness of the results/algorithms. | Yongyi YAN Zengqiang CHEN Zhongxin LIU | 2014 | Control Theory and Technology2014，12，2： | 10 |
| 11 | Semi-tensor product of matrices approach to reachability of finite automata with application to language recognition显示文摘 | Yongyi YAN Zengqiang CHEN Zhongxin LIU | 2014 | Frontiers of Computer Science2014，8，6： | 9 |
| 12 | DESIGN AND ANALYSIS FOR NEW DISCRETE TRACKING-DIFFERENTIATORS显示文摘In this paper,some kinds of linear and nonlinear tracking-differentiators are designed by using suitable exponent functions instead of switch functions,and the stability of these tracking-differentiators is proved.From the result of simulations,it is manifest that the tracking speeds of these kinds of linear and nonlinear tracking-differentiators are very high,and their design procedures are simple. | Wang Xinhua Chen Zengqiang Yuan ZhuzhiDept. of Automation,Nankai Univ.,Tianjin 300071,China. | 2003 | Applied Mathematics(A Journal of Chinese Universities)2003，18，2： | 9 |
| 13 | Pinning weighted complex networks with heterogeneous delays by a small number of feedback controllers显示文摘Weighted complex dynamical networks with heterogeneous delays in both continuous-time and discrete-time domains are controlled by applying local feedback injections to a small fraction of network nodes. Some generic stability criteria ensuring delay-independent stability are derived for such controlled networks in terms of linear matrix inequalities (LMIs), which guarantee that by placing a small number of feedback controllers on some nodes the whole network can be pinned to some desired homogenous states. In some particular cases, a single controller can achieve the control objective. It is found that stabilization of such pinned networks is completely determined by the dynamics of the individual uncoupled node, the overall coupling strength, the inner-coupling matrix, and the smallest eigenvalue of the coupling and control matrix. Numerical simulations of a weighted network composing of a 3-dimensional nonlinear system are finally given for illustration and verification. | XIANG LinYing LIU ZhongXin CHEN ZengQiang YUAN ZhuZhi | 2008 | Science in China(Series F)2008，51，5： | 8 |
| 14 | Constrained predictive control based on T-S fuzzy model for nonlinear systems显示文摘A constrained generalized predictive control (GPC) algorithm based on the T-S fuzzy model is presented for the nonlinear system. First, a Takagi-Sugeno (T-S) fuzzy model based on the fuzzy cluster algorithm and the orthogonal least square method is constructed to approach the nonlinear system. Since its consequence is linear, it can divide the nonlinear system into a number of linear or nearly linear subsystems. For this T-S fuzzy model, a GPC algorithm with input constraints is presented. This strategy takes into account all the constraints of the control signal and its increment, and does not require the calculation of the Diophantine equations. So it needs only a small computer memory and the computational speed is high. The simulation results show a good performance for the nonlinear systems. | Su Baili Chen Zengqiang Yuan Zhuzhi | 2007 | Journal of Systems Engineering and Electronics2007，18，1： | 6 |
| 15 | Post-translational regulation of FOXO显示文摘Forkhead 框 O (FOXO ) 家庭抄写因素在一系列细胞的进程起关键作用,包括房间周期,房间死亡,新陈代谢,和氧化压力抵抗。FOXO 蛋白质与他们的活动有关仔细服从于几 translational 以后修正,它是。在这份报纸,我们考察 FOXO 和他们的生物功能的 translational 以后修正。 | Qi Xie Jing Chen Zengqiang Yuan | 2012 | Acta Biochimica et Biophysica Sinica2012，44，11： | 6 |
| 16 | Formation Control for Nonlinear Multi-agent Systems with Linear Extended State Observer显示文摘This paper investigates the formation control problem for nonlinear multi-agent systems with a virtual leader. A distributed formation control strategy based on linear extended state observer(LESO) is proposed under the hypothesis that velocity of the agent s neighbors could not be measured. Some sufficient conditions are established to ensure that the nonlinear multi-agent systems form a predefined formation with switching topology when the nonlinear function is known. Moreover, the tracking errors are bounded with external disturbance. Lastly,a numerical example with different scenarios is presented to demonstrate the validity of the obtained results. | Wen Qin Zhongxin Liu Zengqiang Chen | 2014 | IEEE/CAA Journal of Automatica Sinica2014，1，2： | 6 |
| 17 | High AOA decoupling control for aircraft based on ADRC显示文摘In this paper, a practical decoupling control scheme for fighter aircraft is proposed to achieve high angle of attack(AOA)tracking and super maneuver action by utilizing the thrust vector technology. Firstly, a six degree-of-freedom(DOF) nonlinear model with 12 variables is given. Due to low sufficiency of the aerodynamic actuators at high AOA, a thrust vector model with rotatable engine nozzles is derived. Secondly, the active disturbance rejection control(ADRC) is used to realize a three-channel decoupling control such that a strong coupling between different channels can be treated as total disturbance, which is estimated by the designed extended state observer. The control surface allocation is implemented by the traditional daisy chain method. Finally,the effectiveness of the presented control strategy is demonstrated by some numerical simulation results. | LIU Junjie SUN Mingwei CHEN Zengqiang SUN Qinglin | 2020 | Journal of Systems Engineering and Electronics2020，31，2： | 5 |
| 18 | Controlled synchronization of complex network with different kinds of nodes显示文摘In this paper, a new dynamical network model is introduced, in which the nodes of the network are different. It is shown that by the designed controllers, the state of the network can exponentially synchronize onto a homogeneous stationary state. Some criteria are derived and some examples are presented. The numerical simulations coincide with theoretical analysis. | Zhengquan YANG Zhongxin LIU Zengqiang CHEN Zhuzhi YUAN | 2008 | 控制理论与应用(英文版)2008，6，1： | 4 |
| 19 | Effects of sintered metal distributor on fluidization quality of the air dense medium fluidized bed显示文摘Dry coal beneficiation using an air dense medium fluidized bed (ADMFB) requires the formation of a sta- ble and uniform bed from the dense medium. Others have shown that the structure and geometric parameters of the air distributor have a significant influence on the experimentally observed fluidization quality. In this study we used a sintered metal distributor (SMD) in the ADMFB separator and study its effect on the fluidization quality. The results show that for the same open area ratio (OAR), a smaller aper- ture in the SMD will provide improved fluidization quality. If aperture size is held constant bigger open area ratios result in improved fluidization quality. And, the fluidization quality also improves when the pressure drop across the SMD increases. A model relating distributor pressure drop and the geometric parameters of the SMD is also proposed. | Yang Xuliang Zhao Yuemin Luo Zhenfu Chen Zengqiang Song Shulei | 2011 | Mining Science and Technology2011，21，5： | 4 |
| 20 | Multivariable PI Type Generalized Predictive Control显示文摘Tills Paper presents a multivariable generalized predictive controller with proportion and integration structure by modifying the quadratic criterion of the usual MGPC. The control performance has been improved greatly.The effectiveness of the controller is demonstrated by the simulation result. | Chen, Zengqiang Zhao, Tianhang Yuan, Zhuzhi | 1998 | Journal of Systems Engineering and Electronics1998，9，2： | 4 |
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