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| 1 | Effect of Jinhua Qinggan granules on novel coronavirus pneumonia in patients显示文摘OBJECTIVE: To evaluate the effectiveness and safety of Jinhua Qinggan granules in the treatment of patients with novel coronavirus pneumonia(COVID-19).METHODS: Eighty cases of COVID-19 diagnosed from January 24 to February 17, 2020 in Beijing YouAn Hospital Affiliated to Capital Medical University were retrospectively analyzed. All 80 patients received symptomatic and supportive treatment.Among them, 44 patients took Jinhua Qinggan granules(treatment group) within 24 h of admission, and the remaining 36 patients either did not take Jinhua Qinggan granules or took the granules for less than 2 d(control group). In this study, we compared the duration of viral nucleic acid detection and of pneumonia absorption improvement between the two groups.RESULTS: Among the 80 cases, 37 were male(46%)and 43 were female(54%) with age ranging from15 to 86 years, with an average age of 51.19 years.The average duration of viral nucleic acid detection was(7 ± 4) d in the Jinhua Qinggan administration group and(10 ± 4) d for the control group(P =0.010), following which, nucleic acid tests were negative. Of the two groups, 56.82% in the Jinhua Qinggan treatment group and 27.78% in the control group demonstrated negative nucleic acid tests within 7 d or less. The 7-day viral clearance rate was significantly higher in the Jinhua Qinggan group compared with the control group(P = 0.009). Furthermore, the pneumonia recovery time indicated by chest CT was(8 ± 4) d in the Jinhua Qinggan group, which was significantly shorter than the control group, at(10 ± 5) d(P = 0.021). No adverse reactions were found in the treatment group after taking this medicine.CONCLUSION: In patients with COVID-19, Jinhua Qinggan granules can effectively shorten the duration of nucleic acid detection and promote the absorption of pneumonia inflammatory exudate without obvious adverse reactions. | Liu Zengli Li Xiuhui Gou Chunyan Li Li Luo Xiaolan Zhang Chun Zhang Yin Zhang Jiaying Jin Aihua Li Hongyan Zeng Yuan Li Tongzeng Wang Xiaojun | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 11 |
| 2 | STAT1 Antisense Oligonucleotides Attenuate the Proinflammatory Cytokine Release of Alveolar Macrophages in Bleomycin-Induced Fibrosis显示文摘To investigate the effect of signal transducers and activators of transcription 1 (STAT1) antisense oligonucleotides (ASON) on concentrations of TNF-α, IL-8, NO secreted by alveolar macrophages (AMs) in bleomycin-induced rat pulmonary fibrosis, five adult female Wistar rats were intratracheally instilled with bleomycin. After 7 days, the rats were killed by right ventricle of heart exsanguinations under ketamine anaesthesia and bronchoalveolar lavage (BAL) was performed to obtain AMs. AMs were divided into four groups, treated with STAT1 ASON, STAT1 sense oligonucleotides (SON), dexamethasone (DEX) and medium alone (control), respectively. AMs and media were collected after culture for 36 h. The mRNA and protein expressions of STAT1 and ICAM-1 in AMs were detected by RT-PCR and ELISA, respectively. The concentrations of TNF-α, IL-8, NO in cultured medium were detected.The STAT1 mRNA expression by AMs in the STAT1 ASON group was lower than those of AMs in the STAT1 SON group, the DEX group and the control group (p < 0.05). Moreover, the STAT1 mRNA expression by AMs in the DEX group was also lower than those of AMs in the STAT1 SON group and the control group (p < 0.05), but the STAT1 mRNA expression by AMs in the STAT1 SON group was not different from that of the control group (p >0.05). The protein expressions of STAT1 and ICAM-1 and the mRNA expression of ICAM-1 showed similar changes to the STAT1 mRNA expression by AMs. The concentrations of TNF-α, IL-8, NO in cultured medium from STAT1 ASON group were lower than those from STAT1 SON, DEX and the control groups (p < 0.05). Moreover,the concentrations of TNF-α, IL-8, NO in cultured medium from DEX group were also lower than those from the control and STAT1 SON group (p < 0.05), but no difference between STAT1 SON group and the control (p > 0.05).The results suggest that STAT1 ASON could inhibit the secretion of TNF-α, IL-8, NO in AMs, and STAT1 could become a target of treating pulmonary fibrosis. | Xianming Fan~(1,3) Zengli Wang~2 ~1Department of Respiratory Medicine,the Affiliated Hospital of Luzhou Medical College,Luzhou 646000,China ~2Department of Respiratory Medicine,West China Hospital,Sichuan University,Chengdu 610041,China ~3Corresponding to:Dr.Xianming Fan,Department of Respiratory Medicine,the Affiliated Hospital of Luzhou Medical College,Luzhou 646000,China. | 2005 | Cellular & Molecular Immunology2005，2，3： | 8 |
| 3 | Signaling pathways in cancer-associated fibroblasts:recent advances and future perspectives显示文摘As a critical component of the tumor microenvironment(TME),cancerassociated fibroblasts(CAFs)play important roles in cancer initiation and progression.Well-known signaling pathways,including the transforming growth factor-β(TGF-β),Hedgehog(Hh),Notch,Wnt,Hippo,nuclear factor kappa-B(NF-κB),Janus kinase(JAK)/signal transducer and activator of transcription(STAT),mitogen-activated protein kinase(MAPK),and phosphoinositide 3-kinase(PI3K)/AKT pathways,as well as transcription factors,including hypoxia-inducible factor(HIF),heat shock transcription factor 1(HSF1),P53,Snail,and Twist,constitute complex regulatory networks in theTMEtomodulate the formation,activation,heterogeneity,metabolic characteristics and malignant phenotype of CAFs.Activated CAFs remodel the TME and influence the malignant biological processes of cancer cells by altering the transcriptional and secretory characteristics,and this modulation partially depends on the regulation of signaling cascades.The results of preclinical and clinical trials indicated that therapies targeting signaling pathways in CAFs demonstrated promising efficacy but were also accompanied by some failures(e.g.,NCT01130142 and NCT01064622).Hence,a comprehensive understanding of the signaling cascades in CAFs might help us better understand the roles of CAFs and the TME in cancer progression and may facilitate the development of more efficient and safer stroma-targeted cancer therapies.Here,we review recent advances in studies of signaling pathways in CAFs and briefly discuss some future perspectives on CAF research. | Zengli Fang Qingcai Meng Jin Xu Wei Wang Bo Zhang Jiang Liu Chen Liang Jie Hua Yingjun Zhao Xianjun Yu Si Shi | 2023 | Cancer Communications2023，43，1： | 5 |
| 4 | Effect of torrefaction on structure and fast pyrolysis behavior of corncobs显示文摘 | Anqing Zheng Zengli Zhao Sheng Chang Zhen Huang Xiaobo Wang Fang He Haibin Li | 2013 | Bioresource Technology2013，，： | 1 |
| 5 | Effects of high-pro- tein diets on body weight, glycaemic control, blood lipids and blood pressure in type 2 diabetes: Meta-analysls of randomised controlled trials 显示文摘 | Dong Jiayi Zhang Zengli Wang Peiyu | 2013 | BrJNutr2013，110，5： | 1 |
| 6 | The SKI proto-oncogene restrains the resident CD103^(+)CD8^(+) T cell response in viral clearance显示文摘Acute viral infection causes illness and death.In addition,an infection often results in increased susceptibility to a secondary infection,but the mechanisms behind this susceptibility are poorly understood.Since its initial identification as a marker for resident memory CD8^(+)T cells in barrier tissues,the function and regulation of CD103 integrin(encoded by ITGAE gene)have been extensively investigated.Nonetheless,the function and regulation of the resident CD103^(+)CD8^(+)T cell response to acute viral infection remain unclear.Although TGFβsignaling is essential for CD103 expression,the precise molecular mechanism behind this regulation is elusive.Here,we reveal a TGFβ–SKI–Smad4 pathway that critically and specifically directs resident CD103^(+)CD8^(+)T cell generation for protective immunity against primary and secondary viral infection.We found that resident CD103^(+)CD8^(+)T cells are abundant in both lymphoid and nonlymphoid tissues from uninfected mice.CD103 acts as a costimulation signal to produce an optimal antigenic CD8^(+)T cell response to acute viral infection.There is a reduction in resident CD103^(+)CD8^(+)T cells following primary infection that results in increased susceptibility of the host to secondary infection.Intriguingly,CD103 expression inversely and specifically correlates with SKI proto-oncogene(SKI)expression but not R-Smad2/3 activation.Ectopic expression of SKI restricts CD103 expression in CD8^(+)T cells in vitro and in vivo to hamper viral clearance.Mechanistically,SKI is recruited to the Itgae loci to directly suppress CD103 transcription by regulating histone acetylation in a Smad4-dependent manner.Our study therefore reveals that resident CD103^(+)CD8^(+)T cells dictate protective immunity during primary and secondary infection.Interfering with SKI function may amplify the resident CD103^(+)CD8^(+)T cell response to promote protective immunity. | Bing Wu Ge Zhang Zengli Guo Gang Wang Xiaojiang Xu Jian-liang Li Jason K.Whitmire Junnian Zheng Yisong Y.Wan | 2021 | Cellular & Molecular Immunology2021，18，10： | 1 |
| 7 | Asthma-like tracheobronchial amyloidosis:a case report and review of the literature显示文摘Tracheobronchial amyloidosis(TBA)is a rare disorder which refers to localized aberrant protein deposits within the airways.Because of the lack of characteristic presentation,long lasting and insidious course,patients with TBA are often misdiagnosed as other pulmonary diseases.At present bronchoscopic biopsy was the gold standard for the diagnosis of TBA.We present a case of TBA which was misdiagnosed as asthma due to asthma-like wheezing and the effectiveness of anti-asthmatic treatment.The definite diagnosis was confirmed by CT scan,bronchoscopic findings and Congo red staining of biopsy specimen.The literature involving the recent progres- sion of diagnosis and treatment of TBA that is reviewed. | Hui Mao Xiaodong Yang Zengli Wang Xuerong Chen Qun Yi | 2008 | Journal of Nanjing Medical University2008，22，5： | 1 |
| 8 | Effect of oral l -arginine supplementation on blood pressure: A meta-analysis of randomized, double-blind, placebo-controlled trials显示文摘 | Jia-Yi Dong Li-Qiang Qin Zengli Zhang Youyou Zhao Junkuan Wang Fabrizio Arigoni Weiguo Zhang | 2011 | American Heart Journal2011，，6： | 1 |
| 9 | Gefitinib facilitates PINK1/Parkin-mediated mitophagy by enhancing mitochondrial recruitment of OPTN显示文摘Gefitinib,a well-known epidermal growth factor receptor(EGFR)tyrosine kinase inhibitor for the targeted therapy of lung cancer,induces autophagy in association with drug resistance.However,it remains unclear whether gefitinib treatment can affect the selective form of autophagy(i.e.,mitophagy)and be beneficial for the treatment of human diseases with decreased autophagy,such as neurodegenerative diseases.Here,we show that gefitinib treatment promotes PINK1/Parkin-mediated mitophagy in both nonneuronal and neuronal cells,and this effect is independent of EGFR.Moreover,we found that gefitinib treatment increases the recruitment of the autophagy receptor optineurin(OPTN)to damaged mitochondria,which is a downstream signaling event in PINK1/Parkin-mediated mitophagy.In addition,gefitinib treatment significantly alleviated neuronal damage in TBK1-deficient neurons,resulting in impeded mitophagy.In conclusion,our study suggests that gefitinib promotes PINK1/Parkin-mediated mitophagy via OPTN and may be beneficial for the treatment of neurodegenerative diseases that are associated with defective mitophagy. | Ningning Li Shan Sun Guoqiang Ma Hongyu Hou Qilian Ma Li Zhang Zengli Zhang Hongfeng Wang Zheng Ying | 2022 | Fundamental Research2022，2，5： | 0 |
| 10 | Long-term in vivo chimeric cells tracking in non-human primate显示文摘Non-human primates(NHPs)are increasingly used in preclinical trials to test the safety and efficacy of biotech-nology therapies.Nonetheless,given the ethical issues and costs associated with this model,it would be highly advantageous to use NHP cellular models in clinical studies.However,developing and maintaining the naive state of primate pluripotent stem cells(PSCs)remains difficult as does in vivo detection of PSCs,thus limiting biotech-nology application in the cynomolgus monkey.Here,we report a chemically defined,xeno-free culture system for culturing and deriving monkey PSCs in vitro.The cells display global gene expression and genome-wide hypometh-ylation patterns distinct from monkey-primed cells.We also found expression of signaling pathways components that may increase the potential for chimera formation.Crucially for biomedical applications,we were also able to integrate bioluminescent reporter genes into monkey PsCs and track them in chimeric embryos in vivo and in vitro.The engineered cells retained embryonic and extra-embryonic developmental potential.Meanwhile,we generated a chimeric monkey carrying bioluminescent cells,which were able to track chimeric cells for more than 2 years in living animals.Our study could have broad utility in primate stem cell engineering and in utilizing chimeric monkey models forclinical studies. | Junmo Wu Yu Kang Xiang Luo Shaoxing Dai Yuxi Shi Zhuoyao Li Zengli Tang Zhenzhen Chen Ran Zhu Pengpeng Yang Zifan Li Hong Wang Xinglong Chen Ziyi Zhao Weizhi ji Yuyu Niu | 2024 | Protein & Cell2024，15，3： | 0 |
| 11 | Bronchiectasis: still a problem显示文摘 | Wang Zengli | 2014 | Chinese Medical Journal2014，，1： | 0 |
| 12 | Ultrasmall iron-quercetin metal natural product nanocomplex with antioxidant and macrophage regulation in rheumatoid arthritis显示文摘Oxidative stress,due to the disruption of the balance between reactive oxygen species(ROS)generation and the antioxidant defense system,plays an important role in the pathogenesis of rheumatoid arthritis(RA).Excessive ROS leads to the loss of biological molecules and cellular functions,release of many inflammatory mediators,stimulate the polarization of macrophages,and aggravate the inflammatory response,thus promoting osteoclasts and bone damage.Therefore,foreign antioxidants would effectively treat RA.Herein,ultrasmall iron-quercetin natural coordination nanoparticles(Fe-Qur NCNs)with excellent anti-inflammatory and antioxidant properties were constructed to effectively treat RA.Fe-Qur NCNs obtained by simple mixing retain the inherent ability to remove ROS of quercetin and have a better water-solubility and biocompatibility.In vitro experiments showed that Fe-Qur NCNs could effectively remove excess ROS,avoid cell apoptosis,and inhibit the polarization of inflammatory macrophages by reducing the activation of the nuclear factor-κ-gene binding(NF-κB)pathways.In vivo experiments showed that the swollen joints of mice with rheumatoid arthritis treated with Fe-Qur NCNs significantly improved,with Fe-Qur NCNs largely reducing inflammatory cell infiltration,increasing antiinflammatory macrophage phenotypes,and thus inhibiting osteoclasts,which led to bone erosion.This study demonstrated that the new metal-natural coordination nanoparticles could be an effective therapeutic agent for the prevention of RA and other diseases associated with oxidative stress. | Zhihui Han Xiang Gao Yuanjie Wang Shuning Cheng Xiaoyan Zhong Yong Xu Xiaozhong Zhou Zengli Zhang Zhuang Liu Liang Cheng | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 0 |
| 13 | Design optimization of guide vane for mitigating elbow erosion using computational fluid dynamics and response surface methodology显示文摘A90°elbow equipped with guide vanes was developed with the intent of reducing elbow erosion.Numerical models were formed to predict the maximum erosion rate of elbow and Face-1,and the response surface methodology was used to study the relationship between the erosion rate and structural parameters of guide vane.A second-order response surface model was established to determine the relationship between R and variables,and a reduced cubic(RC)polynomial model was obtained to reveal the relation-ship between R2 and the three factors.The numerical results show that the low-speed region is expended and the maximum discrete particle matter(DPM)concentration is reduced after installing the guide vane.This internal component provides a shelter for the elbow from the direct impact of high-speed solids. | Anjun Li Zhenbo Wang Liyun Zhu Zengli Wang Jingyuan Shi Wensan Yang | 2022 | Particuology2022，20，4： | 0 |
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