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| 1 | Therapeutic effects of the artemisinin analog SM934 on lupus-prone MRLIIpr mice via inhibition of TLR-triggered B-cell activation and plasma cell formation显示文摘我们以前报导了那 SM934,水溶性的 artemisinin 衍生物,是在鼠科的豺狼座模型的一个可行处理。在当前的学习,我们进一步在豺狼座容易的 MRL/lpr 老鼠上调查了 SM934 的修改剂量政体的治疗学的效果并且在 B 房间回答上探索了它的效果,在全身的豺狼座 erythematosus (SLE ) 的一个中央病原的事件。当口头上地管理了时两次每日, SM934 显著地延长了 MRL/lpr 老鼠的寿命,改善 lymphadenopathy 症状并且减少浆液的层次反原子的抗体(言论集) 并且病原的 cytokines IL-6, IL-10 和 IL-21。而且, SM934 处理由增加静止 B 房间数字在 MRL/lpr 老鼠的怒气恢复了 B 房间分隔空间,维持幼芽的中心 B 房间数字,减少激活的 B 房间数字和减少的血浆房间(PC ) 数字。前 vivo, SM934 压制了触发的像使用费的受体(TLR ) B 房间的激活和增长,以及抗体分泌物。而且,现在的学习证明 SM934 由 downregulating TLR7/9 mRNA 表示, MyD88 蛋白质表示和 NF-κ 防碍 B 房间内在的小径; B phosphorylation。在人的外部血 mononuclear 房间(PBMC ) ,与在 MRL/lpr 鼠标的结果一致, SM934 禁止了联系 TLR 的 B 房间激活和 PC 区别。在结论, SM934 的两次每日的 dosing 政体由压制 B 房间激活和血浆房间形成在豺狼座容易的 MRL/lpr 老鼠上有治疗学的效果。 | Yanwei Wu Shijun He Bingxin Bai Luyao Zhang Lu Xue Zemin Lin Xiaoqian Yang Fenghua Zhu Peilan He Wei Tang Jianping Zuo | 2016 | Cellular & Molecular Immunology2016，13，3： | 31 |
| 2 | An investigation on tether-tugging de-orbit of defunct geostationary satellites显示文摘In recent years,defunct satellites mitigation in the geostationary orbit(GEO) has become a hot issue in the space field.How to transfer defunct geostationary satellites to the graveyard orbit safely,economically and efficiently presents new challenges to spacecraft dynamics and control.This paper conducts an in-depth investigation on tether-tugging de-orbit issues of defunct geostationary satellites.Firstly,a four-phase tether-tugging de-orbit scheme including acceleration,equilibrium,rotation and return is proposed.This scheme takes into consideration how to avoid the risks of tether ripping,tug-target collision,and tether twist,and how to achieve the mission objective of fuel saving.Secondly,the dynamics model of the tether combination system is established based on Lagrange equation,and the four phases of tether-tugging de-orbit scheme are simulated respectively.Simulation results indicate that the scheme is theoretically feasible and satisfies the design objectives of safety,economy and efficiency,providing a technical approach for engineering application. | LIU HaiTao YANG LePing ZHANG QingBin ZHU YanWei | 2012 | Science China(Technological Sciences)2012，55，7： | 18 |
| 3 | Synthesis of mesoporous Cu/Mg/Fe layered double hydroxide and its adsorption performance for arsenate in aqueous solutions显示文摘The mesoporous Cu/Mg/Fe layered double hydroxide(Cu/Mg/Fe-LDH) with carbonate intercalation was synthesized and used for the removal of arsenate from aqueous solutions.The Cu/Mg/Fe-LDH was characterized by Fourier transform infrared spectrometry,X-ray diffraction crystallography,scanning electron microscopy,X-ray photoelectron spectroscopy and Brunauer-Emmett-Teller.Effects of various physico-chemical parameters such as pH,adsorbent dosage,contact time and initial arsenate concentration on the adsorption of arsenate onto Cu/Mg/Fe-LDH were investigated.Results showed that it was efficient for the removal of arsenate,and the removal efficiency of arsenate increased with the increment of the adsorbent dosage,while the arsenate adsorption capacity decreased with increase of initial pH from 3 to 11.The adsorption isotherms can be well described by the Langmuir model with R 2 > 0.99.Its adsorption kinetics followed the pseudo second-order kinetic model.Coexisting ions such as HPO42-,CO32-,SO42and NO3could compete with arsenate for adsorption sites on the Cu/Mg/Fe-LDH.The adsorption of arsenate on the adsorbent can be mainly attributed to the ion exchange process.It was found that the synthesized Cu/Mg/Fe-LDH can reduce the arsenate concentration down to a final level of < 10 μg/L under the experimental conditions,and makes it a potential material for the decontamination of arsenate polluted water. | Yanwei Guo Zhiliang Zhu Yanling Qiu Jianfu Zhao | 2013 | Journal of Environmental Sciences2013，25，5： | 11 |
| 4 | SERK Receptor-like Kinases Control Division Patterns of Vascular Precursors and Ground Tissue Stem Cells during Embryo Development in Arabidopsis显示文摘During embryo development, the vascular precursors and ground tissue stem cells divide to renew them-selves and produce the vascular tissue, endodermal cells, and cortical cells. However, the molecular mech-anisms regulating division of these stem cells have remained largely elusive. In this study, we show that loss of function of SOMATIC EMBRYOGENESIS RECEPTOR-UKE KINASE (SERK) genes results in aberrant em-bryo development. Fewer cortical, endodermal, and vascular cells are generated in the embryos of serk1 serk2bak1 triple mutants. WUSCHEL-RELATED HOMBOBOX5 (WOXS) is ectopically expressed in vascular cells of serkl serk2 bak1 embryos. The first transverse division of vascular precursors in mid-globular em-bryos and second asymmetric division of ground tissue stem cells in early-heart embryos are abnormally altered to a longitudinal division. The embryo defects can be partially rescued by constitutively activated mitogen-activated protein kinase (MAPK) kinase kinase YODA (YDA) and MAPK kinase MKK5. Taken together, our results reveal that SERK-mediated signals regulate division patterns of vascular precursors and ground tissue stem cells, likely via the YDA-MKK4/5 cascade, during embryo development. | Huiqiang Li Zeping Cai Xiaojuan Wang Meizhen Li Yanwei Cui Nan Cui Fei Yang Mingsong Zhu Junxiang Zhao Wenbin Du Kai He Jing Yi Frans E.Tax Suiwen Hou Jia Li Xiaoping Gou | 2019 | Molecular Plant2019，12，7： | 7 |
| 5 | Structural evolution and superconductivity tuned by valence electron concentration in the Nb-Mo-Re-Ru-Rh high-entropy alloys显示文摘The crystal structure and physical properties of Nb_(25)Mo_(5+x)Re_(35)Ru_(25-x)Rh_(10)(0≤x≤10)and Nb_(5)Mo_(35-y)Re_(15+y)Ru_(35)Rh_(10)(0≤y≤15)high-entropy alloys(HEAs)have been studied by X-ray diffraction,electrical resistivity,magnetic susceptibility,and specific heat measurements.The results show that the former HEAs with valence electron concentration(VEC)values of 6.7-6.9 crystallize in a noncentrosymmetric cubicα-Mn structure,while the latter ones with VEC values of 7.1-7.25 adopt a centrosymmetric hexagonal close-packed(hcp)structure.Despite different structures,both series of HEAs are found to be bulk superconductors with a full energy gap,and the superconducting transition temperature Tc tends to decrease with the increase of VEC.Nevertheless,the Tc values of the hcp-type HEAs are higher than those of theα-Mn-type ones,likely due to a stronger electron phonon coupling.Furthermore,we show that VEC and electronegativity difference are two key parameters to control the stability ofα-Mn and hcp-type HEAs.These results not only are helpful for the design of such HEAs,but also represent the first realization of structurally different HEA superconductors without changing the constituent elements. | Bin Liu Jifeng Wu Yanwei Cui Qjnqing Zhu Guorui Xiao Siqi Wu Guang-han Cao Zhi Ren | 2021 | Journal of Materials Science & Technology2021，，26： | 5 |
| 6 | Formation keeping control through inter-satellite electromagnetic force显示文摘Satellite formation keeping through inter-satellite electromagnetic force provides an attractive alternative for future space missions due to its distinct advantages of no propellant consumption or plume contamination as compared to conventional approaches.However,the internal force nature as well as the high nonlinearity and coupling of electromagnetic force brings new control challenges for this novel technique.In this paper,analysis on the dynamics characteristics and special control issues in the presence of electromagnetic force is carried out on the basis of the derived relatively translational dynamics.Considering the model uncertainties,external disturbances and sensor noise,a combined nonlinear control scheme involving feed-forward and feedback control components is proposed for electromagnetic-force-based formation keeping.The feed-forward component is directly obtained through desired configuration and dynamics under nominal conditions while the feedback component is realized utilizing active disturbance rejection control methodology with some reasonable improvement.Numerical simulation is presented to verify the feasibility and validity of the combined control scheme. | CAI WeiWei YANG LePing ZHU YanWei ZHANG YuanWen | 2013 | Science China(Technological Sciences)2013，56，5： | 4 |
| 7 | Bi-level Coordinated Planning of Active Distribution Network Considering Demand Response Resources and Severely Restricted Scenarios显示文摘Due to the uncertainty and fluctuation of distributed generation(DG)and load,the operation of active distribution network(ADN)is affected by multi-dimension factors which are described by massive operation scenarios.Efficient and accurate screening of severely restricted scenarios(SRSs)has become a new challenge in ADN planning.In this paper,a novel bi-level coordinated planning model which combines the short-time-scale operation problem with the long-time-scale planning problem is proposed.At the upper level,the demand response(DR)resource,an effective non-component planning resource characterized by low capacity price,high energy price,and short contract term,is co-optimized with the configuration of lines and energy storage systems(ESSs)to achieve the economic trade-off between the investment cost and the operation cost under SRSs.At the lower level,with the planning scheme obtained from the upper level,massive operation problems are optimized to minimize the daily operation cost;and the SRSs are provided to the upper level through a shadow-price-based scenario screening method,which simulates the planning information(i.e.,the restricted degrees of operation scenarios)feedback process from ADN operators to ADN planners.Case studies on a 62-node distribution system in Jianshan New District,Zhejiang Province,China,illustrate the effectiveness of the proposed bi-level coordinated planning model considering DR resources and SRSs. | Huang Yixin Lin Zhenzhi Liu Xinyi Yang Li Dan Yangqing Zhu Yanwei Ding Yi Wang Qin | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，5： | 3 |
| 8 | A guidance method for coplanar orbital interception based on reinforcement learning显示文摘This paper investigates the guidance method based on reinforcement learning(RL)for the coplanar orbital interception in a continuous low-thrust scenario.The problem is formulated into a Markov decision process(MDP)model,then a welldesigned RL algorithm,experience based deep deterministic policy gradient(EBDDPG),is proposed to solve it.By taking the advantage of prior information generated through the optimal control model,the proposed algorithm not only resolves the convergence problem of the common RL algorithm,but also successfully trains an efficient deep neural network(DNN)controller for the chaser spacecraft to generate the control sequence.Numerical simulation results show that the proposed algorithm is feasible and the trained DNN controller significantly improves the efficiency over traditional optimization methods by roughly two orders of magnitude. | ZENG Xin ZHU Yanwei YANG Leping ZHANG Chengming | 2021 | Journal of Systems Engineering and Electronics2021，32，4： | 2 |
| 9 | Ceria supported Ru^(0)-Ru^(δ+) clusters as efficient catalyst for arenes hydrogenation显示文摘Selective hydrogenation of aromatic amines,especially chemicals such as aniline and bis(4-aminocyclohexyl)methane for non-yellowing polyurethane,is of particular interests due to the extensive applications.To conquer the existing difficulties,in selective hydrogenation,,the Ru^(0)-Ru^(δ+)/CeO2 catalyst with solid frustrated Lewis pairs was developed for aromatic amines hydrogenation with excellent activity and selectivity under relative milder conditions.The morphology,electronic and chemical properties,especially the Ru^(O)-Ru^(δ+) clusters and reducible ceria were characterized by X-ray diffraction(XRD),transmission electron microscopy(TEM),sca nning electronic microscopy(SEM),X-ray photoelectron sp ectroscopy(XPS),CO_(2) tempe rature programmed deso rption(CO_(2)-TPD),H_(2) tempe rature programmed reduction(H_(2)-TPR),H_(2) diffuse reflectance Fourier transform infrared spectroscopy(H_(2)-DRIFT),Raman,etc.The 2% Ru/CeO_(2) catalyst exhibited good conversion of 95% and selectivity greater than 99% toward cyclohexylamine.The volcano curve describing the activity and Ru state was found.Owning to the 'acidic site isolation' by surrounding alkaline sites,condensation between the neighboring amine molecules could be effectively suppressed.The catalyst also showed good stability and applicability for other aromatic amines and heteroarenes containing different functional groups. | Yanwei Cao Huan Zheng Gangli Zhu Haihong Wu Lin He | 2021 | Chinese Chemical Letters2021，32，2： | 2 |
| 10 | An inspiration to the studies on mechanisms of acupuncture and moxibustion action derived from 2021 Nobel Prize in Physiology or Medicine显示文摘The editorial board of Acupuncture and Herbal Medicine recently convened an academic seminar with a focus on studies regarding the mechanisms mediating acupuncture efficacy and moxibustion action inspired by the 2021 Nobel Prize in Physiology or Medicine.Specifically,Professor Bailong Xiao introduced the Nobel Prize for research on the mechanically activated Piezo ion channel,evaluating the structure of the Piezo channel and its physiological and pathological functions,and proposed a possible role for the Piezo channel in acupuncture mechanical stimulation.Professor Michael Xi Zhu introduced the discovery of the transient receptor potential(TRP)family,reporting that the therapeutic effects of Chinese medicine and acupuncture may be achieved via the TRP family,and that information regarding associations between the meridian and lymphatic systems may have important research and medical value.In addition,Professor Tianle Xu reviewed the history of ion channel research,particularly the physiological and pharmacological effects of non-classical ion channels(eg,the acid sensing ion channel family)and pointed out that the characterization and neural circuits of acupuncture deqi manipulation are important for elucidating the mechanisms of acupuncture actions.Professor Yongming Li similarly proposed that the 2021 Nobel Prize may open the door to disclosing the histological basis of acupuncture and moxibustion and analyzing the main scientific concerns regarding the clinical translation of acupuncture and moxibustion from basic to translational research.Finally,Professor Yi Guo summarized the study progress of the acupoint microenvironment induced by acupuncture over the course of nearly 30 years and put forward the hypothesis that acupuncture may initiate the physical-chemical coupling network by activating ion channel receptors in acupoints via physical and mechanical stimulation.Therefore,we conclude that a primary achievement of the 2021 Nobel Prize in Physiology or Medicine is in helping interpret how acupuncture and moxibustion adjust homeostasis(ie,by activating mechanical and thermal sensation),which is conducive to validating and promoting the clinical efficacy of acupuncture modalities. | Yi Guo Yongming Li Tianle Xu Michael Xi Zhu Zhifang Xu Baomin Dou Yanwei Li Zhihan Chen | 2022 | Acupuncture and Herbal Medicine2022，2，1： | 2 |
| 11 | Bi-allelic mutations in DNAH7 cause asthenozoospermia by impairing the integrality of axoneme structure显示文摘Asthenozoospermia is the most common cause of male infertility.Dynein protein arms play a crucial role in the motility of both the cilia and flagella,and defects in these proteins generally impair the axoneme structure and cause primary ciliary dyskinesia.But relatively little is known about the influence of dynein protein arm defects on sperm flagella function.Here,we recruited 85 infertile patients with idiopathic asthenozoospermia and identified bi-allelic mutations in DNAH7(NM_018897.3)from three patients using whole-exome sequencing.These variants are rare,highly pathogenic,and very conserved.The spermatozoa from the patients with DNAH7 bi-allelic mutations showed specific losses in the inner dynein arms.The expression of DNAH7 in the spermatozoa from the DNAH7-defective patients was significantly decreased,but these patients were able to have their children via intra-cytoplasmic sperm injection treatment.Our study is the first to demonstrate that bi-allelic mutations in DNAH7 may impair the integrality of axoneme structure,affect sperm motility,and cause asthenozoospermia in humans.These findings may extend the spectrum of etiological genes and provide new clues for the diagnosis and treatment of patients with asthenozoospermia. | Xiaoli Wei Yanwei Sha Zijie Wei Xingshen Zhu Fengming He Xiaoya Zhang Wensheng Liu Yifeng Wang Zhongxian Lu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，10： | 2 |
| 12 | Conserved and differentiated functions of CIK receptor kinases in modulating stem cell signaling in Arabidopsis显示文摘The shoot apical meristem(SAM)and root apical meristem(RAM)act as pools of stem cells that give rise to aboveground and underground tissues and organs in higher plants,respectively.The CLAVATA3(CLV3)-WUSCHEL(WUS)negative-feedback loop acts as a core pathway controlling SAM homeostasis,while CLV3/EMBRYO SURROUNDING REGION(ESR)40(CLE40)and WUSCHEL-RELATED HOMEOBOX5(WOX5),homologs of CLV3 and WUS,direct columella stem cell fate.Moreover,CLV3 INSENSITIVE KINASES(CIKs)have been shown to be essential for maintaining SAM homeostasis,whereas whether they regulate the distal root meristem remains to be elucidated.Here,we report that CIKs are indispensable for transducing the CLE40 signal to maintain homeostasis of the distal root meristem.We found that the cik mutant roots displayed disrupted quiescent center and delayed columella stem cell(CSC)differentiation.Biochemical assays demonstrated that CIKs interact with ARABIDOPSIS CRINKLY4(ACR4)in a ligand-independent manner and can be phosphorylated by ACR4 in vitro.In addition,the phosphorylation of CIKs can be rapidly induced by CLE40,which partially depends on ACR4.Although CIKs act as conserved and redundant regulators in the SAM and RAM,our results demonstrated that they exhibit differentiated functions in these meristems. | Yafen Zhu Chong Hu Yanwei Cui Li Zeng Sunjingnan Li Mingsong Zhu Fanhui Meng Shuting Huang Li Long Jing Yi Jia Li Xiaoping Gou | 2021 | Molecular Plant2021，14，7： | 2 |
| 13 | Design and optimization of an automatic hydraulic steer-by-wire system for an agricultural chassis显示文摘To meet the requirements of fast steering at low vehicle speed and slow steering at high vehicle speed,the automatic steering of agricultural chassis must control both the wheel steering angle and the steering angle’s angular speed.This study applied hydraulic steer-by-wire technology to the automatic steering control of agricultural chassis.First,the transmission mechanism of the designed steering system was optimized.According to the rule of least squares,aiming at the minimum sum of squares of errors between 10 ideal outer wheel angles and real outer wheel angles,the optimal solution of hole spacing on both sides of the steering hydraulic cylinder piston rod was 925 mm.The outer wheel angle error of the optimized steering mechanism throughout the steering stroke was less than 0.15°.Additionally,a hydraulic steer-by-wire system was developed,and the parameters of its critical components were calculated.Then,the compound control strategy of the steering cylinder piston rod displacement and moving speed was formulated for this automatic steering system.The entire control system included a valve control signal calculation model,an initial velocity calculation model,a correction velocity calculation model,and an attenuation velocity calculation model,and the formulae of each model were deduced.Based on the optimized parameters and the developed control strategy,a simulation model was built in AMESim,and simulation results showed that the proposed control strategy could achieve simultaneous controls of piston rod displacement and speed at different vehicle speeds and loads.The horizontal and vertical displacements of the right wheel center were plotted for typical vehicle speeds and steering commands.The results of this study provided a new idea for the application of hydraulic steer-by-wire technology in the automatic steering of agricultural chassis. | Yinhao Jin Yanwei Yuan Licheng Zhu Decheng Wang Bo Zhao Xianfa Fang | 2022 | International Journal of Agricultural and Biological Engineering2022，15，1： | 1 |
| 14 | A comparative analysis of aerosol properties in dust and haze-fog days in a Chinese urban region显示文摘 | Xingna Yu Bin Zhu Yan Yin Jun Yang Yanwei Li Xiaoli Bu | 2010 | Atmospheric Research2010，，2： | 1 |
| 15 | Superconductivity and strong spin-orbit coupling in a new noncentrosymmetric compound ThIrP显示文摘A new noncentrosymmetric phosphide ThIrP has been synthesized and characterized. X-ray difraction analysis shows that this compound crystallizes in a LaPtSi-type tetragonal lattice(space group I41md, Z = 4), whose lattice parameters are a = b =4.0676(1) ?, c = 14.3354(2) ?, and V = 237.191(8) ?3. Moreover, ThIrP is discovered to be an intermediately coupled,type-Ⅱ superconductor with possibly multiple gaps below Tc= 5.07 K. The upper critical magnetic field, Sommerfield coefficient, and Ginzburg-Laudau parameter are determined based on physical property measurements, which are Bc2= 0.83 T, γ =7.5 mJ mol-1 K-2, and κGL= 7.5, respectively. The electronic band structure calculations point out nearly equal contributions of Ir and Th atoms on the density of states around the Fermi surface. In addition, the spin-orbit coupling induced band splitting reaches as large as 270 meV along the Γ-Z line. Our results suggest that ThIrP provides a platform to study the interplay between inversion-symmetry breaking, strong spin-orbit coupling, and superconductivity. | GuoRui Xiao QinQing Zhu YanWei Cui WuZhang Yang BaiZhuo Li SiQi Wu Guang-Han Cao Zhi Ren | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，10： | 1 |
| 16 | Baicalin reduces the permeability of the blood-brain barrier during hypoxia in vitro by increasing the expression of tight junction proteins in brain microvascular endothelial cells显示文摘 | Zhu HaiYan Wang ZhiYao Xing YanWei | 2012 | J Ethnopharmacol2012，141，2： | 1 |
| 17 | A comparative analysis of aerosol properties in dust and haze-fog days in a Chinese urban region显示文摘 | Xingna Yu Bin Zhu Yan Yin Jun Yang Yanwei Li Xiaoli Bu | 2010 | Atmospheric Research2010，，2： | 1 |
| 18 | Facile synthesis of meso- porous Ce-Fe bimetal oxide and its enhanced adsorption of arsenate from aqueous solutions 显示文摘 | Chen Bo Zhu Zhiliang Guo Yanwei | 2013 | Journal of Colloid and Interface Science2013，398，9： | 1 |
| 19 | Optimal reconfiguration of constellation using adaptive innovation driven multiobjective evolutionary algorithm显示文摘Constellation reconfiguration is a critical issue to recover from the satellite failure,maintain the regular operation,and enhance the overall performance.The constellation reconfiguration problem faces the difficulties of high dimensionality of design variables and extremely large decision space due to the great and continuously growing constellation size.To solve such real-world problems that can be hardly solved by traditional algorithms,the evolutionary operators should be promoted with available domain knowledge to guide the algorithm to explore the promising regions of the trade space.An adaptive innovationdriven multi-objective evolutionary algorithm(MOEA-AI)employing automated innovation(AI)and adaptive operator selection(AOS)is proposed to extract and apply domain knowledge.The available knowledge is extracted from the final or intermediate solution sets and integrated into an operator by the automated innovation mechanism.To prevent the overuse of knowledgedependent operators,AOS provides top-level management between the knowledge-dependent operators and conventional evolutionary operators.It evaluates and selects operators according to their actual performance,which helps to identify useful operators from the candidate set.The efficacy of the MOEAAI framework is demonstrated by the simulation of emergency missions.It was verified that the proposed algorithm can discover a non-dominant solution set with better quality,more homogeneous distribution,and better adaptation to practical situations. | HU Jiaxin YANG Leping HUANG Huan ZHU Yanwei | 2021 | Journal of Systems Engineering and Electronics2021，32，6： | 1 |
| 20 | Research of cloud manufacturing and resource encapsulation technology 显示文摘 | HU Chunyang WANG Yanwei ZHU Panfeng | 2011 | Applied Mechanics and Materials Information Technolo- gy for Manufacturing Systems II2011，5860，： | 1 |
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