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| 1 | Apoptosis and its relationship with cell proliferation,p53,Waf1p21,bcl-2 and c-mycin esophageal carcinogenesis studied with a high-risk population in northern China显示文摘Apoptosisanditsrelationshipwithcelproliferation,p53,Waf1p21,bcl2andcmycinesophagealcarcinogenesisstudiedwithahighriskpopul... | WANG LiDong1, ZHOU Qi1, WEI JunPing1, YANG WanCai1, ZHAO Xin1, WANG LiXia1, ZOU Jian Xiang1, GAO ShanShan1, LI YongXin1 and YANG C.S.2Keywords esophageal neoplasms apoptosis precancerous lesions Waf1 p21 gene p53 | 1998 | World Journal of Gastroenterology1998，4，4： | 295 |
| 2 | Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis显示文摘AIM To observe the inhibition of antisenseoligonucleotides (asON) phosphorthioate to thetissue inhibitors metalloproteinase-1 (TIMP-1)gene and protein expression in the liver tissue ofimmunologically induced hepatic fibrosis rats.The possibility of reversing hepatic fibrosisthrough gene therapy was observed.METHODS Human serum albumin (HSA) wasused to attack rats, as hepatic fibrosis model, inwhich asONs were used to block the gene andprotein expressing TIMP-1. According to theanalysis of modulator, structure protein, codingseries of TIMP-1 genome, we designed fourdifferent asONs. These asONs were injected intothe hepatic fibrosis models through coccygealvein. The results was observed by RT-PCR formeasuring TIMP-1 mRNA expression,immunohistochemistry and in situ hybridizationfor collagen Ⅰ, Ⅲ, special staining of collagenfiber, and electron microscopic examination.RESULTS Hepatic fibrosis could last within 363days in our modified model. The expressinglevel of TIMP-1 was high during hepatic fibrosisprocess. It has been proved by theimmunohistochemical and the electronmicroscopic examination that the asONphosphorthioate of TIMP-1 could exactly expressin vivo. The effect of colchicine wasdemonstrated to inhibit the expressing level ofmRNA and the content of collagen Ⅰ, Ⅲ in theliver of experimental hepatic fibrosis rats.However, the electron microscopy research andthe pathologic grading of hepatic fibrosisshowed that there was no significant differencebetween the treatment group and the modelgroup (P>0.05).CONCLUSION The experimental rat model ofhepatic fibrosis is one of the preferable modelsto estimate the curative effect of anti-hepaticfibrosis drugs. The asON phosphorthioate ofTIMP-1 could block the gene and proteinexpression of TIMP-1 in the liver of experimentalhepatic fibrosis rats at the mRNA level. It ispossible to reverse hepatic fibrosis, and it isexpected to study a new drug of anti-hepaticfibrosis on the genetic level. Colchicine has verylimited therapeutic effect on hepatic fibrosis,furthermore, its toxicity and side effects areobvious. | Qing He Nie Yong Qian Cheng Yu Mei Xie Yong Xing Zhou Yi Zhan Cao The Center of Infectious Disease Diagnosis and Treatment of PLA,Tangdu Hospital,Forth Military Medical University,Xi’an 710038,Shaanxi Province,ChinaDr,Qing He Nie graduated from Qinghai Medical College as a doctor in 1983,got master degree at Beijing 302 Army Hospital in 1993,got doctor degree at the Third Military Medical University in 1998,engaged in postdoctoral research at the Fourth Military Medical University from 1998 to 2000,now an associate professor,specialized in clinical and experimental research of infectious diseases,had more than 90 papers published,coauthor of ten books,first author of one book. | 2001 | World Journal of Gastroenterology2001，7，3： | 73 |
| 3 | Spatio-temporal rupture process of the 2008 great Wenchuan earthquake显示文摘Focal mechanism and dynamic rupture process of the Wenchaun Ms8.0 earthquake in Sichuan province on 12 May 2008 were obtained by inverting long period seismic data from the Global Seismic Network (GSN), and characteristics of the co-seismic displacement field near the fault were quantitatively ana-lyzed based on the inverted results to investigate the mechanism causing disaster. A finite fault model with given focal mechanism and vertical components of the long period P-waves from 21 stations with evenly azimuthal coverage were adopted in the inversion. From the inverted results as well as after-shock distribution, the causative fault of the great Wenchuan earthquake was confirmed to be a fault of strike 225°/dip 39°/rake 120°, indicating that the earthquake was mainly a thrust event with right-lateral strike-slip component. The released scalar seismic moment was estimated to be about 9.4×1020―2.0×1021 Nm, yielding moment magnitude of Mw7.9―8.1. The great Wenchuan earthquake occurred on a fault more than 300 km long, and had a complicated rupture process of about 90 s duration time. The slip distribution was highly inhomogeneous with the average slip of about 2.4 m. Four slip-patches broke the ground surface. Two of them were underneath the regions of Wenchuan-Yingxiu and Beichuan, respectively, with the first being around the hypocenter (rupture initiation point), where the largest slip was about 7.3 m, and the second being underneath Beichuan and extending to Pingwu, where the largest slip was about 5.6 m. The other two slip-patches had smaller sizes, one having the maximum slip of 1.8 m and lying underneath the north of Kangding, and the other having the maximum slip of 0.7 m and lying underneath the northeast of Qingchuan. Average and maximum stress drops over the whole fault plane were estimated to be 18 MPa and 53 MPa, respectively. In addition, the co-seismic displacement field near the fault was analyzed. The results indicate that the features of the co-seismic displacement field were coincident with those of the intensity distribution in the meizo-seismal area, implying that the large-scale, large-amplitude and surface-broken thrust dislocation should be responsible for the serious disaster in the near fault area. | ZHANG Yong FENG WanPeng XU LiSheng ZHOU ChengHu CHEN YunTai | 2009 | Science China Earth Sciences2009，52，2： | 68 |
| 4 | Standard triple therapy for Helicobacter pylori infection in China: A meta-analysis显示文摘AIM:To assess the efficacy and safety of standard triple therapy compared with other pre-existing and new therapies in China.METHODS:Literature searches were conducted in the following databases:PubMed,EMBASE,the Cochrane Central Register of Controlled Trials,the VIP database,the China National Knowledge Infrastructure database,and the Chinese Biomedical Database.A meta-analysis of all randomized controlled trials(RCTs)comparing standard triple therapy for the eradication of Helicobacter pylori with pre-existing and new therapies in China was performed using Comprehensive Meta-Analysis 2.0.There were 49 studies that met our criteria and the qualities of these studies were assessed using the Jadad scale.The Mantel-Haenszel method was used for pooling dichotomous data.We also conducted subgroupanalyses according to age,duration of treatment and drug type.Sensitivity analyses and a cumulative metaanalysis were also performed with CMA 2.0.Publication bias was evaluated using Egger’s test,Begg’s test or a funnel plot.RESULTS:A total of 49 RCTs including 8332 patients were assessed.This meta-analysis showed that standard triple therapy with proton pump inhibitors(PPIs),amoxicillin(AMO)and clarithromycin(CLA)was inferior to sequential therapy[relative risk(RR)=0.863;95%confidence interval(CI):0.824-0.904],but was not superior to quadruple therapy(RR=1.073;95%CI:0.849-1.357)or other triple therapies(RR=1.01;95%CI:0.936-1.089).The meta-analysis also suggested that standard triple therapy is slightly more effective than dual therapy(RR=1.14;95%CI:0.99-1.31).However,the differences were not statistically significant.We removed the only trial with a regimen lasting14 d by sensitivity analysis and found that 7-d standard triple therapy was superior to 7-d dual therapy(RR=1.222;95%CI:1.021-1.461).Moreover,a sub-analysis based on the duration of quadruple therapy indicated that the 7-d and 10-d standard triple therapies were inferior to sequential therapy(RR=0.790;95%CI:0.718-0.868;RR=0.917;95%CI:0.839-1.002,respectively).Additionally,there were no significant differences in cure rate or adverse events among standard triple therapy,quadruple therapy,and other triple therapies(RR=0.940;95%CI:0.825-1.072;RR=1.081;95%CI:0.848-1.378,respectively).Standard triple therapy had a higher occurrence of side effects than sequential therapy(RR=1.283;95%CI:1.066-1.544).CONCLUSION:The eradication rates with a standard triple therapy consisting of PPI,AMO,and CLA are suboptimal in China,and new treatment agents need to be developed. | Ben Wang Zhi-Fa Lv You-Hua Wang Hui Wang Xiao-Qun Liu Yong Xie Xiao-Jiang Zhou | 2014 | World Journal of Gastroenterology2014，20，40： | 46 |
| 5 | Active Tectonics of the Longmen Shan Region on the Eastern Margin of the Tibetan Plateau显示文摘有为在在西藏的高原的东方边缘的 theLongmen 掸人的活跃 tectonics 的似地球形状的证据的巨大的数量。我们包括 Wenchuan-Maowen, Beichuan-Yingxiu 和 Pengxian-Guanxian 差错调查了一些典型似地球形状的标记,平台偏移量,陡坡,控制差错的僵绳,右快门山脉,右隧道偏移量,抓住在,粉碎带,和拉开盆。电子自旋共振(ESR ) 和热照明(TL ) 变老用从在沉积的表面下面拿的淤泥的沙被获得。根据这些数据,我们推测推进和走向滑倒的率,和结果显示在高原边缘弄短的 Cenozoictectonic 与插入不到 1.10 mm/aand 的率是次要的率滑倒罢工不到 1.46 mm/a。Longmen 掸人是 NNE-trendingdextral 的一个地区与 6:1-1.3:1 的滑倒剧降比率砍。从 NW 到 SE,戳部件变得更小,而走向滑倒部件变得更大。 | ZHOU Rongjun LI Yong Alexander L.DENSMORE Michael A. ELLIS HE Yulin LI Yongzhao LI Xiaogang | 2007 | Acta Geologica Sinica(English Edition)2007，81，4： | 37 |
| 6 | Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis显示文摘在哺乳动物的精子发生被 piRNA 表示的二个波浪描绘:一个人对应于负责的经典 piRNAs 因为 silencing retrotransponsons 和第二个波浪主要在 pachytene spermatocytes 从 nontransposon intergenic 区域被导出,但是这些 pachytene piRNAs 的功能大部分是未知的。这里,我们在在老鼠伸长指示巨大的 mRNA 消除报导 pachytene piRNAs 的参与 spermatids (ES ) 。我们证明包含鼠科的 PIWI (MIWI ) 和 deadenylase CAF1 的导致 piRNA 的 silencing 建筑群(pi-RISC ) 有选择地在 ES 被装配,它负责经由在体的房间类似于 miRNAs 的行动的机制导致 mRNA deadenylation 和腐烂。如此的一个高度安排的节目看起来充分利用 pachytene piRNAs 的能力从 nontransposon intergenic 区域导出的多样化的指向的庞大的全部剧目。这些调查结果建议 pachytene piRNAs 负责为精子生产作准备,从 ES 使广阔细胞的节目失去活性。 | Lan-Tao Gou Peng Dai Jian-Hua Yang Yuanchao Xue Yun-Ping Hu Yu Zhou Jun-Yan Kang Xin Wang Hairi Li Min-Min Hua Shuang Zhao Si-Da Hu Li-Gang Wu Hui-Juan Shi Yong Li Xiang-Dong Fu Liang-Hu Qu En-Duo Wang Mo-Fang Liu | 2014 | Cell Research2014，24，6： | 39 |
| 7 | Active Tectonics and Erosional Unloading at the Eastern Margin of the Tibetan Plateau显示文摘The eastern margin of the Tibetan Plateau is marked by an extremely steep mountain front with relief of over 5 km. This topography,coupled with abundant Mesozoic thrusts within the margin,explains why tectonic maps of the India-Asia collision typically show the eastern margin as a major thrust zone. Actually,it does not like that. Field observations suggest that the margin is better characterized as a zone of NNE-directed dextral shear with extensive strike-slip faulting and secondary thrusting. The high relief and steep gradients are partially explained by erosional unloading of an elastic lithosphere;the pre-erosion inherited topography may be the inherited Mesozoic thrust belt landscape modified by a component of Cenozoic tectonic shortening. | Alexander L. Densmore LI Yong Michael A. Ellis ZHOU Rongjun | 2005 | Journal of Mountain Science2005，2，2： | 34 |
| 8 | Dissection of genetic overlap of salt tolerance QTLs at the seedling and tillering stages using backcross introgression lines in rice显示文摘QTLs for salt-tolerance(ST)related traits at the seedling and tillering stages were identified using 99 BC2F8 introgression lines(IL)derived from a cross between IR64(indica)as a recurrent parent and Binam(japonica)from Iran as the donor parent.Thirteen QTLs affecting survival days of seedlings(SDS), score of salt toxicity of leaves(SST),shoot K + concentration(SKC)and shoot Na + concentration(SNC) at the seedling stage and 22 QTLs underlying fresh weight of shoots(FW),tiller number per plant(TN) and plant height(PH)at the tillering stage were identified.Most QTLs detected at the tillering stage showed obvious differential expression to salt stress and were classified into three types based on their differential behaviors.Type I included 11 QTLs which were expressed only under the non-stress condition.Type II included five QTLs expressed in the control and the salt stress conditions,and three of them(QPh5,QPh8 and QTn9)had similar quantity and the same direction of gene effect,suggesting their expression was less influenced by salt stress.Type III included six QTLs which were detectable only under salt stress,suggesting that these QTLs were apparently induced by the stress.Thirteen QTLs affecting trait difference or trait stability of ILs between the stress and non-stress conditions were identified and the Binam alleles at all loci except QPh4,QTn2 and QFw2a decreased trait difference.The three QTLs less influenced by the stress and 13 QTLs affecting trait stability were considered as ST QTLs which contributed to ST.Comparing the distribution of QTLs detected at the seedling and tillering stages,most(69%)of them were genetically independent.Only four were the same or adjacent regions on chromosomes 1,2,8 and 11 harboring ST QTLs detected at the two stages,suggesting that partial genetic overlap of ST across the two stages occurs.It is likely,therefore,to develop ST rice variety for both stages by pyramiding of ST QTLs of different stages or selection against the overlapping QTLs between the two stages via marker-assisted selection(MAS). | ZANG JinPing 1 ,SUN Yong 1 ,WANG Yun 1 ,YANG Jing 1 ,LI Fang 1 ,ZHOU YongLi 1 ,ZHU LingHua 1 , Reys JESSICA2,Fotokian MOHAMMADHOSEIN 2,XU JianLong 1&LI ZhiKang 1,2 1Institute of Crop Sciences/National Key Facility for Crop Gene Resources&Genetic Improvement,Chinese Academy of Agricul- tural Sciences,Beijing 100081,China 2International Rice Research Institute,DAPO Box 7777,Metro Manila,Philippines | 2008 | Science China(Life Sciences)2008，51，7： | 32 |
| 9 | Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma显示文摘Sorafenib is the first-line medication for advanced hepatocellular carcinoma(HCC),but it can only extend limited survival.It is imperative to find a combination strategy to increase sorafenib efficacy.Artesunate is such a preferred candidate,because artesunate is clinically well-tolerated and more importantly both drugs can induce ferroptosis through different mechanisms.In this study we investigated the combined effect of sorafenib and artesunate in inducing ferroptosis of HCC and elucidated the involved molecular mechanisms.We showed that artesunate greatly enhanced the anticancer effects of low dose of sorafenib against Huh7,SNU-449,and SNU-182 HCC cell lines in vitro and against Huh7 cell xenograft model in Balb/c nude mice.The combination index method confirmed that the combined effect of sorafenib and artesunate was synergistic.Compared with the treatment with artesunate or sorafenib alone,combined treatment induced significantly exacerbated lipid peroxidation and ferroptosis,which was blocked by N-acetyl cysteine and ferroptosis inhibitors liproxstatin-1 and deferoxamine mesylate,but not by inhibitors of other types of cell death(z-VAD,necrostatin-1 and belnacasan).In Huh7 cells,we demonstrated that the combined treatment induced oxidative stress and lysosome-mediated ferritinophagy,two essential aspects of ferroptosis.Sorafenib at low dose mainly caused oxidative stress through mitochondrial impairments and SLC7A11-invovled glutathione depletion.Artesunate-induced lysosome activation synergized with sorafenib-mediated pro-oxidative effects by promoting sequential reactions including lysosomal cathepsin B/L activation,ferritin degradation,lipid peroxidation,and consequent ferroptosis.Taken together,artesunate could be repurposed to sensitize sorafenib in HCC treatment.The combined treatment can be easily translated into clinical applications. | Zhong-jie Li Hui-qi Dai Xiao-wei Huang Ji Feng Jing-huan Deng Zi-xuan Wang Xiao-mei Yang Yu-jia Liu Yong Wu Pan-hong Chen Huan Shi Ji-gang Wang Jing Zhou Guo-dong Lu | 2021 | Acta Pharmacologica Sinica2021，42，2： | 31 |
| 10 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 11 | Structural and Geochronological Evidence for Multiple Episodes of Tertiary Deformation along the Ailaoshan-Red River Shear Zone, Southeastern Asia, Since the Paleocene显示文摘结构的分析证明 Ailaoshan 红的河剪碎带(ASRRSZ ) inAilao 山由三不同 deformational domaias 组成。这些领域可以代表三个事件左侧面滑倒由 ASRRSZ 富有经验。如此的变丑的第一个事件在 transtensional 政体下面在整个 ASRRSZ 的东方高级的带发生了并且生产了角闪岩等级的 L 类型侦探棉火药。第二个事件左侧面滑动形成的高度套印高级的带的火车地区。它的 deformational 机制类似于 simples 听见并且使变形的岩石是绿色片岩等级的 L-S 糜棱岩。第三个事件 ofleft 侧面滑倒在 ASRRSZ 的一条西方的低档带主要发生了。这变丑在 transpressional 政体发生了,形成了一个左首的戳系统的一个全面结构模式并且生产了 low-greenschist 等级的 phyllonltes。Geochronological 数据显示三个事件左侧面滑倒发生在近似 58-56 妈前,至少从约 27 妈 to22 妈并且在近似 13-12 妈分别地。第一个事件在 ASRRSZ 滑倒看起来在 -60 对应于印度和亚洲的起始的碰撞妈。第二个事件几乎在象最集中的压缩的一样的时间发生了并且在西藏高举。最近的事件可能在近似 16-13 妈后面在西藏代表进一步东方的材料流动。因此,东南的亚洲的 ASRRSZ 可能经历了三个主要事件第三级左侧面自从印度亚洲碰撞,在 intracontinental 集中期间滑倒。 | ZHANG Jinjiang ZHONG Dalai SANG Haiqing ZHOU Yong | 2006 | Acta Geologica Sinica(English Edition)2006，80，1： | 27 |
| 12 | Different histological subtypes of parotid gland tumors: CT findings and diagnostic strategy显示文摘AIM:To present computed tomography(CT) findings of different histological subtypes of parotid gland masses in detail and to establish diagnostic strategy.METHODS:From January 2009 to November 2011,56 patients were collected through the histopathology and Picture Archiving and Communication Systems records,which revealed 5 basal cell adenoma(BCA),16 pleomorphic adenoma(PA),25 Warthin's tumor(War-T),3 Kimura's disease(KD) and 7 parotid carcinoma(PCa) cases.All the CT images were retrospectively analyzed by two radiologists in consensus,based on their description of morphology(location,number,size,margin and fibrous capsule) and enhancement patterns of masses.In addition,the diagnostic efficiency of diagnostic strategy is tested.RESULTS:War-T and BCA patients' mean age was 59.9 ± 12.6 years and 58.4 ± 18.2 years;the significant difference was seen in War-T vs PA and BCA vs PA.About 40% of War-Ts presented with bilateral multifocal lesions,a higher ratio than others.Seventy two percent of War-Ts were limited to the superficial lobe,followed by BCA 60% and PA 40%.Vessel facing sign and enlarged lymph nodes were both frequent in War-T,which respectively accounts for 84% and 76% of cases.Rapid contrast enhancement and decreases were unique for War-T.BCA and PA showed obvious delayed enhancement.The diagnostic strategy of parotid gland tumor had a good diagnostic efficiency,with high accuracy,sensitivity and specificity.CONCLUSION:Determination of the histological subtypes of parotid gland masses might be possible based on CT findings and clinical data.A diagnostic strategy with high diagnostic efficiency was established. | Zhi-Feng Xu Fang Yong Tian Yu Ying-Yu Chen Qiang Gao Tao Zhou Ai-Zhen Pan Ren-Hua Wu | 2013 | World Journal of Radiology2013，5，8： | 25 |
| 13 | Impact of hypoxic preconditioning on apoptosis and its possible mechanism in orthotopic liver autotransplantation in rats显示文摘BACKGROUND:Hepatocyte apoptosis is a severe form of cell death after hepatic ischemia-reperfusion injury(HIRI), and its relief is an important issue in liver transplantation. Hypoxic preconditioning(HP)is considered to have protective effects on HIRI.This study was designed to explore the impact of HP on apoptosis and its possible mechanism during orthotopic liver autotransplantation. METHODS:A modified orthotopic liver autotransplantation model was used to simulate HIRI.Sprague-Dawley rats were randomly divided into normal control,autotransplantation (AT)and HP groups.The HP group was subjected to an 8%oxygen atmosphere for 90 minutes before surgery.At 1,6 and 24 hours after surgery,the rats were killed and their liver tissue was sampled to assess the expression of Bcl-2 protein.The samples were subjected to blood chemistry study,morphological study under a light or transmission electron microscope,and quantitative study of mitochondria. RESULTS:The serum levels of ALT and AST in the HP group were lower than those in the AT group at 1,6 and 24 hours after orthotopic liver autotransplantation(P<0.05).Bcl-2 protein expression was increased in the HP group at each measurement point(P<0.05).Light microscopy showed that hepatic injury in the AT group was much more severe than in the HP group.Hepatocytes in the AT group showed typical apoptosis signs under a transmission electron microscope.The ultrastructural appearance of hepatocytes in the HP group was much better than in the AT group,and the area,perimeter and diameter of the mitochondria were smaller in the HP group than in the AT group(P<0.05). CONCLUSIONS:Hepatocytes sense and respond to decreased tissue oxygenation.Stimulation by HP relieves apoptosis by upregulating expression of Bcl-2 protein and its protection of mitochondria after orthotopic liver autotransplantation. | Jin, Cheng Zhang, Pei-Jian Wu, Xiao-Min Zhou, Bin Li, Yong Liu, Xin-Yan Feng, Min Tao, Li-De | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，1： | 26 |
| 14 | Three-dimensional finite element analysis of weakened roots restored with different cements in combination with titanium alloy posts显示文摘Background It is very difficult and relatively unpredictable to preserve and restore severely weakened pulpless roots. To provide much needed benefit basis for clinical practice, this study was carried out to analyze the stress distribution in weakened roots restored with different cements in combination with titanium alloy posts. Finite element analysis (FEA) was employed in the study. Methods A pseudo three-dimensional model of a maxillary central incisor with flared root canal, theoretically restored with titanium alloy posts in combination with different cements, was established. The analysis was performed by use of ANSYS software. The tooth was assumed to be isotropic, homogenous and elastic. A load of 100 N at an angle of 45°to the longitudinal axis was applied at the palatal surface of the crown. The distributions of stresses in weakened roots filled with cements of different elastic modulus were analyzed by the three-dimensional FEA model. Results Several stress trends were observed when the stress cloud atlas obtained in the study was analyzed. With the increase of the elastic modulus of cements from 1.8 GPa to 22.4 GPa, the stress values in dentin decreased from 39.58 MPa to 31.43 MPa and from 24.51 MPa to 20.76 MPa (respectively, for maximum principle stress values and Von Mises stress values). When Panavia F and zinc phosphate cement were used, the stress peak values in dentin were very small with no significant difference observed, and the Von Mises stress values were 20.87 MPa and 20.76 MPa respectively. On the other hand, maximum principle stress value and Von Mises stress value in cement layer increased with the increase of the elastic modulus of cements. Conclusions The result of this study demonstrated that elastic modulus was indeed one of the important parameters to evaluate property of the cements. Our three-dimensional FEA model study also found that the cement with elastic modulus similar to that of dentin could reinforce weakened root and reduce the stress in dentin. Thus, it may be a better choice for the restoration of weakened roots in clinical practice. | LI Li-li WANG Zhong-yi BAI Zhong-cheng MAO Yong GAO Bo XIN Hai-tao ZHOU Bing ZHANG Yong LIU Bing | 2006 | Chinese Medical Journal2006，，4： | 26 |
| 15 | Effects of spironolactone on electrical and structural remodeling of atrium in congestive heart failure dogs显示文摘背景:Renin-angiotensin-aldosterone 系统被表明了与充血心力衰竭(CHF ) 并且在伊朗的银币纤维性颤动(AF ) 被联系。这研究调查了螺内酯的效果,一种醛固酮对手,在上在伊朗的银币,在 CHF 狗的电的改变和纤维变性导致了由长期快速的室的踱步。方法:21 条狗随机被划分成假冒操作组,控制组,和螺内酯组。在控制组和螺内酯组,狗是室的每分钟在 220 敲击踱步 6 个星期。另外,在 15 mg x kg 的螺内酯(-1) x d (-1) 1 个星期在快速的室的踱步前被给狗直到踱步停止了。经胸廓和 transoesophageal echocardiographic 考试被执行检测中庭的结构、功能的变化。Swan2 Ganz 漂浮导管被用来测量缝 adynamics 变化。房的的有效不应期(AERP ) , AERP 分散(AERPd ) , intra 中庭和内部中庭的传导时间(CT ) 和 intra 中庭传导速度(CV ) 是坚定的。AF 的 inducibility 和持续时间也在所有组被测量。最后,在伊朗的银币,纤维变性被确定,马森染色。结果:在狗是室的以后, AERP 没显著地变化踱步 6 个星期。然而,显著地增加的 AERPd, intra 中庭和内部中庭的 CT,和 CV 显然减少了,它否定地被相关到 at 伊朗的银币纤维变性(r =-0.74, P <
0.05 ) 。同时,左中庭被扩大,心脏的缝 adynamics 在在狗上踱步变得更坏。尽管螺内酯不能有效地影响心脏的缝 adynamics,它能显然在伊朗的银币喷射部分改进左(P <
0.05 ) 。螺内酯处理没改变 AERP 持续时间,但是这药戏剧性地减少 AERPd (P <
0.05 ) ,弄短的 intra 中庭和内部中庭的传导时间(P <
0.05 ) ,并且增加的中庭 CV。而且,螺内酯减少了 AF 的 inducibility 和持续时间(P <
0.05 ) ,以及在伊朗的银币,纤维变性(P< 0.01 ) 导致了由长期快速的室的踱步。结论:螺内酯在导致由的充血心力衰竭狗贡献 AF 预防长期快速的室的踱步,它在伊朗的银币纤维变性减小和缝 adynamics 的独立人士与有关。 | YANG Shu-sen HAN Wei ZHOU Hong-yan DONG Guo WANG Bai-chun HUO Hong WEI Na CAO Yong ZHOU Guo XIU Chun-hong LI Wei-min | 2008 | Chinese Medical Journal2008，，1： | 26 |
| 16 | Furazolidone-based triple and quadruple eradication therapy for Helicobacter pylori infection显示文摘AIM: To evaluate the efficacy of furazolidone-based triple and quadruple therapy in eradicating Helicobacter pylori(H. pylori) in a multi-center randomized controlled trial.METHODS: A total of 720 H. pylori positive patients with duodenal ulcer disease were enrolled at 10 different hospitals in Jiangxi province in China. The patients were randomly assigned to four treatment groups as follows: patients in Groups 1 and 3 received rabeprazole(10 mg), amoxicillin(1000 mg) and furazolidone(100 mg) twice daily for 7 and 10 d, respectively; patients in Groups 2 and 4 received rabeprazole(10 mg), bismuth(220 mg), amoxicillin(1000 mg) and furazolidone(100 mg) twice daily for 7 and 10 d, respectively. The primary outcome measure was H. pylori eradication rate 4 wk after treatment by intention-to-treat and per protocol analysis, while the secondary outcome measures were symptom and sign changes at the end of treatment and 4 wk after the end of treatment, as well as the proportion of patients who developed adverse events.RESULTS: The demographic data of the four groups were not significantly different. Overall, 666 patients completed the scheme and were re-assessed with the 13C-urea breath test. The intention-to-treat analysis of the H. pylori eradication rates in Groups 1, 2, 3 and 4 were 74.44%, 82.78%, 78.89% and 86.11%, respectively. The H. pylori eradication rate in Group 4 was significantly higher than that in Group 1. According tothe per protocol analysis, the H. pylori eradication rates in Groups 1, 2, 3 and 4 were 81.21%, 89.22%, 85.54% and 92.26%, respectively. The H. pylori eradication rate in Group 4 was significantly higher than that in Group 1. The number of adverse events was 15(8.3%), 16(8.9%), 15(8.3%) and 17(9.4%) in Groups 1, 2, 3 and 4, respectively, including dizziness, vomiting, diarrhea, nausea, skin rash, itchy skin, and malaise. The symptoms were relieved without special treatment in all of the patients.CONCLUSION: Both 7- and 10-d quadruple furazolidone-based therapies achieve satisfactory H. pylori eradication rates. | Yong Xie Yin Zhu Hong Zhou Zhi-Fa Lu Zhen Yang Xu Shu Xiao-Bai Guo Hui-Zhen Fan Jian-Hua Tang Xue-Ping Zeng Jian-Bo Wen Xiao-Qing Li Xing-Xing He Jiu-Hong Ma Dong-Sheng Liu Cai-Bin Huang Ning-Jian Xu Nong-Rong Wang Nong-Hua Lu | 2014 | World Journal of Gastroenterology2014，20，32： | 24 |
| 17 | Total parathyroidectomy combined with partial autotransplantation for the treatment of secondary hyperparathyroidism显示文摘为长期的肾的失败引起的第二等的甲状腺机能过盛的背景药治疗可能在疾病的早阶段是可得到的,但是它不是为严肃的病人同样有效的。学习的目的是评估通过 2006 年 9 月, parathroidectomy 和自体移植从 1999 年 9 月与第二等的 hyperparathyroidism.Methods 在尿毒症的病人与前臂自体移植相结合的全部的 parathyroidectomy 的效果在 20 个病人被执行。在外科手术前的甲状旁腺的 ultrasonography 和外科的探索的结果之间的连贯被比较。intraoperatively,浆液钙集中和未经触动的甲状旁腺的荷尔蒙(iPTH ) 外科手术前地被监视, 71 增生的甲状旁腺的腺全部的 postoperatively.Results A 是在 20 个病人的 resected。在 B-ultrasonography 和 intraoperative 探索之间的甲状旁腺的本地化的一致率是 94.4% 。平均 iPTH 价值是(110.90 捩瑡潩獮漠捣牵敲 ? 湩㈠瀠瑡敩瑮 ????? 湡 ? 桴牥 ? 慷 ? 潮瀠牥潩数慲楴敶搠慥桴 ? 湯汣獵潩 ? 慌慰潲 ' 盏妻鏂邽惮嫆啼蠹缿?畣敲瑴条 ? 湡 ? 獡楰慲楴湯椠 ? 晥楦楣湥 ? 湡 ? 慳敦映牯氠癩牥爠獥 ' 虡 N 湯 .????? | ZOU Qiang WANG Hong-ying ZHOU Jian LAO Zheng-yin XUE Jun LI Ming-xin LI Hai-ming JIN Yi-ting GU Yong ZHANG Yan-ling | 2007 | Chinese Medical Journal2007，，20： | 22 |
| 18 | Diagnostic efficiency and complication rate of CT-guided lung biopsy: a single center experience of the procedures conducted over a 10-year period显示文摘计算断层摄影术( CT )指导了的背景 transthoracic 肺活体检视是一种生长得很好的技术因为这研究客观的肺的 lesions.The 的诊断是在中国 population.Methods 评估诊断效率和 指导CT 的肺活体检视的复杂并发症率 指导CT 的切针肺活体检视在在1月之间的 1014 个病人上在我们的机构被执行 2000 并且2010年10月 .A 胸拍被像关于基本耐心的信息的 biopsy.Data ,最后的 diagn 仅仅 53 个病人没得到期末考试 biopsy.Final 诊断的从肺的诊断在 131 个病人发现 639 恶意的损害( 63.0 )和 322 良性的损害( 31.8 ) .Pneumothoraxoccurred ,脊间的 drain.Small hemoptysis 的 15 要求的插入在 41 个病人发生了,温和 parenchymal 出血处于 16 patients.The 外套复杂并发症率发生了肺的损害的 指导CT 的切针活体检视是的 18.5 .Conclusions 有高诊断的 accuracy.It | YUAN Dong-mei LU Yan-ling YAO Yan-wen LIU Hong-bing WANG Qian XIAO Xin-wu CAO E-hong SHI Yi ZHOU Xiao-jun t SONG Yong | 2011 | Chinese Medical Journal2011，，20： | 22 |
| 19 | Antisense to cyclin D1 reverses the transformed phenotype of human gastric cancer cells显示文摘INTRODUCTIONStudiesonthefunctionsofcelularprotooncogenesandtumorsuppresorgenesindicatethatmostofthesegenesmediatesignaltrans... | CHEN Bing 1, ZHANG Xue Yong 2, ZHANG Yu Jing 3, ZHOU Ping 3, GU Yan 4 and FAN Dai Ming 2 | 1999 | World Journal of Gastroenterology1999，5，1： | 23 |
| 20 | Long non-coding RNAs in cancer显示文摘Long non-coding RNAs (lncRNAs) are a group of RNA transcripts that exceed 200 nt in length, yet lack significant open reading frames (ORFs) [1–4]. In contrast | GONG ZhaoJian ZHANG ShanShan ZHANG WenLing HUANG HongBin LI Qiao DENG Hao MA Jian ZHOU Ming XIANG Juan Juan WU MingHua LI XiaYu XIONG Wei LI XiaoLing LI Yong ZENG ZhaoYang LI GuiYuan | 2012 | Science China(Life Sciences)2012，55，12： | 22 |
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