|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 2 | 柑桔黄龙病的鉴定和柯赫氏定理(英文)显示文摘黄龙(梢)病被认为是世界柑橘生产上的毁灭性病害已超过一个世纪,但该病害的病原学至今还没有清晰地建立起来。根据16S rRNA基因序列分析,一组被称为'Candidatus Liberibacter species'的难培养细菌被认为与黄龙病相关。然而,要确定'Ca.Liberibacter spp.'是黄龙病病原的柯赫氏定理并没有真正完成。令我们担忧的是,近年来有些文献频频指出'Ca.Liberibacter spp.'是黄龙病的病原,其实该细菌与柑橘寄主的直接病理反应还没有完全确定。我们建议,在黄龙病病原学清楚之前,文献报道在这方面需要有准确的阐述。 | Chen J Deng X Civerolo E L Lee R F Jones J B Zhou C Hartung J S Manjunath K L Brlansky R H | 2011 | 植物病理学报2011，41，2： | 10 |
| 3 | The heterodimeric structure of heterogeneous nuclear ribonucleoprotein C1/C2 dictates 1,25-dihydroxyvitamin D-directed transcriptional events in osteoblasts显示文摘Heterogeneous nuclear ribonucleoprotein(hnRNP) C plays a key role in RNA processing but also exerts a dominant negative effect on responses to 1,25-dihydroxyvitamin D(1,25(OH)2D) by functioning as a vitamin D response element-binding protein(VDRE-BP). hnRNPC acts a tetramer of hnRNPC1(huC1) and hnRNPC2(huC2), and organization of these subunits is critical to in vivo nucleic acid-binding. Overexpression of either huC1 or huC2 in human osteoblasts is sufficient to confer VDRE-BP suppression of 1,25(OH)2D-mediated transcription. However, huC1 or huC2 alone did not suppress 1,25(OH)2D-induced transcription in mouse osteoblastic cells. By contrast, overexpression of huC1 and huC2 in combination or transfection with a bone-specific polycistronic vector using a ‘‘self-cleaving'' 2A peptide to co-express huC1/C2 suppressed1,25D-mediated induction of osteoblast target gene expression. Structural diversity of hnRNPC between human/NWPs and mouse/rat/rabbit/dog was investigated by analysis of sequence variations within the hnRNP CLZ domain. The predicted loss of distal helical function in hnRNPC from lower species provides an explanation for the altered interaction between huC1/C2 and their mouse counterparts. These data provide new evidence of a role for hnRNPC1/C2 in 1,25(OH)2D-driven gene expression, and further suggest that species-specific tetramerization is a crucial determinant of its actions as a regulator of VDR-directed transactivation. | Thomas S Lisse Kanagasabai Vadivel S Paul Bajaj Rui Zhou Rene F Chun Martin Hewison John S Adams | 2014 | Bone Research2014，2，2： | 2 |
| 4 | Effects of U50,488H on transient outward and ultra-rapid delayed rectifier K+ currents in young human atrial myocytes显示文摘 | Xiao G S Zhou J J Cheung Y F | 2003 | Eur J Pharmacol2003，473，： | 2 |
| 5 | Trusted P2P transactions with fuzzy reputation aggregation 显示文摘 | SONG S S HWANG K ZHOU R F | 2005 | IEEE Internet Computing2005，9，6： | 1 |
| 6 | Study on an antiwear and extreme pressure additive of surface coated LaF3 nanoparticles in liquid paraffin显示文摘 | Zhou J F Wu Z S Zhang Z J | 2001 | Wear2001，249，： | 1 |
| 7 | Correlation betw een myopia and major biometric parameters of the eye:a retrospective clinical study显示文摘 | Xie R Zhou XT Lu F Chen M Xue A Chen S | 2009 | Optom Vis Sci2009，86，5： | 1 |
| 8 | Discrete Gabor transforms with complexity O(NlogN) 显示文摘 | QIU S ZHOU F CRANDALL PE | 1999 | Signal Process1999，77，2： | 1 |
| 9 | Study on an antiwear and extreme pressure additive of surface coated LaF3 nanoparticles in liquid paraffin显示文摘 | Zhou J F Wu Z S Zhang Z J | 2001 | Wear2001，249，： | 1 |
| 10 | Research on environmental-friendly anodizing process for magnesium alloys显示文摘 | LUO S L DAI L ZHOU H H CHAI L Y KUANG Y F | 2005 | Journal of Hunan University (Natural Sciences)2005，32，3： | 1 |
| 11 | PCI proteins eIF-3e and eIF-3m define distinct translation initiation factor 3 complexes 显示文摘 | Zhou C Arslan F Wee S | 2005 | BMC Biol2005，3，： | 1 |
| 12 | Therapeutic interventions for enhancing collateral development by administration of growth factors:basic principles, early results and potential hazards 显示文摘 | EPSTEIN S E FUCHS S ZHOU Y F | 2001 | Cardiovasc Res2001，49，： | 1 |
| 13 | Proteomic analysis of hypertrophied myocardial protein patterns in renovascularly hypertensive and spontaneously hypertensive rats 显示文摘 | Zhou S G Zhou S F Huang H Q | 2006 | J Proteome Res2006，5，11： | 1 |
| 14 | A new laboratory evalua-tion method for the adhesive performance of cracksealants显示文摘 | Hu X D Zhou F J Hu S | 2011 | Journal of Testing and Evaluation2011，39，2： | 1 |
| 15 | Oxidation behavior and breakdown of an aluminide coating on DZ40M alloy at high temperatures显示文摘 | Liu P S Liang K M Zhou H Y Guan H R Sun X F Jin T Yang K N | 2001 | Oxidation of Metals2001，55，56： | 1 |
| 16 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 17 | Computational prediction and identification of dengue vires-specific CD4^+ T-cell epitopes 显示文摘 | Wen J S Jiang L F Zhou J M | 2008 | Virus Research2008，132，： | 1 |
| 18 | Structural and Magnetic Properties of Mn-Implanted Si显示文摘 | Zhou S Q Potzger K Zhang G F | 2007 | Phys Rev B2007，75，85： | 1 |
| 19 | Effect of monogalactosyldiacylglycerol on the interaction between photosystem Ⅱ core complex and its antenna complexes in liposomes of thylakoid lipids 显示文摘 | Zhou F Liu S Hu Z H | 2009 | Photosynthesis Research2009，99，： | 1 |
| 20 | Slinding wear behavior of TiN and CrN coated 2024 aluminum alloy against an A1203 ball显示文摘 | ZHOU F SUH C M KIM S S | 2002 | Tribology Letters2002，13，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员