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| 1 | Endothelium-specific SIRT1 overexpression inhibits hyperglycemia-induced upregulation of vascular cell senescence显示文摘The rapidly increasing prevalence of diabetes mellitus worldwide is one of the most serious and challenging health problems in the 21st century.Mammalian sirtuin 1(SIRT1) has been shown to decrease high-glucose-induced endothelial cell senescence in vitro and prevent hyperglycemia-induced vascular dysfunction.However,a role for SIRT1 in prevention of hyperglycemia-induced vascular cell senescence in vivo remains unclear.We used endothelium-specific SIRT1 transgenic(SIRT1-Tg) mice and wild-type(WT) mice to construct a 40-week streptozotocin(STZ)-induced diabetic mouse model.In this mode,42.9% of wild-type(WT) mice and 38.5% of SIRT1-Tg mice were successfully established as diabetic.Forty weeks of hyperglycemia induced significant vascular cell senescence in aortas of mice,as indicated by upregulation of expression of senescence-associated markers including p53,p21 and plasminogen activator inhibitor-1(PAI-1).However,SIRT1-Tg diabetic mice displayed dramatically decreased expression of p53,p21 and PAI-1 compared with diabetic WT mice.Moreover,manganese superoxide dismutase expression(MnSOD) was significantly downregulated in the aortas of diabetic WT mice,but was preserved in diabetic SIRT1-Tg mice.Furthermore,expression of the oxidative stress adaptor p66Shc was significantly decreased in aortas of SIRT1-Tg diabetic mice compared with WT diabetic mice.Overall,these findings suggest that SIRT1-mediated inhibition of hyperglycemia-induced vascular cell senescence is mediated at least partly through the reduction of oxidative stress. | CHEN HouZao WAN YanZhen ZHOU Shuang LU YunBiao ZHANG ZhuQin ZHANG Ran CHEN Feng HAO DeLong ZHAO Xiang GUO ZhiChen LIU DePei LIANG ChihChuan | 2012 | Science China(Life Sciences)2012，55，6： | 14 |
| 2 | Preparation and anisotropic properties of textured structural ceramics: A review显示文摘Ceramics are usually composed of randomly oriented grains and intergranular phases, so their properties are the statistical average along each direction and show isotropy corresponding to the uniform microstructures. Some methods have been developed to achieve directional grain arrangement and preferred orientation growth during ceramic preparation, and then textured ceramics with anisotropic properties are obtained. Texture microstructures give particular properties to ceramics along specific directions, which can effectively expand their application fields. In this review, typical texturing techniques suitable for ceramic materials, such as hot working, magnetic alignment, and templated grain growth(TGG), are discussed. Several typical textured structural ceramics including α-Al2O3 and related nacre bioinspired ceramics, Si3N4 and SiAlON, h-BN, MB2 matrix ultra-high temperature ceramics, MAX phases and their anisotropic properties are presented. | Zhuo ZHANG Xiaoming DUAN Baofu QIU Zhihua YANG Delong CAI Peigang HE Dechang JIA Yu ZHOU | 2019 | Journal of Advanced Ceramics2019，8，3： | 14 |
| 3 | Target gene therapy of glioma: overexpression of BAX gene under the control of both tissue-specific promoter and hypoxia-inducible element显示文摘杀死肿瘤的基因的 Glioma 特定的抄写作为有希望的基因被利用了在 glioma 病人的治疗学的形式。Musashi1 (Msi1 ) 和 GFAP 基因倡导者两个都是癌症特定的倡导者。优化 HIF 有约束力的地点(optHBS ) 顺序最新象在癌症基因治疗用作 enhancer 的 EPO HRE 一样被发现有效。我们构造了 4optHBS-Msi1/GFAP 倡导者并且测试了他们的能力调停在 glioma 房间导致 apoptosis 的 BAX 表示排队。我们的结果证明 4optHBS-Msi1/GFAP 倡导者是有在指向的 glioma 基因治疗的潜在的申请的显然强壮、 glioma 选择的倡导者,并且 4optHBS-Msi1/GFAP-BAX 是为 glioma 基因治疗的珍贵工具。 | Jiwei Huang Jun Gao Xiang Lv Guilin Li Delong Hao Xiaoying Yao Liquan Zhou Depei Liu Renzhi Wang | 2010 | Acta Biochimica et Biophysica Sinica2010，42，4： | 11 |
| 4 | Laser-Assisted Reduction of Highly Conductive Circuits Based on Copper Nitrate for Flexible Printed Sensors显示文摘Stretchable electronic sensing devices are defining the path toward wearable electronics. High-performance flexible strain sensors attached on clothing or human skin are required for potential applications in the entertainment,health monitoring, and medical care sectors. In this work,conducting copper electrodes were fabricated onpolydimethylsiloxane as sensitive stretchable microsensors by integrating laser direct writing and transfer printing approaches. The copper electrode was reduced from copper salt using laser writing rather than the general approach of printing with pre-synthesized copper or copper oxide nanoparticles. An electrical resistivity of 96 l X cm was achieved on 40-lm-thick Cu electrodes on flexible substrates. The motion sensing functionality successfully demonstrated a high sensitivity and mechanical robustness.This in situ fabrication method leads to a path toward electronic devices on flexible substrates. | Shi Bai Shigang Zhang Weiping Zhou Delong Ma Ying Ma Pooran Joshi Anming Hu | 2017 | Nano-Micro Letters2017，9，4： | 10 |
| 5 | Asymmetric Transfer and Pressure Hydrogenation with Earth-Abundant Transition Metal Catalysts显示文摘 | Zhenfeng Zhang Nicholas Andrew Butt Muxing Zhou Delong Liu Wanbin Zhang | 2018 | Chinese Journal of Chemistry2018，36，5： | 8 |
| 6 | Simultaneous incorporation of PTH(1-34) and nano-hydroxyapatite into Chitosan/Alginate Hydrogels for efficient bone regeneration显示文摘Tissue regeneration based on the utilization of artificial soft materials is considered a promising treatment for bone-related diseases.Here,we report cranial bone regeneration promoted by hydrogels that contain parathyroid hormone(PTH)peptide PTH(1-34)and nano-hydroxyapatite(nHAP).A combination of the positively charged natural polymer chitosan(CS)and negatively charged sodium alginate led to the formation of hydrogels with porous structures,as shown by scanning electron microscopy.Rheological characterizations revealed that the mechanical properties of the hydrogels were almost maintained upon the addition of nHAP and PTH(1-34).In vitro experiments showed that the hydrogel containing nHAP and PTH(1-34)exhibited strong biocompatibility and facilitated osteogenic differentiation of rat bone marrow mesenchymal stem cells(rBMSCs)via the Notch signaling pathway,as shown by the upregulated expression of osteogenic-related proteins.We found that increasing the content of PTH(1-34)in the hydrogels resulted in enhanced osteogenic differentiation of BMSCs.Implantation of the complex hydrogel into a rat cranial defect model led to efficient bone regeneration compared to the rats treated with the hydrogel alone or with nHAP,indicating the simultaneous therapeutic effect of nHAP and PTH during the treatment process.Both the in vitro and in vivo results demonstrated that simultaneously incorporating nHAP and PTH into hydrogels shows promise for bone regeneration,suggesting a new strategy for tissue engineering and regeneration in the future. | Zhiyuan Zou Le Wang Zhifei Zhou Qing Sun Delong Liu Yan Chen Hao Hu Yu Cai Sixiong Lin Zhengran Yu Bizhi Tan Wei Guo Zemin Ling Xuenong Zou | 2021 | Bioactive Materials2021，6，6： | 7 |
| 7 | Microstructural evolution of h-BN matrix composite ceramics with La-Al-Si-O glass phase during hot-pressed sintering显示文摘BN/La-Al-Si-O composite ceramics were fabricated by hot-pressed sintering using hexagonal boron nitride(h-BN),lanthanum oxide(La_(2)O_(3)),aluminia(Al_(2)O_(3)),and amorphous silica(SiO_(2))as the raw materials.The effects of sintering temperature on microstructural evolution,bulk density,apparent porosity,and mechanical properties of the h-BN composite ceramics were investigated.The results indicated that La-Al-Si-O liquid phase was formed during sintering process,which provided an environment for the growth of h-BN grains.With increasing sintering temperature,the cristobalite phase precipitation and h-BN grain growth occurred at the same time,which had a significant influence on the densification and mechanical properties of h-BN composite ceramics.The best mechanical properties of BN/La-Al-Si-O composite ceramics were obtained under the sintering temperature of 1700℃.The elastic modulus,flexural strength,and fracture toughness were 80.5 GPa,266.4 MPa,and 3.25 MPa·m^(1/2),respectively. | Baofu QIU Xiaoming DUAN Zhuo ZHANG Chen ZHAO Bo NIU Peigang HE Delong CAI Lei CHEN Zhihua YANG Yujin WANG Dechang JIA Yu ZHOU | 2021 | Journal of Advanced Ceramics2021，10，3： | 2 |
| 8 | Electrospinning of Nanofibers and Their Applications for Energy Devices显示文摘 | Xiaomin Shi Weiping Zhou Delong Ma Qian Ma Denzel Bridges Ying Ma Anming Hu Bala Vaidhyanathan | 2015 | Journal of Nanomaterials2015，，： | 1 |
| 9 | Consensus of leader-followers system of multi-missile with time-delays and switching topologies显示文摘 | Xuejiao Sun Rui Zhou Delong Hou Jiang Wu | 2014 | Optik - International Journal for Light and Electron Optics2014，，3： | 1 |
| 10 | A light-activatable antibiotic with high activation efficiency and uncompromised bactericidal potency in the activated state显示文摘Achieving activatable antibiotics represents one promising solution to tackle the occurrence of side effects,one major issue now plaguing antibiotic usage in collagen-based biomaterials.Despite considerable effort,however,rationale design of activatable antibiotics that display high activation efficiency and uncompromised bactericidal potency in the activated state remains difficult.Here,we demonstrate a design principle that helps to address this challenge.This strategy differs from previous attempts by underscoring photolytic removal of a functionality directly conjugated to the pharmacophore of an antibiotic,enabling not only an activation efficiency significantly improved beyond previous light-activatable antibiotics,but also bactericidal activity in the activated state as potent as the parent drug. | Delong Hou Rui Wang Zhonghui Wang Gaofu Yang Zhou Xu Qi Zeng Yi Chen | 2021 | Journal of Leather Science and Engineering2021，3，1： | 1 |
| 11 | Lotus seed epicarp extract as potential antioxidant and anti-obesity additive in Chinese Cantonese Sausage显示文摘 | QI Suijian ZHOU Delong | 2013 | Meat Science2013，93，2： | 1 |
| 12 | Microphysical characteristics of precipitating cumulus cloud based on airborne Ka-band cloud radar and droplet measurements显示文摘在积云中,大多数云粒子的直径在7到10微米之间,而在层云中,大多数云粒子的直径不超过2微米.云滴有效半径与云中行星边界层(PBL)及PBL上层的气溶胶数浓度(Na)呈负相关.在1500米以上的高液态水含量区域,云滴浓度(Nc)变化不大,Na含量降低.高雷达反射率对应于大的FCDP云粒子浓度和小的气溶胶粒子浓度.积云中的强上升气流增加了云滴的峰值半径和数浓度,拓宽了云滴谱;较低的空气温度有利于粒子的凝结增长,并产生较大的液滴. | Lei Wei Mengyu Huang Rong Zhang Yuhuan Lü Tuanjie Hou Hengchi Lei Delong Zhao Wei Zhou Yuan Fu | 2022 | Atmospheric and Oceanic Science Letters2022，15，2： | 1 |
| 13 | Lotus seed epicarp extract as potential antioxidant and anti-obesity additive in Chinese Cantonese Sau- sage显示文摘 | Qi Suiiian Zhou Delong | 2012 | Meat Science2012，93，2： | 1 |
| 14 | Face recognition based on singular-value feature vectors显示文摘 | PAN Quan ZHANG Mingui ZHOU Delong | 2003 | Optical Engineering2003，42，8： | 1 |
| 15 | The CAS-PEAL large-scale Chinese face database and baseline evaluations显示文摘 | Gao Wen Chen Xilin Zhou Delong | 2008 | IEEE Transactions on Systems Man and Cybernetics-part A2008，38，1： | 1 |
| 16 | The Microphysical Characteristics of Wintertime Cold Clouds in North China显示文摘The microphysical characteristics of wintertime cold clouds in North China were investigated from 22 aircraft observation flights from 2014 to 2017,2020,and 2021.The clouds were generated by mesoscale weather systems with little orographic component.Over the mixed-phase temperature range(–40℃to 0℃),the average fraction of liquid,mixedphase,and ice cloud was 4.9%,23.3%,and 71.8%,respectively,and the probability distribution of ice mass fraction was a half-U-shape,suggesting that ice cloud was the primary cloud type.The wintertime mixed-phase clouds in North China were characterized by large cloud droplet number concentration,small liquid water content(LWC),and small effective diameter of cloud droplets.The main reason for larger cloud droplet number concentration and smaller effective diameter of cloud droplets was the heavy pollution in winter in North China,while for smaller LWC was the lower temperature during flights and the difference in air mass type.With the temperature increasing,cloud droplet number concentration,LWC,and the size of ice particles increased,but ice number concentration and effective diameter of cloud droplets decreased,similar to other mid-latitude regions,indicating the similarity in the temperature dependence of cloud properties of mixed-phase clouds.The variation of the cloud properties and ice habit at different temperatures indicated the operation of the aggregation and riming processes,which were commonly present in the wintertime mixed-phase clouds.This study fills a gap in the aircraft observation of wintertime cold clouds in North China. | Xuexu WU Minghuai WANG Delong ZHAO Daniel ROSENFELD Yannian ZHU Yuanmou DU Wei ZHOU Ping TIAN Jiujiang SHENG Fei WANG Deping DING | 2022 | Advances in Atmospheric Sciences2022，39，12： | 1 |
| 17 | Face Recognition Based on Singular Value Feature Vectors显示文摘 | Pan Quan Zhang Mingui Zhou Delong | 2003 | Optical Engineering2003，42，8： | 1 |
| 18 | Lotus seed epicarp extract as potential antioxidant and anti-obesity additive in Chinase Cantonese Sausage显示文摘 | Suijian QI Delong Zhou | | 0，，： | 1 |
| 19 | Lotus seed epicarp extract as potential antioxidant and anti-obesity additive in Chinase Cantonese Sausage显示文摘 | SUIJIAN QI DELONG ZHOU | 2013 | Meat Science2013，，93： | 1 |
| 20 | Output-feedback based partial integrated missile guidance and control law design显示文摘An output-feedback based partial integrated guidance and control(IGC) law for missile interceptor is proposed with the smooth finite time convergence property. Firstly, a novel outputfeedback based smooth sliding mode control is proposed for a class of nonlinear systems in the presence of immeasurable state and disturbance. The finite time convergence property of this control scheme is proved based on the Lyapunov stability and homogeneous principle. Then, the proposed control method is applied to the design of partial IGC law. A kind of scaling methods is also developed to reach the rapid convergence of the system. An important dominance of this control scheme is the smooth characteristic,which may result in chattering free convergence. The simulation results indicate the high precision and smooth elevator deflection of the proposed output feedback base partial IGC law. | Xuejiao Sun Rui Zhou Delong Hou | 2016 | Journal of Systems Engineering and Electronics2016，27，6： | 0 |
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