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| 1 | Paeoniflorin attenuates neuroinflammation and dopaminergic neurodegeneration in the MPTP model of Parkinson's disease by activation of adenosine A1 receptor显示文摘 | Liu HQ Zhang WY Luo XT Ye Y Zhu XZ | 2006 | 中国生物学文摘2006，20，10： | 34 |
| 2 | Mechanism of frost heave by film water migration under temperature gradient显示文摘IT is well known that there exists unfrozen film water in frozen soils due to the action of sur-face energy among soil particles and frost heave occurs by water migration under the tempera-ture gradient. The problem is how to determine the amount of frost heave quantitatively. The amount of frost heave induced by ice segregation can be calculated by the following e-quations: | Xu, XZ Wang, JC Zhang, LX Deng, YS Chuvilin, EM Yershov, ED Ishizaki, T Fukuda, M | 1997 | Chinese Science Bulletin1997，42，15： | 6 |
| 3 | Subvellerolactone C, a New Lactarane Sesquiterpene from Lactarius Subvellereus显示文摘SubvellerolactoneC,aNewLactaraneSesquiterpenefromLactariusSubvellereus￥JingZHANGandXiaoZhaoFENG(InstituteofMateriaMedica,Chin... | Zhang, J Feng, XZ | 1996 | Chinese Chemical Letters1996，7，12： | 2 |
| 4 | Design,synthesis,and anti-inflammatory evaluation of a series of novel amino acid-binding 1,5-diarylpyrazole derivatives显示文摘Aim: To design and synthesize a series of novel amino acid-binding 1,5-diarylpyrazole derivatives, which are intended to act as prodrugs with better aqueous solubility than celecoxib, and which will exert potent anti-inflammatory activi-ties after being converted to their parent compounds in vivo. Methods: To introduce an amino acid, celecoxib analogs containing amino or methylamino group were synthesized first through multi-step chemical reactions. All the synthesized compounds were screened in an intact cell-based assay in vitro and in carrageenan-induced mouse paw edema in vivo. Some active compounds were selected for further evaluation in a carrageenan-induced rat paw edema model. The preliminary pharmacokinetics experiments were conducted using high performance liquid chromatography/mass spectrometry (HPLC/MS). Results: Celecoxib, 6 of the 1,5-diarylpyrazole class of celecoxib analogs, and their amino acid derivatives (hydrochloride salts) were synthesized. In vitro screening, the hydrochloride salts showed decreased inhibitory effects on cyclooxygenase (COX)- 1 and COX-2 compared with their parent compounds, but some exhibited potent anti-inflammatory activity in vivo. Compound 4a was selected for further evaluation, and its anti-inflammatory effect was equivalent to that of celecoxib after oral administration in the carrageenan-induced rat paw edema model. At three doses (25 mg/kg, 50 mg/kg, and 100 mg/kg) the percentage inhibition on edema was 20.7%, 52.6%, and 62.6% (for compound 4a) and 27.8%, 38.4%, and 40.1% (for celecoxib), respectively. Preliminary pharmacokinetic evaluations support the hypothesis that compound 4a was actually converted to its parent compound, compound 4. Conclusion: The compound bound with amino acid acts like prodrug, which can exert anti-inflammatory effect similar to celecoxib after being converted to its parent compound. This finding will be of great benefit in carrying out structural modifications of prodrug-like selective COX-2 inhibitors. | Li MH Yin LL Cai MJ Zhang WY Huang Y Wang X Zhu XZ Shen JK | 2005 | Acta Pharmacologica Sinica2005，26，7： | 2 |
| 5 | Vulnerability to unidirectional conduction block and reentry in rabbit left ventricular wedge preparation: effect of stimulation sequence and location 显示文摘 | Chen XZ Zhang H Jin YB | 2009 | Chinese J Physiol2009，52，： | 1 |
| 6 | Prevention of filtering surgery failure by subconjunctival injection of a novel peptide hydrogel into rabbit eyes显示文摘 | Liang L Xu XD Zhang XZ | 2010 | Biomed Mater2010，5，4： | 1 |
| 7 | Funetionalized amphiphilic byperbranched polymers for targeted drug delivery显示文摘 | Chen S Zhang XZ Cheng SX | 2008 | Biomacromolecules2008，9，： | 1 |
| 8 | Apoplosis of breast cancer cell MCF-7 induced by norcantharidin(NCTD)显示文摘 | Sang JL Li XZ Zhang HJ | 2002 | Cell Res2002，12，3： | 1 |
| 9 | Transplantation of adipose-derived stem cel s overexpressing hHGF into cardiac tissue显示文摘 | Zhu XY Zhang XZ Xu L | | 0，，04： | 1 |
| 10 | High prcvance of thalassemia in mi- grant population in Guangdong province,China显示文摘 | Li B Zhang XZ Yin AH | 2014 | BMC Public Health2014，14，： | 1 |
| 11 | MRI of gallstones with different compositions显示文摘 | Tsai HM Zhang X Lin XZ | 2004 | AJR2004，182，： | 1 |
| 12 | Guided migration of neu- ral stem cells derived from human embryonic stem cells by an electric field显示文摘 | Feng JF Liu J Zhang XZ | 2012 | Stem Cells2012，30，2： | 1 |
| 13 | Is CD133 a biomarker for cancer stem ceils of colorectal cancer and brain tumors A meta-analysis 显示文摘 | Yang K Chen XZ Zhang B | 2011 | Int Biol Markers2011，26，3： | 1 |
| 14 | Y-Shaped P (UA-Y-NIPAAm) Copolymer for Drug Delivery 显示文摘 | Li YY Zhang XZ Cheng H | 2006 | Biomacromolecules2006，7，： | 1 |
| 15 | S100A4 mediated cell inva- sion and metastasis of esophageal squamous cell eareinoma via the reg- ulation of MMP-2 and E-cadherin activity 显示文摘 | Zhang HY Zheng XZ Wang XH | 2012 | Mo Bio Rep2012，39，1： | 1 |
| 16 | Application to evaluation of early stage efficacy by ECG scoring method after thrombolysis in patients with acute myocardial infraction显示文摘 | Peng ZJ Pan H | 2001 | Internat J Cardiov Med2001，3，： | 1 |
| 17 | Clinical features of punctate inner choroidopathy in Chinese patients 显示文摘 | Zhang XZ Wen F Zuo C Li M Chen H Huang S | 2011 | Retina2011，31，8： | 1 |
| 18 | Prevalence, awareness, treatment & control of hypertension in rural Liaoning province, China显示文摘 | Dong GH Sun ZQ Zhang XZ | 2008 | Indian J Med Res2008，128，： | 1 |
| 19 | Efficacy of acupuncture for acute migraine attack: a multicenter single blinded, randomized controlled trial显示文摘 | Wang LP Zhang XZ Guo J | 2012 | Pain Med2012，13，5： | 1 |
| 20 | Neuroprotective effects of extract of Acanthopanax senticosus harms on SH-SY5Y cells overexpressing wild-type or A53T mutantα-synuclein显示文摘 | Li XZ Zhang SN Wang KX | 2014 | Phytomedicine2014，21，5： | 1 |
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