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| 1 | Management of cytokine release syndrome related to CAR-T cell therapy显示文摘Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release syndrome (CRS) is one of the most clinically important and potentially life-threatening toxicities. This syndrome is a systemic immune storm that involves the mass cytokines releasing by activated immune cells. This phenomenon causes multisystem damages and sometimes even death. In this study, we reported the management of a patient with recurrent and refractory multiple myeloma and three patients with acute lymphocytic leukemia who suffered CRS during CAR-T treatment. The early application of tocilizumab, an anti-IL-6 receptor antibody, according to toxicity grading and clinical manifestation is recommended especially for patients who suffer continuous hyperpyrexia, hypotensive shock, acute respiratory failure, and whose CRS toxicities deteriorated rapidly. Moreover, low doses of dexamethasone (5-10 mg/day) were used for refractory CRS not responding to tocilizumab. The effective management of the toxicities associated with CRS will bring additional survival opportunities and improve the quality of life for patients with cancer. | Hongli Chen Fangxia Wang Pengyu Zhang Yilin Zhang Yinxia Chen Xiaohu Fan Xingmei Cao Jie Liu Yun Yang Baiyan Wang Bo Lei Liufang Gu Ju Bai Lili Wei Ruili Zhang Qiuchuan Zhuang Wanggang Zhang Wanhong Zhao Aili He | 2019 | Frontiers of Medicine2019，13，5： | 21 |
| 2 | Fractal classification and natural classification of coal pore structure based on migration of coal bed methane显示文摘According to the data of 146 coal samples measured by mercury penetration, coal pores are classified into two levels of <65 nm diffusion pore and >65 nm seeping pore by fractal method based on the characteristics of diffusion, seepage of coal bed methane(CBM) and on the research results of specific pore volume and pore structure. The diffusion pores are further divided into three categories: <8 nm micropore, 8-20 nm transitional pore, and 20-65 nm mini-pore based on the relationship between increment of specific surface area and diameter of pores, while seepage pores are further divided into three categories: 65-325 nm mesopore, 325-1000 nm transitional pore, and >1000 nm macropore based on the abrupt change in the increment of specific pore volume. | Xuehai Fu Yong Qin Wanhong Zhang Chongtao Wei Rongfu Zhou | 2005 | Chinese Science Bulletin2005，50，S1： | 16 |
| 3 | Mechanical properties and enhancement mechanisms of titanium-graphene nanocomposites显示文摘Molecular dynamics(MD)simulations of the titanium-graphene nanocomposites(TiGNCs)under uniaxial tension are carried out to investigate the mechanical properties and reinforcement mechanism of graphene in composites.It is found that introduction of mechanically robust graphene limits the strain-induced dislocation and araorphization and thereby highly improves the mechanical properties of metallic titanium that are greatly affected by the crystal stacking orientation of graphene and titanium layers.The thickness of titanium layers,interface interaction and working temperature play an important role in the mechanical strength and elastic moduli of composites.The results show the mechanical properties of TiGNCs are monotonically enhanced with reduction of the titanium layer thickness and working temperature,and the Young5s modulus obtained by MD simulation are higher than that predicted by the rule of mixture(ROM)due to consideration of interfacial interaction in computational calculation.In addition,once the critical thickness of titanium layer is reached,graphene wrinkles are induced in composites because of Poisson's effect induced large lateral compression stress in the interface region.This study provides helpful insights into fundamental understanding reinforcing mechanism of graphene and ultimately contribute to the optimal design and performance of mechanically robust graphene-based metallic composites. | Wanhong Tang Jie Zhang Jianyang Wu Jinyou Shao Peng Ding Guozhen Hou Xiaoming Chen | 2020 | Acta Mechanica Sinica2020，36，4： | 7 |
| 4 | Preparation and evaluation of a new releasable PEGylated tumor necrosis factor-α(TNF-α) conjugate for therapeutic application显示文摘To design a releasable PEGylated TNF-α(rPEG-TNF-α ), a cathepsin B-sensitive dipeptide (Val-Cit moiety) was inserted into conventional PEG-modified TNF- (PEG-TNF- ), facilitating its clinical use for anti-tumor therapy. Comparative pharmaco- kinetic and pharmacodynamic studies showed that the half-lives of both PEGylated forms of TNF-α were ~60-fold greater than that of unmodified TNF-α . In addition, the in vitro bioactivity of rPEG-TNF-α was greater than that of PEG-TNF-α with the same degree of PEG modification. Release of TNF-α from rPEG-TNF-α in vitro was dependent on the presence of cathepsin B and was inhibited by a cathepsin B inhibitor. Despite the potent cytotoxicity of unmodified TNF-α against normal cells, its PEGylated forms at higher TNF-α concentrations showed low cytotoxic activity against these cells. In contrast, both forms of PEGylated TNF-α showed potent cytotoxic activity against the B16 and L929 cell lines, with rPEG-TNF-α being 5- and 9- fold more potent, respectively, than PEG-TNF-α . Moreover, rPEG-TNF-α was a more potent in vivo antitumor agent than PEG-TNF-α . | DAI ChuanYun FU Ya CHEN ShaoCheng LI Biao YAO Bo LIU WanHong ZHU LiQing CHEN Nan CHEN Ji ZHANG Qiang | 2013 | Science China(Life Sciences)2013，56，1： | 4 |
| 5 | The long non-coding RNA expression profile of Coxsackievirus A16 infected RD cells identified by RNA-seq显示文摘Coxsackievirus A16(CVA16) is one of major pathogens of hand, foot and mouth disease(HFMD) in children. Long non-coding RNAs(Inc RNAs) have been implicated in various biological processes,but they have not been associated with CVA16 infection. In this study, we comprehensively characterized the landscape of Inc RNAs of normal and CVA16 infected rhabdomyosarcoma(RD)cells using RNA-Seq to investigate the functional relevance of Inc RNAs. We showed that a total of 760 Inc RNAs were upregulated and 1210 Inc RNAs were downregulated. Out of these dysregulated Inc RNAs, 43.64% were intergenic, 22.31% were sense, 15.89% were intronic, 8.67% were bidirectional, 5.59% were antisense, 3.85% were s RNA host Inc RNAs and 0.05% were enhancer. Six dysregulated Inc RNAs were validated by quantitative PCR assays and the secondary structures of these Inc RNAs were projected. Moreover, we conducted a bioinformatics analysis of an Inc RNAs(ENST00000602478) to elucidate the diversity of modification and functions of Inc RNAs. In summary, the current study compared the dysregulated Inc RNAs profile upon CVA16 challenge and illustrated the intricate relationship between coding and Inc RNAs transcripts. These results may not only provide a complete picture of transcription in CVA16 infected cells but also provide novel molecular targets for treatments of HFMD. | Yingying Shi Huilin Tu Xiong Chen Yingying Zhang Liujun Chen Zhongchun Liu Jiqun Sheng Song Han Jun Yin Biwen Peng Xiaohua He Wanhong Liu | 2016 | Virologica Sinica2016，31，2： | 4 |
| 6 | miR-378 attenuates muscle regeneration by delaying satellite cell activation and differentiation in mice显示文摘骨胳的肌肉质量和动态平衡大部分在出生后的肌肉开发和新生期间取决于成年肌肉干细胞(卫星房间) 。我们最近证明 miR-378 的全球 overexpression 显著地在老鼠减少了骨胳的肌肉质量。在当前的学习,我们使用了 miR-378 转基因(Tg ) 估计的老鼠在里面 vivo 骨胳的肌肉生长和新生上的 miR-378 的功能的效果。骨胳的肌肉纸巾的代表性的分析证明 myofibers 的数字和尺寸比在野类型的老鼠在 miR-378 Tg 老鼠是显著地更低的。在 miR-378 Tg 老鼠的稀释导致 cardiotoxin 的肌肉新生被发现与推迟的卫星房间激活和区别被联系。机械学地, miR-378 被发现直接在 vitro 并且在 vivo 在肌肉房间指向 Igf1r。这些 miR-378 Tg 老鼠可以为在人在联系肌肉的疾病调查骨胳的肌肉的生理、病理学的角色提供一个模型,特别地在 sarcopenia。 | Ping Zeng Wanhong Han Changyin Li Hu Li Dahai Zhu Yong Zhang Xiaohong Liu | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 4 |
| 7 | Large manipulative experiments reveal complex effects of food supplementation on population dynamics of Brandt's voles显示文摘Although food supplementation is well known to increase population density,there is still debate on the causative effects of food supplementation on reproduction,survival,and immigration.Large manipulative experiments,which exclude any confounding effects of dispersal and predation,are essential for clarifying the debate.In this study,we investigated the effects of food supplementation on Brandt's vole population dynamics and plant community in eight large enclosures(0.48 ha each) from2010 to 2014.Food supplementation showed significant positive effects on population density due to increases in recruitment;however,it showed a complex effect on survival of voles:positive in non-breeding seasons,but negative in breeding seasons.In addition,food supplementation increased the quality of plants(as reflected by increased crude protein content),but decreased the quantity of less preferred plants in experimental enclosures.Thus,food seems to have direct positive effects on small rodents through improvement of food supply and indirect negative effects through food-induced density-dependent effects,and may have long-term effects on rodents through altering plant community composition and abundance. | Baofa Yin Guoliang Li Xinrong Wan Guozhen Shang Wanhong Wei Zhibin Zhang | 2017 | Science China(Life Sciences)2017，60，8： | 4 |
| 8 | Outlier deletion based improvement on the StOMP algorithm for sparse solution of large-scale underdetermined problems显示文摘StOMP algorithm is well suited to large-scale underdetermined applications in sparse vector estimations.It can reduce computation complexity and has some attractive asymptotical statistical properties.However,the estimation speed is at the cost of accuracy violation.This paper suggests an improvement on the StOMP algorithm that is more efficient in finding a sparse solution to the large-scale underdetermined problems.Also,compared with StOMP,this modified algorithm can not only more accurately estimate parameters for the distribution of matched filter coefficients,but also improve estimation accuracy for the sparse vector itself.Theoretical success boundary is provided based on a large-system limit for approximate recovery of sparse vector by modified algorithm,which validates that the modified algorithm is more efficient than StOMP.Actual computations with simulated data show that without significant increment in computation time,the proposed algorithm can greatly improve the estimation accuracy. | ZHANG WanHong ZHOU Tong HUANG BoXue | 2014 | Science China(Information Sciences)2014，57，9： | 2 |
| 9 | A novel approach for the oxidative degradation of organic pollutants in aqueous solutions mediated by iron tetrasulfophthalocyanine under visible light radiation显示文摘 | Tao Xia Ma Wanhong Zhang Tianyong | 2002 | Chem Eur J2002，8，6： | 1 |
| 10 | Efficient photooxidative degradation of organic compounds in the presence of iron tetrasulfophthalocyanine under visible light irradiation显示文摘 | Tao Xia Ma Wanhong Zhang Tianyong | 2001 | Angewandte Chemie International Edition2001，40，16： | 1 |
| 11 | Volatile organic compound emissions from straw-amended agricultural soils and their relations to bacterial communities:A laboratory study显示文摘A laboratory study was conducted to investigate volatile organic compound(VOC) emissions from agricultural soil amended with wheat straw and their associations with bacterial communities for a period of 66 days under non-flooded and flooded conditions. The results indicated that ethene, propene, ethanol, i-propanol, 2-butanol, acetaldehyde, acetone,2-butanone, 2-pentanone and acetophenone were the 10 most abundant VOCs, making up over 90% of the total VOCs released under the two water conditions. The mean emission of total VOCs from the amended soils under the non-flooded condition(5924 ng C/(kg·hr)) was significantly higher than that under the flooded condition(2211 ng C/(kg·hr)). One 'peak emission window' appeared at days 0–44 or 4–44, and over 95% of the VOC emissions occurred during the first month under the two water conditions. Bacterial community analysis using denaturing gradient gel electrophoresis(DGGE) showed that a relative increase of Actinobacteria, Bacteroidetes, Firmicutes and γ-Proteobacteria but a relative decrease of Acidobacteria with time were observed after straw amendments under the two water conditions. Cluster analysis revealed that the soil bacterial communities changed greatly with incubation time, which was in line with the variation of the VOC emissions over the experimental period. Most of the above top 10 VOCs correlated positively with the predominant bacterial species of Bacteroidetes, Firmicutes and Verrucomicrobia but correlated negatively with the dominant bacterial species of Actinobacteria under the two water conditions. These results suggested that bacterial communities might play an important role in VOC emissions from straw-amended agricultural soils. | Juan Zhao Zhe Wang Ting Wu Xinming Wang Wanhong Dai Yujie Zhang Ran Wang Yonggan Zhang Chengfei Shi | 2016 | Journal of Environmental Sciences2016，28，7： | 1 |
| 12 | 显示文摘 | Zhang Miao Chen Chuncheng Ma Wanhong | 2008 | Angew Chem Int Ed2008，47，： | 1 |
| 13 | Transgenic Analysis of a Salt -inhibited OsZFP1 Gene from Rice显示文摘 | Kong Jin Cao Wanhong Zhang Jinsong | 2004 | Acta Botanica Sinica2004，46，5： | 1 |
| 14 | Transgenic analysis of a salt-inhibited OsZFP1 gene from rice显示文摘 | Kong Jin Cao Wanhong Zhang Jinsong | 2004 | Acta Bot Sin2004，46，5： | 1 |
| 15 | A novel approach for the oxidative degradation of organic pollutants in aqueous solutions mediated by iron tetrasulfophthalocyanine under visible light radiation 显示文摘 | Tao Xia Ma Wanhong Zhang Tianyong | 2002 | Chemistry-A European Journal2002，8，6： | 1 |
| 16 | A novel approach for the oxidative degradation of organic pollutants in aqueous solutions mediated by iron tetrasulfophthalocyanine under visible light radiation显示文摘 | Tao Xia Ma Wanhong Zhang Tianyong | 2002 | Chem Eur J2002，8，6： | 1 |
| 17 | Formation of disinfec-tion by-products after pre-oxidation with chlorine dioxide or ferrate 显示文摘 | XIN Yang GUO Wanhong ZHANG Xing | 2013 | Water Research2013，47，15： | 1 |
| 18 | Efficient photooxidative degradation of organic compounds in the presence of iron tetrasulfophthalocyanine under visible light irradiation显示文摘 | Tao Xia Ma Wanhong Zhang Tianyong | 2001 | Angewandte Chemie International Edition2001，40，16： | 1 |
| 19 | SYBR Green I-based product-enhanced reverse transcriptase assay for quantification of retroviral PFV and detection of the divalent cation preference of PFV RT显示文摘Dear Editor,Prototype foamy virus(PFV)belongs to the genus Spumavirus in the Spumaretrovirinae subfamily of Retroviridae.Although PFV and HIV have much in common,research into PFV has lagged far behind that into HIV,as PFV appeared to be non-pathogenic both in accidentally infected humans and in experimentally infected animals.In recent decades,however,more attention has been focused on PFV because it seems to | Xiaofang Yi Yan Sun Qingmei Liu Zhi Li Wanhong Liu Xiaohua He Linjuan Zhang Yuxin Wang | 2014 | Virologica Sinica2014，29，5： | 0 |
| 20 | Antibacterial properties of extracts of Solidago canadensis and their potential use as dietary supplements in red swamp crayfish(Procambarus clarkii)显示文摘Canadian goldenrod(Solidago canadensis)is one of the most destructive invasive weeds in Southeastern China.To evaluate its potential application as dietary supplement in red swamp crayfish(Procambarus clarkii),the antibacterial properties of aqueous and ethanol extracts of this plant against three major pathogenic bacteria in crayfish aquaculture were examined.Inhibition zone tests and determination of minimum inhibitory concentration revealed that the extracts had lower antibacterial activity than extracts from two traditional medicinal plants that possess antibacterial properties,garlic(Allium sativum)and cortex phellodendri(Phellodendron chinense).However,they did exhibit greater antibacterial effects than extracts from another widely used medicinal plant,Sophora flavescens,and an aquatic weed,Alternanthera philoxeroides.Aqueous extracts of Canadian goldenrod gave greater inhibition than the ethanol extracts.Crayfish fed a diet with 2%these aqueous extracts exhibited significantly higher enzyme activity of alkaline phosphatase,catalase and phenoloxidase(P<0.05).Based on the results of this study,we conclude that aqueous extracts of Canadian goldenrod are highly promising for the development of new dietary supplement for use in crayfish aquaculture. | Manhong YE Lei ZHANG Jiaqi GE Haifeng SUN Jingjing NI Shengmei YANG Wanhong WEI | 2015 | Frontiers of Agricultural Science and Engineering2015，2，4： | 0 |
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