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| 1 | Distributed Vibration Sensor With Laser Phase-Noise Immunity by Phase-Extraction φ-OTDR显示文摘We have demonstrated a distributed vibration sensor based on phase-sensitive optical time-domain reflectometer (φ-OTDR) system exhibiting immunity to the laser phase noise. Two laser sources with different linewidth and phase noise levels are used in the φ-OTDR system, respectively. Based on the phase noise power spectrum density of both lasers, the laser phase is almost unchanged during an extremely short period of time, hence, the impact of phase noise can be suppressed effectively through phase difference between the Rayleigh scattered light from two adjacent sections of the fiber which define the gauge length. Based on the phase difference method, the external vibration can be located accurately at 41.01 km by the(φ-OTDR system incorporating these two lasers. Meanwhile, the average signal-to-noise ratio (SNR) of the retrieved vibration signal by using Laser I is found to be -37.7 dB, which is comparable to that of -37.5 dB by using Laser II although the linewidth and the phase noise level of the two lasers are distinct. The obtained results indicate that the phase difference method can enhance the performance of(φ-OTDR system with laser phase-noise immunity for distributed vibration sensing, showing potential application in oil-gas pipeline monitoring, perimeter security, and other fields. | Yuying SHAO Huanhuan LIU Peng PENG Fufei PANG Guoqin YU Zhen CHEN Na CHEN Tingyun WANG | 2019 | Photonic Sensors2019，9，3： | 5 |
| 2 | Neutrophil-derived heparin binding protein triggers vascular leakage and synergizes with myeloperoxidase at the early stage of severe burns(With video)显示文摘Background:Burn shock caused by vascular leakage is one of the main causes of high mortality in severe burn injury.However,the pathophysiological mechanism of vascular leakage is still unclear.The purpose of this study was to explore the molecular mechanism of vascular leakage in the early stage of severe burn and provide a new target for the treatment of severe burns.Methods:Neutrophils were isolated from human peripheral blood by magnetic beads sorting.ELISA was used to detect neutrophil-derived granule proteins and glycocalyx injury products in plasma.The vascular leakage and neutrophil movement were assessed by in vivo laser confocal imaging in mice,and high-quality video were provided.Adhesion-related molecules were investigated by qRT-PCR.The damage to glycocalyx of mice vascular endothelial cellswas observed by transmission electron microscope and scanning electron microscope.Proteomic analysis,flow cytometry and immunofluorescence were used to further study the relationship between human peripheral blood neutrophil-derived hypochlorite(HOCl)and CD44 of human vascular endothelial cells.Results:In this study,we found that rapidly increasing activated neutrophils secrete heparin binding protein(HBP)andmyeloperoxidase(MPO)after severe burn injury.Increased HBP triggers vascular leakage with synergy of MPO,results in systemic edema and burn shock.Furthermore,we found that the MPO catalytic product HOCl but not MPO triggers CD44 extracellular domain shedding from vascular endothelial cells to damage the glycocalyx.Damage to the glycocalyx results in firm adhesion of neutrophils and increases vascular leakage.However,MPO inhibitors partially protect the glycocalyx of vascular endothelial cells.The combination of HBP and MPO inhibitors markedly reduces vascular leakage and systemic edema in the early stage of severe burns.Conclusions:Taken together,these data reveal that neutrophil-derived HBP and MPO play an important synergies role in triggering vascular leakage at the early stage of severe burns.Targeted intervention in these two biomolecules may introduce new strategies for helping to reduce large amount of fluid loss and subsequent burn shock. | Lu Liu Yiming Shao Yixuan Zhang Yunxi Yang Jiamin Huang Linbin Li Ran Sun Yuying Zhou Yicheng Su Bingwei Sun | 2021 | Burns & Trauma2021，9，1： | 3 |
| 3 | Dynamic simulation of variable capacity refrigeration systems under abnormal conditions显示文摘 | Nan Liang Shuangquan Shao Changqing Tian Yuying Yan | 2010 | Applied Thermal Engineering2010，，10： | 1 |
| 4 | Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3–Gi signaling complexes显示文摘Dear Editor,Lipids are essential for all life on earth and play critical roles in energy storage and the formation of cellular membranes.Sphingosine-1-phosphate(S1P)is a naturally occurring bioactive lysophospholipid that regulates fundamental physiological processes by activating five G protein-coupled receptors(S1PR1-S1PR5).S1PRs are widely distributed on many cell types,including cells in the cardiovascular,immune,and central nervous systems. | Chang Zhao Lin Cheng Wei Wang Heli Wang Yongbo Luo Yuying Feng Xuehui Wang Hong Fu Ye Cai Shengyong Yang Ping Fu Wei Yan Zhenhua Shao | 2022 | Cell Research2022，32，2： | 1 |
| 5 | Preface显示文摘High-speed rails(HSR)are playing an important role in the transportation systems across the world.In Japan,the Shinkansens carry more than 250million passengers each year.In Europe,the trans-European high-speed rail network is in operation.At the beginning of 2011,U.S.President has called for a six-year,$53 billion budget for HSR. | shao yui | 2017 | Journal of Modern Transportation2017，25，1： | 0 |
| 6 | Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia显示文摘Seizures due to cortical dysplasia are notorious for their poor prognosis even with medications and surgery,likely due to the widespread seizure network.Previous studies have primarily focused on the disruption of dysplastic lesions,rather than remote regions such as the hippocampus.Here,we first quantified the epileptogenicity of the hippocampus in patients with late-stage cortical dysplasia.We further investigated the cellular substrates leading to the epileptic hippocampus,using multiscale tools including calcium imaging,optogenetics,immunohistochemistry and electrophysiology.For the first time,we revealed the role of hippocampal somatostatin-positive interneurons in cortical dysplasia-related seizures.Somatostatin-positive were recruited during cortical dysplasia-related seizures.Interestingly,optogenetic studies suggested that somatostatin-positive interneurons paradoxically facilitated seizure generalization.By contrast,parvalbumin-positive interneurons retained an inhibitory role as in controls.Electrophysiological recordings and immunohistochemical studies revealed glutamate-mediated excitatory transmission from somatostatin-positive interneurons in the dentate gyrus.Taken together,our study reveals a novel role of excitatory somatostatin-positive neurons in the seizure network and brings new insights into the cellular basis of cortical dysplasia. | Yang Zheng Cenglin Xu Jinyi Sun Wenjie Ming Sijie Dai Yuying Shao Xiaoyun Qiu Menghan Li Chunhong Shen Jinghong Xu Fan Fei Jiajia Fang Xuhong Jiang Guoqing Zheng Weiwei Hu Yi Wang Shuang Wang Meiping Ding Zhong Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 7 | Mechanism of activation and biased signaling in complement receptor C5aR1显示文摘The complement system plays an important role in the innate immune response to invading pathogens.The complement fragment C5a is one of its important effector components and exerts diverse physiological functions through activation of the C5a receptor 1(C5aR1)and associated downstream G protein andβ-arrestin signaling pathways.Dysfunction of the C5a-C5aR1 axis is linked to numerous inflammatory and immune-mediated diseases,but the structural basis for activation and biased signaling of C5aR1 remains elusive.Here,we present cryo-electron microscopy structures of the activated wild-type C5aR1–Gi protein complex bound to each of the following:C5a,the hexapeptidic agonist C5apep,and the G protein-biased agonist BM213.The structures reveal the landscape of the C5a–C5aR1 interaction as well as a common motif for the recognition of diverse orthosteric ligands.Moreover,combined with mutagenesis studies and cell-based pharmacological assays,we deciphered a framework for biased signaling using different peptide analogs and provided insight into the activation mechanism of C5aR1 by solving the structure of C5aR1I116A mutant–Gi signaling activation complex induced by C089,which exerts antagonism on wild-type C5aR1.In addition,unusual conformational changes in the intracellular end of transmembrane domain 7 and helix 8 upon agonist binding suggest a differential signal transduction process.Collectively,our study provides mechanistic understanding into the ligand recognition,biased signaling modulation,activation,and Gi protein coupling of C5aR1,which may facilitate the future design of therapeutic agents. | Yuying Feng Chang Zhao Yue Deng Heli Wang Liang Ma Sicen Liu Xiaowen Tian Bo Wang Yan Bin Peipei Chen Wei Yan Ping Fu Zhenhua Shao | 2023 | Cell Research2023，33，4： | 0 |
| 8 | Revealing the promising near-room-temperature thermoelectric performance in Ag_(2)Se single crystals显示文摘With high carrier mobility and intrinsic low lattice thermal conductivity,Ag_(2)Se compounds have attracted increasing attention for thermoelectric application near room temperature.Due to its phase transition at~406 K and resulting thermal volume expansion,the growth and thermoelectric properties of large-sized Ag_(2)Se single crystals have seldom been reported so far.In this work,the vertical Bridgeman method was used for growing bulk Ag_(2)Se single crystal,with an orientation preference along lowsymmetric(201)plane.The Hall mobility as high as 2000 cm^(2)/(V·s)and weak electron-phonon coupling contributes to a high electronic quality BE of~7.0 in near-room-temperature b-Ag_(2)Se single crystals,which is superior to the high-temperature phase a-Ag_(2)Se.The observed low lattice thermal conductivity of 0.8 W/(m·K)at 300 K is due to the low group speeds and strong anharmonicity.A promising peak zT of 0.66 at 375 K and an average zT of 0.65 at 300-375 K were realized in b-Ag_(2)Se crystals.The low Vickers hardness and good ductile properties were confirmed by experiment and theoretical analysis.This work not only synthesized large-sized and highly-orientated Ag_(2)Se crystals,but also revealed its great potential of thermoelectric performance and mechanical properties for various applications near room temperature. | Siqi Lin Linlin Guo Xianghu Wang Yue Liu Yuying Wu Rongbin Li Hezhu Shao Min Jin | 2023 | Journal of Materiomics2023，9，4： | 0 |
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