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| 1 | Glycosylation of dentin matrix protein 1 is a novel key element for astrocyte maturation and BBB integrity显示文摘血大脑障碍(BBB ) 是在 endothelial 房间和星形细胞之间形成的一条紧密的边界,它在循环把大脑与大多数病原体以及神经毒素分开并且保护。然而,详细说明了涉及 BBB 的形成的分子的播放器完全不被知道。牙质矩阵蛋白质 1 (DMP1 )-proteoglycan (PG ) 被知道涉及骨头和牙质的矿化作用,也与未知功能包括大脑在软纸巾被表示。在现在的学习,我们报导 DMP1-PG 在大脑星形细胞被表示并且在 BBB 充实单位。DMP1 的唯一的 glycosylation 地点在在鼠标的蛋白质的 N 终端域是 serine89 (S89 ) 。有 DMP1 的变异的老鼠削尖把 S89 改变到 glycine (S89G ) 的变化,它蛋白质的完全根除的 glycosylation,表明的严重 BBB 混乱。DMP1 变异的鼠标的另一个品种,缺乏 DMP1 的 C 终端域,表明了正常 BBB 功能。S89G-DMP1 星形细胞的极性被破坏,房间房间粘附被松开。通过一组分析,我们发现 DMP1 glycosylation 极其在 vitro 并且在 vivo 为星形细胞成熟被要求。S89G-DMP1 变异的星形细胞没能表示 aquaporin 4 并且减少了 laminin 和 ZO1 表示,它导致了 BBB 的混乱。有趣地,在 nestin 倡导者驾驶的老鼠大脑的野类型的 DMP1-PG 的 overexpression 在野类型层次以外提高了 laminin 和 ZO1 表示并且能有效地抵抗的静脉内的导致甘露糖醇的 BBB 可逆的洞。一起拿,我们的学习不仅揭示了一个新奇元素,即, DMP1-PG,调整了 BBB 形成,而且把新功能分到 DMP1-PG。 | Bo Jing Chunxue Zhang Xianjun Liu Liqiang Zhou Jiping Liu Yinan Yao Juehua Yu Yuteng Weng Min Pan Jie Liu Zuolin Wang Yao Sun Yi Eve Sun | 2018 | Protein & Cell2018，9，3： | 5 |
| 2 | In vivo printing of growth factor-eluting adhesive scaffolds improves wound healing显示文摘Acute and chronic wounds affect millions of people around the world,imposing a growing financial burden on patients and hospitals.Despite the application of current wound management strategies,the physiological healing process is disrupted in many cases,resulting in impaired wound healing.Therefore,more efficient and easy-to-use treatment modalities are needed.In this study,we demonstrate the benefit of in vivo printed,growth factor-eluting adhesive scaffolds for the treatment of full-thickness wounds in a porcine model.A custom-made handheld printer is implemented to finely print gelatin-methacryloyl(GelMA)hydrogel containing vascular endothelial growth factor(VEGF)into the wounds.In vitro and in vivo results show that the in situ GelMA crosslinking induces a strong scaffold adhesion and enables printing on curved surfaces of wet tissues,without the need for any sutures.The scaffold is further shown to offer a sustained release of VEGF,enhancing the migration of endothelial cells in vitro.Histological analyses demonstrate that the administration of the VEGF-eluting GelMA scaffolds that remain adherent to the wound bed significantly improves the quality of healing in porcine wounds.The introduced in vivo printing strategy for wound healing applications is translational and convenient to use in any place,such as an operating room,and does not require expensive bioprinters or imaging modalities. | Kristo Nuutila Mohamadmahdi Samandari Yori Endo Yuteng Zhang Jacob Quint Tannin ASchmidt b Ali Tamayol Indranil Sinha | 2022 | Bioactive Materials2022，7，2： | 3 |
| 3 | Glycosylation of dentin matrix protein 1 is critical for fracture healing via promoting chondrogenesis显示文摘Fractures are frequently occurring diseases that endanger human health. Crucial to fracture healing is cartilage formation, which provides a bone-regeneration environment. Cartilage consists of both chondrocytes and extracellular matrix (ECM). The ECM of cartilage includes collagens and various types of proteoglycans (PGs), which play important roles in maintaining primary stability in fracture healing. The PG form of dentin matrix protein 1 (DMP1-PG) is involved in maintaining the health of articular cartilage and bone. Our previous data have shown that DMP1-PG is richly expressed in the cartilaginous calluses of fracture sites. However, the possible significant role of DMP1-PG in chondrogenesis and fracture healing is unknown. To further detect the potential role of DMP1-PG in fracture repair, we established a mouse fracture model by using a glycosylation site mutant DMP1 mouse (S89G-DMP1 mouse). Upon inspection, fewer cartilaginous calluses and down-regulated expression levels of chondrogenesis genes were observed in the fracture sites of S89G-DMP1 mice. Given the deficiency of DMP1-PG, the impaired IL-6/JAK/STAT signaling pathway was observed to affect the chondrogenesis of fracture healing. Overall, these results suggest that DMP1-PG is an indispensable proteoglycan in chondrogenesis during fracture healing. | Hui Xue Dike Tao Yuteng Weng Qiqi Fan Shuang Zhou Ruilin Zhang Han Zhang Rui Yue Xiaogang Wang Zuolin Wang Yao Sun | 2019 | Frontiers of Medicine2019，13，5： | 2 |
| 4 | Electron-deficient Cu site catalyzed acetylene hydrochlorination显示文摘Rational design of catalytic sites to activate the C≡C bond is of paramount importance to advance acetylene hydrochlorination. Herein, Cu sites with electron-rich and electron-deficient states were constructed by controlling the impregnation solutions. The π electrons flowing from acetylene to Cu site are facilitated over the electron-deficient Cu sites, achieving high activation of C≡C bond. The contradiction between the increased activation of acetylene required for enhanced catalytic activity and the resistance of Cu site to reduction by acetylene required for maintaining catalytic stability can be balanced by establishing strong interactions of Cu site with pyrrolic-N species. The catalytic activity displays a volcano shape scaling relationship as a function of Cu particle size. Tribasic copper chloride is concomitantly generated with the construction of electron-deficient Cu sites. The H–Cl bond of HCl can be activated over the tribasic copper chloride, accelerating the surface reaction of vinyl chloride production. This strategy of inducing electron deficiency provides new insight into the rational design of catalysts for the synthesis of vinyl chloride with a high catalytic performance. | Bolin Wang Chunxiao Jin Shujuan Shao Yuxue Yue Yuteng Zhang Saisai Wang Renqin Chang Haifeng Zhang Jia Zhao Xiaonian Li | 2023 | Green Energy & Environment2023，8，4： | 0 |
| 5 | Bandgaps and vibration isolation of local resonance sandwich-like plate with simply supported overhanging beam显示文摘The concept of local resonance phononic crystals proposed in recent years provides a new chance for theoretical and technical breakthroughs in the structural vibration reduction.In this paper,a novel sandwich-like plate model with local resonator to acquire specific low-frequency bandgaps is proposed.The core layer of the present local resonator is composed by the simply supported overhanging beam,linear spring and mass block,and well connected with the upper and lower surface panels.The simply supported overhanging beam is free at right end,and an additional linear spring is added at the left end.The wave equation is established based on the Hamilton principle,and the bending wave bandgap is further obtained.The theoretical results are verified by the COMSOL finite element software.The bandgaps and vibration characteristics of the local resonance sandwich-like plate are studied in detail.The factors which could have effects on the bandgap characteristics,such as the structural damping,mass of vibrator,position of vibrator,bending stiffness of the beam,and the boundary conditions of the sandwich-like plates,are analyzed.The result shows that the stopband is determined by the natural frequency of the resonator,the mass ratio of the resonator,and the surface panel.It shows that the width of bandgap is greatly affected by the damping ratio of the resonator.Finally,it can also be found that the boundary conditions can affect the isolation efficiency. | Chenxu QIANG Yuxin HAO Wei ZHANG Jinqiang LI Shaowu YANG Yuteng CAO | 2021 | Applied Mathematics and Mechanics(English Edition)2021，42，11： | 0 |
| 6 | HSCA-Net: A Hybrid Spatial-Channel Attention Network in Multiscale Feature Pyramid for Document Layout Analysis显示文摘Document images often contain various page components and complex logical structures,which make document layout analysis task challenging.For most deep learning-based document layout analysis methods,convolutional neural networks(CNNs)are adopted as the feature extraction networks.In this paper,a hybrid spatial-channel attention network(HSCA-Net)is proposed to improve feature extraction capability by introducing attention mechanism to explore more salient properties within document pages.The HSCA-Net consists of spatial attention module(SAM),channel attention module(CAM),and designed lateral attention connection.CAM adaptively adjusts channel feature responses by emphasizing selective information,which depends on the contribution of the features of each channel.SAM guides CNNs to focus on the informative contents and capture global context information among page objects.The lateral attention connection incorporates SAM and CAM into multiscale feature pyramid network,and thus retains original feature information.The effectiveness and adaptability of HSCA-Net are evaluated through multiple experiments on publicly available datasets such as PubLayNet,ICDAR-POD,and Article Regions.Experimental results demonstrate that HSCA-Net achieves state-of-the-art performance on document layout analysis task. | Honghong Zhang Canhui Xu Cao Shi Henyue Bi Yuteng Li Sami Mian | 2023 | Journal of Artificial Intelligence and Technology2023，3，1： | 0 |
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