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| 1 | Assessment of the diagnostic performance and interobserver variability of endocytoscopy in Barrett's esophagus:A pilot ex-vivo study显示文摘AIM:To investigate a classification of endocytoscopy(ECS)images in Barrett’s esophagus(BE)and evaluate its diagnostic performance and interobserver variability.METHODS:ECS was applied to surveillance endoscopic mucosal resection(EMR)specimens of BE ex-vivo.The mucosal surface of specimen was stained with 1%methylene blue and surveyed with a catheter-type endocytoscope.We selected still images that were most representative of the endoscopically suspect lesion and matched with the final histopathological diagnosis to accomplish accurate correlation.The diagnostic performance and inter-observer variability of the new classification scheme were assessed in a blinded fashion by physicians with expertise in both BE and ECS and inexperienced physicians with no prior exposure to ECS.RESULTS:Three staff physicians and 22 gastroenterology fellows classified eight randomly assigned unknown still ECS pictures(two images per each classification)into one of four histopathologic categories as follows:(1)BEC1-squamous epithelium;(2)BEC2-BE without dysplasia;(3)BEC3-BE with dysplasia;and(4)BEC4-esophageal adenocarcinoma(EAC)in BE.Accuracy of diagnosis in staff physicians and clinical fellows were,respectively,100%and 99.4%for BEC1,95.8%and83.0%for BEC2,91.7%and 83.0%for BEC3,and95.8%and 98.3%for BEC4.Interobserver agreement of the faculty physicians and fellows in classifying each category were 0.932 and 0.897,respectively.CONCLUSION:This is the first study to investigate classification system of ECS in BE.This ex-vivo pilot study demonstrated acceptable diagnostic accuracy and excellent interobserver agreement. | Yutaka Tomizawa Prasad G Iyer Louis M Wongkeesong Navtej S Buttar Lori S Lutzke Tsung-Teh Wu Kenneth K Wang | 2013 | World Journal of Gastroenterology2013，19，46： | 2 |
| 2 | Three case of malignant lymphoma of the breast显示文摘 | YASUHIRO S YUTAKA T AKIRA O | 2000 | Jpn J Clin Oncol2000，30，： | 1 |
| 3 | Identification and characterization of transcriptional regulatory elements of the human aromatase cytochrome p450 gene显示文摘 | Satoshi N Yutakas S | 1996 | J Steroid Biochem Molec Biol1996，56，1： | 1 |
| 4 | Constitutional liquation during dissimilar friction stir welding of Al and Mg alloys显示文摘 | Yutaka S Sato Seung Hwan C Park Masato Michiuchi | 2004 | Scripta Materialia2004，50，： | 1 |
| 5 | Angiotension Ⅱ plays a pathogenic role in immune-mediated renal injury in mice显示文摘 | Yutaka H Takeshi S Masaya Y | 1999 | J Clin Invest1999，103，5： | 1 |
| 6 | Synthesis of dideoxypurinenucleosides vie the palladium catalyzed reduction of 9-(2,5 di-o-acetyl 3 bromo-3-deoxy-β-D-xylofurano syl) purine derivatives显示文摘 | Hiroshi S Yusuke A Yutaka H | 1996 | Nucleosides & Nucleotides1996，15，13： | 1 |
| 7 | Using selective correlation coefficient for robust image registration 显示文摘 | SHUN'ICHI K YUTAKA S SATORU I | 2003 | Pattern Recognition2003，36，5： | 1 |
| 8 | Triterpenoid glucuronide saponins from root bark of Aralia armata显示文摘 | MEI H KAZUNORIO YUTAKA S | 1995 | Phytochemistry1995，39，1： | 1 |
| 9 | Treatment of thoracolumbar fractures with vertebroplasty in combination with posterior instrumentation 显示文摘 | Masahiro K Yutaka I Daisuke S | 2005 | Neurosurg Q2005，15，9： | 1 |
| 10 | Hiroshi S, Modulative magnetic interaction in π-diradicals of directly meso-linked porphyrin dimmers 显示文摘 | Jotaro N Yutaka S | 2005 | Polyhedron2005，24，： | 1 |
| 11 | CDC2/CDK1 Expression in Esophageal Adenocarcinoma and Precursor Lesions Serves as a Diagnostic and Cancer Progression Marker and Potential Novel Drug Target显示文摘 | Donna E Hansel Surajit Dhara RuChih C Huang Raheela Ashfaq Mari Deasel Yutaka Shimada Harold S Bernstein John Harmon Malcolm Brock Arlene Forastiere M Kay Washington Anirban Maitra Elizabeth Montgomery | 2005 | The American Journal of Surgical Pathology2005，，3： | 1 |
| 12 | Radiofrequency ablation for hepatocellular carcinoma induces glypican-3 peptide-specific cytotoxic T lymphocytes显示文摘 | Daisuke N Yutaka M Hirofumi S | 2012 | Inter Journal Oncology2012，40，： | 1 |
| 13 | Production of the carotenoids lycopene, b-carotene, and astaxanthin in the food yeast Candidi utilis显示文摘 | YUTAKA M KEUI K TISHIKO S | 1998 | Applied and Environmental Mierobioligy1998，64，4： | 1 |
| 14 | β-Amyrin synthase cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants 显示文摘 | Tetsuo K Masaaki S Yutaka E | 1998 | EurJBiochem1998，256，： | 1 |
| 15 | Accelerated oxidiation of chrom- iun by trace of sodium chloride vapor显示文摘 | YUTAKA S M H N | 1991 | Materials Transactions1991，32，10： | 1 |
| 16 | Amniotic membrane as a carrier for cultivated human corneal endothelial cell transplantation 显示文摘 | Yutaka I Yoichiro S Takahiro N | 2004 | Invest Ophthalmol Vis Sci2004，45，3： | 1 |
| 17 | Catalytic asymmetric synthesis of R207910显示文摘 | YUTAKA S RIE M SAE M | 2010 | J Am Chem Soc2010，132，： | 1 |
| 18 | Prognosis for Pedunculated hepatocellular carcinoma显示文摘 | Yutaka H Azusa S Hisao T | | 0，，1： | 1 |
| 19 | European Society of Hypertension guidelines for blood pressure monitoring at home: a summary report of the Second International Consensus Conference on Home Blood Pressure Monitoring显示文摘 | Gianfranco Parati George S Stergiou Roland Asmar Grzegorz Bilo Peter de Leeuw Yutaka Imai Kazuomi Kario Empar Lurbe Athanasios Manolis Thomas Mengden Eoin O?Brien Takayoshi Ohkubo Paul Padfield Paolo Palatini Thomas Pickering Josep Redon Miriam Revera Lui | 2008 | Journal of Hypertension2008，，8： | 1 |
| 20 | Hydrogen and ethanol production from glycerol-containing wastes discharged after biodiesel nmnufacturing process显示文摘 | TAKESHI I YUTAKA N KOICHIRO S | 2005 | Journal of Bioscience and Bioengineering2005，，100： | 1 |
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