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| 1 | Petrogenesis and tectonic significance of the early Paleozoic Delenuoer ophiolite in the Central Qilian Shan, northeastern Tibetan Plateau显示文摘The newly discovered early Paleozoic Delenuoer ophiolite,in the western margin of the Central Qilian Shan,is composed of serpentinized peridotite,cumulate gabbro,diabase,massive basalt,and pillow basalt.This study presents geochronological and geochemical data for the cumulate gabbro and basalt.LA-ICP-MS U-Pb dating of zircons from the cumulate gabbro yielded a magmatic crystallization age of 472±4 Ma.The basalts have normal mid-ocean ridge basalt(N-MORB)compositions and a narrow range ofεNd(t)values(+4.5 to+5.3),which indicates they were derived from a depleted mantle source.On the basis of regional geological constraints,it is proposed that the Delenuoer ophiolite is a westward extension of the South Ophiolite Belt(Yushigou-Youhulugou-Donggou-Dongcaohe Ophiolite Belt)in the North Qilian Shan.The Delenuoer ophiolite,along with the Gulangxia-Delenuoer fault,defines the westernmost part of the tectonic boundary between the North and Central Qilian Shan.This ophiolite may have formed during southward subduction of the Qilian Ocean slab during the early Paleozoic. | Zhen Ma Jinrong Wang Liangliang Zhang Yixin Liu Yunyun Gao Xiang Zhang Sheng Yu Cheng Zhang | 2020 | Geoscience Frontiers2020，11，6： | 2 |
| 2 | Insulin-like growth factor 2 mRNA binding protein 2 promotes aerobic glycolysis and cell proliferation in pancreatic ductal adenocarcinoma via stabilizing GLUT1 mRNA显示文摘Insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) is a member of the IGF2BP protein family consisting of IGF2BP1~3 with the capacity of binding to many transcripts and regulating RNA stability, localization, and translation. In this study, we discovered that expression of IGF2BP2 was upregulated and led to a poor prognosis in pancreatic ductal adenocarcinoma (PDAC). IGF2BP2 protein was gradually elevated from normal pancreas, pancreatic intraepithelial neoplasia to PDAC in an LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx1-Cre mouse model. Furthermore, we demonstrated that IGF2BP2 promoted aerobic glycolysis and PDAC cell proliferation through directly binding to and stabilizing GLUT1 mRNA. In summary, our study unveiled an important role of IGF2BP2 in PDAC development by modulating aerobic glycolysis and as a potential therapeutic target for PDAC treatment. | Shan Huang Zheng Wu Yunyun Cheng Wenzhen Wei Linlin Hao | 2019 | Acta Biochimica et Biophysica Sinica2019，51，7： | 2 |
| 3 | Credit Card Fraud Detection Based on Machine Learning显示文摘In recent years,the rapid development of e-commerce exposes great vulnerabilities in online transactions for fraudsters to exploit.Credit card transactions take a salient role in nowadays’online transactions for its obvious advantages including discounts and earning credit card points.So credit card fraudulence has become a target of concern.In order to deal with the situation,credit card fraud detection based on machine learning is been studied recently.Yet,it is difficult to detect fraudulent transactions due to data imbalance(normal and fraudulent transactions),for which Smote algorithm is proposed in order to resolve data imbalance.The assessment of Light Gradient Boosting Machine model which proposed in the paper depends much on datasets collected from clients’daily transactions.Besides,to prove the new model’s superiority in detecting credit card fraudulence,Light Gradient Boosting Machine model is compared with Random Forest and Gradient Boosting Machine algorithm in the experiment.The results indicate that Light Gradient Boosting Machine model has a good performance.The experiment in credit card fraud detection based on Light Gradient Boosting Machine model achieved a total recall rate of 99%in real dataset and fast feedback,which proves the new model’s efficiency in detecting credit card fraudulence. | Yong Fang Yunyun Zhang Cheng Huang | 2019 | Computers, Materials & Continua2019，，7： | 1 |
| 4 | Fibroblast exosomal TFAP2C induced by chitosan oligosaccharides promotes peripheral axon regeneration via the miR-132-5p/CAMKK1 axis显示文摘Chitosan and its degradation product,oligosaccharides,have been shown to facilitate peripheral nerve regeneration.However,the underlying mechanisms are not well understood.In this study,we analyzed the protein expression profiles in sciatic nerves after injury using proteomics.A group of proteins related to exosome packaging and transport is up-regulated by chitosan oligosaccharides(COS),implying that exosomes are involved in COS-induced peripheral nerve regeneration.In fact,exosomes derived from fibroblasts(f-EXOs)treated with COS significantly promoted axon extension and regeneration.Exosomal protein identification and functional studies,revealed that TFAP2C is a key factor in neurite outgrowth induced by COS-f-EXOs.Furthermore,we showed that TFAP2C targets the pri-miRNA-132 gene and represses miR-132-5p expression in dorsal root ganglion neurons.Camkk1 is a downstream substrate of miR-132-5p that positively affects axon extension.In rats,miR-132-5p antagomir stimulates CAMKK1 expression and improves axon regeneration and functional recovery in sciatic nerves after injury.Our data reveal the mechanism for COS in axon regeneration,that is COS induce fibroblasts to produce TFAP2C-enriched EXOs,which are then transferred into axons to promote axon regeneration via miR-132-5p/CAMKK1.Moreover,these results show a new facet of fibroblasts in axon regeneration in peripheral nerves. | Yahong Zhao Jina Liu Sha Liu Panpan Yang Yunyun Liang Jinyu Ma Susu Mao Cheng Sun Yumin Yang | 2023 | Bioactive Materials2023，，8： | 1 |
| 5 | Phase diagram of the CsBr-CaBr_2 system显示文摘The phase diagram of the CsBr-CaBr2 system was re-determined by using differential thermal analysis and high temperature and room temperature X-ray diffraction analysis. It is concluded that there are three intermediate compounds in this system: a congruently melting compound, CsCaBr3, with a melting point of 823°C and two incongruently melting compounds, Cs2CaBr4 and Cs3Ca2Br7, whose peritectic points being 597°C and 635°C, respectively. X-ray diffraction analysis indicated that compound CsCaBr3 is of slightly distorted perovskite structure. | BAO Xinhua CHEN Nianyi LU Wencong CHENG Zhixuan LUO Yunyun LU Weiying XIA Yiben | 2006 | Rare Metals2006，25，3： | 1 |
| 6 | Temperature-responsive peristome-structured smart surface for the unidirectional controllable motion of large droplets显示文摘The manipulation of fast,unidirectional motion for large droplets shows important applications in the fields of fog collection and biochemical reactions.However,driving large droplets(>5μL)to move directionally and quickly remains challenging due to the nonnegligible volume force.Herein,we fabricated a scalable,bionic peristome substrate with a microcavity width of 180μm using a 3D printing method,which could unidirectionally drive a large water droplet(~8μL)at a speed reaching 12.5 mm/s by temperature-responsive wettability.The substrate surface was grafted with PNIPAAm,which could reversibly change its wettability in response to temperature,thereby enabling a temperature-responsive smart surface that could regulate droplet movement in real-time by changing the temperature.A series of temperature-responsive smart patterns were designed to induce water transport along specific paths to further realize controllable droplet motion with the antibacterial treatment of predesignated areas.The ability to achieve temperature-responsive unidirectional motion and dynamic control of droplet movement could allow programmable fluidic biosensors and precision medical devices. | Yunyun Song Jialei Yang Xu Zhang Zhongqiang Zhang Xinghao Hu Guanggui Cheng Yan Liu Guojun Lv Jianning Ding | 2023 | Microsystems & Nanoengineering2023，9，5： | 0 |
| 7 | Design, Synthesis and Biological Activities of Novel 4,5-Disubstituted-3-S-(β-D-acetylglycosyl)- 1,2,4-triazole Derivatives显示文摘 | CHENG Dandan WEI Wei LI Yuxin HUA Xuewen ZHOU Yunyun LIU Jingbo LI Yonghong YU Shujing XIONG Lixia LI Zhengming | 2017 | Chemical Research in Chinese Universities2017，33，5： | 0 |
| 8 | Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity显示文摘Interleukin-2(IL-2)is a pleiotropic cytokine that orchestrates bidirectional immune responses via regulatory T cells(Tregs)and effector cells,leading to paradoxical consequences.Here,we report a strategy that exploited genetic code expansion-guided incorporation of the latent bioreactive artificial amino acid fluorosulfate-L-tyrosine(FSY)into IL-2 for proximity-enabled covalent binding to IL-2Rαto selectively promote Treg activation.We found that FSY-bearing IL-2 variants,such as L72-FSY,covalently bound to IL-2Rαvia sulfur-fluoride exchange when in proximity,resulting in persistent recycling of IL-2 and selectively promoting the expansion of Tregs but not effector cells.Further assessment of L72-FSY-expanded Tregs demonstrated that L72-FSY maintained Tregs in a central memory phenotype without driving terminal differentiation,as demonstrated by simultaneously attenuated expression of lymphocyte activation gene-3(LAG-3)and enhanced expression of programmed cell death protein-1(PD-1).Subcutaneous administration of L72-FSY in murine models of pristane-induced lupus and graft-versus-host disease(GvHD)resulted in enhanced and sustained therapeutic efficacy compared with wild-type IL-2 treatment.The efficacy of L72-FSY was further improved by N-terminal PEGylation,which increased its circulatory retention for preferential and sustained effects.This proximity-enabled covalent binding strategy may accelerate the development of pleiotropic cytokines as a new class of immunomodulatory therapies. | Bo Zhang Jiaqi Sun Yeshuang Yuan Dezhong Ji Yeting Sun Yudong Liu Shengjie Li Xingxing Zhu Xunyao Wu Jin Hu Qiu Xie Ling Wu Lulu Liu Boyang Cheng Yuanjie Zhang Lingjuan Jiang Lidan Zhao Fei Yu Wei Song Min Wang Yue Xu Shiliang Ma Yunyun Fei Lihe Zhang Demin Zhou Xuan Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 9 | Arbitrary terahertz chirality construction and flexible manipulation enabled by anisotropic liquid crystal coupled chiral metasurfaces显示文摘Chiral metasurfaces integrated with active materials can dynamically control the chirality of electromagnetic waves,making them highly significant in physics,chemistry,and biology.Herein,we theoretically proposed a general and feasible design scheme to develop a chiral metadevice based on a bilayer anisotropic metasurface and a monolayer liquid crystal(LC),which can construct and flexibly manipulate arbitrary terahertz(THz)chirality.When the twist angle between the anisotropic axes of two metasurfacesθis not 0°,the spatial mirror symmetry of the chiral metadevice is broken,resulting in a strong THz chiral response.In addition,the introduction of anisotropic LCs not only enhances the chiral response of the metadevice but also induces the flipping modulation and frequency tunability of the chirality.More importantly,by optimizing theθ,we can flexibly design the arbitrary chiral response and the operating frequency of chirality,thereby promoting the emergence of various chiral manipulation devices.The experimental results show that the maximum circular dichroism can reach-33 d B at 0.94 THz and flip to 28 d B at 0.69 THz by rotating the LC optical axis from the x to y axis,with the maximum operating frequency tunable range of~120 GHz.We expect this design strategy can create new possibilities for the advancement of active THz chiral devices and their applications,including chiral spectroscopy,molecular recognition,biosensing,and fingerprint detection. | XINHAO JIANG YUNYUN JI FEI FAN SONGLIN JIANG ZHIYU TAN HUIJUN ZHAO JIERONG CHENG SHENGJIANG CHANG | 2023 | Photonics Research2023，11，11： | 0 |
| 10 | Study on the Optimization of Extraction Technology of Rose laevigate Michx. Polysaccharides and Its in vitro Antioxidant Activity显示文摘[Objectives]This study was conducted to optimize the optimal process conditions for extracting polysaccharides from Rose laevigate Michx.with hot water.[Methods]The extraction rate of R.laevigate was used as an evaluation index,and extraction temperature,material-to-liquid ratio,extraction time and extraction times were selected as influencing factors.On the basis of single factor tests,L 9(34)orthogonal tests were carried out for optimization,and the content of polysaccharides was determined by the phenol-sulfuric acid method.The in vitro antioxidant activity of the extracted R.laevigate polysaccharides was studied.[Results]The effects of various influencing factors on the extraction rate of R.laevigate polysaccharides ranked as material-liquid ratio>extraction temperature>extraction times>extraction time.The optimal extraction process was extraction temperature 80℃,extraction time 2 h,and material-to-liquid ratio 1∶25,extraction times 3 times,under which the extraction rate was(9.55±0.12)%.R.laevigate polysaccharides had certain scavenging capacities of DPPH free radicals and hydroxyl free radicals,and its scavenging capacity of DPPH free radicals was better than that of hydroxyl free radicals.[Conclusions]This study provides a theoretical basis for the optimization of the extraction process of R.laevigate polysaccharides and the in-depth development and application of polysaccharides. | Guochen HU Han LIU Qianqian TANG Li CHENG Chenzhong JIN Yunyun ZHOU Xuejiao ZHANG Guiying LIU | 2021 | Agricultural Biotechnology2021，10，6： | 0 |
| 11 | Positive direction of polarization-induced electric field improves formic acid electrooxidation on Pd显示文摘Adjusting the adsorption energy of adsorbates on catalyst can directly regulate the catalytic performance and reaction pathways of heterogeneous catalysis.Herein,we report a novel strategy,introducing polarization-induced electric field(PIEF)with different directions,to manipulate the adsorption energy of intermediates and reaction pathway of formic acid electrooxidation on Pd.Tourmaline nanoparticles are applied as the PIEF provider,of which the direction is successfully controlled via aligning the dipoles in tourmaline in a strong external electric field.Experimental and theoretical results systematically reveal that positive PIEF leads to an electron-deficient state of Pd,reduced adsorption energy of COad,enhanced adsorption energy of*HCOOH and*OH,and promoted formate pathway of formic acid electrooxidation.Pd/TNP+/FTO,with the aid of positive PIEF,shows three-fold enhancement in the formic acid electrooxidation(4.74 mA·cm^(−2))with high durability and anti-poisoning ability compared with pristine Pd.This study leads a new route to design formic acid electrocatalysts and provides an understanding on how to control the adsorption energy of adsorbates on electrocatalysts by an internal electric field. | Shuozhen Hu Yunyun Cheng Guoming Luo Kai Huang Cheng Shi Jie Xu Cheng Lian Shigang Sun Xinsheng Zhang | 2023 | Nano Research2023，16，8： | 0 |
| 12 | Single atom site conjugated copper polyphthalocyanine assisted carbon nanotubes as cathode for reversible Li-CO_(2) batteries显示文摘Recently,Li-CO_(2) battery has gradually become a research hotspot due to its high discharge capacity,energy density and environmental benefits.However,it has been an important problem for researchers because of its slow decomposition kinetics and difficult to generalize to practical application.Herein,we prepared copper polyphthalocyanine-carbon nanotubes composites(CuPPc-CNTs)by solvothermal in-situ polymerization of copper phthalocyanine on the surface of carbon nanotubes as cathode for reversible Li-CO_(2) batteries,which exhibits a high discharge capacity of 18,652.7 mAh·g^(-1) at current density of 100 mA·g^(-1),1.64 V polarization at 1,000 mA·g^(-1),and a stable cycles number of 160 is close to 1,630 h of charge-discharge process at 200 mA·g^(-1).Copper polyphthalocyanine has highly efficient copper single-atom catalytic sites with excellent CO_(2) adsorption and activation,while carbon nanotubes provide a conductive network.The synergistic effect of the two compounds enables it to have excellent catalytic activity.The density functional theory(DFT)calculation proved that the addition of copper polyphthalocyanine significantly improved the CO_(2) adsorption and activation process.This study provides an opportunity for the research of covalent organic polymers(COPs)single-atom catalyst in Li-CO_(2) battery field. | Yunyun Xu Cheng Jiang Hao Gong Hairong Xue Bin Gao Peng Li Kun Chang Xianli Huang Tao Wang Jianping He | 2022 | Nano Research2022，15，5： | 0 |
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