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| 1 | Modeled effects of climate change on actual evapotranspiration in different eco-geographical regions in the Tibetan Plateau显示文摘从 1981 ~ 2010,高山的生态系统和在西藏的高原(TP ) 的效果的地区性的差别的土壤水分蒸发蒸腾损失总量上的气候变化的效果从 80 个气象学的车站基于 Lund-Potsdam-Jena 动态植被模型和数据被学习。在实际土壤水分蒸发蒸腾损失总量(AET ) 和在 TP 的水平衡的变化被分析。在最后 30 年,在 TP 的气候变化被显著地增加的温度,稍微增加的降水,和减少的潜在的土壤水分蒸发蒸腾损失总量(宠物) 描绘,它在 2000 前是重要的。AET 在 TP 的大多数部分展出了增加的趋势。降水和 AET 之间的差别在东南的高原减少了并且在西北的高原增加了。在大气的水需求的减少将在 AET 导致一个减少的趋势。然而,因为增加的降水,在大多数区域的 AET 增加了。增加的降水与增加的 AET 在 86% 区域被观察,而减少的降水与减少的 AET 在 73% 区域被观察。 | YIN Yunhe WU Shaohong ZHAO Dongsheng ZHENG Du PAN Tao | 2013 | Journal of Geographical Sciences2013，23，2： | 28 |
| 2 | Effective and persistent antitumor activity of HER2-directed CAR-T cells against gastric cancer cells in vitro and xenotransplanted tumors in vivo显示文摘 | Yanjing Song Chuan Tong Yao Wang Yunhe Gao Hanren Dai Yelei Guo Xudong Zhao Yi Wang Zizheng Wang Weidong Han Lin Chen | 2018 | Protein & Cell2018，9，10： | 11 |
| 3 | Synthesis,characterization and cell imaging properties of rare earth compounds based on hydroxamate ligand显示文摘Six binuclear rare earth compounds were synthesized through the ligand of 4-Bromo-N-hydroxy-Nmethyl-benzamide(sH_2 bha). Compounds 1-3 are isomorphous, and compound 1 is crystallized in the monoclinic system with the P2_1/c space group. Compounds 4 and 5 are isomorphous, and compound 4 is crystallized in the triclinic system with the P-1 space group. Compound 6 is crystallized in the triclinic system with the P-1 space group. The compounds were characterized by thermogravimetric analysis(TGA) and IR spectroscopy. The fluorescence spectrum in the visible area shows characteristic peaks of Eu, Tb, and Dy compounds. The efficiency of Eu compound on the viability of PC3 cells was assessed using CCK8 assays. From the CCK8 results, ionic concentration may have a great effect on PC3 cells' proliferation. Eu compound shows red fluorescence in the cytoplasm of PC3 cell. As for Eu compound, it might have potential application in cell imaging technology. | Linyan Yang Yanping Zhang Liwei Hu Yunhe Zong Ruili Zhao Tianming Jin Wen Gu | 2018 | Journal of Rare Earths2018，36，4： | 3 |
| 4 | Mitochondria targeting drugs for neurodegenerative diseases——Design, mechanism and application显示文摘Neurodegenerative diseases(NDDs) such as Alzheimer’s disease(AD) and Parkinson ’s disease(PD) are a heterogeneous group of disorders characterized by progressive degeneration of neurons.NDDs threaten the lives of millions of people worldwide and regretfully remain incurable.It is well accepted that dysfunction of mitochondria underlies the pathogenesis of NDDs.Dysfunction of mitochondria results in energy depletion,oxidative stress,calcium overloading,caspases activation,which dominates the neuronal death of NDDs.Therefore,mitochondria are the preferred target for intervention of NDDs.So far various mitochondria-targeting drugs have been developed and delightfully some of them demonstrate promising outcome,though there are still some obstacles such as targeting specificity,delivery capacity hindering the drugs development.In present review,we will elaborately address 1) the strategy to design mitochondria targeting drugs,2) the rescue mechanism of respective mitochondria targeting drugs,3) how to evaluate the therapeutic effect.Hopefully this review will provide comprehensive knowledge for understanding how to develop more effective drugs for the treatment of NDDs. | Jiajia Xu Wei Du Yunhe Zhao Kahleong Lim Li Lu Chengwu Zhang Lin Li | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 2 |
| 5 | Investigate the kinetics of coke solution loss reaction with an alkali metal as a catalyst based on the improved genetic algorithm显示文摘The kinetics of coke solution loss reaction with and without sodium carbonate were investigated under the reaction atmosphere of carb on dioxide. The variables of gas flow rate and coke particle size were explored to eliminate the external and inteirial diffusion, respectively. Then, the improved method combining with the least square and the genetic algorithm was proposed to solve the homogeneous model and the shrinking core model. It was found that the improved genetic algorithm method has good stability by studying the fitness function at each generation. In the homogeneous model, the activation energy with and without sodium carbonate was 54.89 and 95.56 kJ/mol, respectively. And. the activation energy with and without sodium carbonate in the shrinking core model was 49.83 and 92.18 kJ/mol, respectively. Therefore, it was concluded that the sodium carbonate has the catalytic action. In addition, results showed that the estimated conversions were agreed well with the experimental ones, which indicated that the calculated kinetic parameters were valid and the proposed method was successfully developed. | Zhao Lei Yunhe Zhang Ping Cui | 2018 | International Journal of Coal Science & Technology2018，5，4： | 2 |
| 6 | The evolution of China’s regulation of agricultural biotechnology显示文摘To ensure safe use of genetically modified organisms(GMOs),since 1993,China has made great efforts to establish and improve the safety regulatory system for GMOs.Here,we summarize and analyze the regulatory framework of agricultural GMOs,and the progress in regulatory approval of GM crops in China.In general,the development of GMO safety regulations underwent four stages:exploration(1993–2000),development(2001–2010),improvement(2011–2020)and current(2021-present)stage.The first formal regulation was promulgated in 1993,which provided a basis for further development of the regulations,during the exploration stage,when insect-resistant GM cotton,expressing genes from Bacillus thuringiensis(Bt),was approved for cultivation.During the development stage,the Chinese government issued a series of administrative measures,which covered almost all the fields relative to GMO safety when the basic regulatory system was established.Along with the controversy over GMO safety,the regulations have been further,and greatly improved,during improvement stage.From 2021,a few additional revisions have been made,and meanwhile,the new regulation on gene-edited crops was introduced with the development of biotechnology,forming a relative complete regulation and law system for China.The well-developed GMO regulations establishes a firm basis for safe use of GM crops in China.Currently,GM cotton and GM papaya have been widely grown on a large scale in China that have brought great economic and ecological benefits.In addition,12 corn events,3 soybean events,and 2 rice events have also obtained biosafety certification,but presently,these lines have yet to enter commercial production.However,several GM soybean and corn events have entered pilot industrialization,and can soon be expected to be commercially grown in China.In addition to planting,six GM crops,including soybean,corn,cotton,canola,papaya and sugar beet,with a total of 64 events,have been approved for import as processing material in China. | Jingang Liang Xiaowei Yang Yue Jiao Danxia Wang Qiang Zhao Yu Sun Yunhe Li Kongming Wu | 2022 | aBIOTECH2022，3，4： | 2 |
| 7 | Evaluation of the impact of ST - segment eleration on Q lead hy echocardiography on left ventricular remodeling in the patients with myocardial infarction显示文摘 | Zhao yunhe Zhang xiuming Cul lifang et hi | 2001 | Internat J cardiav Meal2001，3，4： | 1 |
| 8 | Unsupervised object detection with scene-adaptive concept learning显示文摘Object detection is one of the hottest research directions in computer vision,has already made impressive progress in academia,and has many valuable applications in the industry.However,the mainstream detection methods still have two shortcomings:(1)even a model that is well trained using large amounts of data still cannot generally be used across different kinds of scenes;(2)once a model is deployed,it cannot autonomously evolve along with the accumulated unlabeled scene data.To address these problems,and inspired by visual knowledge theory,we propose a novel scene-adaptive evolution unsupervised video object detection algorithm that can decrease the impact of scene changes through the concept of object groups.We first extract a large number of object proposals from unlabeled data through a pre-trained detection model.Second,we build the visual knowledge dictionary of object concepts by clustering the proposals,in which each cluster center represents an object prototype.Third,we look into the relations between different clusters and the object information of different groups,and propose a graph-based group information propagation strategy to determine the category of an object concept,which can effectively distinguish positive and negative proposals.With these pseudo labels,we can easily fine-tune the pretrained model.The effectiveness of the proposed method is verified by performing different experiments,and the significant improvements are achieved. | Shiliang PU Wei ZHAO Weijie CHEN Shicai YANG Di XIE Yunhe PAN | 2021 | Frontiers of Information Technology & Electronic Engineering2021，22，5： | 1 |
| 9 | A Killer-Protector System Regulates Both Hybrid Sterility and Segregation Distortion in Rice显示文摘 | Jiangyi Yang Xiaobo Zhao Ke Cheng Hongyi Du Yidan Ouyang Jiongjiong Chen Shuqing Qiu Jianyan Huang Yunhe Jiang Liwen Jiang Jihua Ding Jia Wang Caiguo Xu Xianghua Li Qifa Zhang | 2012 | Science2012，，6100： | 1 |
| 10 | Arctic sea-ice motion and its re- lation to pressure field显示文摘 | Yunhe Zhao and Antony K Liu | 2007 | Journal of Oceanography2007，63，： | 1 |
| 11 | Enterogenic Stenotrophomonas maltophilia migrates to the mammary gland to induce mastitis by activating the calcium-ROS-AMPK-mTOR-autophagy pathway显示文摘Background Mastitis is an inflammatory disease of the mammary gland that has serious economic impacts on the dairy industry and endangers food safety.Our previous study found that the body has a gut/rumen-mammary gland axis and that disturbance of the gut/rumen microbiota could result in‘gastroenterogenic mastitis'.However,the mechanism has not been fully clarified.Recently,we found that long-term feeding of a high-concentrate diet induced mastitis in dairy cows,and the abundance of Stenotrophomonas maltophilia(S.maltophilia)was significantly increased in both the rumen and milk microbiota.Accordingly,we hypothesized that‘gastroenterogenic mastitis'can be induced by the migration of endogenous gut bacteria to the mammary gland.Therefore,this study investigated the mechanism by which enterogenic S.maltophilia induces mastitis.Results First,S.maltophilia was labelled with superfolder GFP and administered to mice via gavage.The results showed that treatment with S.maltophilia promoted the occurrence of mastitis and increased the permeability of the blood-milk barrier,leading to intestinal inflammation and intestinal leakage.Furthermore,tracking of ingested S.maltophilia revealed that S.maltophilia could migrate from the gut to the mammary gland and induce mastitis.Subsequently,mammary gland transcriptome analysis showed that the calcium and AMPK signalling pathways were significantly upregulated in mice treated with S.maltophilia.Then,using mouse mammary epithelial cells(MMECs),we verified that S.maltophilia induces mastitis through activation of the calcium-ROS-AMPK-mTOR-autophagy pathway.Conclusions In conclusion,the results showed that enterogenic S.maltophilia could migrate from the gut to the mammary gland via the gut-mammary axis and activate the calcium-ROS-AMPK-mTOR-autophagy pathway to induce mastitis.Targeting the gut-mammary gland axis may also be an effective method to treat mastitis. | Zhaoqi He Caijun Zhao Yuhong He Zhuoyu Liu Guyue Fan Kun Zhu Yiqi Wang Naisheng Zhang Yunhe Fu Xiaoyu Hu | 2024 | Journal of Animal Science and Biotechnology2024，15，1： | 0 |
| 12 | Visual recognition of cardiac pathology based on 3D parametric model reconstruction显示文摘Visual recognition of cardiac images is important for cardiac pathology diagnosis and treatment.Due to the limited availability of annotated datasets,traditional methods usually extract features directly from twodimensional slices of three-dimensional(3D)heart images,followed by pathological classification.This process may not ensure the overall anatomical consistency in 3D heart.A new method for classification of cardiac pathology is therefore proposed based on 3D parametric model reconstruction.First,3D heart models are reconstructed based on multiple 3D volumes of cardiac imaging data at the end-systole(ES)and end-diastole(ED)phases.Next,based on these reconstructed 3D hearts,3D parametric models are constructed through the statistical shape model(SSM),and then the heart data are augmented via the variation in shape parameters of one 3D parametric model with visual knowledge constraints.Finally,shape and motion features of 3D heart models across two phases are extracted to classify cardiac pathology.Comprehensive experiments on the automated cardiac diagnosis challenge(ACDC)dataset of the Statistical Atlases and Computational Modelling of the Heart(STACOM)workshop confirm the superior performance and efficiency of this proposed approach. | Jinxiao XIAO Yansong LI Yun TIAN Dongrong Xu Penghui LI Shifeng ZHAO Yunhe PAN | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，9： | 0 |
| 13 | Eco-geographical Regionalization of China:An Approach Using the Rough Set Method显示文摘Eco-geographical regionalization involves dividing land into regions by considering both intra-regional consistency and interregional disparity and is based on the pattern of differentiation of eco-geographical elements.Owing to the complexity of the land surface,and the limitation of data and appropriate methods,regions in China have hitherto been mapped manually,meaning that the process of mapping was non-repeatable.To make the regionalization technique repeatable,this study aimed to extract and quantify the expert knowledge of regionalization using an automated method.The rough set method was adopted to extract rules of regionalization based on the existing eco-geographical regionalization map of China,as well as its corresponding meteorological and geological datasets.Then,the rules for regionalization were obtained hierarchically for each natural domain,each temperature zone,and each humidity region.Owing to differences in zonal differentiation,the rule extraction sequence for the eastern monsoon zone and Tibetan Alpine zone was temperature zone first followed by humidity region,with the reverse order being applied for the northwest arid/semi-arid zone.Results show that the extracted indicators were similar to those of the existing(expert-produced)regionalization scheme but more comprehensive.The primary indicator for defining temperature zones was the≥10℃ growing season,and the secondary indicators were the January and July mean temperatures.The primary and secondary indicators for identifying humid regions were aridity index and precipitation,respectively.Eco-geographical regions were mapped over China using these rules and the gridded indicators.Both the temperature zones and humidity regions mapped by the rules show≥85%consistency with the existing regionalization,which is higher than values for mapping by the commonly used simplified method that uses the classification of one indicator.This study demonstrates that the proposed rough set method can establish eco-geographical regionalization that is quantitative and repeatable and able to dynamically updated. | DENG Haoyu WU Shaohong YIN Yunhe GAO Jiangbo ZHAO Dongsheng | 2022 | Chinese Geographical Science2022，32，1： | 0 |
| 14 | Antioxidant-enriched autologous biogel promoted diabetic wound healing by remodeling inherent posttraumatic inflammatory patterning and restoring compromised microenvironment homeostasis显示文摘Successful wound healing depends on the reconstruction of proper tissue homeostasis,particularly in the posttraumatic inflammatory tissue microenvironment.Diabetes jeopardizes tissues’immune homeostasis in cutaneous wounds,causing persistent chronic inflammation and cytokine dysfunction.Previously,we developed an autologous regeneration factor(ARF)technology to extract the cytokine composite from autologous tissue to restore immune homeostasis and promote wound healing.However,treatment efficacy was significantly compromised in diabetic conditions.Therefore,we proposed that a combination of melatonin and ARF,which is beneficial for proper immune homeostasis reconstruction,could be an effective treatment for diabetic wounds.Our research showed that the utilization of melatonin-mediated ARF biogel(AM gel)promoted diabetic wound regeneration at a more rapid healing rate.RNA-Seq analysis showed that AM gel treatment could restore more favorable immune tissue homeostasis with unique inflammatory patterning as a result of the diminished intensity of acute and chronic inflammation.Currently,AM gel could be a novel and promising therapeutic strategy for diabetic wounds in clinical practice through favorable immune homeostatic reconstructions in the tissue microenvironment and proper posttraumatic inflammation patterning. | Yixi Yang Le Wang Yonglin Zhou Yijun He Shaozhang Lin Yuwei Zeng Yunhe Zhou Wei Li Zaopeng He Qi Zhao Lihao Chen Zijie Li Wenhao Wang Zhi-Yong Zhang | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
| 15 | Ultraviolet‑Irradiated All‑Organic Nanocomposites with Polymer Dots for High‑Temperature Capacitive Energy Storage显示文摘Polymer dielectrics capable of operating efficiently at high electric fields and elevated temperatures are urgently demanded by next-generation electronics and electrical power systems.While inorganic fillers have been extensively utilized to improved high-temperature capacitive performance of dielectric polymers,the presence of thermodynamically incompatible organic and inorganic components may lead to concern about the long-term stability and also complicate film processing.Herein,zero-dimensional polymer dots with high electron affinity are introduced into photoactive allyl-containing poly(aryl ether sulfone)to form the all-organic polymer composites for hightemperature capacitive energy storage.Upon ultraviolet irradiation,the crosslinked polymer composites with polymer dots are efficient in suppressing electrical conduction at high electric fields and elevated temperatures,which significantly reduces the high-field energy loss of the composites at 200℃.Accordingly,the ultraviolet-irradiated composite film exhibits a discharged energy density of 4.2 J cm^(−3)at 200℃.Along with outstanding cyclic stability of capacitive performance at 200℃,this work provides a promising class of dielectric materials for robust high-performance all-organic dielectric nanocomposites. | Jiale Ding Yao Zhou Wenhan Xu Fan Yang Danying Zhao Yunhe Zhang Zhenhua Jiang Qing Wang | 2024 | Nano-Micro Letters2024，16，3： | 0 |
| 16 | Effect of intervention treatment from different stages on prognosis in children with central coordination disturbance显示文摘BACKGROUND: Central coordination disturbance is regarded as the early-stage symptom of brain injury-induced cerebral palsy. This disease manifests itself as motor disorder, abnormal attitudinal reflex and muscular tension. Early intervention may improve its prognosis. OBJECTIVE: To observe the effects of intervention treatment from different stages on the prognosis of central coordination disturbance following brain injury in children patients. DESIGN: A contrast observation experiment. SETTING: Department of Neurology and Rehabilitation, Urumqi Children’s Hospital. PARTICIPANTS: Totally 151 children who were diagnosed as central coordination disturbance from January 2002 to December 2003 in the Department of Neurology and Rehabilitation of Urumqi Children’s Hospital were recruited. All the children patients, including 101 male and 50 female, aged from 3 months to 1 year old, met the diagnosis criteria of central coordination disturbance from Vojta. They were divided into slight, moderate and severe abnormity according to Vojta attitudinal reflex. All 151 patients were divided into 2 groups according to their age at diagnosis: 3-6 months old group (n=74), 62 severe, 10 moderate and 2 slight; 7-12 months old group (n=77), 66 severe, 7 moderate and 4 slight. All the relatives of children patients were informed of the experiment. METHODS: ① Both groups received physical training (PT) as the main treatment; Hand training was given if necessary. All of the patients received additional hyperbaric oxygen therapy, bioelectric therapy, scalp acupuncture, drug treatment and family training. The importance of integration of hospital and family based rehabilitation was stressed. Those who did not catch up with the normal development or had abnormal reflexes continued to receive treatment. ② Around the age of 2 years old, all children did a final evaluation using Bayley Scales of Infant Development (BSID). Mental development index (MDI) and physical development index (PDI) were taken as evaluative criteria. Children with scores 80 and above on MDI and PDI were considered to have normal motor and mental development; 79 and below were considered delayers. The Diagnostic Criteria of Cerebral Palsy and Infant-Secondary School Social Adaptation Scale were used in the final evaluation[scores≤5 was extremely severe (extremely severe cerebral palsy), 6 was severe(severe cerebral palsy), 7 was moderate(moderate cerebral palsy), 8 was slight(slight cerebral palsy), 9 was borderline(slight cerebral palsy), 10 was normal, 11 was above average, 12 was excellent and ≥13 was extremely excellent]. ③ Final evaluative results of 2 groups were compared. And u test was used for the comparison of Bayley development index and Chi-square test for the comparison of normalization rate. MAIN OUTCOME MEASURES: BSID MDI and PDI as well as the normalization rate of motor function and mental behavior of children patients at 2 years old. RESULTS: Totally 151 children patients entered the stage of result analysis. ①Two groups of children patients were given integrated rehabilitation therapy , and evaluated at 2 years old . The 3-6 months old group had higher MDI and PDI than the 7-12 months old group(91.81±19.99 vs 71.93±18.98;91.55±23.61 vs 68.95±23.51,u=6.265,5.894,P < 0.01). ②After being given integrated rehabilitation therapy, children patients of 3-6 months old group had significantly higher normalization rate of motor function and mental behavior than 7-12 months old group (73%,27%,χ2=29.723 9,P < 0.01). ③Six slight and 17 moderate central coordination disturbance children of 2 groups all completely recovered; After intervention treatment, among 128 severe central coordination disturbance children, 52 recovered and 76 were still abnormal, in which, 43 slight cerebral palsy, 18 moderate cerebral palsy, 5 severe cerebral palsy and 10 extremely severe cerebral palsy. CONCLUSION: To perform integrated intervention treatment before 6 months old can better improve and promote mental and physical development levels of children patients with central coordination disturbance after brain injury than 6 months later. | Xi Chen Wei Zhao Yunhe Wang Yan Zhu Lixian Gu Qing Han | 2006 | Neural Regeneration Research2006，1，2： | 0 |
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