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| 1 | Enabling practical electrocatalyst-assisted photoelectro- chemical water splitting with earth abundant materials显示文摘 | Xiaogang Yang Rui Liu Yumin He James Thorne Zhi Zheng Dunwei Wang | 2015 | Nano Research2015，8，1： | 11 |
| 2 | Whole-genome resequencing of Osmanthus fragrans provides insights into flower color evolution显示文摘Osmanthus fragrans is a well-known ornamental plant that has been domesticated in China for 2500 years.More than 160 cultivars have been found during this long period of domestication,and they have subsequently been divided into four cultivar groups,including the Yingui,Jingui,Dangui,and Sijigui groups.These groups provide a set of materials to study genetic evolution and variability.Here,we constructed a reference genome of O.fragrans‘Liuyejingui’in the Jingui group and investigated its floral color traits and domestication history by resequencing a total of 122 samples,including 119 O.fragrans accessions and three other Osmanthus species,at an average sequencing depth of 15×.The population structure analysis showed that these 119 accessions formed an apparent regional cluster.The results of linkage disequilibrium(LD)decay analysis suggested that varieties with orange/red flower color in the Dangui group had undergone more artificial directional selection;these varieties had the highest LD values among the four groups,followed by the Sijigui,Jingui,and Yingui groups.Through a genome-wide association study,we further identified significant quantitative trait loci and genomic regions containing several genes,such as ethylene-responsive transcription factor 2 and Arabidopsis pseudoresponse regulator 2,that are positively associated with petal color.Moreover,we found a frameshift mutation with a 34-bp deletion in the first coding region of the carotenoid cleavage dioxygenase 4 gene.This frameshift mutation existed in at least one site on both alleles in all varieties of the Dangui group.The results from this study shed light on the genetic basis of domestication in woody plants,such as O.fragrans. | Hongguo Chen Xiangling Zeng Jie Yang Xuan Cai Yumin Shi Riru Zheng Zhenqi Wang Junyi Liu Xinxin Yi Siwei Xiao Qiang Fu Jingjing Zou Caiyun Wang | 2021 | Horticulture Research2021，8，1： | 5 |
| 3 | Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA显示文摘Nasopharyngeal carcinoma(NPC)is a malignant tumor that usually occurs in people from Southeast Asia and Southern China.NPC is prone to migration and invasion,leading to poor prognosis.A large number of circular RNAs(circ RNAs)exacerbate the process of metastasis in NPC;however,their underlying mechanisms remain unclear.We found that the circular RNA circ CCNB1,encoded by the oncogene CCNB1,was downregulated in NPC biopsies and cell lines.In vitro assays show that circ CCNB1 inhibits NPC cell migration and invasion.Moreover,circ CCNB1 induces a protein,nuclear factor 90(NF90),to bind and prolong the half-life of tight junction protein 1(TJP1)m RNA.Upregulation of TJP1 enhances tight junctions between cancer cells and inhibits NPC cell migration and invasion.This study reveals a novel biological function of circ CCNB1 in the migration and invasion of NPC by enhancing the tight junctions of cancer cells by binding to NF90 proteins and TJP1 m RNA,and may provide a potential therapeutic target for NPC. | Mengyao Zhao Yian Wang Fenghua Tan Lingyun Liu Xiangchan Hou Chunmei Fan Le Tang Yongzhen Mo Yumin Wang Qijia Yan Zhaojian Gong Zheng Li Qianjin Liao Can Guo He Huang Xi Zeng Guiyuan Li Zhaoyang Zeng Wei Xiong Fuyan Wang | 2022 | Science China(Life Sciences)2022，65，11： | 4 |
| 4 | Adaptive PMD Compensation in 10 Gbit/s RZ Optical Communication System显示文摘We report an experiment of adaptive compensation for polarization mode dispersion (PMD) in 10Gbit/s return zero (RZ) optical communication system. The quasi-real-time PMD compensation is realized. The algorithm so-called particle swarm optimization (PSO) is used to control feedback compensation system. | Yu Li Zhang Xiaoguang Zhou Guangtao Shen Yu Zheng Yuan Li Chaoyang Liu Yumin Chen Lin Yang Bojun | 2003 | 光学学报2003，23，S1： | 3 |
| 5 | A novel integrated non-targeted metabolomic analysis reveals significant metabolite variations between different lettuce (Lactuca sativa. L) varieties显示文摘Lettuce is an important leafy vegetable that represents a significant dietary source of antioxidants and bioactive compounds.However,the levels of metabolites in different lettuce cultivars are poorly characterized.In this study,we used combined GC×GC-TOF/MS and UPLC-IMS-QTOF/MS to detect and relatively quantify metabolites in 30 lettuce cultivars representing large genetic diversity.Comparison with online databases,the published literature,standards as well using collision cross-section values enabled putative identification of 171 metabolites.Sixteen of these 171 metabolites(including phenolic acid derivatives,glycosylated flavonoids,and one iridoid)were present at significantly different levels in leaf and head type lettuces,which suggested the significant metabolomic variations between the leaf and head types of lettuce are related to secondary metabolism.A combination of the results and metabolic network analysis techniques suggested that leaf and head type lettuces contain not only different levels of metabolites but also have significant variations in the corresponding associated metabolic networks.The novel lettuce metabolite library and novel non-targeted metabolomics strategy devised in this study could be used to further characterize metabolic variations between lettuce cultivars or other plants.Moreover,the findings of this study provide important insight into metabolic adaptations due to natural and human selection,which could stimulate further research to potentially improve lettuce quality,yield,and nutritional value. | Xiao Yang Shiwei Wei Bin Liu Doudou Guo Bangxiao Zheng Lei Feng Yumin Liu Francisco A.Tomás-Barberán Lijun Luo Danfeng Huang | 2018 | Horticulture Research2018，5，1： | 3 |
| 6 | lncRNA NEAT1 prompts autophagy and apoptosis in MPTP-induced Parkinson’s disease by impairing miR-374c-5p显示文摘Long non-coding RNAs(lncRNAs)play biological roles in brain disorder and neurodegenerative diseases.As the functions of lncRNA NEAT1 in Parkinson’s disease(PD)remain unknown,in the present study,we aimed to explore the roles and underlying molecular mechanisms of NEAT1 in PD.A PD mouse model induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)and a cell model of SH-SY5Y induced by N-methyl-4-phenylpyridinium(MPP+)were established.The ratio of tyrosine hydroxylase(TH+)cells was determined by immunofluorescence assay,and the behavioral changes in mice were observed using pole tests and rotarod tests.The cellular viability and apoptosis of SH-SY5Y were detected by MTT assay and flow cytometric analysis,respectively,and the number of autophagosomes was subsequently measured by transmission electron microscopy.High-performance liquid chromatography was performed to detect the content of dopamine,and a dual-luciferase reporter assay was used to clarify the target of NEAT1 simultaneously.The results demonstrated that the level of NEAT1 was upregulated in the MPTP-induced PD mice,dopamine neurons,and the SH-SY5Y cells treated with MPP+,whereas the level of miR-374c-5p was downregulated.NEAT1 level was positively correlated with MPP+in a concentration-dependent manner.NEAT1 inhibition efficiently facilitated cell proliferation but inhibited apoptosis and autophagy in the MPP+-treated SH-SY5Y cells.Additionally,silencing of NEAT1 increased the TH+rate of neurons and suppressed autophagy greatly in PD mice.As a possible target of NEAT1,miR-374c-5p could impact on the apoptosis and autophagy of the SH-SY5Y cells.NEAT1 inhibition upregulated the expression of miR-374c-5p,enhanced SH-SY5Y cell viability,and repressed autophagy and apoptosis in MPTP-induced PD mice.These findings indicated a potential therapeutic role of NEAT1 in treating PD. | Li Dong Yumin Zheng Lianbo Gao Xiaoguang Luo | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 3 |
| 7 | Leapfrog and Inheritance of New Rural Construction in Urbanization——A Case Study of Haiyang Village of Jiangxia District of Wuhan City in China显示文摘The paper has introduced characteristics and study status of new rural construction, illustrated the connotation of leapfrog development of new rural construction, and considered that new rural construction is an important measure to solve 'three rural' problems. How to conduct new rural construction in urbanization is a critical issue in social and economic development in China. Based on the favorable condition and development mode of current new rural construction, by taking new rural construction of Haiyang Village in Jiangxia District of Wuhan City for example, it has analyzed the leapfrog development in terms of traditional agriculture, villagers' life quality and rural concept, and the inheritance in terms of culture and rural appearance, so as to give enlightenments to new rural construction in the future. | DONG Qiaofeng LIN Yumin ZHENG Bin | 2012 | Journal of Landscape Research2012，4，8： | 2 |
| 8 | Genetic bases of rice grain shape: so many genes, so little known显示文摘 | Rongyu Huang Liangrong Jiang Jingsheng Zheng Tiansheng Wang Houcong Wang Yumin Huang Zonglie Hong | 2012 | Trends in Plant Science2012，，： | 2 |
| 9 | Generation of ApoE deficient dogs via combination of embryo injection of CRISPR/Cas9 with somatic cell nuclear transfer显示文摘Atherosclerotic cardiovascular disease is the leading cause of death in the world which is resulted from complex interactions among multiple genetic and environmental factors(WHO).Atherosclerosis is a chronic inflammatory disease characterized by accumulation of lipids in the arterial wall(Gofman and Lindgren,1950).Tremendous clinical and experimental efforts have | Chong Feng Xiaomin Wang Hui Shi Quanmei Yan Min Zheng Jing Li Quanjun Zhang Yumin Qin Yougang Zhong Jidong Mi Liangxue Lai | 2018 | Journal of Genetics and Genomics2018，45，1： | 2 |
| 10 | SbMYB3 transcription factor promotes root-specific f lavone biosynthesis in Scutellaria baicalensis显示文摘Scutellaria baicalensis Georgi produces abundant root-specific f lavones(RSFs),which provide various benefits to human health.We have elucidated the complete biosynthetic pathways of baicalein and wogonin.However,the transcriptional regulation of f lavone biosynthesis in S.baicalensis remains unclear.We show that the SbMYB3 transcription factor functions as a transcriptional activator involved in the biosynthesis of RSFs in S.baicalensis.Yeast one-hybrid and transcriptional activation assays showed that SbMYB3 binds to the promoter of flavone synthase II-2(SbFNSII-2)and enhances its transcription.In S.baicalensis hairy roots,RNAi of SbMYB3 reduced the accumulation of baicalin and wogonoside,and SbMYB3 knockout decreased the biosynthesis of baicalein,baicalin,wogonin,and wogonoside,whereas SbMYB3 overexpression enhanced the contents of baicalein,baicalin,wogonin,and wogonoside.Transcript profiling by qRT–PCR demonstrated that SbMYB3 activates SbFNSII-2 expression directly,thus leading to more abundant accumulation of RSFs.This study provides a potential target for metabolic engineering of RSFs. | Yumin Fang Jie Liu Minmin Zheng Sanming Zhu Tianlin Pei Mengying Cui Lijing Chang Hanwen Xiao Jun Yang Cathie Martin Qing Zhao | 2023 | Horticulture Research2023，10，2： | 2 |
| 11 | Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model显示文摘Dear Editor,Respiratory syncytial virus(RSV)is the leading cause of serious lower respiratory tract disease in children under 5 years of age worldwide,causing an estimated 3.2 million hospitalizations and 120,000 deaths in children globally per year.Furthermore,nearly all children can be infected with RSV by 2 years of age,and individuals can be repeatedly re-infected with RSV throughout life,which poses great threats to infants,the elderly. | Ruxue Zhang Yumin Zhang Wei Zheng Weijuan Shang Yan Wu Ning Li Jun Xiong Hualiang Jiang Jingshan Shen Gengfu Xiao Yuanchao Xie Leike Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 2 |
| 12 | Ubiquitin-specific protease 24 promotes EV71 infection by restricting K63-linked polyubiquitination of TBK1显示文摘TANK-binding kinase 1(TBK1)is an essential protein kinase for activation of interferon regulatory factor 3(IRF3)and induction of the type I interferons(IFN-I).Although the biochemical regulation of TBK1 activation has been studied,little is known about how enterovirus 71(EV71)employs the deubiquitinases(DUBs)to regulate TBK1 activation for viral immune evasion.Here,we found that EV71 infection upregulated the expression of ubiquitinspecific protease 24(USP24).Further studies revealed that USP24 physically interacted with TBK1,and can reduce K63-linked polyubiquitination of TBK1.Knockdown of USP24 upregulated TBK1 K63-linked polyubiquitination,promoted the phosphorylation and nuclear translocation of IRF3,and in turn improved IFN-I production during EV71 infection.As a consequence,USP24 knockdown dramatically inhibited EV71 infection.This study revealed USP24 as a novel regulator of TBK1 activation,which promotes the understanding of immune evasion mechanisms of EV71 and could provide a potential strategy for treatment of EV71 infection. | Lichao Zang Jin Gu Xinyu Yang Yukang Yuan Hui Guo Wei Zhou Jinhong Ma Yan Chen Yumin Wu Hui Zheng Weifeng Shi | 2023 | Virologica Sinica2023，38，1： | 2 |
| 13 | Silencing glypican-3 expression induces apoptosis in human hepatocellular carcinoma cells显示文摘 | Shiyuan Liu Yumin Li Wei Chen Pengfei Zheng Tao Liu Wenting He Junqiang Zhang Xiangting Zeng | 2012 | Biochemical and Biophysical Research Communications2012，，4： | 1 |
| 14 | Chitin derived nitrogen-doped porous carbons with ultrahigh specific surface area and tailored hierarchical porosity for high performance supercapacitors显示文摘In this study,we report the fabrication of nitrogen rich activated nanosized carbon with hierarchical micro/mesoporous and ultrahigh specific surface area by template-free and one-step carbonization-activation method,which greatly simplified the process and avoided the waste of reagents.Chitin nanoparticles were prepared by a mechanical induced sol-gel transition process in NaOH/Urea solvent and a subsequent carbonization utilizing NaOH for activation and urea for N doping,resulting in activated carbon(ACNC-800)with extraordinary specific surface area(2631 m^(2)/g)and high nitrogen content(7.1%).Further characterization and electrochemical tests demonstrate high electrochemical performance of the activated nanocarbon.Under the current density of 0.5 A/g,the specific capacitance of the three-electrode system is 245 F/g and that of the two-electrode system is 227 F/g.The assembled capacitors exhibit superior rate performance and good cycle stability(98%capacitance retention after 10000 charge-discharge cycles).This work introduces a simple and efficient strategy to prepare N-doped carbon with hierarchical porosity applied to high performance supercapacitors. | Si Zheng Jianwei Zhang Hongbing Deng Yumin Du Xiaowen Shi | 2021 | Journal of Bioresources and Bioproducts2021，6，2： | 1 |
| 15 | Degumming of ramie fibers by alkalophilic bacteria and their polysaccharide-degrading enzymes显示文摘 | ZHENG Lianshuang DU Yumin ZHANG Jiayao | 2001 | Bioresource Technology2001，78，： | 1 |
| 16 | Ultrafine NiO- La2O3-Al2O3 aerogel: a promising catalyst for CH4/CO2 reforming显示文摘 | Xu Zheng Li Yumin Zhang Jiyan | 2001 | Applied Catalysis A: General2001，213，1： | 1 |
| 17 | Degumming of ramie fibers by alkalophilic bacteria and their polysaccharide-degrading enzymes 显示文摘 | ZHENG Lianshuang DU Yumin ZHANG Jiayao | 2001 | Bioresource Technology2001，5，1： | 1 |
| 18 | Delivery of an Rhs-family nuclease effector reveals direct penetration of the gram-positive cell envelope by a type VI secretion system in Acidovorax citrulli显示文摘The type VI secretion system(T6SS)is a double-tubular nanomachine widely found in gram-negative bacteria.Its spear-like Hcp tube is capable of penetrating a neighboring cell for cytosol-to-cytosol protein delivery.However,gram-positive bacteria have been considered impenetrable to such T6SS action.Here we report that the T6SS of a plant pathogen,Acidovorax citrulli(AC),could deliver an Rhsfamily nuclease effector RhsB to kill not only gram-negative but also gram-positive bacteria.Using bioinformatic,biochemical,and genetic assays,we systematically identified T6SS-secreted effectors and determined that RhsB is a crucial antibacterial effector.RhsB contains an N-terminal PAAR domain,a middle Rhs domain,and an unknown C-terminal domain.RhsB is subject to self-cleavage at both its N-and C-terminal domains and its secretion requires the upstream-encoded chaperone EagT2 and VgrG3.The toxic Cterminus of RhsB exhibits DNase activities and such toxicity is neutralized by either of the two downstream immunity proteins,RimB1 and RimB2.Deletion of rhsB significantly impairs the ability of killing Bacillus subtilis while ectopic expression of immunity proteins RimB1 or RimB2 confers protection.We demonstrate that the AC T6SS not only can effectively outcompete Escherichia coli and B.subtilis in planta but also is highly potent in killing other bacterial and fungal species.Collectively,these findings highlight the greatly expanded capabilities of T6SS in modulating microbiome compositions in complex environments. | Tong-Tong Pei Yumin Kan Zeng-Hang Wang Ming-Xuan Tang Hao Li Shuangquan Yan Yang Cui Hao-Yu Zheng Han Luo Xiaoye Liang Tao Dong | 2022 | mLife2022，1，1： | 1 |
| 19 | Degumming of ramie fibers by alkalophilic bacteria and their polysaccha- ride-degrading enzymes 显示文摘 | ZHENG Lianshuang DU Yumin ZHANG Jiayao | 2001 | Bioresource Technology2001，78，1： | 1 |
| 20 | A new approach to chemically modified chitosan sulfates and study of their influences on the inhibition of Escherichia coli and Staphylococcus aureus growth 显示文摘 | Huang Ronghua Du Yumin Zheng Lianshuang | 2003 | Reactive & Functional Polymers2003，11，： | 1 |
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