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| 1 | Ten cities cross-sectional questionnaire survey of children asthma and other allergies in China显示文摘Asthma,rhinitis and eczema(allergic or non-allergic)have increased throughout the world during the last decades,especially among children.Changes in the indoor environment are suspected to be important causes.China has experienced a dramatic change in indoor environmental exposures during the past two decades.However,such changes and their associations with children’s asthma and other health aspects have not been thoroughly studied.China,Children,Homes,Health(CCHH),Phase I,was a cross-sectional questionnaire survey of 48219 children 1–8 years old in 10 Chinese cities during 2010–2012.The questionnaire includes the International Study of Asthma and Allergies in Childhood(ISAAC)core health questions and additional questions regarding housing,life habits and outdoor environment.In health analyses,children aged 3–6 years old were included.The prevalences of doctor diagnosed asthma varied from 1.7%to 9.8%(mean 6.8%),a large increase from 0.91%in 1999 and 1.50%in2000.The prevalence of wheeze,rhinitis and atopic eczema(last 12 months)varied from 13.9%to 23.7%,24.0%to 50.8%and4.8%to 15.8%,respectively.Taiyuan had the lowest prevalences of all illnesses and Shanghai the highest,except for wheezewhere the highest value was for Urumqi.We found(1)no obvious association between disease prevalences and ambient PM10concentrations and(2)higher prevalences of disease in humid climates with hot summers and cold winters,but with no centrally heated buildings.Associations between the diseases and economic status as indexed by Gross Domestic Product(GDP)requires further study. | ZHANG YinPing LI BaiZhan HUANG Chen YANG Xu QIAN Hua DENG QiHong ZHAO ZhuoHui LI AnGui ZHAO JiaNing ZHANG Xin QU Fang HU Yu YANG Qin WANG Juan ZHANG Ming WANG Fang ZHENG XiaoHong LU Chan LIU ZhiJian SUN YueXia MO JinHan ZHAO YiLi LIU Wei WANG TingTing NORBCK Dan BORNEHAG Carl-Gustaf SUNDELL Jan | 2013 | Chinese Science Bulletin2013，58，34： | 22 |
| 2 | Risk assessment of gas control and spontaneous combustion of coal under gas drainage of an upper tunnel显示文摘The adjustment of the gas drainage rate has an immediate impact on air leakage in gob,thus resulting in the change of self-heating of coal.While regulating the gas drainage parameters,the risk of spontaneous combustion of coal should be considered.The risk assessment of gas control and spontaneous combustion of coal under gas drainage in a tunnel was investigated at different gas drainage rates.The distributions of the air volume along the working face,the gas management effects and the width of the oxidation zone were subjected to risk analysis.As the simulation results showed,with increasing gas drainage rate,although the safety of gas dilution by ventilation was assured,the intensifying air leakage caused the oxidation zone to move into the deeper gob and led to an increase in the width of the oxidation zone.A risk assessment method was proposed to determine a suitable gas drainage rate for the upper tunnel.The correctness of the risk assessment and the validity of the numerical modelling were confirmed by the field measurements. | Tingxiang Chu Pin Li Yuexia Chen | 2019 | International Journal of Mining Science and Technology2019，29，3： | 9 |
| 3 | Olfactory ensheathing cell transplantation improves sympathetic skin responses in chronic spinal cord injury显示文摘Forty-three patients with chronic spinal cord injury for over 6 months were transplanted with embryonic olfactory ensheathing cells, 2–4 × 106, into multiple sites in the injured area under the surgical microscope. The sympathetic skin response in patients was measured with an electromyography/evoked potential instrument 1 day before transplantation and 3–8 weeks after transplantation.Spinal nerve function of patients was assessed using the American Spinal Injury Association impairment scale. The sympathetic skin response was elicited in 32 cases before olfactory ensheathing cell transplantation, while it was observed in 34 cases after transplantation. Concomitantly,sympathetic skin response latency decreased significantly and amplitude increased significantly after transplantation. Transplantation of olfactory ensheathing cells also improved American Spinal Injury Association scores for movement, pain and light touch. Our findings indicate that olfactory ensheathing cell transplantation improves motor, sensory and autonomic nerve functions in patients with chronic spinal cord injury. | Zuncheng Zheng Guifeng Liu Yuexia Chen Shugang Wei | 2013 | Neural Regeneration Research2013，8，30： | 6 |
| 4 | Integrated Control of Lateral and Vertical Vehicle Dynamics Based on Multi-agent System显示文摘The existing research of the integrated chassis control mainly focuses on the different evaluation indexes and control strategy. Among the different evaluation indexes, the comprehensive properties are usually not considered based on the non-linear superposition principle. But, the control strategy has some shortages on tyre model with side-slip angle, road adhesion coefficient, vertical load and velocity. In this paper, based on belief, desire and intention(BDI)-agent model framework, the TYRE agent, electric power steering(EPS) agent and active suspension system(ASS) agent are proposed. In the system(SYS) agent, the coordination mechanism is employed to manage interdependences and conflicts among other agents, so as to improve the flexibility, adaptability, and robustness of the global control system. Due to the existence of the simulation demand of dynamic performance, the vehicle multi-body dynamics model is established by SIMPACK. And then the co-simulation analysis is conducted to evaluate the proposed multi-agent system(MAS) controller. The simulation results demonstrate that the MAS has good effect on the performance of EPS and ASS. Meantime, the better road feeling for the driver is provided considering the multiple and complex driving traffic. Finally, the MAS rapid control prototyping is built to conduct the real vehicle test. The test results are consistent to the simulation results, which verifies the correctness of simulation. The proposed research ensures the driving safety, enhances the handling stability, and improves the ride comfort. | HUANG Chen CHEN Long YUN Chaochun JIANG Haobin CHEN Yuexia | 2014 | Chinese Journal of Mechanical Engineering2014，27，2： | 3 |
| 5 | Modeling and test on height adjustment system of electrically-controlled air suspension for agricultural vehicles显示文摘To reduce the damages of pavement,vehicle components and agricultural product during transportation,an electric control air suspension height adjustment system of agricultural transport vehicle was studied by means of simulation and bench test.For the oscillation phenomenon of vehicle height in driving process,the mathematical model of the vehicle height adjustment system was developed,and the controller of vehicle height based on single neuron adaptive PID control algorithm was designed.The control model was simulated via Matlab/Simulink,and bench test was conducted.Results show that the method is feasible and effective to solve the agricultural vehicle body height unstable phenomenon in the process of switching.Compared with other PID algorithms,the single neuron adaptive PID control in agricultural transport vehicle has shorter response time,faster response speed and more stable switching state.The stability of the designed vehicle height adjustment system and the ride comfort of agricultural transport vehicle were improved. | Chen Yuexia Chen Long Wang Ruochen Xu Xing Shen Yujie Liu Yanling | 2016 | International Journal of Agricultural and Biological Engineering2016，9，2： | 3 |
| 6 | Phosphatase activity and culture conditions of the yeast Candida mycoderma sp. and analysis of organic phosphorus hydrolysis ability显示文摘Orthophosphate is an essential but limiting macronutrient for plant growth. About 67%cropland in China lacks sufficient phosphorus, especially that with red soil. Extensive soil phosphorus reserves exist in the form of organic phosphorus, which is unavailable for root uptake unless hydrolyzed by secretory acid phosphatases. Thus, many microorganisms with the ability to produce phosphatase have been exploited. In this work, the activity of an extracellular acid phosphatase and yeast biomass from Candida mycoderma was measured under different culture conditions, such as p H, temperature, and carbon source. A maximal phosphatase activity of 8.47 × 105± 0.11 × 105U/g was achieved by C. Mycoderma in 36 hr under the optimal conditions. The extracellular acid phosphatase has high activity over a wide p H tolerance range from 2.5 to 5.0(optimum p H 3.5). The effects of different phosphorus compounds on the acid phosphatase production were also studied. The presence of phytin, lecithin or calcium phosphate reduced the phosphatase activity and biomass yield significantly. In addition, the p H of the culture medium was reduced significantly by lecithin. The efficiency of the strain in releasing orthophosphate from organic phosphorus was studied in red soil(used in planting trees) and rice soil(originating as red soil). The available phosphorus content was increased by 230% after inoculating20 days in rice soil and decreased by 50% after inoculating 10 days in red soil. This work indicates that the yeast strain C. mycoderma has potential application for enhancing phosphorus utilization in plants that grow in rice soil. | Mang Yan Liufang Yu Liang Zhang Yuexia Guo Kewei Dai Yuru Chen | 2014 | Journal of Environmental Sciences2014，26，11： | 2 |
| 7 | Forty-five terawatt vortex ultrashort laser pulses from a chirped-pulse amplification system显示文摘We report on a vortex laser chirped-pulse amplification(CPA)system that delivers pulses with a peak power of 45 TW.A focused intensity exceeding 1019 W/cm2 has been demonstrated for the first time by the vortex amplification scheme.Compared with other schemes of strong-field vortex generation with high energy flux but narrowband vortex-converting elements at the end of the laser,an important advantage of our scheme is that we can use a broadband but size-limited q-plate to realize broadband mode-converting in the front end of the CPA system,and achieve high-power amplification with a series of amplifiers.This method is low cost and can be easily implemented in an existing laser system.The results have verified the feasibility to obtain terawatt and even petawatt vortex laser amplification by a CPA system,which has important potential applications in strong-field laser physics,for example,generation of vortex particle beams with orbital angular momentum,fast ignition for inertial confinement fusion and simulation of the extreme astrophysical environment. | Zhenkuan Chen Shuiqin Zheng Xiaoming Lu Xinliang Wang Yi Cai Congying Wang Maijie Zheng Yuexia Ai Yuxin Leng Shixiang Xu Dianyuan Fan | 2022 | High Power Laser Science and Engineering2022，10，5： | 1 |
| 8 | Chaotic Motion in a Nonlinear Car Model Excited by Multi-frequency Road Surface Profile显示文摘In order to solve the problem that existing nonlinear suspension models have not considered chaotic motion in primary and other resonances, and numerical calculation model is too simplified to capture the accurate critical conditions for the chaotic motion, a nonlinear suspension model and its new paths of chaos are investigated. Primary resonances, secondary resonances, and combined resonances are performed using multiple-time scales method. Based on the Melnikov functions, the critical conditions for the chaotic motion of the nonlinear system are found, which is 0.246 7 for the primary resonance, and 0.338 8 for the secondary resonance. The effects of parameters on chaotic range are considered, and results show that nonlinear stiffness of suspension k2 has the largest impact on the chaotic range while damping coefficient C1 has the smallest one. The chaotic responses on the area of the primary and secondary resonances are discussed via Lyapunov exponents and numerical integration of the equations of motion. It is found from Lyapunov exponents and Poincare′ maps that motions are chaos over critical conditions, and has shown two very different paths of chaos on the primary and secondary resonances. Chaotic motion patterns in the primary and secondary resonances are obtained with more accurate critical conditions, which is a necessary complement to nonlinear study in nonlinear suspension mode. | Yuexia CHEN Long CHEN King XU Ruochen WANG Xiaofeng YANG | 2017 | Chinese Journal of Mechanical Engineering2017，30，3： | 1 |
| 9 | Remote monitoring contributes to preventing overwork-related events in health workers on the COVID-19 frontlines显示文摘Fighting on the frontlines against the coronavirus disease 2019(COVID-19)pandemic,health workers are at high risk of virus infection and overwork-related sudden death and disorders including cardiovascular diseases and stress.When we noted the increase of overwork-related sudden deaths in physicians and nurses in the first 2 weeks after lockdown of Wuhan,we organized the‘Touching Your Heart’program by remote monitoring,aiming to protect health workers from overwork-related disorders through integrated volunteer work by physicians and medical engineering researchers from Wuhan Huoshenshan Hospital,Nanjing Medical University,and Tiangong University.By remotely monitoring the health conditions of the medical aid team working atWuhan Huoshenshan Hospital,the programsuccessfully helped in avoiding severe overwork-related events.The results from our program should be used to remind frontline health workers around the world to take precautions against overworked-related severe events,and showthat precision monitoring is effective in improving work efficiency and maintaining a sustainable workforce during emergency situations like a pandemic. | Faming Zhang Huiquan Wang Ruijuan Chen Wenzhi Hu Yuexia Zhong Xin Wang | 2020 | Precision Clinical Medicine2020，3，2： | 1 |
| 10 | The TripleSat constellation:a new geospatial data service model显示文摘With the increase of different sensors,applications and customers,the demand from data providers and users is for a new geospatial data service model,which supports low cost,high dexterity,and which would provide a comprehensive service.Based on such requirements and demands,the 21AT TripleSat constellation terminal and data delivery and management system has been developed by a Beijing based high-tech enterprise,Twenty First Century Aerospace Technology Co.,Ltd.(21AT).The company is the first commercial Earth observation satellite operator and service provider in China.This new geospatial data service model allows the user to directly access multi-source satellite data,manage the data order,and carry out automatic massive data production and delivery.The solution also implements safe and hierarchical user management,statistical data analysis,and automatic information reports.In addition,a mobile application is also available for users to easily access system functions.This new geospatial solution has already been successfully applied and installed in many customer sites in China,and is now available globally for international clients interested in fast geospatial solutions.It enables the success of customers’operational services.Besides providing TripleSat Constellation images,the multi-source data access system also allows the users to access other satellite data sources,based on customized agreement.This paper describes and discusses this new geospatial data service model. | Qiang Wen Jianjun He Shengyong Guan Ting Chen Yin Hu Wenbin Wu Feng Liu Yuexia Qiao Suet Yheng Kok Samuel Yeong | 2017 | Geo-Spatial Information Science2017，20，2： | 1 |
| 11 | Effects of Na2CO3 and NaCl stresses on the antioxidant enzymes of chloroplasts and chlorophyll fluorescence parameters of leaves of Puccinellia tenuiflora (Turcz.) scribn.et Merr.显示文摘 | Yuexia Wang Guorong Sun Biao Suo Gang Chen Jianbo Wang Yan Yan | 2008 | Acta Physiologiae Plantarum2008，，2： | 1 |
| 12 | A targeted nanoplatform co-delivery of pooled siRNA and doxorubicin for reversing of multidrug resistance in breast cancer显示文摘Multi-drug resistance(MDR)has become the largest obstacle to the success of cancer patients receiving traditional chemotherapeutics or novel targeted drugs.Here,we developed a targeted nanoplatform based on biodegradable boronic acid modifiedε-polylysine to co-deliver P-gp siRNA,Bcl-2 siRNA,and doxorubicin for overcoming the challenge.The targeted nanoplatform showed a robust suppressing efficiency for the invasion,proliferation,and colony formation of adriamycin(ADR)resistant breast cancer cell line(MCF-7/ADR)cells in vitro.The ATP responsiveness of the nanoplatform was also proved in the research.In the in vivo antitumor experiment,the targeted nanoplatform showed a significant inhibition of tumor growth with good biocompatibility.The goal of this study is to develop a novel and facile strategy to prepare a highly efficient and safe gene and drug delivery system for MDR breast cancer based on biocompatibleε-polylysine polymers. | Hongmei Liu Ding Ma Jinpeng Chen Li Ye Yiping Li Yuexia Xie Xue Zhao Hanbing Zou Xiaojing Chen Jun Pu Peifeng Liu | 2022 | Nano Research2022，15，7： | 0 |
| 13 | A dynamic tire model based on HPSO-SVM显示文摘In order to accurately describe the force mechanism of tires on agricultural roads and improve the life cycle of agricultural tires,a tire-deformable terrain model was established.The effects of tread pattern,wheel spine,tire sidewall elasticity,inflation pressure and soil deformation were considered in the model and fitted with a support vector machine(SVM)model.Hybrid particle swarm optimization(HPSO)was used to optimize the parameters of SVM prediction model,of which inertia weight and learning factor were improved.To verify the performance of the model,a tire force prediction model of agricultural vehicle with the improved SVM method was investigated,which was a complex nonlinear problem affected by many factors.Cross validation(CV)method was used to evaluate the training precision accuracy of the model,and then the improved HPSO was adopted to select parameters.Results showed that the choice randomness of specifying the parameters was avoided and the workload of the parameter selection was reduced.Compared with the dynamic tire model without considering the influence of tread pattern and wheel spine,the improved SVM model achieved a better prediction performance.The empirical results indicate that the HPSO based parameters optimization in SVM is feasible,which provides a practical guidance to tire force prediction of agricultural transport vehicles. | Yuexia Chen Long Chen Chen Huang Ying Lu Chen Wang | 2019 | International Journal of Agricultural and Biological Engineering2019，12，2： | 0 |
| 14 | RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis显示文摘Cellular senescence provides a protective barrier against tumorigenesis in precancerous or normal tissues upon distinct stressors.However,the detailed mechanisms by which tumor cells evade premature senescence to malignant progression remain largely elusive.Here we reported that RBM4 adversely impacted cellular senescence to favor glutamine-dependent survival of esophageal squamous cell carcinoma(ESCC)cells by dictating the activity of LKB1,a critical governor of cancer metabolism.The level of RBM4 was specifically elevated in ESCC compared to normal tissues,and RBM4 overexpression promoted the malignant phenotype.RBM4 contributed to overcome H-RAS-or doxorubicin-induced senescence,while its depletion caused P27-dependent senescence and proliferation arrest by activating LKB1-AMPK-mTOR cascade.Mechanistically,RBM4 competitively bound LKB1 to disrupt the LKB1/STRAD/MO25 heterotrimeric complex,subsequently recruiting the E3 ligase TRIM26 to LKB1,promoting LKB1 ubiquitination and degradation in nucleus.Therefore,such molecular process leads to bypassing senescence and sustaining cell proliferation through the activation of glutamine metabolism.Clinically,the ESCC patients with high RBM4 and low LKB1 have significantly worse overall survival than those with low RBM4 and high LKB1.The RBM4 high/LKB1 low expression confers increased sensitivity of ESCC cells to glutaminase inhibitor CB-839,providing a novel insight into mechanisms underlying the glutamine-dependency to improve the efficacy of glutamine inhibitors in ESCC therapeutics. | Lei Chen Wenjing Zhang Dan Chen Quan Yang Siwen Sun Zhenwei Dai Zhengzheng Li Xuemei Liang Chaoqun Chen Yuexia Jiao Lili Zhi Lianmei Zhao Jinrui Zhang Xuefeng Liu Jinyao Zhao Man Li Yang Wang Yangfan Qi | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 0 |
| 15 | Extension and application of a database for the rapid identification of Vibrio using MALDI-TOF MS显示文摘Rapid and accurate identification of Vibrio species has been problematic because phenotypic characteristics are variable within species and biochemical identification requires two or more days to complete.Matrix-assisted laser desorption ionization–time of flight mass spectrometry(MALDI-TOF MS)has become a powerful tool for rapidly distinguishing between related bacterial species.However,its accuracy depends on the number of strains in a database.In the current study,we extend and apply the Vibrio database based on MALDI-TOF MS.A total of 74 strains of Vibrio representing 28 species were identified and included in new database.A phylogenetic tree based on rpoB sequence and dendrograms were constructed.We analyzed 30 clinical Vibrio of three species to evaluate the new database and carried out PCA dendrogram analyses for differences of strains.We created a new database that offered fast and accurate Vibrio identification.MSP and PCA dendrogram analyses provided technical support to track sources and incidences of Vibrio infection.In addition,the discovery of characteristic and differential peaks is useful for the future identification of Vibrio.This represents a powerful tool for the rapid and accurate classification and identification of Vibrio and closely related species. | Jing Wu Yuexia Zhou Xiaofei Liu Yuan Cao Chengjin Hu Yingjian Chen | 2020 | Acta Oceanologica Sinica2020，39，10： | 0 |
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