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| 1 | Clinical features and outcomes of diffuse large B-cell lymphoma based on nodal or extranodal primary sites of origin:Analysis of 1,085 WHO classified cases in a single institution in China显示文摘Objective: To explore the clinicobiologic features and outcomes of diffuse large B-cell lymphoma(DLBCL)patients in China according to the primary site.Methods: A total of 1,085 patients diagnosed with DLBCL in National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College during a 6-year period were enrolled. Their clinical characteristics and outcomes were analyzed according to the primary site.Results: In the 1,085 patients, 679(62.6%) cases were nodal DLBCL(N-DLBCL) and 406 cases(37.4%) were extranodal DLBCL(EN-DLBCL). The most common sites of N-DLBCL were lymphonodus(64.8%), Waldeyer's ring(19.7%), mediastinum(12.8%) and spleen(2.7%), while in EN-DLBCL, stomach(22.4%), intestine(16.0%),nose and sinuses(8.9%), testis(8.4%), skin(7.9%), thyroid(6.9%), central nervous system(CNS)(6.4%), breast(5.7%), bone(3.4%), and salivary gland(2.7%) were most common. N-DLBCL patients tend to present B symptoms, bulky disease, and elevated LDH more often, while age >60 years, extranodal sites >1, Ann Arbor stage I or II, bone marrow involvement, and Ki-67 index >90% were usually seen in EN-DLBCL. The 5-year overall survival(OS) rate and progression-free survival(PFS) rate for all patients were 62.5% and 54.2%. The 5-year OS rate for patients with N-DLBCL and EN-DLBCL were 65.5% and 56.9%(P=0.008), and the 5-year PFS were57.0% and 49.0%(P=0.020). Waldeyer's ring originated DLBCL possessed the highest 5-year OS rate(83.6%) and PFS rate(76.9%) in N-DLBCL. The top five EN-DLBCL subtypes with favorable prognosis were stomach,breast, nose and sinuses, lung, salivary gland, with 5-year OS rate: 70.3%, 69.6%, 69.4%, 66.7% and 63.6%,respectively. While CNS, testis, oral cavity and kidney originated EN-DLBCL faced miserable prognosis, with 5-year OS rate of 26.9%, 38.2%, and 42.9%.Conclusions: In our study, primary sites were associated with clinical characteristics and outcomes. Compared with EN-DLBCL, N-DLBCL had better prognosis. | Yuankai Shi Ying Han Jianliang Yang Peng Liu Xiaohui He Changgong Zhang Shengyu Zhou Liqiang Zhou Yan Qin Yongwen Song Yueping Liu Shulian Wang Jing Jin Lin Gui Yan Sun | 2019 | Chinese Journal of Cancer Research2019，31，1： | 19 |
| 2 | Drug resistance mutation profiles of the drug-nave and first-line regimen-treated HIV-1-infected population of Suzhou, China显示文摘Little is known about the prevalence of drug-resistant mutations in HIV-1-positive individuals in Suzhou, China. To elucidate the transmitted drug resistance(TDR) and acquired drug resistance mutation(ADR) profiles, we collected blood specimens from 127 drug-naive and 117 first-line drugtreated HIV-1-infected individuals sampled from 2014 to 2016 in Suzhou. We successfully amplified po/fragments from 100 drug-naive and 20 drug-treated samples. We then determined the drugresistant mutations to protease(PR) and reverse-transcriptase(RT) inhibitors according to the Stanford drug resistance database. Overall, 11 and 13 individuals had transmitted(drug-naive group) and acquired(treated group) resistance mutations, respectively. Six transmitted drugresistant mutations were found, including two mutations(L33F and L76V) in the protease region and four(K70N/E and V179D/E) in the RT region. Only L76 V was a major mutation, and K70N/E and V179D/E are known to cause low-level resistance to RT inhibitors. All 13 treated participants who had major drug resistance mutations demonstrated intermediate to high resistance to efavirenz and nevirapine, and six had a treatment duration of less than three months. No major mutations to RT inhibitors were found, implying that the epidemic of transmitted resistance mutations was not significant in this area. Our results suggest that more frequent virus load and drug resistance mutation tests should be conducted for individuals receiving antiretroviral treatment, especially for newly treated patients. Our research provides insights into the occurrence of HIV-1 drug resistance in Suzhou and will help to optimize the treatment strategy for this population. | Tingting Li Feng Qian Ting Yuan Weilu Xu Li Zhu Jinlong Huang Haiyan Wang Yueping Zhu Yinling Wang Xiaohong Li Saihong Gu Zhuqing Tan Hui Chen Xiangrong Luo Wei Zhu Weniuan Lu Ping Xu Ming Li Yuying Chen Yong Gao Rongge Yang Chuanwu Zhu Binlian Sun | 2017 | Virologica Sinica2017，32，4： | 2 |
| 3 | Landslide hazards triggered by the 2008 Wenchuan earthquake, Sichuan, China显示文摘 | Yueping Yin Fawu Wang Ping Sun | 2009 | Landslides2009，，2： | 1 |
| 4 | Design of automatic aquaculture workboat driven by air propellers显示文摘 | Sun Yueping Zhao Yuyan Zhao Dean | 2014 | Applied Mechanics and Materials2014，，： | 1 |
| 5 | Landslide hazards triggered by the 2008 Wenchuan earthquake, Sichuan, China显示文摘 | Yueping Yin Fawu Wang Ping Sun | 2009 | Landslides2009，，2： | 1 |
| 6 | In vivo anti-tumor and immunomodulation activities of different molecular weight lambda-carrageenans from Chondrus ocellatus显示文摘 | Yueping Sun Hua Xin | 2004 | Pharmacological Research2004，，50： | 1 |
| 7 | Landslide hazards triggered by the 2008 Wenchuan earthquake, Sichuan, China显示文摘 | YIN Yueping WANG Fawu SUN Ping | 2009 | Landslides2009，6，2： | 1 |
| 8 | In vivo antitumor and immunomodulation activities of different nolecular weight lambdacarrageenans from Chondrus ocellatus显示文摘 | Zhou Gefei Sun Yueping Xin Hua etal | 2004 | Pharmacological Reaseareh2004，50，： | 1 |
| 9 | In vivo anti -tumor and immunomodulation activities of different molecular weight lambda - carrageenans from Chondrus ocellatus显示文摘 | Gefei Zhu Yueping Sun Hua Xin | 2004 | Pharmacological Research2004，50，： | 1 |
| 10 | Landslide hazards triggered by the 2008 Wenchuan earthquake, Sichuan, China显示文摘 | Yueping Yin Fawu Wang Ping Sun | 2009 | Landslides2009，，2： | 1 |
| 11 | Implication ofp53 in growth arrest and apoptosis induced by the synthetic retinoid CD437 in human lung cancer cells显示文摘 | Sun SY YueP WuGS | 1999 | Cancer Res1999，59，12： | 1 |
| 12 | Landslide hazards triggered by the 2008 Wenchuan earthquake, Sichuan, China显示文摘 | Yueping Yin Fawu Wang Ping Sun | 2009 | Landslides2009，，2： | 1 |
| 13 | Dual-band microstrip bandpass filter using stepped-impedance resonators with new coupling schemes显示文摘 | Zhang Yueping Sun Mei | 2006 | IEEE Transactions on Microwave Theory and Techniques2006，54，10： | 1 |
| 14 | Expression of SARS-coronavirus nucleocapsid protein in Escherichia coli and Lactococcus lactis for serodiagnosis and mucosal vaccination显示文摘 | Huadong Pei Jingfang Liu Yun Cheng Chaomin Sun Chen Wang Yueping Lu Jie Ding Jian Zhou Hua Xiang | 2005 | Applied Microbiology and Biotechnology2005，，2： | 1 |
| 15 | Landslide hazards triggered by the 2008 Wenchuan earthquake, Sichuan, China显示文摘 | Yueping Yin Fawu Wang Ping Sun | 2009 | Landslides2009，，2： | 1 |
| 16 | One dimensional La 0.8 Sr 0.2 Co 0.2 Fe 0.8 O 3? δ /Ce 0.8 Gd 0.2 O 1.9 nanocomposite cathodes for intermediate temperature solid oxide fuel cells显示文摘 | Erqing Zhao Zheng Jia Li Zhao Yueping Xiong Chunwen Sun Manuel E. Brito | 2012 | Journal of Power Sources2012，，： | 1 |
| 17 | An Improved Non-Parametric Method for Multiple Moving Objects Detection in the Markov Random Field显示文摘Detecting moving objects in the stationary background is an important problem in visual surveillance systems.However,the traditional background subtraction method fails when the background is not completely stationary and involves certain dynamic changes.In this paper,according to the basic steps of the background subtraction method,a novel non-parametric moving object detection method is proposed based on an improved ant colony algorithm by using the Markov random field.Concretely,the contributions are as follows:1)A new nonparametric strategy is utilized to model the background,based on an improved kernel density estimation;this approach uses an adaptive bandwidth,and the fused features combine the colours,gradients and positions.2)A Markov random field method based on this adaptive background model via the constraint of the spatial context is proposed to extract objects.3)The posterior function is maximized efficiently by using an improved ant colony system algorithm.Extensive experiments show that the proposed method demonstrates a better performance than many existing state-of-the-art methods. | Qin Wan Xiaolin Zhu Yueping Xiao Jine Yan Guoquan Chen Mingui Sun | 2020 | Computer Modeling in Engineering & Sciences2020，，7： | 1 |
| 18 | Landslide hazards triggered by the 2008 Wenchuan earthquake, Sichuan, China显示文摘 | Yin Yueping Wang Fawu Sun Ping | 2009 | Landslides2009，6，2： | 1 |
| 19 | Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer显示文摘 | Jingting Jiang Yibei Zhu Changping Wu Yueping Shen Wenxiang Wei Lujun Chen Xiao Zheng Jing Sun Binfeng Lu Xueguang Zhang | 2010 | Cancer Immunology Immunotherapy2010，，11： | 1 |
| 20 | Clinical Analysis on Children Anorexia Treated by Baobaole-decoction in 200 Cases显示文摘 | Yongping Du Yueping Zhang Zongren Wang Yu Niu Qinyou Ren Chunxiang Zhou Jing Sun | 2006 | Journal of US-China Medical Science2006，3，5： | 0 |
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