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| 1 | Hydropower reservoirs on the upper Mekong River modify nutrient bioavailability downstream显示文摘Hydropower development is the key strategy in many developing countries for energy supply,climate-change mitigation and economic development.However,it is commonly assumed that river dams retain nutrients and therefore reduce downstream primary productivity and fishery catches,compromising food security and causing trans-boundary disputes.Contrary to expectation,here we found that a cascade of reservoirs along the upper Mekong River increased downstream bioavailability of nitrogen andphosphorus.The dams caused phytoplankton density to increase with hydraulic residence time and stratification of the stagnant reservoirs caused hypoxia at depth.This allowed the release of bioavailable phosphorus from the sediment and an increase in dissolved inorganic nitrogen as well as a shift in nitrogen species from nitrate to ammonium,which were transported downstream by the discharge of water from the base of the dam.Our findings provide a new perspective on the environmental impacts of river dams on nutrient cycling and ecosystem functioning,with potential implications for sustainable development of hydropower worldwide. | Qiuwen Chen Wenqing Shi Jef Huisman Stephen C.Maberly Jianyun Zhang Juhua Yu Yuchen Chen Daniele Tonina Qitao Yi | 2020 | National Science Review2020，7，9： | 15 |
| 2 | Modulating macrophage activities to promote endogenous bone regeneration: Biological mechanisms and engineering approaches显示文摘A coordinated interaction between osteogenesis and osteoimmune microenvironment is essential for successful bone healing.In particular,macrophages play a central regulatory role in all stages of bone repair.Depending on the signals they sense,these highly plastic cells can mediate the host immune response against the exterior signals of molecular stimuli and implanted scaffolds,to exert regenerative potency to a varying extent.In this article,we first encapsulate the immunomodulatory functions of macrophages during bone regeneration into three aspects,as sweeper,mediator and instructor.We introduce the phagocytic role of macrophages in different bone healing periods(‘sweeper’)and overview a variety of paracrine cytokines released by macrophages either mediating cell mobilisation,vascularisation and matrix remodelling(‘mediator’),or directly driving the osteogenic differentiation of bone progenitors and bone repair(‘instructor’).Then,we systematically classify and discuss the emerging engineering strategies to recruit,activate and modulate the phenotype transition of macrophages,to exploit the power of endogenous macrophages to enhance the performance of engineered bone tissue. | Yiming Niu Zhenzhen Wang Yuchen Shi Lei Dong Chunming Wang | 2021 | Bioactive Materials2021，6，1： | 14 |
| 3 | Vertical Distribution Characteristics of PM2.5 Observed by a Mobile Vehicle Lidar in Tianjin, China in 2016显示文摘We present mobile vehicle lidar observations in Tianjin, China during the spring, summer, and winter of 2016. Mobile observations were carried out along the city border road of Tianjin to obtain the vertical distribution characteristics of PM_(2.5). Hygroscopic growth was not considered since relative humidity was less than 60% during the observation experiments. PM_(2.5) profile was obtained with the linear regression equation between the particle extinction coefficient and PM_(2.5) mass concentration. In spring, the vertical distribution of PM_(2.5) exhibited a hierarchical structure. In addition to a layer of particles that gathered near the ground, a portion of particles floated at 0.6–2.5-km height. In summer and winter, the fine particles basically gathered below 1 km near the ground. In spring and summer, the concentration of fine particles in the south was higher than that in the north because of the influence of south wind. In winter, the distribution of fine particles was opposite to that measured during spring and summer. High concentrations of PM_(2.5) were observed in the rural areas of North Tianjin with a maximum of 350 μg m–3 on 13 December2016. It is shown that industrial and ship emissions in spring and summer and coal combustion in winter were the major sources of fine particles that polluted Tianjin. The results provide insights into the mechanisms of haze formation and the effects of meteorological conditions during haze–fog pollution episodes in the Tianjin area. | Lihui LYU Yunsheng DONG Tianshu ZHANG Cheng LIU Wenqing LIU Zhouqing XIE Yan XIANG Yi ZHANG Zhenyi CHEN Guangqiang FAN Leibo ZHANG Yang LIU Yuchen SHI Xiaowen SHU | 2018 | Journal of Meteorological Research2018，32，1： | 5 |
| 4 | mTOR regulates NLRP3 inflammasome activation via reactive oxygen species in murine lupus显示文摘 | Xiaojing Li Xuefang Zhang Yuchen Pan Guoping Shi Jing Ren Hongye Fan Huan Dou Yayi Hou | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 4 |
| 5 | Shape and position of Earth's bow shock near-lunar orbit based on ARTEMIS data显示文摘Earth's bow shock is the result of interaction between the supersonic solar wind and Earth's magnetopause. However, data limitations mean the model of the shape and position of the bow shock are based largely on near-Earth satellite data. The model of the bow shock in the distant magnetotail and other factors that affect the bow shock, such as the interplanetary magnetic field(IMF) B_y, remain unclear. Here, based on the bow shock crossings of ARTEMIS from January 2011 to January 2015, new coefficients of the tail-flaring angle a of the Chao model(one of the most accurate models currently available) were obtained by fitting data from the middle-distance magnetotail(near-lunar orbit, geocentric distance -20R_E>X>-50R_E). In addition, the effects of the IMF B_y on the flaring angle a were analyzed. Our results showed that:(1) the new fitting coefficients of the Chao model in the middle-distance magnetotail are more consistent with the observed results;(2) the tail-flaring angle a of the bow shock increases as the absolute value of the IMF B_y increases. Moreover, positive IMF B_y has a greater effect than negative IMF B_y on flaring angle. These results provide a reference for bow shock modeling that includes the IMF B_y. | LIU Ji SHI QuanQi TIAN AnMin Lü JianYong WU Hao WANG Ming FU SuiYan YANG YuChen ZONG QiuGang ZHANG Jiang FENG YongYong PU ZuYin | 2016 | Science China Earth Sciences2016，59，8： | 3 |
| 6 | Highly active sites of low spin Fe^(Ⅱ)N_(4)species:The identification and the ORR performance显示文摘Over recent years,catalytic materials of Fe-N-C species have been recognized being active for oxygen reduction reaction(ORR).However,the identification of active site remains challenging as it generally involves a pyrolysis process and mixed components being obtained.Herein Fe_(3)C/C and Fe_(2)N/C samples were synthesized by temperature programmed reduction of Fe precursors in 15%CH_(4)/H_(2)and pure NH_(3),respectively.By acid leaching of Fe_(2)N/C sample,only single sites of FeN_(4)species were presented,providing an ideal model for identification of catalytic functions of the single sites of FeN_(4)in ORR.A correlation was conducted between the concentration of Fe^(Ⅱ)N_(4)in low spin state by Mossbauer spectra and the kinetic current density at 0.8 V in alkaline media,and such a structure-performance correlation assures the catalytic roles of low spin Fe^(Ⅱ)N_(4) species as highly active sites for the ORR. | Huizhu Cai Bingbing Chen Xiao Zhang Yuchen Deng Dequan Xiao Ding Ma Chuan Shi | 2021 | Nano Research2021，14，1： | 2 |
| 7 | Polydopamine-modified collagen sponge scaffold as a novel dermal regeneration template with sustained release of platelet-rich plasma to accelerate skin repair:A one-step strategy显示文摘Although employed to release growth factors(GFs)for regenerative medicine,platelet-rich plasma(PRP)has been hindered by issues like burst effect.Based on collagen sponge scaffolds(CSSs)modified with polydopamine(pDA),a novel dermal regeneration template(DRT)was designed.However,whether it could efficiently deliver PRP and even foster wound healing remained unclear.In this work,after PRP was prepared and pDA-modified CSSs(pDA-CSSs)were fabricated,microscopic observation,GFs release assay and in-vitro biological evaluations of pDA-CSSs with PRP(pDA-CSS@PRP)were performed,followed by BALA-C/nu mice full-thickness skin defects implanted with pDA-CSS@PRP covered by grafted skins(termed as a One-step strategy).As a result,scanning electron microscope demonstrated more immobilized platelets on pDA-CSS′surface with GFs’controlled release via enzyme-linked immunosorbent assay,compared with CSSs.In line with enhanced in-vitro proliferation,adhesion and migration of keratinocytes&endothelial cells,pDA-CSS@PRP were histologically revealed to accelerate wound healing with less scar via rapid angiogenesis,arrangement of more mature collagen,guiding cells to spread,etc.In conclusion,pDA-CSSs have potential to serve as a novel DRT capable of delivering PRP,which may foster full-thickness skin defect healing by means of a One-step strategy. | Zijun Zheng Minxiong Li Pengwei Shi Yanbin Gao Jun Ma Yuchen Li Lei Huang Zhangfeifan Yang Lei Yang | 2021 | Bioactive Materials2021，6，8： | 2 |
| 8 | Transmitter Cooperation by Joint Dirty Paper Coding in Ad-hoc Networks 显示文摘 | Shi Yuchen Bai Baoming | 2010 | The Journal of China Universities of Posts and Telecommunications2010，17，1： | 1 |
| 9 | Diarylquinoline compounds induce autophagy-associated cell death byinhibiting the Akt pathway and increasing reactive oxygen species in human nasopharyngealcarcinoma cells显示文摘 | Yuchen Cai Zhihui Wan Tiemin Sun Yanxia Shi Yueli Sun Peiyu Huang Su Li Wenqi Jiang | 2013 | Oncology Reports2013，，3： | 1 |
| 10 | Down-regulation of TIPE2 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus显示文摘 | Di Li Lijun Song Yuchen Fan Xia Li Yingjie Li Jie Chen Faliang Zhu Chun Guo Yongyu Shi Lining Zhang | 2009 | Clinical Immunology2009，，： | 1 |
| 11 | StRAP2.3, an ERF-Ⅶ transcription factor, directly activates StInvInh2 to enhance cold-induced sweetening resistance in potato显示文摘Potato invertase inhibitor(StInvInh2)positively regulates cold-induced sweetening(CIS)resistance by inhibiting the activity of vacuolar invertase.The distinct expression patterns of StInvInh2 have been thoroughly characterized in different potato genotypes,but the related CIS ability has not been characterized.The understanding of the regulatory mechanisms that control StInvInh2 transcription is unclear.In this study,we identified an ERF‐Ⅶ transcription factor,StRAP2.3,that directly regulates StInvInh2 to positively modulate CIS resistance.Acting as a nuclear-localized transcriptional activator,StRAP2.3 directly binds the ACCGAC cis-element in the promoter region of StInvInh2,enabling promoter activity.Overexpression of StRAP2.3 in CIS-sensitive potato tubers induced StInvInh2 mRNA abundance and increased CIS resistance.In contrast,silencing StRAP2.3 in CIS-resistant potato tubers repressed the expression of StInvInh2 and decreased CIS resistance.We conclude that cold-responsive StInvInh2 is due to the binding of StRAP2.3 to the ACCGAC cis-element in the promoter region of StInvInh2.Overall,these findings indicate that StRAP2.3 directly regulates StInvInh2 to positively modulate CIS resistance,which may provide a strategy to improve the processing quality of potatoes. | Weiling Shi Yuhao Song Tiantian Liu Qiuqin Ma Wang Yin Yuchen Shen Tengfei Liu Chunyan Jiang Kai Zhang Dianqiu Lv Botao Song Jichun Wang Xun Liu | 2021 | Horticulture Research2021，8，1： | 1 |
| 12 | Improving the efficiency of quantum hash function by dense coding of coin operators in discrete-time quantum walk显示文摘Li et al. first proposed a quantum hash function(QHF) in a quantum-walk architecture. In their scheme, two two-particle interactions, i.e., I interaction and π-phase interaction are introduced and the choice of I or π-phase interactions at each iteration depends on a message bit. In this paper, we propose an efficient QHF by dense coding of coin operators in discrete-time quantum walk. Compared with existing QHFs, our protocol has the following advantages: the efficiency of the QHF can be doubled and even more; only one particle is enough and two-particle interactions are unnecessary so that quantum resources are saved. It is a clue to apply the dense coding technique to quantum cryptographic protocols, especially to the applications with restricted quantum resources. | YuGuang Yang YuChen Zhang Gang Xu XiuBo Chen Yi-Hua Zhou WeiMin Shi | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 1 |
| 13 | Removal of Cu from the nickel electrolysis anolyte using nickel thiocarbonate显示文摘 | Xingyu Chen Ailiang Chen Zhongwei Zhao Xuheng Liu Yuchen Shi Dezhi Wang | 2012 | Hydrometallurgy2012，，： | 1 |
| 14 | Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine显示文摘Dear Editor,Embryonic stem cells(ESCs)have been assumed to possess immature mitochondria and to favor anaerobic glycolysis over oxidative phosphorylation(OXPHOS)for energy production.This proposition is largely based on the findings that ESCs possess globular mitochondria with blurred cristae,and the facts that ESCs have higher glycolysis activity and lower mitochondrial respiration capacity than somatic cells(Kondoh et al.,2007;Folmes et al.,2011,2012;Zhang et al.,2012;Xu et al.,2013;Ito and Suda,2014;Gu et al.,2016).However,recent studies have shown that mitochondrial autophagy and mitochondrial dynamics are pivotal for ESC self-renewal and pluripotency(Todd et al.,2010;Liu et al.,2016,2020;Wang et al.,2019;Zhong et al.,2019).These studies have raised a fundamental question:what is the contribution and functional mechanism of mitochondrial respiration in pluripotency regulation? | Jiani Cao Meng Li Kun Liu Xingxing Shi Ning Sui Yuchen Yao Xiaojing Wang Shiyu Li Yuchang Tian Shaojing Tan Qian Zhao Liang Wang Xiahua Chai Lin Zhang Chong Liu Xing Li Zhijie Chang Dong Li Tongbiao Zhao | 2023 | Protein & Cell2023，14，5： | 1 |
| 15 | Upregulation of B7-H1 expression is associated with macrophage infiltration in hepatocellular carcinomas显示文摘 | Jie Chen Guosheng Li Hong Meng Yuchen Fan Yonghong Song Shurong Wang Faliang Zhu Chun Guo Lining Zhang Yongyu Shi | 2012 | Cancer Immunology, Immunotherapy2012，，1： | 1 |
| 16 | Implementation of a TPM-Based Security Enhanced Browser Password Manager显示文摘In order to enhance the security of a browser password manager, we propose an approach based on a hardware trusted platform module(TPM). Our approach encrypts users' passwords with keys generated by the TPM, which uses a master password as the credential for authorization to access the TPM. Such a hardware-based feature may provide an efficient way to protect users' passwords. Experiment and evaluation results show that our approach performs well to defend against password stealing attack and brute force attack. Attackers cannot get passwords directly from the browser, therefore they will spend incredible time to obtain passwords. Besides, performance cost induced by our approach is acceptable. | HE Yuchen WANG Rui SHI Wenchang | 2016 | Wuhan University Journal of Natural Sciences2016，21，1： | 1 |
| 17 | Internet of Things Intrusion Detection System Based on Convolutional Neural Network显示文摘In recent years, the Internet of Things (IoT) technology has developedby leaps and bounds. However, the large and heterogeneous networkstructure of IoT brings high management costs. In particular, the low costof IoT devices exposes them to more serious security concerns. First, aconvolutional neural network intrusion detection system for IoT devices isproposed. After cleaning and preprocessing the NSL-KDD dataset, this paperuses feature engineering methods to select appropriate features. Then, basedon the combination of DCNN and machine learning, this paper designs acloud-based loss function, which adopts a regularization method to preventoverfitting. The model consists of one input layer, two convolutional layers,two pooling layers and three fully connected layers and one output layer.Finally, a framework that can fully consider the user’s privacy protection isproposed. The framework can only exchange model parameters or intermediateresults without exchanging local individuals or sample data. This paperfurther builds a global model based on virtual fusion data, so as to achievea balance between data privacy protection and data sharing computing. Theperformance indicators such as accuracy, precision, recall, F1 score, and AUCof the model are verified by simulation. The results show that the model ishelpful in solving the problem that the IoT intrusion detection system cannotachieve high precision and low cost at the same time. | Jie Yin Yuxuan Shi Wen Deng Chang Yin Tiannan Wang Yuchen Song Tianyao Li Yicheng Li | 2023 | Computers, Materials & Continua2023，，4： | 0 |
| 18 | Reliability and validity of the hidden hunger assessment scale in China-revised for high school students显示文摘Objective:Hidden hunger remains a severe public health problem that affects millions of people worldwide.In China,challenges related to dietary imbalance and hidden hunger persist.Micronutrient inadequacy deserves more attention among adolescents,given its vital role in their growth and development;however,this problem appears to have been largely ignored.High school students,in particular,are often at a high risk of hidden hunger but have limited assessment tools available.Therefore,this study aims to revise the hidden hunger assessment scale for high school students(HHAS-HSS)in China and assess its reliability and validity.Methods:Based on a literature review,expert consultation,pre-experiment,and formal survey,a hidden hunger assessment scale was revised for high school students.The formal survey involved 9336 high school students in 11 of the 16 cities in Anhui Province,China,and 9038 valid questionnaires were collected and included in the analysis.The item analysis,internal consistency reliability,test-retest reliability,content validity,exploratory factor analysis,and confirmatory factor analysis of the HHAS-HSS were examined.Results:The HHAS-HSS included a total of 4 dimensions and 12 items:'vegetables and food diversity'(three items),'fruits and dairy products'(three items),'micronutrient-dense foods'(four items),and'health condition and eating habits'(two items).The results showed a Cronbach's alpha of 0.758,a split-half reliability of 0.829,and a test-retest reliability of o.793,indicating good internal consistency.Using the Bartlett's test and Kaiser-Meyer-Olkin test(KMO)to test the exploratory factor analysis presented a four-factor model of the HHAS-HSS,the KMO0 value was 0.820(P<0.001),which indicated the possibility for factor confirmatory factor analysis.Using the maximum variance rotation method,four factors were obtained,and the cumulative variance explained rate was 57.974%.Confirmatory factor analysis also supported the division of the scale into four dimensions,and the fitting indices were x^(2)=1417.656,x^(2)/df=29.534,goodness-of-fit index=0.974,adjusted goodnessof-fit index=0.958,parsimonious goodness-of-fit index=0.600,normed fit index=0.938,incremental fit index=0.940,Tucker-Lewis index=0.917,comparative fit index=0.939,and root mean square error of approximation=0.056.Except for x^(2)/df,all the indices reached the fitting standard,and the above results showed that the construct validity of the scale reached an acceptable level.Conclusions:The HHAS-HSS has good validity and reliability for Chinese high school students.It is a convenient self-report measure of hidden hunger risk. | Ning Zhang Minao Wang Yuchen Zhang Huake Cao Yang Yang Yuhang Shi Yang Pei Feixiang Yang Yinan Du | 2023 | Global Health Journal2023，7，2： | 0 |
| 19 | Pre-operative nasal probe tests with adrenaline and lidocaine ease insertion during flexible bronchoscopy and reduce post-operative bleeding:a randomized controlled trial显示文摘Background:Nasal insertion is the preferred method for non-intubated patients in flexible bronchoscopy;however,the relatively narrow nasal cavity results in difficulties related to bronchoscope insertion.This study aimed to investigate whether pre-operative nasal probe tests could reduce the time to pass the glottis,improve the first-pass success rate and patients’tolerance,and reduce postoperative bleeding.Methods:This three-arm prospective randomized controlled trial was conducted in a tertiary hospital between May and October 2020.Three hundred patients requiring diagnosis and treatment using flexible bronchoscopy were randomly allocated to three groups:control group,simple cotton bud detection group(CD group),and adrenaline+lidocaine detection group(AD group).The primary outcome was the time to pass the glottis.Secondary outcomes included the first-pass success rate,the patients’tolerance scores,and post-operative bleeding.One-way analysis of variance,Kruskal-WallisH test,Chi-squared test,Fisher’s exact test,and Bonferroni’s multiple comparison tests were used in this study.Results:In total,189 men and 111 women were enrolled in this study,with a mean age of 55.72±12.86 years.The insertion time was significantly shorter in the AD group than in the control group(18.00 s[12.00–26.50 s]vs.24.00 s[14.50–45.50 s],P=0.005).Both the AD(99%vs.83%,χ2=15.62,P<0.001)and CD groups(94%vs.83%,χ2=5.94,P=0.015)had a significantly higher first-pass success rate than the control group.Compared with the control group,post-operative bleeding(1%vs.13%,χ2=11.06,P<0.001)was significantly lower in the AD group.However,no significant difference was found in the patients’tolerance scores.Conclusions:Pre-operative nasal cavity probe tests especially with adrenaline and lidocaine during flexible bronchoscopy can significantly reduce the time to pass the glottis,improve the first-pass success rate,and reduce post-operative nasal bleeding.Pre-operative nasal probe tests are recommended as a time-saving procedure for patients undergoing flexible bronchoscopy.Trial registration:Chinese Clinical Trial Registry(ChiCTR),ChiCTR2000032668;http://gffzz62a03ee25e6f4a77hcuocok5up6kx6onq.ffgz.tsg.suse.edu.cn/showprojen.aspx?proj=53321. | Wenjun Zhu Yuchen Zhang Jingyu Shi Xiaoqin Wang Renjiao Li Jia Liu Ping Li Dan Liu Fengming Luo | 2022 | Chinese Medical Journal2022，，15： | 0 |
| 20 | Research and application of leek roots in medicinal field显示文摘Some Chinese herbs have been used to prevent and treat diseases,and are also used as common food ingredients.These Chinese herbs are potential resource for research and development of new drugs.Leek roots is a typical medicine of food and medicine continuum.It has a long history of medicinal applications and edible food in China.In this paper,the origin,biological active components,pharmacological action and clinical application of leek roots were introduced.We hope that this review will contribute to the development of leek roots for pharmaceutical research and clinical applications,as well as related health products. | Huaijian Wang Ying Tian Hao Tan Mengru Zhou Miao Li Yuchen Zhi Yanbin Shi Xuefeng Li | 2023 | Chinese Herbal Medicines2023，15，3： | 0 |
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