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| 1 | Occurrence of the Iron–rich Melt in the Heijianshan Iron Deposit, Eastern Tianshan, NW China: Insights into the Origin of Volcanic Rock–hosted Iron Deposits显示文摘Long-standing controversy persists over the presence and role of iron–rich melts in the formation of volcanic rock-hosted iron deposits. Conjugate iron–rich and silica–rich melt inclusions observed in thin-sections are considered as direct evidence for the presence of iron-rich melt, yet unequivocal outcrop-scale evidence of iron-rich melts are still lacking in volcanic rock-hosted iron deposits. Submarine volcanic rock-hosted iron deposits, which are mainly distributed in the western and eastern Tianshan Mountains in Xinjiang, are important resources of iron ores in China, but it remains unclear whether iron-rich melts have played a role in the mineralization of such iron ores. In this study, we observed abundant iron-rich agglomerates in the brecciated andesite lava of the Heijianshan submarine volcanic rock–hosted iron deposit, Eastern Tianshan, China. The iron-rich agglomerates occur as irregular and angular masses filling fractures of the host brecciated andesite lava. They show concentric potassic alteration with silicification or epidotization rims, indicative of their formation after the wall rocks. The iron-rich agglomerates have porphyritic and hyalopilitic textures, and locally display chilled margins in the contact zone with the host rocks. These features cannot be explained by hydrothermal replacement of wall rocks(brecciated andesite lava) which is free of vesicle and amygdale, rather they indicate direct crystallization of the iron-rich agglomerates from iron-rich melts. We propose that the iron-rich agglomerates were formed by open-space filling of volatile-rich iron-rich melt in fractures of the brecciated andesite lava. The iron-rich agglomerates are compositionally similar to the wall-rock brecciated andesite lava, but have much larger variation. Based on mineral assemblages, the iron-rich agglomerates are subdivided into five types, i.e., albite-magnetite type, albite-K-feldsparmagnetite type, K-feldspar–magnetite type, epidote-magnetite type and quartz-magnetite type, representing that products formed at different stages during the evolution of a magmatic-hydrothermal system. The albite-magnetite type represents the earliest crystallization product from a residual ironrich melt; the albite-K-feldspar-magnetite and K-feldspar-magnetite types show features of magmatichydrothermal transition, whereas the epidote-magnetite and quartz-magnetite types represent products of hydrothermal alteration. The occurrence of iron-rich agglomerates provides macroscopic evidence for the presence of iron-rich melts in the mineralization of the Heijianshan iron deposit. It also indicates that iron mineralization of submarine volcanic rock-hosted iron deposits is genetically related to hydrothermal fluids derived from iron-rich melts. | LI Houmin LI Lixing DING Jianhua LI Yanhe SONG Zhe MENG Jie MA Yubo | 2018 | Acta Geologica Sinica(English Edition)2018，92，2： | 5 |
| 2 | Water filtration rate and infiltration/accumulation of low density lipoproteins in 3 different modes of endothelial/smooth muscle cell co-cultures显示文摘Using different endothelial/smooth muscle cell co-culture modes to simulate the intimal structure of blood vessels, the water filtration rate and the infiltration/accumulation of LDL of the cultured cell layers were studied. The three cell culture modes of the study were: (i) The endothelial cell monolayer (EC/Φ); (ii) endothelial cells directly co-cultured on the smooth muscle cell monolayer (EC-SMC); (iii) endothelial cells and smooth muscle cells cultured on different sides of a Millicell-CM membrane (EC/SMC). It was found that under the same condition, the water filtration rate was the lowest for the EC/SMC mode and the highest for the EC/Φ mode, while the infiltration/accumulation of DiI-LDLs was the lowest in the EC/Φ mode and the highest in the EC-SMC mode. It was also found that DiI-LDL infiltration/accumulation in the cultured cell layers increased with the increasing water filtration rate. The results from the in vitro model study therefore suggest that the infiltration/accumulation of the lipids within the arterial wall is positively correlated with concentration polarization of atherogenic lipids, and the integrity of the endothelium plays an important role in the penetration and accumulation of atherogenic lipids in blood vessel walls. | DING ZuFeng, FAN YuBo & DENG XiaoYan School of Biological Science & Medical Engineering, Beihang University, Beijing 100191, China | 2009 | Science China(Life Sciences)2009，52，11： | 4 |
| 3 | The molecular chaperone Hsp90α deficiency causes retinal degeneration by disrupting Golgi organization and vesicle transportation in photoreceptors显示文摘Heat shock protein 90(Hsp90)is an abundant molecular chaperone with two isoforms,Hsp90α and Hsp90p.Hsp90β deficiency causes embryonic lethality,whereas Hsp90α deficiency causes few abnormities except male sterility.In this paper,we reported that Hsp90α was exclusively expressed in the retina,testis,and brain.Its deficiency caused retinitis pigmentosa(RP),a disease leading to blindness.In Hsp90α-deficient mice,the retina was deteriorated and the outer segment of photoreceptor was deformed.Immunofluorescence staining and electron microscopic analysis revealed disintegrated Golgi and aberrant intersegmental vesicle transportation in Hsp90α-deficient photoreceptors.Proteomic analysis identified microtubule-associated protein IB(MAP1B)as an Hsp90α-associated protein in photoreceptors.Hspcx deficiency increased degradation of MAP1B by inducing its ubiquitination,causing a-tubulin deacetylation and microtubule destabilization.Furthermore,the treatment of wild-type mice with 17-DMAG,an Hsp90 inhibitor of geldanamycin derivative,induced the same retinal degeneration as Hsp90α deficiency.Taken together,the microtubule destabilization could be the underlying reason for Hsp90α deficiency-induced RP. | Yuan Wu Xiudan Zheng Yubo Ding Min Zhou Zhuang Wei Tao Liu Kan Liao | 2020 | Journal of Molecular Cell Biology2020，12，3： | 4 |
| 4 | Proteomic profiling of lipid droplet-associated proteins in primary adipocytes of normal and obese mouse显示文摘在 adipocytes 的类脂化合物微滴用作动物的主要长期的精力存储仓库。正在增加类脂化合物微滴不仅仅是一个静态的中立类脂化合物存储地点,而是事实上有活力、多功能的细胞器的识别。在结构上,类脂化合物微滴由嵌入在或跳了到 phospholipid 层的 phospholipid 单层和蛋白质包围的一个中立类脂化合物核心组成。类脂化合物微滴的表面上的蛋白质对微滴结构和动力学关键。理解类脂化合物有大中央类脂化合物微滴的主要 adipocyte 的联系微滴的 proteome,从 C57BL/6 老鼠的白脂肪质的织物的类脂化合物微滴被孤立。,和由结合的液体层析双人脚踏车团 spectrometry。以前包括 73 的 193 蛋白质的一个总数 unreported 蛋白质被识别。而且,编码同位素的亲密关系标签(ICAT ) 被用来比较类脂化合物的差别在瘦的正常和高脂肪的导致食谱的肥胖的 C57BL/6 老鼠之间的联系微滴的 proteomes。23,蛋白质由 ICAT 分析确定了, 3 蛋白质是起来调整的, 4 蛋白质在从肥胖的老鼠的脂肪质的织物的类脂化合物微滴是下面调整的。重要地,类脂化合物微滴, perilipin A 和 vimentin 的二结构的蛋白质,极大地从肥胖的老鼠在脂肪质的织物的类脂化合物微滴被减少,为类脂化合物的含有的减少的蛋白质机械微滴稳定性。 | Yubo Ding Yibo Wu Rong Zeng Kan Liao | 2012 | Acta Biochimica et Biophysica Sinica2012，44，5： | 3 |
| 5 | The molecular chaperone Hsp90 maintains Golgi organization and vesicular trafficking by regulating microtubule stability显示文摘Hsp90 is an abundant and special molecular chaperone considered to be the regulator of many transcription factors and signaling kinases. Its high abundance is indicative of its involvement in some more fundamental processes. In this study, we provide evidence that Hsp90 is required for microtubule stabilization, Golgi organization, and vesicular trafficking. We showed that Hsp90 is bound to microtubule-associated protein 4 (MAP4), which is essential for maintaining microtubule acetylation and stabilization. Hsp90 depletion led to the decrease in MAP4, causing microtubule deacetylation and destabilization. Furthermore, in Hsp90-depleted cells, the Golgi apparatus was fragmented and anterograde vesicle trafficking was impaired, with phenotypes similar to those induced by silencing MAP4. These disruptive effects of Hsp90 depletion could be rescued by the expression of exogenous MAP4 or the treatment of trichostatin A that increases microtubule acetylation as well as stability. Thus, microtubule stability is an essential cellular event regulated by Hsp90. | Yuan Wu Yubo Ding Xiudan Zheng Kan Liao | 2020 | Journal of Molecular Cell Biology2020，12，6： | 3 |
| 6 | The effect of mechanical loads on the degradation of aliphatic biodegradable polyesters显示文摘Aliphatic biodegradable polyesters have been the most widely used synthetic polymers for developing biodegradable devices as alternatives for the currently used permanent medical devices.The performances during biodegradation process play crucial roles for final realization of their functions.Because physiological and biochemical environment in vivo significantly affects biodegradation process,large numbers of studies on effects of mechanical loads on the degradation of aliphatic biodegradable polyesters have been launched during last decades.In this review article,we discussed the mechanism of biodegradation and several different mechanical loads that have been reported to affect the biodegradation process.Other physiological and biochemical factors related to mechanical loads were also discussed.The mechanical load could change the conformational strain energy and morphology to weaken the stability of the polymer.Besides,the load and pattern could accelerate the loss of intrinsic mechanical properties of polymers.This indicated that investigations into effects of mechanical loads on the degradation should be indispensable.More combination condition of mechanical loads and multiple factors should be considered in order to keep the degradation rate controllable and evaluate the degradation process in vivo accurately.Only then can the degradable devise achieve the desired effects and further expand the special applications of aliphatic biodegradable polyesters. | Ying Li Zhaowei Chu Xiaoming Li Xili Ding Meng Guo Haoran Zhao Jie Yao Lizhen Wang Qiang Cai Yubo Fan | 2017 | Regenerative Biomaterials2017，4，3： | 2 |
| 7 | Lectin-like oxidized low-density lipoprotein receptor-1 regulates autophagy and Toll-like receptor 4 in the brain of hypertensive mice显示文摘 | Zufeng Ding Shijie Liu Xianwei Wang Magomed Khaidakov Yubo Fan Xiaoyan Deng David Xiang Jawahar L. Mehta | 2015 | Journal of Hypertension2015，，3： | 1 |
| 8 | 2020 update on human coronaviruses:One health,one world显示文摘Since human coronavirus(HCoVs)was first described in the 1960s,seven strains of respiratory human coronaviruses have emerged and caused human infections.After the emergence of severe acute respiratory syndrome coronavirus(SARS-CoV)and Middle East respiratory syndrome coronavirus(MERS-CoV),a pneumonia outbreak of coronavirus disease 2019(COVID-19)caused by a novel coronavirus(SARS-CoV-2)has represented a pandemic threat to global public health in the 21st century.Without effectively prophylactic and therapeutic strategies including vaccines and antiviral drugs,these three coronaviruses have caused severe respiratory syndrome and high case-fatality rates around the world.In this review,we detail the emergence event,origin and reservoirs of all HCoVs,compare the differences with regard to structure and receptor usage,and summarize therapeutic strategies for COVID-19 that cause severe pneumonia and global pandemic. | Xinbin Zhao Yuecheng Ding Jing Du Yubo Fan | 2020 | Medicine in Novel Technology and Devices2020，，4： | 1 |
| 9 | Effect of LDL concentration polarization on the uptake of LDL by human endothelial cells and smooth muscle cells co-cultured显示文摘为了证实我们的假设,低密度的脂蛋白( LDL )的那集中极化在 atherogenesis 的本地化起一个重要作用,我们调查了墙的效果砍压力和水过滤率(或灌注压力)在钠表面 LDL 集中( cw )和由人的脉管的 endothelial 房间和在可渗透的膜上co有教养的光滑的肌肉房间的 LDL 举起上使用一种平行板的流动房间技术和一个流动 cytometry 方法。结果显示举起荧光灯由 co 有教养的房间的标记的 LDL (DiI-LDL ) 断然以一种非线性的方式与 cw 被相关。当 cw 是低的时,举起与增加 cw 很严厉地增加了。然后,增加变得渐渐,当 cw 在远处到达了 160 g/ml 时,举起看起来外面被铺平。现在的学习因此提供了那集中极化可以在动脉的系统发生并且由动脉的墙与 LDL 的举起有积极关联的进一步试验性的证据,它关于 atherogenesis 的本地化支持我们的假设。 | Zufeng Ding Yubo Fan Xiaoyan Deng | 2009 | Acta Biochimica et Biophysica Sinica2009，41，2： | 1 |
| 10 | Molecular cloning and functional analysis of a recombinant ribosome-inactivating protein (alpha-momorcharin) from Momordica charantia显示文摘 | Shuzhen Wang Yubo Zhang Honggao Liu Ying He Junjie Yan Zhihua Wu Yi Ding | 2012 | Applied Microbiology and Biotechnology2012，，4： | 1 |
| 11 | A computational fluid study on hemodynamics in visceral arteries in a complicated type B aortic dissection after thoracic endovascular repair显示文摘Objective:To report a numerical research on the effect of a renal artery arising from false lumen(FL)on the treatment outcome of thoracic endovascular repair(TEVAR)for complicated type B aortic dissection(TBAD).Methods:The original patient-specific model with the right renal artery(RRA)partially supplied by the FL(TFM)was reconstructed from its postoperative computed tomography images.Two additional models were reconstructed by artificially modifying the RRA either fully arising from the FL(CFM)or true lumen(CTM).Computational fluid dynamics(CFD)simulations were performed.Results:First,for all the models,the flow splits to all the visceral arteries were much less than those of a healthy aorta.Second,the flow split to RRA in the CFM and in CTM was the least and largest respectively.Third,in TFM,the pressure gradient between the true lumen(TL)and FL was negative at the proximal FL and the entire FL was full of active blood flow.In the contrast,in CTM and CFM,the pressure differences between the two lumens remained positive and little flow was present in FL.Finally,both TL and proximal FL of this particular patient expanded and the diameters of all visceral arteries decreased at one-year follow-up.Conclusions:Compared to a healthy aorta,a renal artery arising from FL following TEVAR would result in severe visceral ischemia including RA and superior mesenteric artery(SMA).In addition,our numerical simulation of the postoperative hemodynamics of this particular patient perfectly matched with its TL remodeling,FL expansion and contraction of the visceral arteries at one-year follow-up,and a patient-specific CFD simulation may be adopted to obtain information on visceral perfusion after endovascular repair for TBAD patients. | Kaihong Wang Da Li Ding Yuan Jichun Zhao Tinghui Zheng Yubo Fan | 2021 | Medicine in Novel Technology and Devices2021，，1： | 0 |
| 12 | Effect of swirling flow on LDL and ox-LDL uptake in rabbit thoracic aorta显示文摘Object To elucidate the physiological significance of the spiral flow in the arterial system from the viewpoint of atherogenic lipid transport,an ex vivo experimental comparative | Zufeng Ding,Xiaoyan Deng,Yubo Fan,Fan Zhan,Hongyan Kang(School of Biological Science and Medical Engineering,Beihang University,Beijing,China) | 2009 | 医用生物力学2009，24，S1： | 0 |
| 13 | The Regulatory Effect of Braided Silk Fiber Skeletons with Differential Porosities on In Vivo Vascular Tissue Regeneration and Long-Term Patency显示文摘The development of small-diameter vascular grafts that can meet the long-term patency required for implementation in clinical practice presents a key challenge to the research field.Although techniques such as the braiding of scaffolds can offer a tunable platform for fabricating vascular grafts,the effects of braided silk fiber skeletons on the porosity,remodeling,and patency in vivo have not been thoroughly investigated. | Xili Ding Weirong Zhang Peng Xu Wentao Feng Xiaokai Tang Xianda Yang Lizhen Wang Linhao Li Yan Huang Jing Ji Diansheng Chen Haifeng Liu Yubo Fan | 2023 | Research2023，，2： | 0 |
| 14 | A Scalable Synthesis of 6,19-Dihydroxyandrostenedione显示文摘从商业地可得到的 19-hydroxyandrostenedione 开始,为 6,19-dihydroxyandrostenedione 的准备的一个实际协议被报导。这混合物是为 cyclocitrinols 的合成的关键中介。与到钥匙走的 allylic 酒精的 stereospecific epoxidation 和后面的异构化,一个六步的过程在高产量提供了需要的产品。没有勤劳层析的需要,顺序对按比例增加容易。 | Yubo Yan Ting Li Tao Liu Qingyu Dou Kai Ding Weisheng Tian | 2013 | Chinese Journal of Chemistry2013，31，1： | 0 |
| 15 | Biomechanical study on implantable and interventional medical devices显示文摘Implants,including artificial joints,bone fixation devices,and other orthopedic implants,oral implants,and vascular interventional devices,are used to repair or replace human tissues or organs and restore their functions.Since biodegradable implants have advantage of avoiding long-term complications(including bone stress shielding,restenosis,thrombosis,and secondary surgery)while remaining safe and productive,personalized biodegradable implants will be an irresistible trend in the clinic for implantable and interventional medical devices.However,innovation of personalized biodegradable implants faces several challenges,including the interaction between the implant and its surrounding tissues or cells,the coordination of structural strength of implants and its degradation,the topological microstructure of implant and its fatigue properties,reliability,and safety.In this review,we introduced critical progresses achieved in the fields related to implants,including mechanical properties of materials,interaction between implants and host tissue,effect of stress on degradation;furthermore,we highlighted the optimized design and manufacture of implants as well as the evaluation of their reliability. | Lizhen Wang Xili Ding Wentao Feng Yuanming Gao Shudong Zhao Yubo Fan | 2021 | Acta Mechanica Sinica2021，37，6： | 0 |
| 16 | Reshapeable,rehealable and recyclable sensor fabricated by direct ink writing of conductive composites based on covalent adaptable network polymers显示文摘Covalent adaptable network(CAN)polymers doped with conductive nanoparticles are an ideal candidate to create reshapeable,rehealable,and fully recyclable electronics.On the other hand,3D printing as a deterministic manufacturing method has a significant potential to fabricate electronics with low cost and high design freedom.In this paper,we incorporate a conductive composite consisting of polyimine CAN and multi-wall carbon nanotubes into direct-ink-writing 3D printing to create polymeric sensors with outstanding reshaping,repairing,and recycling capabilities.The developed printable ink exhibits good printability,conductivity,and recyclability.The conductivity of printed polyimine composites is investigated at different temperatures and deformation strain levels.Their shape-reforming and Joule heating-induced interfacial welding effects are demonstrated and characterized.Finally,a temperature sensor is 3D printed with defined patterns of conductive pathways,which can be easily mounted onto 3D surfaces,repaired after damage,and recycled using solvents.The sensing capability of printed sensors is maintained after the repairing and recycling.Overall,the 3D printed reshapeable,rehealable,and recyclable sensors possess complex geometry and extend service life,which assist in the development of polymer-based electronics toward broad and sustainable applications. | Xu He Yuchen Lin Yuchen Ding Arif M Abdullah Zepeng Lei Yubo Han Xiaojuan Shi Wei Zhang Kai Yu | 2022 | International Journal of Extreme Manufacturing2022，4，1： | 0 |
| 17 | Jointly Part-of-Speech Tagging and Semantic Role Labeling Using Auxiliary Deep Neural Network Model显示文摘Previous studies have shown that there is potential semantic dependency between part-of-speech and semantic roles.At the same time,the predicate-argument structure in a sentence is important information for semantic role labeling task.In this work,we introduce the auxiliary deep neural network model,which models semantic dependency between part-of-speech and semantic roles and incorporates the information of predicate-argument into semantic role labeling.Based on the framework of joint learning,part-of-speech tagging is used as an auxiliary task to improve the result of the semantic role labeling.In addition,we introduce the argument recognition layer in the training process of the main task-semantic role labeling,so the argument-related structural information selected by the predicate through the attention mechanism is used to assist the main task.Because the model makes full use of the semantic dependency between part-of-speech and semantic roles and the structural information of predicate-argument,our model achieved the F1 value of 89.0%on the WSJ test set of CoNLL2005,which is superior to existing state-of-the-art model about 0.8%. | Yatian Shen Yubo Mai Xiajiong Shen Wenke Ding Mengjiao Guo | 2020 | Computers, Materials & Continua2020，，10： | 0 |
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