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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Major complications of operative and diagnostic lapar0scopy for gynecologic disease 显示文摘 | WANG PH LEE WL YUAN CC | 2001 | J Am Assoc Gynecol Laparosc2001，8，1： | 1 |
| 3 | Major complications of operative and diagnostic laparoscopy for gynecologic disease显示文摘 | Wang PH Lee WL Yuan CC | 2001 | J Am Assoc Gynecol laparosc2001，8，1： | 1 |
| 4 | Regulation of transport pathways in tumor vessels:role of tumor type and microenvironment显示文摘 | Hobbs SK Monsky WL Yuan F | 1998 | Proc Natl Acad Sci USA1998，95，： | 1 |
| 5 | Major complications of operative and dingnostic laparoscopy for gynecologic disease显示文摘 | Wang DH Lee WL Yuan CC | 2001 | J Am Assoc Gynecol Laparosc2001，8，： | 1 |
| 6 | Major complications of operative and diagnostic laparoscopy for gynecologic disease 显示文摘 | Wang PH Lee WL Yuan CC | 2001 | J Am Assoc Gynecol Lparosc2001，8，1： | 1 |
| 7 | Clinical Follow- Up Study on Diatetes Patients Participating in a Health Management Plan 显示文摘 | Tang PL Yuan WL Tseng HF | 2005 | Journal of Nursing Research2005，4，13： | 1 |
| 8 | Effects of electro-acupuncture on the expression of c-jun and c-fos in spared dorsal root ganglion and associated spinal laminae following removal of adjacent dorsal root ganglia in cats显示文摘 | Wang TT Yuan WL Ke Q | 2006 | Neuroscience2006，140，4： | 1 |
| 9 | Major complications of operative and diagnostic laparoscopy for gynecologic disease显示文摘 | Wang PH Lee WL Yuan cc | 2001 | J A m Assoc Gynecol Lapamsc2001，8，1： | 1 |
| 10 | Regulation of transport pathways in tumor vessels:Role of tumor type and microenviron- ment 显示文摘 | Hobbs SK Monsky WL Yuan F | 1998 | Proc Na1998，95，8： | 1 |
| 11 | Major complications of operarive and diagnostic laparoscopy for gynecologic disease显示文摘 | Wang PH Lee WL Yuan CC | 2001 | J Am Assoc Gynecol Lparons2001，8，1： | 1 |
| 12 | Clinical Follow-Up Study on Diatetes Patients Participating in a Health Management Plan 显示文摘 | Tang PL Yuan WL Tseng HF | 2005 | Journal of Nursing Research2005，4，13： | 1 |
| 13 | Preliminary Study of the Effect ofFK506 Nanospheric-Suspension Eye Drops on Rejection of Pene-trating Keratoplasty 显示文摘 | Fei WL Chen JQ Yuan J | 2008 | J Ocul Pharaiacol Ther2008，24，2： | 1 |
| 14 | Comparison of photodynamic therapy and pulsed dye laser in patients with port wine stain birthmarks: a retrospective analysis显示文摘 | Yuan KH Li Q Yu WL | 2008 | Photodiag Photodyn Ther2008，5，1： | 1 |
| 15 | Photodynamic therapy in treatment of port wine stain birthmarks--recent progress显示文摘 | Yuan KH Li Q Yu WL | 2009 | Photodiag Photodyn Ther2009，6，34： | 1 |
| 16 | Comparisoa phmdrncmetherapy and pulsed dye laser in pcttints with pm wine stain birth-aiiLS: a retroective analysis 显示文摘 | Yuan KH Li Q Yu WL | | fotodiio&is Photorn T-her 2O08 5(l)0，557，： | 1 |
| 17 | Regulation of transport pathways in rumor vessels: role of tumor type and micrcenvironment显示文摘 | Hobbs SK Monsky WL Yuan F | 1998 | Proc NatlAcad Sci USA1998，95，8： | 1 |
| 18 | Brahma- related gene 1 inhibits proliferation and migration of human aortic smooth muscle cells by directly up - regulating Ras - related associated with diabetes in the pathophysiologic processes of aortic dissection 显示文摘 | Liao WL Tan MW Yuan Y | 2015 | J Thorac Cardiovasc Surg2015，150，5： | 1 |
| 19 | Expancling the epi- demioogic profile:Risk factors for active tuberculosis in people immi- grating to ontario显示文摘 | WOBESER WL YUAN L NAUS M | 2000 | CMAJ2000，163，7： | 1 |
| 20 | A cyclooxygenase-2-dependent prostaglandin E2biosynthetic system in the Golgi apparatus显示文摘 | Yuan C Smith WL | 2015 | J Biol Chem2015，290，： | 1 |
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