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| 1 | Endoplasmic reticulum stress-mediated pathways to both apoptosis and autophagy: Significance for melanoma treatment显示文摘Melanoma is the most aggressive form of skin cancer.Disrupted intracellular signaling pathways are responsible for melanoma's extraordinary resistance to current chemotherapeutic modalities. The pathophysiologic basis for resistance to both chemo- and radiation therapy is rooted in altered genetic and epigenetic mechanisms that, in turn, result in the impairing of cell death machinery and/or excessive activation of cell growth and survival-dependent pathways. Although most current melanoma therapies target mitochondrial dysregulation,there is increasing evidence that endoplasmic reticulum(ER) stress-associated pathways play a role in the potentiation,initiation and maintenance of cell death machinery and autophagy. This review focuses on the reliability of ER-associated pathways as therapeutic targets for melanoma treatment. | Mohamed Hassan Denis Selimovic Matthias Hannig Youssef Haikel Robert T Brodell Mossaad Megahed | 2015 | World Journal of Experimental Medicine2015，5，4： | 15 |
| 2 | HepG2 cells support viral replication and gene expression of hepatitis C virus genotype 4 in vitro显示文摘瞄准:与丙肝的长期的复制建立一个房间文化系统病毒(HCV ) 染色体和病毒的抗原的表示在试管内。方法:HepG2 房间线被孵化与长期的丙肝从一个病人与浆液为它的危险性测试到 HCV。房间和上层清液在文化期间在各种各样的时间点被收获。文化上层清液为它感染天真的房间的能力被测试。存在减(反感觉) 在房间的核心和 E1 抗原的 RNA 海滨,和察觉被 RT-PCR 和免疫学的技术(流动血细胞计数和西方的污点) 分别地检验。结果:细胞内部的 HCV RNA 首先在 d 上被检测 3 在感染以后然后能一致地在至少三个月的一个时期上在房间和上层清液被检测。新鲜房间能从有教养的感染的房间感染上层清液。流动 cytometric 分析证明表面和在房子里使用的细胞内部的 HCV 抗原表示使 polyclonal 成为了抗体(反核心,和 anti-E1 ) 。西方的污点分析证明在分子量的产生免疫性的肽的簇的表示在一个月内在 31 和 45 kDa 之间延长了感染的房间的旧文化而这簇在 uninfected HepG2 房间是无法发现的。结论:HepG2 房间线产生 HCV 感染而且支持它的复制在试管内不仅。HCV 结构的蛋白质的表示能在感染的 HepG2 房间被检测。这些房间也能够流病毒的粒子进接着对 uninfected 房间变得传染的培养基。 | Mostafa K El-Awady Ashraf A Tabll Yasmine S El-Abd Mahmoud M Bahgat Hussein A Shoeb Samar S Youssef Noha G Bader El Din El-Rashdy M Redwan Maha El-Demellawy Moataza H Omran Wael T El-Garf Said A Goueli | 2006 | World Journal of Gastroenterology2006，12，30： | 2 |
| 3 | Radiolarian and Planktic Foraminifera Biostratigraphy of the Early Albian Organic Rich Beds of Fahdene Formation,Northern Tunisia显示文摘The lower part of Fahdene Formation outcropping in northeastern Tunisia is represented by pelagic sequences and characterized by an important siliciclastic fraction that includes radiolarian and organic-rich beds of Allam Member.?Litho-biostratigraphic analysis based on planktic foraminifera and radiolaria shows that deposition of organic-rich beds of Allam Member is confined to the Microhedbergella rischi Zone through the lower part of Ticinella primula Zone.?Age diagnostic radiolaria recovered from these beds has been identified to constrain a direct age of black shale deposition.The assemblages can be correlated with the radiolarian biochronozone U.A.10–11 indicating an Early Albian to early Middle Albian in age.Radiolarian assemblages composed of species characteristic of U.A.10 biochronozone(A.montisserei,D.gracilis)are associated with radiolarian taxa belonging to Costata Zone(U.A.9 Pseudoeucyrtis hanni and Thanarla pseudodecora),which can be correlated with Dercourt Member in the Ionian Zone and Paquier level of the Vocontian Basin(southeast of France).Biostratigraphic and abundance curves analysis has demonstrated significant diversification of cryptocephalic Nassellaria and Archaeodictyomitrae,probably adapted to eutrophic conditions that characterized the Aptian-Albian transition.Ecological conditions may have governed the stratigraphic range of many cosmopolitan taxa(i.e.,Pseudodictyomitrae lodogaensis)compared with stratigraphic distributions schemes reported from other domains.The timing of black shales deposition was diachronic due to local geodynamic conditions and upwelling currents distribution.The Allam black shales are correlative with the oceanic anoxic event OAE1b which is characterized by the widespread of supraregionnally organic-rich beds in the Mediterranean Tethys basins across the Aptian-Albian transition. | M Ben Fadhel T Zouaghi A Amri M Ben Youssef | 2014 | Journal of Earth Science2014，25，1： | 2 |
| 4 | Substitution of wheat starch with non-wheat starches and cross-linked waxy barley starch affects sensory properties and staling of Arabic bread显示文摘 | Imad T Youssef H Sossy S et a1 | 1999 | Journal of the Science of Food and Agriculture1999，79，： | 1 |
| 5 | Primary hyperoxaluria type 1 in Tunisian children显示文摘 | Gargah T Khelil N Youssef G | | 0，，2： | 1 |
| 6 | The prognostic role of u- terine atery Doppler studies in patients with late - onset preeclampsia显示文摘 | Ghi T Youssef A Piva M | 2009 | Am J Obstet Gynec012009，201，1： | 1 |
| 7 | Radiolabeled cell distribution after intramyocardial,intracoronary,and interstitial retrograde coronary venous delivery:implications for current clinical trials显示文摘 | Hou D Youssef E A Brinton T J | 2005 | Circulation2005，112，9： | 1 |
| 8 | Disturbance classification utilizing dynamic time warping classifier显示文摘 | Youssef A M Abdel-Galil T K El-Saadany E F | 2004 | IEEE Trans on Power Delivery2004，19，1： | 1 |
| 9 | Type Ⅱ monocytes modulate T cell-mediated central nervous system autoimmune disease显示文摘 | Prod'homme T Youssef S | 2007 | Nat Med2007，13，： | 1 |
| 10 | Rhamnolipid Biosurfactant Mixtures for Environmental Remeditation 显示文摘 | Nguyen Thu T Youssef Noha H Melnemey Miehael J | 2008 | Water Res2008，42，67： | 1 |
| 11 | Substitution of wheat starch with non-wheat starches and cross-linked waxy barley starch affects sensory properties and staling of Arabic bread显示文摘 | Imad T Youssef H Sossy S | 1999 | Journal of the Science of Food and Agriculture1999，79，： | 1 |
| 12 | Comparative study between bo- tulinum toxin injection and partial division of pnborectalis for treating anismus显示文摘 | Farid M Youssef T Mahdy T | 2009 | Int J Colorectal Dis2009，24，3： | 1 |
| 13 | Thyroid surgery: Use of the LigaSure vessel sealing system versus conventional knot tying显示文摘 | Youssef T Mahdy T Farid M | 2008 | Int J Surg2008，6，4： | 1 |
| 14 | Advanced glycation end products and thei-r receptors co-localise in rat organs susceptible to diabetic microvascular injury显示文摘 | Soulis T Thallas V Youssef S | 1997 | Diabetologia1997，40，6： | 1 |
| 15 | Type II monocytes modulate T cell-mediated central nervous system autoimmune disease 显示文摘 | Weber M S Prod′ homme T Youssef S | 2007 | Nat Med2007，13，8： | 1 |
| 16 | Disturb- ance Classification Utilizing Dynamic Time Warping Classifier 显示文摘 | Youssef A M Abdel - Galil T K El - Saadany E F | 2004 | IEEE Transactions on Power Delivery2004，19，1： | 1 |
| 17 | Oxidative stress in Alz- heimer's disease: Primary villain or physiological by-product 显示文摘 | Sutherland G T Chami B Youssef P | 2013 | Redox Report2013，18，4： | 1 |
| 18 | Randomized clinical trial of Desarda versus Lichtenstein repair for treatment of pri- mary inguinal hernia显示文摘 | Youssef T El-Ally K Farid M | 2015 | In J Surg2015，20，： | 1 |
| 19 | Overexpression of cyclinD1 in rat esophageal carcinogenesis model显示文摘 | Youssef EM Hasuma T Morishima Y | 1997 | Jpn J Cancer Res1997，88，1： | 1 |
| 20 | Anatomical adaptive strategies to flooding and rhizophere oxidation in mangrove seedlings显示文摘 | YOUSSEF T SAENGER P | 1996 | Aust J Bot1996，44，： | 1 |
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