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| 1 | Deep-learning-based inverse design model for intelligent discovery of organic molecules显示文摘The discovery of high-performance functional materials is crucial for overcoming technical issues in modern industries.Extensive efforts have been devoted toward accelerating and facilitating this process,not only experimentally but also from the viewpoint of materials design.Recently,machine learning has attracted considerable attention,as it can provide rational guidelines for efficient material exploration without time-consuming iterations or prior human knowledge.In this regard,here we develop an inverse design model based on a deep encoder-decoder architecture for targeted molecular design.Inspired by neural machine language translation,the deep neural network encoder extracts hidden features between molecular structures and their material properties,while the recurrent neural network decoder reconstructs the extracted features into new molecular structures having the target properties.In material design tasks,the proposed fully data-driven methodology successfully learned design rules from the given databases and generated promising light-absorbing molecules and host materials for a phosphorescent organic light-emitting diode by creating new ligands and combinatorial rules. | Kyungdoc Kim Seokho Kang Jiho Yoo Youngchun Kwon Youngmin Nam Dongseon Lee Inkoo Kim Youn-Suk Choi Yongsik Jung Sangmo Kim Won-Joon Son Jhunmo Son Hyo Sug Lee Sunghan Kim Jaikwang Shin Sungwoo Hwang | 2018 | npj Computational Materials2018，，1： | 4 |
| 2 | Interleukin-24 is correlated with differentiation and lymph node numbers in rectal cancer显示文摘AIM:To assess the significance of interleukin(IL)-24 and vascular endothelial growth factor(VEGF)expression in lymph-node-positive rectal cancer. METHODS:Between 1998 and 2005,90 rectal adenocarcinoma patients with lymph node involvement were enrolled.All patients received radical surgery and postoperative pelvic chemoradiotherapy of 50.4-54.0 Gy.Chemotherapy of 5-fluorouracil and leucovorin or levamisole was given intravenously during the first and last week of radiotherapy,and then monthly for about 6 mo.Expression of IL-24 and VEGF was evaluated by immunohistochemical staining of surgical specimens, and their relations with patient characteristics and survival were analyzed.The median follow-up of surviving patients was 73 mo(range:52-122 mo). RESULTS:IL-24 expression was found in 81 out of 90 patients;31 showed weak intensity and 50 showedstrong intensity.VEGF expression was found in 64 out of 90 patients.Negative and weak intensities of IL-24 expression were classified as negative expression for analysis.IL-24 expression was significantly reduced in poorly differentiated tumors in comparison with well or moderately differentiated tumors(P=0.004),N2b to earlier N stages(P=0.016),and stageⅢc to stageⅢ a orⅢb(P=0.028).The number of involved lymph nodes was also significantly reduced in IL-24-positive patients in comparison with IL-24-negative ones. There was no correlation between VEGF expression and patient characteristics.Expression of IL-24 and VEGF was not correlated with survival,but N stage and stages were significantly correlated with survival. CONCLUSION:IL-24 expression was significantly correlated with histological differentiation,and inversely correlated with the degree of lymph node involvement in stageⅢrectal cancer. | Youngmin Choi Mee-Sook Roh Young-Seoub Hong Hyung-Sik Lee Won-Joo Hur | 2011 | World Journal of Gastroenterology2011，17，9： | 3 |
| 3 | Do Predictors of Incomplete Kawasaki Disease Exist for Infants?显示文摘 | Sol Ji No Dong Ouk Kim Kyong Min Choi Lucy Youngmin Eun | 2013 | Pediatric Cardiology2013，，2： | 1 |
| 4 | Understanding the Role of Nanoparticles in Nano-oil Lubrication显示文摘 | Kwangho Lee Yujin Hwang Seongir Cheong Youngmin Choi Laeun Kwon Jaekeun Lee Soo Hyung Kim | 2009 | Tribology Letters2009，，2： | 1 |
| 5 | Antioxidant and antiproliferative properties of a tocotrienol-rich fraction from grape seeds显示文摘 | Youngmin Choi Junsoo Lee | 2008 | Food Chemistry2008，，4： | 1 |
| 6 | Visible light-induced reactions of humic acids on TiO2显示文摘 | Youngmin Cho Wonyong Choi | 2002 | Journal of Photochemistry and Photobiology A:Chemistry2002，148，： | 1 |
| 7 | Changes in Tocopherols,Tocotrienols,and Fatty Acid Contents in Grape Seed Oils during Oxidation显示文摘 | HOIKYUNG KIM SANG-GYUN KIM YOUNGMIN CHOI | 2008 | J Am Oil Chem Soe2008，，85： | 1 |
| 8 | Life-cycle cost-effective optimum design of steel bridges显示文摘 | Lee Kwangmin Cho Hyonam Choi Youngmin | 2004 | Journal of Constructional Steel Research2004，60，11： | 1 |
| 9 | Antioxidant activity of methanolic extracts from some grains consumed in Korea显示文摘 | Youngmin Choi Heon-Sang Jeong Junsoo Lee | 2006 | Food Chemistry2006，，1： | 1 |
| 10 | Bilayered scaffold for engineering eellularized blood vessels 显示文摘 | Ju Youngmin Choi J Atala A | 2010 | Biomaterials2010，31，15： | 1 |
| 11 | Visible light activity of TiO2 for the photoreduction of CCl4 and Cr( Ⅵ ) in the presence of nonionic surfactant(Brij) 显示文摘 | Youngmin Cho Hyunsook Kyung wonyong Choi | 2004 | Applied Catalysis B: Environmental2004，52，： | 1 |
| 12 | In?uence of intravenous contrast agent on dose calculations of intensity modulated radiation therapy plans for head and neck cancer显示文摘 | Youngmin Choi eung-Kee Kim Hyung-Sik Lee etal | 2006 | Radiotherapy and Oneology2006，81，2： | 1 |
| 13 | Antioxidant activity of methanolic extracts from some grains consumed in Korea显示文摘 | Youngmin Choi Heon Sang Jeong Junsoo Lee | 2007 | Food Chemistry2007，103，： | 1 |
| 14 | Vi- sible Ligh Induced Degradation of Carbon Tetrachoride on Dye Sensitized TiO2 显示文摘 | Cho Youngmin Choi Wonyong Lee Chung-Hak | 2001 | Environ Sci Technol2001，35，5： | 1 |
| 15 | A novel chitosan nanocapsule for enhanced skin penetration of cyclosporin A and effective hair growth in vivo显示文摘Hair loss due to medical conditions,such as alopecia,male pattern baldness,and cancer chemotherapy treatment,has been a comm onproblem for many in dividuals.Cyclospori n A(CsA),a fungal metabolite,has been reported to be a hair growth modulatory agent and is apotential drug for hair regeneration.However,the effect of topical application of CsA is limited by its poor water solubility.Several deliverysystems developed to enhance its solubility still showed poor skin penetration.To overcome these limitations,in this study,we have developed a novel chitosan nanocapsule platform using Pluro nic F127 and chitosan without any chemical crosslinking or complicated preparati on steps for the enhanced water solubility and high tran sdermal penetration of CsA.The chitosan nanocapsules(ChiNCs)optimized in terms of structural stability by using chitosan with various molecular weights ranging from 3 to 100 kDa enhanced the skin permeation of CsA through humancadaver skin in vitro.Topical administration of the CsA loaded ChiNCs in creased the hair follicles by c.a.7 times higher than that of thecontrol group,and effectively induced hair growth in C57BL/6 mice in vivo.These results suggest that ChiNCs could be used as a platform foreffective transdermal delivery of various hydrophobic drugs. | Jin Sil Lee Youngmin Hwang Hyeryeon Oh Sunghyun Kim Jin-Hwa Kim Jeung-Hoon Lee Yong Chui Shin Giyoong Tae Won II Choi | 2019 | Nano Research2019，12，12： | 1 |
| 16 | Consistency of intensity ratio between spectral lines with similar self-absorption characteristics during ungated laser induced breakdown spectroscopy measurements显示文摘This work reports that the intensity ratio of spectral lines having similar self-absorption characteristics during laser induced breakdown spectroscopy(LIBS) analysis can become nearly constant over a wide range of irradiation conditions if the intensities are integrated over a sufficiently long time. It is shown that the plasma temperature and intensity ratio of these spectral lines have temporal similarity. The spectral lines with similar self-absorption properties may be selected to improve the accuracy and consistency of LIBS analysis results under an environment with fluctuating measurement conditions. | Jung-Hwan IN Youngmin MOON Jang-Hee CHOI Sungho JEONG | 2019 | Plasma Science and Technology2019，21，3： | 0 |
| 17 | Voxelated opto-physically unclonable functions via irreplicable wrinkles显示文摘The increased prevalence of the Internet of Things(IoT)and the integration of digital technology into our daily lives have given rise to heightened security risks and the need for more robust security measures.In response to these challenges,physical unclonable functions(PUFs)have emerged as promising solution,offering a highly secure method to generate unpredictable and unique random digital values by leveraging inherent physical characteristics.However,traditional PUFs implementations often require complex hardware and circuitry,which can add to the cost and complexity of the system.We present a novel approach using a random wrinkles PUF(rw-PUF)based on an optically anisotropic,facile,simple,and cost-effective material.These wrinkles contain randomly oriented liquid crystal molecules,resulting in a two-dimensional retardation map corresponding to a complex birefringence pattern.Additionally,our proposed technique allows for customization based on specific requirements using a spatial light modulator,enabling fast fabrication.The random wrinkles PUF has the capability to store multiple data sets within a single PUF without the need for physical alterations.Furthermore,we introduce a concept called‘polyhedron authentication,’which utilizes three-dimensional information storage in a voxelated random wrinkles PUF.This approach demonstrates the feasibility of implementing high-level security technology by leveraging the unique properties of the rw-PUF. | Kitae Kim Se-Um Kim Moon-Young Choi Mohsin Hassan Saeed Youngmin Kim Jun-Hee Na | 2023 | Light(Science & Applications)2023，12，11： | 0 |
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