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| 1 | Minimally invasive surgery for upper gastrointestinal cancer: Our experience and review of the literature显示文摘Minimally invasive surgery(MIS) for upper gastro-intestinal(GI) cancer, characterized by minimal access, has been increasingly performed worldwide. It not only results in better cosmetic outcomes, but also reduces intraoperative blood loss and postoperative pain, leading to faster recovery; however, endoscopically enhanced anatomy and improved hemostasis via positive intracorporeal pressure generated by CO2 insufflation have not contributed to reduction in early postoperative complications or improvement in long-term outcomes. Since 1995, we have been actively using MIS for operable patients with resectable upper GI cancer and have developed stable and robust methodology in conducting totally laparoscopic gastrectomy for advanced gastric cancer and prone thoracoscopic esophagectomy for esophageal cancer using novel technology including da Vinci Surgical System(DVSS). We have recently demonstrated that use of DVSS might reduce postoperative local complications including pancreatic fistula after gastrectomy and recurrent laryngeal nerve palsy after esophagectomy. In this article, we present the current status and future perspectives on MIS for gastric and esophageal cancer based on our experience and a review of the literature. | Koichi Suda Masaya Nakauchi Kazuki Inaba Yoshinori Ishida Ichiro Uyama | 2016 | World Journal of Gastroenterology2016，22，19： | 13 |
| 2 | Feasibility and safety of endoscopic submucosal dissection for lower rectal tumors with hemorrhoids显示文摘AIM: To evaluate the feasibility and safety of endoscopic submucosal dissection(ESD) for lower rectal lesions with hemorrhoids.METHODS: The outcome of ESD for 23 lesions with hemorrhoids(hemorrhoid group) was compared with that of 48 lesions without hemorrhoids extending to the dentate line(non-hemorrhoid group) during the same study period. RESULTS: Median operation times(ranges) in the hemorrhoid and non-hemorrhoid groups were 121(51-390) and 130(28-540) min. The en bloc resection rate and the curative resection rate in the hemorrhoid group were 96% and 83%, and they were 100% and 90% in the non-hemorrhoid group, respectively. In terms of adverse events, perforation and postoperative bleeding did not occur in both groups. In terms of the clinical course of hemorrhoids after ESD, the rate of complete recovery of hemorrhoids after ESD in lesions with resection of more than 90% was significantly higher than that in lesions with resection of less than 90%.CONCLUSION: ESD on lower rectal lesions with hemorrhoids could be performed safely, similarly to that on rectal lesions extending to the dentate line without hemorrhoids. In addition, all hemorrhoids after ESD improved to various degrees, depending on the resection range. | Shinwa Tanaka Takashi Toyonaga Yoshinori Morita Namiko Hoshi Tsukasa Ishida Yoshiko Ohara Tetsuya Yoshizaki Fumiaki Kawara Eiji Umegaki Takeshi Azuma | 2016 | World Journal of Gastroenterology2016，22，27： | 6 |
| 3 | Factors associated with residual gastroesophageal reflux disease symptoms in patients receiving proton pump inhibitor maintenance therapy显示文摘AIM To elucidate the factors associated with residual gastroesophageal reflux disease(GERD) symptoms in patients receiving proton pump inhibitor(PPI) maintenance therapy in clinical practice.METHODS The study included 39 GERD patients receiving maintenance PPI therapy. Residual symptoms were assessed using the Frequency Scale for Symptoms of GERD(FSSG) questionnaire and the Gastrointestinal Symptom Rating Scale(GSRS). The relationships between the FSSG score and patient background factors, including the CYP2C19 genotype, were analyzed.RESULTS The FSSG scores ranged from 1 to 28 points(median score: 7.5 points), and 19 patients(48.7%) had a score of 8 points or more. The patients' GSRS scores were significantly correlated with their FSSG scores(correlation coefficient = 0.47, P < 0.005). In erosive esophagitis patients, the FSSG scores of the CYP2C19 rapid metabolizers(RMs) were significantly higher than the scores of the poor metabolizers and intermediate metabolizers(total scores: 16.7 ± 8.6 vs 7.8 ± 5.4, P < 0.05; acid reflux-related symptom scores: 12 ± 1.9 vs 2.5 ± 0.8, P < 0.005). In contrast, the FSSG scores of the CYP2C19 RMs in the non-erosive reflux disease patients were significantly lower than those of the other patients(total scores: 5.5 ± 1.0 vs 11.8 ± 6.3, P < 0.05; dysmotility symptom-related scores: 1.0 ± 0.4 vs 6.0 ± 0.8, P < 0.01). CONCLUSION Approximately half of the GERD patients receiving maintenance PPI therapy had residual symptoms associated with a lower quality of life, and the CYP2C19 genotype appeared to be associated with these residual symptoms. | Fumiaki Kawara Tsuyoshi Fujita Yoshinori Morita Atsushi Uda Atsuhiro Masuda Masaya Saito Makoto Ooi Tsukasa Ishida Yasuyuki Kondo Shiei Yoshida Tatsuya Okuno Yoshihiko Yano Masaru Yoshida Hiromu Kutsumi Takanobu Hayakumo Kazuhiko Yamashita Takeshi Hirano Midori Hirai Takeshi Azuma | 2017 | World Journal of Gastroenterology2017，23，11： | 5 |
| 4 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer显示文摘 | Toshiaki Watanabe Michio Itabashi Yasuhiro Shimada Shinji Tanaka Yoshinori Ito Yoichi Ajioka Tetsuya Hamaguchi Ichinosuke Hyodo Masahiro Igarashi Hideyuki Ishida Megumi Ishiguro Yukihide Kanemitsu Norihiro Kokudo Kei Muro Atsushi Ochiai Masahiko Oguchi Ya | 2012 | International Journal of Clinical Oncology2012，，1： | 5 |
| 5 | Long-term effect of lamivudine treatment on the incidence of hepatocellular carcinoma in patients with hepatitis B virus infection显示文摘 | Mika Kurokawa Naoki Hiramatsu Tsugiko Oze Takayuki Yakushijin Masanori Miyazaki Atsushi Hosui Takuya Miyagi Yuichi Yoshida Hisashi Ishida Tomohide Tatsumi Shinichi Kiso Tatsuya Kanto Akinori Kasahara Sadaharu Iio Yoshinori Doi Akira Yamada Masahide Oshita | 2012 | Journal of Gastroenterology2012，，5： | 4 |
| 6 | Laparoscopic versus open D2 gastrectomy for advanced gastric cancer: a retrospective cohort study显示文摘 | Toshihiko Shinohara Seiji Satoh Seiichiro Kanaya Yoshinori Ishida Keizo Taniguchi Jun Isogaki Kazuki Inaba Katsuhiko Yanaga Ichiro Uyama | 2013 | Surgical Endoscopy2013，，1： | 3 |
| 7 | Novel Integrated Robotic Approach for Suprapancreatic D2 Nodal Dissection for Treating Gastric Cancer: Technique and Initial Experience显示文摘 | Ichiro Uyama Seiichiro Kanaya Yoshinori Ishida Kazuki Inaba Koichi Suda Seiji Satoh | 2012 | World Journal of Surgery2012，，2： | 2 |
| 8 | Esophageal diverticulum exposed during endoscopic submucosal dissection of superficial cancer显示文摘Endoscopic submucosal dissection(ESD) is now widely accepted as a strategy to treat superficial esophageal neoplasms.The rate of adverse events,such as perforation,has been decreasing with the improvement of devices and techniques.In this paper,we report a case of esophageal cancer that had a diverticulum under cancerous epithelium.The diverticulum was not detected during preoperative examination,and led to perforation during the ESD procedure.Our case shows that,although rare,some diverticula can exist underneath the mucosal surface without obvious depression.If there is any sign of hidden diverticula during ESD,surgeons should proceed with caution or,depending on the case,the procedure should be discontinued to avoid adverse events. | Shinwa Tanaka Takashi Toyonaga Yoshiko Ohara Tetsuya Yoshizaki Fumiaki Kawara Tsukasa Ishida Namiko Hoshi Yoshinori Morita Takeshi Azuma | 2015 | World Journal of Gastroenterology2015，21，10： | 2 |
| 9 | Overlap Method: Novel Intracorporeal Esophagojejunostomy after Laparoscopic Total Gastrectomy显示文摘 | Kazuki Inaba Seiji Satoh Yoshinori Ishida Keizo Taniguchi Jun Isogaki Seiichiro Kanaya Ichiro Uyama | 2010 | Journal of the American College of Surgeons2010，，6： | 2 |
| 10 | Endoscopic submucosal dissection for early gastric cancer in anastomosis site after distal gastrectomy显示文摘 | Shinwa Tanaka Takashi Toyonaga Yoshinori Morita Tsuyoshi Fujita Tetsuya Yoshizaki Fumiaki Kawara Chika Wakahara Daisuke Obata Aya Sakai Tsukasa Ishida Nobunao Ikehara Takeshi Azuma | 2014 | Gastric Cancer2014，，2： | 2 |
| 11 | Long-term effect of lamivudine treatment on the incidence of hepatocellular carcinoma in patients with hepatitis B virus infection显示文摘 | Mika Kurokawa Naoki Hiramatsu Tsugiko Oze Takayuki Yakushijin Masanori Miyazaki Atsushi Hosui Takuya Miyagi Yuichi Yoshida Hisashi Ishida Tomohide Tatsumi Shinichi Kiso Tatsuya Kanto Akinori Kasahara Sadaharu Iio Yoshinori Doi Akira Yamada Masahide Oshita | 2012 | Journal of Gastroenterology2012，，5： | 1 |
| 12 | Feasibility and Safety of Endoscopic Submucosal Dissection for Large Colorectal Tumors显示文摘 | Shinwa Tanaka Takashi Toyonaga Yoshinori Morita Namiko Hoshi Tsukasa Ishida Yoshiko Ohara Tetsuya Yoshizaki Fumiaki Kawara Takeshi Azuma | 2015 | Surgical Laparoscopy, Endoscopy & Percutaneous Techniques2015，，3： | 1 |
| 13 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer显示文摘 | Toshiaki Watanabe Michio Itabashi Yasuhiro Shimada Shinji Tanaka Yoshinori Ito Yoichi Ajioka Tetsuya Hamaguchi Ichinosuke Hyodo Masahiro Igarashi Hideyuki Ishida Megumi Ishiguro Yukihide Kanemitsu Norihiro Kokudo Kei Muro Atsushi Ochiai Masahiko Oguchi Ya | 2012 | International Journal of Clinical Oncology2012，，1： | 1 |
| 14 | Potent hydroxy radical-scavenging activity of drought-induced type-2 metallothionein in wild watermelon显示文摘 | NORIYUKI NISHIMURA KINYA AKASHI YOSHINORI ISHIDA | 2004 | Biochemical and Biophysical Research Communications2004，，323： | 1 |
| 15 | Efficacy of forced coagulation with low high-frequency power setting during endoscopic submucosal dissection显示文摘AIM To investigated the hemostatic ability of the S and F1-10 methods in clinical and ex vivo studies.METHODS The hemostatic abilities of the two methods were analyzed retrospectively in all six gastric endoscopic submucosal dissection cases. The treated vessel diameter, compressed vessel frequency, and bleeding frequency after cutting the vessels were noted by therecorded videos. The coagulation mechanism of the two power settings was evaluated using the data recording program and histological examination on macro-and microscopic levels in the ex vivo experiments using porcine tissues.RESULTS F1-10 method showed a significantly better hemostatic ability for vessels ≥ 2 mm in diameter and a trend of overall better coagulation effect, evaluated by the bleeding rate after cutting the vessels. F1-10 method could sustain electrical current longer and effectively coagulate the tissue wider and deeper than the S method in the porcine model.CONCLUSION F1-10 method is suggested to achieve a stronger hemostatic effect than the S method in clinical procedures and ex vivo models. | Tsukasa Ishida Takashi Toyonaga Yoshiko Ohara Tadao Nakashige Yasuaki Kitamura Ryusuke Ariyoshi Hiroshi Takihara Shinichi Baba Tetsuya Yoshizaki Fumiaki Kawara Shinwa Tanaka Yoshinori Morita Eiji Umegaki Namiko Hoshi Takeshi Azuma | 2017 | World Journal of Gastroenterology2017，23，29： | 1 |
| 16 | Potent hydroxyl radical-scavenging activity of drought-induced type-2 metallothionein in wild watermelon显示文摘 | Kinya Akashi Noriyuki Nishimura Yoshinori Ishida Akiho Yokota | 2004 | Biochemical and Biophysical Research Communications2004，，1： | 1 |
| 17 | Laparoscopic versus open D2 gastrectomy for advanced gastric cancer: a retrospective cohort study显示文摘 | Toshihiko Shinohara Seiji Satoh Seiichiro Kanaya Yoshinori Ishida Keizo Taniguchi Jun Isogaki Kazuki Inaba Katsuhiko Yanaga Ichiro Uyama | 2013 | Surgical Endoscopy2013，，1： | 1 |
| 18 | Robot-assisted Thoracoscopic Lymphadenectomy Along the Left Recurrent Laryngeal Nerve for Esophageal Squamous Cell Carcinoma in the Prone Position: Technical Report and Short-term Outcomes显示文摘 | Koichi Suda Yoshinori Ishida Yuichiro Kawamura Kazuki Inaba Seiichiro Kanaya Satoshi Teramukai Seiji Satoh Ichiro Uyama | 2012 | World Journal of Surgery2012，，7： | 1 |
| 19 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer显示文摘 | Toshiaki Watanabe Michio Itabashi Yasuhiro Shimada Shinji Tanaka Yoshinori Ito Yoichi Ajioka Tetsuya Hamaguchi Ichinosuke Hyodo Masahiro Igarashi Hideyuki Ishida Megumi Ishiguro Yukihide Kanemitsu Norihiro Kokudo Kei Muro Atsushi Ochiai Masahiko Oguchi Ya | 2012 | International Journal of Clinical Oncology2012，，1： | 1 |
| 20 | The relationship between 25-hydroxyvitamin D levels and treatment course of pulmonary tuberculosis显示文摘 | Suguru Sato Yoshinori Tanino Junpei Saito Takefumi Nikaido Yayoi Inokoshi Atsuro Fukuhara Naoko Fukuhara Xintao Wang Takashi Ishida Mitsuru Munakata | 2012 | Respiratory Investigation2012，，： | 1 |
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