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| 1 | Effectiveness of probiotic therapy for the prevention of relapse in patients with inactive ulcerative colitis显示文摘AIM: to evaluate the effectiveness of probiotic therapy for suppressing relapse in patients with inactive ulcerative colitis(UC).METHODS: Bio-Three tablets, each containing 2 mg of lactomin(Streptococcus faecalis T-110), 10 mg of Clostridium butyricum TO-A, and 10 mg of Bacillus mesentericus TO-A, were used as probiotic therapy.Sixty outpatients with UC in remission were randomly assigned to receive 9 Bio-Three tablets/day(BioThree group) or 9 placebo tablets/day(placebo group)for 12 mo in addition to their ongoing medications.Clinical symptoms were evaluated monthly or on the exacerbation of symptoms or need for additional medication. Fecal samples were collected to analyze bacterial DNA at baseline and 3-mo intervals. Terminal restriction fragment length polymorphism and cluster analyses were done to examine bacterial components of the fecal microflora.RESULTS: Forty-six patients, 23 in each group,completed the study, and 14 were excluded. The relapse rates in the Bio-Three and placebo groups were respectively 0.0% vs 17.4% at 3 mo(P = 0.036), 8.7%vs 26.1% at 6 mo(P = 0.119), and 21.7% vs 34.8%(P = 0.326) at 9 mo. At 12 mo, the remission rate was 69.5% in the Bio-Three group and 56.6% in the placebo group(P = 0.248). On cluster analysis of fecal flora, 7 patients belonged to cluster Ⅰ, 32 to cluster Ⅱ,and 7 to cluster Ⅲ.CONCLUSION: Probiotics may be effective formaintaining clinical remission in patients with quiescent UC, especially those who belong to cluster Ⅰ on fecal bacterial analysis. | Yasushi Yoshimatsu Akihiro Yamada Ryuichi Furukawa Koji Sono Aisaku Osamura Kentaro Nakamura Hiroshi Aoki Yukiko Tsuda Nobuo Hosoe Nobuo Takada Yasuo Suzuki | 2015 | World Journal of Gastroenterology2015，21，19： | 21 |
| 2 | Effect of dietary docosahexaenoic acid on lipogenesis and lipolysis in black sea bream,Acanthopagrus schlegeli显示文摘Hatchery-reared juvenile black sea breams are characterized by a low level of highly unsaturated fatty acids in their bodies, as compared with wild fish. To assess the effect of docosahaxaenoic acid (DHA) on lipogenic and lipolysis enzymes, one-year fish were reared on a casein-based purified diet and a DHA fortified diet (1.5% DHA ethyl ester/kg diet) for 60 d, followed with a period of 55 d for starvation. Dietary DHA was effectively incorporated into the fish body. Fortification of DHA depressed activities of glucose-6-phosphate dehydrogenase and NADP-isocitrate dehydrogenase as lipogenic enzymes in the hepatopancreas and intraperitoneal fat body. Carnitine palmitoyltransferase as lipolysis enzyme in the hepatopancreas was active in the DHA fortified fish. Starvation after feeding experiment induced increased carnitine palmitoyltransferase activity in both control and DHA fortified fish and the activity remained higher in the DHA fortified fish, while the monoenes were selectively consumed prior to highly unsaturated fatty acids. These results indicated that dietary DHA depressed lipogenesis and activated lipolysis. | JI Hong OM Ahamd Daud YOSHIMATSU Takao UMINO Testuya NAKAGAWA Heisuke FURUHASHI Makoto SAKAMOTO Shuichi | 2007 | Acta Oceanologica Sinica2007，26，1： | 13 |
| 3 | Utility of co-transplanting mesenchymal stem cells in islet transplantation显示文摘Islet transplantation is characterized by the transplantation of isolated islets from donor pancreata into a diabetic recipient. Although it is a viable choice in the treatment of insulin dependent diabetes mellitus, most patients (approximately 90%) require insulin five years after transplantation. Recently, the co-transplantation of mesenchymal stem cells (MSCs) and islets in animal studies has revealed the effectiveness of MSCs co-transplantation for improving islet function. Themechanisms underlying the beneficial impact of MSCs include immunomodulation and the promotion of angiogenesis. In this review, we discuss MSCs and how they support improved graft survival and function. | Naoaki Sakata Masafumi Goto Gumpei Yoshimatsu Shinichi Egawa Michiaki Unno | 2011 | World Journal of Gastroenterology2011，17，47： | 5 |
| 4 | 包含的小岛移植: 过去,现在和未来显示文摘 Islet transplantation could become an ideal treatment for severe diabetes to prevent hypoglycemia shock and irreversible diabetic complications, once some of the major and unresolved obstacles are overcome, including limited donor supplies and side effects caused by permanent immunosuppressant use. Approximately 30 years ago, some groups succeeded in improving the blood glucose of diabetic animals by transplanting encapsulated islets with semi-permeable membranes consisting of polymer. A semi-permeable membrane protects both the inner islets from mechanical stress and the recipient’s immune system (both cellular and humoral immunities), while allowing bidirectional diffusion of nutrients, oxygen, glucose, hormones and wastes, i.e., immune-isolation. This device, which enables immune-isolation, is called encapsulated islets or bio-artificial pancreas. Encapsulation with a semipermeable membrane can provide some advantages: (1) this device protects transplanted cells from the recipient’s immunity even if the xenogeneic islets (from large animals such as pig) or insulin-producing cells are derived from cells that have the potential for differentiation (some kinds of stem cells). In other words, the encapsulation technique can resolve the problem of limited donor supplies; and (2) encapsulation can reduce or prevent chronic administration of immunosuppressants and, therefore, important side effects otherwise induced by immunosuppressants. And now, many novel encapsulated islet systems have been developed and are being prepared for testing in a clinical setting. | Naoaki Sakata Shoichiro Sumi Gumpei Yoshimatsu Masafumi Goto Shinichi Egawa Michiaki Unno | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，1： | 4 |
| 5 | Development of a serotyping enzyme-linked immunosorbent assay system based on recombinant truncated hantavirus nucleocapsid proteins for New World hantavirus infection显示文摘 | Takaaki Koma Kumiko Yoshimatsu Midori Taruishi Daisuke Miyashita Rika Endo Kenta Shimizu Shumpei P. Yasuda Takako Amada Takahiro Seto Ryo Murata Haruka Yoshida Hiroaki Kariwa Ikuo Takashima Jiro Arikawa | 2012 | Journal of Virological Methods2012，，1： | 2 |
| 6 | Role of muscle fibres in contributing firmness of cooked fish显示文摘 | Hatae K Yoshimatsu F Matsumoto J J | 1990 | Journal of Food Science1990，55，3： | 1 |
| 7 | Genetic Diversity of Hantaviruses Isolated in China and Characterization of Novel Hantaviruses Isolated from Niviventer confucianus and Rattus rattus显示文摘 | Hua Wang Kumiko Yoshimatsu Hideki Ebihara | 2000 | Virology2000，278，： | 1 |
| 8 | Central infusion of histamine reduces fat accumulation and upregulates UCP family in leptin-resistant obese mice显示文摘 | Masaki T Yoshimatsu H Chiba S | 2001 | Diabetes2001，50，2： | 1 |
| 9 | Neuropeptide Y suppresses sympathetic activity to interscapular brown adipose tissue inrats显示文摘 | Egawa M Yoshimatsu H Bray G A | 1991 | Regulatory Integrative and Comparative Physiology1991，260，2： | 1 |
| 10 | Protective immunity of Hantaan virus mucleocapsid and envelope protein studied using baculovirus-expressed proteins显示文摘 | Yoo YC Yoshida R | 1993 | Arch Virol1993，130，34： | 1 |
| 11 | Effects of L-earnitine enrichment on the population growth, egg ratio and body size of the marine rotifer,Brachionus rotundiformis显示文摘 | ZHANG D M YOSHIMATSU T MITSUHIRO F | 2005 | Aquaculture2005，19，4： | 1 |
| 12 | Cell cycle regulation in the G1 phase:a promising target for the development of new chemotherapeutic anticancer agents显示文摘 | Owa T Yoshino H Yoshimatsu K | | 0，，12： | 1 |
| 13 | Protective role of antigenic sites on the envelope protein of Hantaan virus defined by monoclonal antibodies显示文摘 | Arikawa J Yao JS Yoshimatsu K | | 0，，1： | 1 |
| 14 | Diagnostic per formance of percutaneous lung biopsy using automated biopsy needles under CT-fluoroscopic guidance for ground glass opacity lesions显示文摘 | Yamagami T Yoshimatsu R Miura H | 2013 | Br J Radiol2013，86，20： | 1 |
| 15 | Treatment of hepatocellular carcinoma: value of percutaneous microwave oagulation 显示文摘 | Murakami R Yoshimatsu S Matsukawa T | 1995 | Am Roentgenol1995，164，： | 1 |
| 16 | A clinical ex- perience in treatment with bevacizumab for unresectable colorec- tal cancer显示文摘 | Fujimoto T Yoshimatsu K Yokomizo H | 2008 | Gan To Kagaku Ryoho2008，35，12： | 1 |
| 17 | Polo-like ki- nases (Plks) and cancer显示文摘 | Takai N Hamanaka R Yoshimatsu J | 2005 | Oncogene2005，24，2： | 1 |
| 18 | Expression of rat uncoupling protein family mRNA levels by chronic treatment with thyroid hormone显示文摘 | Masaki T Yoshimatsu H Sakata T | 2000 | Int J Obes Relat Metab Disord2000，2，： | 1 |
| 19 | An M-CSF receptorc-Fms antibody inhibits mechanical stress-induced root resorptionduring orthodontic tooth movement in mice 显示文摘 | Kitaura H Fujimura Y Yoshimatsu M | 2009 | Angle Orthod2009，79，5： | 1 |
| 20 | Anti-viral ac- tivity of sulfated chitin derivatives against Friend murine leukaemia and herpes simplex type-1 viruses显示文摘 | Ishihara C Yoshimatsu K Tsufi M | 1993 | Vaccine1993，11，6： | 1 |
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