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| 1 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 2 | The growth of brain tumors can be suppressed by multiple transplantation of mesenchymal stem cells expressing cytosine deaminase显示文摘Suicide genes have recently emerged as an attractive alternative therapy for the treatment of various types of intractable cancers.The efficacy of suicide gene therapy relies on efficient gene delivery to target tissues and the localized concentration of final geneproducts. | Chang DY Yoo SW Hong Y Kim S Kim SJ Yoon SH Cho KG Paek SH Lee YD Kim SS Suh-Kim H | 2010 | 中国神经肿瘤杂志2010，8，2： | 3 |
| 3 | Low-temperature sintering and microwave dielectric properties of Ca(Li1/3 Nb2/3)O3-δ ceramics显示文摘 | Liu Peng Kim E S Yoon K H | 2001 | Jpn Journal Application Physics2001，40，： | 2 |
| 4 | Microwave diele- ctric properties of complex perovskit Ba(Mg1/3Ta2/3)O3显示文摘 | KIM E S YOON K H | 1992 | Ferroelectrics1992，133，： | 2 |
| 5 | Continuous HMM applied to quantization of on - line Korean character spaces显示文摘 | JUNG K C YOON S M KIM H J | 2000 | Pattern Recognition Letters2000，21，： | 2 |
| 6 | A problem reduction and decomposition approach for scheduling for a flowshop of batch processing machines 显示文摘 | Sung C S Kim Y H Yoon S H | 2000 | European Journal of Operational Research2000，121，： | 2 |
| 7 | Increased b-carotene production in recombinant Escherichia eoli harboring an engineered isoprenoid precursor pathway with mevalonate addition 显示文摘 | Yoon S H | 2007 | Biotechnol Prog2007，23，： | 1 |
| 8 | Single-nucleotide polymorphisms of the interleukin-18 gene promoter region in rheumatoid arthritis patients: protective effect of AA genotype 显示文摘 | Sivalingam S P Yoon K H Koh D R | 2003 | Tissue Antigens2003，62，6： | 1 |
| 9 | Nitric oxide inhibits the shedding of the glycosylphosphatidylinositol-anchored dipeptidase from porcine renal proximal tubules 显示文摘 | Park S W Yoon H J Lee H B | 2002 | Biochem J2002，364，1： | 1 |
| 10 | Sequence-based screening for putative polyketide synthase gene-harboring clones from a soil metagenome library 显示文摘 | JI S C KIM D YOON J H | 2006 | J Microbiol Biotechnol2006，16，： | 1 |
| 11 | Preparation of spherical activated carbon with high electric double-layer capacitance 显示文摘 | Lee S I Mitani S Yoon S H | 2004 | Carbon2004，42，11： | 1 |
| 12 | Anaerobic and aerobic degradation of pyridine by a newly isolated denitrifying bacterium 显示文摘 | Rhee S K Lee G M Yoon J H | 1997 | Appl Environ Microb1997，63，7： | 1 |
| 13 | 显示文摘 | Park S H Yoon C S Kang S G | 2004 | Electrochimica Acta2004，49，4： | 1 |
| 14 | Measurement of Particle Velocity and Characterization of Deposition in Aluminum Alloy Kinetic Spraying Process 显示文摘 | Wu J Fang H Yoon S | 2005 | Applied Surface Scince2005，252，： | 1 |
| 15 | Tribological properties of biomimetic nano- patterned polymeric surfaces on silicon wafer 显示文摘 | Yoon E S Singh R A Kong H | 2006 | Tribology Letter2006，21，： | 1 |
| 16 | Effect of BaWO4 on the microwave dielectric properties of Ba(Mg1/3 Ta2/3 )O3 ceramics显示文摘 | YOON K H KIM D P KIM E S | 1994 | J Am Ceram Soc1994，77，4： | 1 |
| 17 | Heating of ions by Alfvén waves via nonresonant interactions显示文摘 | Wang C B Wu C S Yoon P H | 2006 | Physical Review Letters2006，96，12： | 1 |
| 18 | Evaluation of traumatic brain injured patients in correlation with functional status by localized 1 H-MR spectroscopy 显示文摘 | Yoon S J Lee J H Kim S T | 2005 | Clin Rehabi2005，19，2： | 1 |
| 19 | Lipase-catalyzed incorporation of conjugated linoleie acid into tricaprylin显示文摘 | KIMA I H YOON C S CHO S H | 2001 | Journal of the American Oil Chemists'' Society2001，78，5： | 1 |
| 20 | Proteomic analysis of porcine pancreas development 显示文摘 | CHOI J S CHO Y K YOON S H | 2009 | BMB Rep2009，42，10： | 1 |
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