| 1 | Mutations in TP53, ZNF750, and RB1 typify ocular sebaceous carcinoma显示文摘Sebaceous carcinoma (SC) of the eyelid is a rare but aggressive malignancy, accounting for 3%—5% of eyelid malignancies in the United States, and up to 35% in Asian populations (Deprez and Uffer, 2009;Xu et al., 2018;Yu et al., 2018). It is frequently mistaken for benign conditions or less aggressive malignancies such as basal cell carcinoma (Muqit et al., 2013), and the effects of delay in diagnosis can be devastating to patients. Aggressive surgical resection is the primary treatment of these tumors and often invoIves orbital exenteration with significant morbidity to patients, and these tumors frequently recur, with local recurrence rate as high as 18%. Importantly, this disease has a high metastatic potential, and there are very limited data guiding systemic treatment options;ultimately 6%—18% of patients diagnosed with SC of the eyelid succumb to metastatic disease (Zurcher et al., 1998;Shields et al., 2004). | Yongyang Bao J. Eva Selfridge Janet Wang Yiqing Zhao Junqi Cui Kishore Guda Zhenghe Wang Yanbo Zhu | 2019 | Journal of Genetics and Genomics2019，46，6： | 4 |
| 2 | Building block copolymer particles via self‐assembly within a droplet显示文摘The self‐assembly of block copolymers(BCPs)within emulsion droplets is a flexible strategy for the preparation of polymer particles.This strategy permits the finetuning of shapes,internal structures,and surface nanostructures of the polymer particles,thus allowing many applications.Although some literature has reviewed the BCP preparation via self‐assembly within a droplet,a comprehensive summary including in‐depth understanding,controllable preparation,and application is lacked.In this review,we systematically delve into the multiple mechanisms that drive BCP self‐assembly within emulsion droplets,such as commensurability effects for minimizing total free energy,interfacial instability,organized spontaneous emulsification,phase separation of multiple components,and entropy effects between BCPs and nanoparticles.Additionally,a strategy combining selective cross‐linking and disassembly can further generate Janus particles featuring unique structures.Next,various applications across multiple disciplines are discussed,including drug delivery,display,biomedical imaging,macromolecular separation,and fuel cells.Finally,we present an overview of the current challenges and future directions for BCP emulsion self‐assembly,covering mechanism investigation,molecular design,stability control,and application exploration.We anticipate deeper understanding,more varieties,enhanced performance,and broader applications can be achieved with BCP emulsion self‐assembly after addressing the challenge. | Sen Zhang Han Bao Xinyi Shen Yongyang Song Shutao Wang | 2023 | Droplet2023，2，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员