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1Recent progresses in mangrove conservation,restoration and research in China显示文摘Aims In this paper,we highlighted some key progresses in mangrove conservation,restoration and research in China during last two decades.Methods Based on intensive literature review,we compared the distribution and areas of existing mangroves among selected provinces of China,discussed the issues associated with mangrove conservation and restoration and highlighted major progresses on mangrove research conducted by key institutions or universities in China's Mainland,Hong Kong,Taiwan and Macao.Important findings The population boom and rapid economic developments have greatly reduced mangrove areas in China since 1980s,leaving only 22700 ha mangroves in China's Mainland in 2001.Chinese government has launched a series of programs to protect mangroves since 1980s and has established mangrove ecosystems as high-priority areas for improving environmental and living resource management.During last three decades,a total of 34 natural mangrove conservation areas have been established,which accounts for 80%of the total existing mangroves areas in China.Mangrove restoration areas in China' Mainland accounted for<7%of the total mangroves areas in 2002.A great deal of research papers on Chinese mangroves has been published in international journals.However,more systematic protection strategies and active restoration measurements are still urgently needed in order to preserve these valuable resources in China.Luzhen Chen Wenqing Wang Yihui Zhang Guanghui Lin 2009Journal of Plant Ecology2009,2,2:42
2Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)显示文摘In recent years,as living standards have continued to improve,the number of diabetes patients in China,along with the incidence of complications associated with the disease,has been increasing.Among these complications,diabetic foot disease is one of the main causes of disability and death in diabetic patients.Due to the differences in economy,culture,religion and level of medical care available across different regions,preventive and treatment methods and curative results for diabetic foot vary greatly.In multidisciplinary models built around diabetic foot,the timely assessment and diagnosis of wounds and appropriate methods of prevention and treatment with internal and external surgery are key to clinical practice for this pathology.In 2019,under the leadership of the Jiangsu Medical Association and Chinese Diabetes Society,the writing group for the Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)was established with the participation of scholars from the specialist areas of endocrinology,burn injury,vascular surgery,orthopedics,foot and ankle surgery and cardiology.Drawing lessons from diabetic foot guidelines from other countries,this guide analyses clinical practices for diabetic foot,queries the theoretical basis and grades and gives recommendations based on the characteristics of the pathology in China.This paper begins with assessments and diagnoses of diabetic foot,then describes treatments for diabetic foot in detail,and ends with protections for high-risk feet and the prevention of ulcers.This manuscript covers the disciplines of internal medicine,surgical,nursing and rehabilitation and describes a total of 50 recommendations that we hope will provide procedures and protocols for clinicians dealing with diabetic foot.Aiping Wang Guozhong Lv Xingbo Cheng Xianghua Ma Wei Wang Jianchao Gui JiHu Meng Lu Guoping Chu Jin’an Chen Hao Zhang Yiqiu Jiang Yuedong Chen Wengbo Yang Lin Jiang Houfa Geng Rendong Zheng Yihui Li Wei Feng Boey Johnson Wenjuan Wang Dalong Zhu Yin Hu 2020Burns & Trauma2020,8,1:34
3Effect of Dark Septate Endophytic Fungus Gaeumannomyces cylindrosporus on Plant Growth, Photosynthesis and Pb Tolerance of Maize (Zea mays L.)显示文摘Dark septate endophytic(DSE) fungi are ubiquitous and cosmopolitan, and occur widely in association with plants in heavy metal stress environment. However, little is known about the effect of inoculation with DSE fungi on the host plant under heavy metal stress.In this study, Gaeumannomyces cylindrosporus, which was isolated from Pb-Zn mine tailings in China and had been proven to have high Pb tolerance, was inoculated onto the roots of maize(Zea mays L.) seedlings to study the effect of DSE on plant growth, photosynthesis,and the translocation and accumulation of Pb in plant under stress of different Pb concentrations. The growth indicators(height, basal diameter, root length, and biomass) of maize were detected. Chlorophyll content, photosynthetic characteristics(net photosynthetic rate, transpiration rate, stomatal conductance, and intercellular CO_2 concentration), and chlorophyll fluorescence parameters in leaves of the inoculated and non-inoculated maize were also determined. Inoculation with G. cylindrosporus significantly increased height,basal diameter, root length, and biomass of maize seedlings under Pb stress. Colonization of G. cylindrosporus improved the efficiency of photosynthesis and altered the translocation and accumulation of Pb in the plants. Although inoculation with G. cylindrosporus increased Pb accumulation in host plants in comparison to non-inoculated plants, the translocation factor of Pb in plant body was significantly decreased. The results indicated that Pb was accumulated mainly in the root system of maize and the phytotoxicity of Pb to the aerial part of the plant was alleviated. The improvement of efficiency of photosynthesis and the decrease of translocation factor of Pb, caused by DSE fungal colonization, were efficient strategies to improve Pb tolerance of host plants.BAN Yihui XU Zhouying YANG Yurong ZHANG Haihan CHEN Hui TANG Ming 2017Pedosphere2017,27,2:16
4Anti-fibrotic role and mechanism of Periplaneta americana extracts in CCl4-induced hepatic fibrosis in rats显示文摘Dingchun Li Wu Li Yihui Chen Lihui Liu Dehong Ma Hongtu Wang Lu Zhang Shenjun Zhao Qin Peng 2018Acta Biochimica et Biophysica Sinica2018,50,5:14
5The 2016 Summer Floods in China and Associated Physical Mechanisms:A Comparison with 1998显示文摘The characteristics of droughts and floods in China during the summers(May–August)of 2016 and 1998 were compared in great detail,together with the associated atmospheric circulations and external-forcing factors.Following results are obtained.(1)The precipitation was mostly above normal in China in summer 2016,with two main rainfall belts located in the Yangtze River valley(YRV)and North China.Compared with 1998,a similar rainfall belt was located over the YRV,with precipitation 100%and more above normal.However,the seasonal processes of Meiyu were different.A typical'Secondary Meiyu'occurred in 1998,whereas dry conditions dominated the YRV in2016.(2)During May–July 2016,the Ural high was weaker than normal,but it was stronger than normal in 1998.This difference resulted from fairly different distributions of sea surface temperature anomalies(SSTAs)over the North Atlantic Ocean during the preceding winter and spring of the two years.(3)Nonetheless,tropical and subtropical circulation systems were much more similar in May–July of 2016 and 1998.The circulation systems in both years were characterized by a stronger than normal and more westward-extending western Pacific subtropical high(WPSH),a weaker than normal East Asian summer monsoon(EASM),and anomalous convergence of moisture flux in the mid and lower reaches of the YRV.These similar circulation anomalies were attributed to the similar tropical SSTA pattern in the preceding seasons,i.e.,the super El Ni?o and strong warming in the tropical Indian Ocean.(4)Significant differences in the circulation pattern were observed in August between the two years.The WPSH broke up in August 2016,with its western part being combined with the continental high and persistently dominating eastern China.The EASM suddenly became stronger,and dry conditions prevailed in the YRV.On the contrary,the EASM was weaker in August 1998 and the'Secondary Meiyu'took place in the YRV.The Madden–Julian Oscillation(MJO)was extremely active in August 2016 and stayed in western Pacific for 25 days.It triggered frequent tropical cyclone activities and further influenced the significant turning of tropical and subtropical circulations in August2016.In contrast,the MJO was active over the tropical Indian Ocean in August 1998,conducive to the maintenance of a strong WPSH.Alongside the above oceanic factors and atmospheric circulation anomalies,the thermal effect of snow cover over the Qinghai–Tibetan Plateau from the preceding winter to spring in 2016 was much weaker than that in 1998.This may explain the relatively stronger EASM and more abundant precipitation in North China in 2016than those in 1998.Yuan YUAN Hui GAO Weijing LI Yanju LIU Lijuan CHEN Bin ZHOU Yihui DING 2017Journal of Meteorological Research2017,31,2:11
6Long-Term Cognitive Improvement After Benfotiamine Administration in Patients with Alzheimer's Disease显示文摘To date,we still lack disease-modifying therapies for Alzheimer's disease(AD).Here,we report that long-term administration of benfotiamine improved the cognitive ability of patients with AD.Five patients with mild to moderate AD received oral benfotiamine(300 mg daily) over 18 months.All patients were examined by positron emission tomography with Pittsburgh compound B(PiB-PET) and exhibited positive imaging with pamyloid deposition,and three received PiB-PET imaging at follow-up.The five patients exhibited cognitive improvement as assayed by the Mini-Mental Status Examination(MMSE) with an average increase of 3.2 points at month18 of benfotiamine administration.The three patients who received follow-up PiB-PET had a 36.7%increase in the average standardized uptake value ratio in the brain compared with that in the first scan.Importantly,the MMSE scores of these three had an average increase of 3 points during the same period.Benfotiamine significantly improved the cognitive abilities of mild to moderate AD patients independently of brain amyloid accumulation.Our study provides new insight to the development of diseasemodifying therapy.Xiaoli Pan Zhichun Chen Guoqiang Fei Shumei Pan Weiqi Bao Shuhua Ren Yihui Guan Chunjiu Zhong 2016Neuroscience Bulletin2016,32,6:9
7Celastrol specifically inhibits the activation of NLRP3 inflammasome显示文摘Dear Editor,Inflammasomes are vital components of the innate immune system that survey microbial infections or sterile challenges in the cytosol(de Zoete et al.,2014).A typical inflammasome is composed of a sensor protein such as NOD like receptor(NLR)or AIM2 like receptor(ALR),theXuesong Sang Yihui Chen Wei Chen Jing Xie Guangxun Meng Jin Zhong Taisheng Li Ailing Lu 2018Science China(Life Sciences)2018,61,3:9
8Methods of computed tomography screening and management of lung cancer in Tianjin: design of a population-based cohort study显示文摘Objective: European lung cancer screening studies using computed tomography(CT) have shown that a management protocol based on measuring lung nodule volume and volume doubling time(VDT) is more specific for early lung cancer detection than a diameter-based protocol. However, whether this also applies to a Chinese population is unclear. The aim of this study is to compare the diagnostic performance of a volume-based protocol with a diameter-based protocol for lung cancer detection and optimize the nodule management criteria for a Chinese population.Methods: This study has a population-based, prospective cohort design and includes 4000 participants from the Hexi district of Tianjin, China. Participants will undergo low-dose chest CT at baseline and after 1 year. Initially, detected lung nodules will be evaluated for diameter and managed according to a routine diameter-based protocol(Clinical Practice Guideline in Oncology for Lung Cancer Screening, Version 2.2018). Subsequently, lung nodules will be evaluated for volume and management will be simulated according to a volume-based protocol and VDT(a European lung nodule management protocol). Participants will be followed up for 4 years to evaluate lung cancer incidence and mortality. The primary outcome is the diagnostic performance of the European volume-based protocol compared to diameter-based management regarding lung nodules detected using low-dose CT.Results: The diagnostic performance of volume-and diameter-based management for lung nodules in a Chinese population will be estimated and compared.Conclusions: Through the study, we expect to improve the management of lung nodules and early detection of lung cancer in Chinese populations.Yihui Du Yingru Zhao Grigory Sidorenkov Geertruida H.de Bock Xiaonan Cui Yubei Huang Monique D.Dorrius Mieneke Rook Harry J.M.Groen Marjolein A.Heuvelmans Rozemarijn Vliegenthart Kexin Chen Xueqian Xie Shiyuan Liu Matthijs Oudkerk Zhaoxiang Ye 2019Cancer Biology & Medicine2019,16,1:7
9The generation of PD-L1 and PD-L2 in cancer cells: From nuclear chromatin reorganization to extracellular presentation显示文摘The immune checkpoint blockade(ICB)targeting on PD-1/PD-L1 has shown remarkable promise in treating cancers.However,the low response rate and frequently observed severe side effects limit its broad benefits.It is partially due to less understanding of the biological regulation of PD-L1.Here,we systematically and comprehensively summarized the regulation of PD-L1 from nuclear chromatin reorganization to extracellular presentation.In PD-L1 and PD-L2 highly expressed cancer cells,a new TAD(topologically associating domain)(chr9:5,400,000-5,600,000)around CD274 and CD273 was discovered,which includes a reported super-enhancer to drive synchronous transcription of PD-L1 and PD-L2.The re-shaped TAD allows transcription factors such as STAT3 and IRF1 recruit to PD-L1 locus in order to guide the expression of PD-L1.After transcription,the PD-L1 is tightly regulated by mi RNAs and RNA-binding proteins via the long 3’UTR.At translational level,PD-L1 protein and its membrane presentation are tightly regulated by post-translational modification such as glycosylation and ubiquitination.In addition,PD-L1 can be secreted via exosome to systematically inhibit immune response.Therefore,fully dissecting the regulation of PD-L1/PD-L2 and thoroughly detecting PD-L1/PD-L2 as well as their regulatory networks will bring more insights in ICB and ICB-based combinational therapy.Zhiwei Fan Changyue Wu Miaomiao Chen Yongying Jiang Yuanyuan Wu Renfang Mao Yihui Fan 2022Acta Pharmaceutica Sinica B2022,12,3:4
10Distribution of bacterial communities across plateau freshwater lake and upslope soils显示文摘Microorganisms are involved in a variety of biogeochemical processes in natural environments.The differences between bacterial communities in freshwaters and upslope soils remain unclear. The present study investigated the bacterial distribution in a plateau freshwater lake,Erhai Lake(southwestern China), and its upslope soils. Illumina MiS eq sequencing illustrated high bacterial diversity in lake sediments and soils. Sediment and soil bacterial communities were mainly composed of Proteobacteria, Acidobacteria, Actinobacteria,Bacteroidetes, Chloroflexi and Planctomycetes. However, a distinctive difference in bacterial community structure was found between soil and sediment ecosystems. Water content, nitrogen and p H affected the distribution of the bacterial community across Erhai Lake and its upslope soils. Moreover, the soil bacterial community might also be shaped by plant types. This work could provide some new insights into plateau aquatic and terrestrial microbial ecology.Yihui Chen Yu Dai Yilin Wang Zhen Wu Shuguang Xie Yong Liu 2016Journal of Environmental Sciences2016,28,5:4
11Regnase-1, a rapid response ribonuclease regulating nflammation and stress responses显示文摘Renfang Mao Riyun Yang Xia Chen Edward W Harhaj Xiaoying Wang Yihui Fan 2017Cellular & Molecular Immunology2017,14,5:3
12Effect of Qingxinkaiqiao compound on cortical mRNA expression of the apoptosis-related genes Bcl-2, BAX, caspase-3, and Aβ in an Alzheimer's disease rat model显示文摘OBJECTIVE: To investigate the effects of Qingxinkaiqiao(QK) compound in a rat model of Alzheimer's disease induced with β-amyloid(Aβ) 1-40.METHODS: Fifty-six three months, male,Sprague-Dawley rats were randomly divided into seven groups: blank control group, surgery group,model group, low-dose QK group, middle-dose QK group, high-dose QK group, and Aricept(donepezil hydrochloride) group, with eight rats in each group. Apart from the control and surgery groups,an Alzheimer's disease model was established in all groups by bilateral hippocampal injection of Aβ1-40. The surgery group received an injection of the same volume of physiological saline. Two days after model establishment, rats from the drug groups were administered the corresponding drugs; the control group and model group were administered an equal volume of physiological saline for 14 days. After treatment, real-time quantitative polymerase chain reaction, immunohistochemistry,and western blot assay were employed to confirm mRNA and protein expressions of Bcl-2, Bax, caspase-3, and Aβ, respectively.RESULTS: Compared with the model group, Bcl-2expression increased and Bax, caspase-3, and Aβexpression decreased in each drug treatment group(P < 0.05, P < 0.01). The expressions of middle-dose QK group were more significant than the high- and low-dose QK groups(P < 0.01, P > 0.05).CONCLUSION: QK treatment resulted in significantly up-regulated Bcl-2 expression, down-regulated Bax, caspase-3, and Aβ expression, and reduced numbers of apoptotic cells in the cortex.Hu Haiyan Wang Yiyu Zhang Yihui Wang Wenhua Xu Dongmei Chen Zhiyu Zhang Xiaoyan Mao Dandan 2016Journal of Traditional Chinese Medicine2016,36,5:3
13Preparation and toxicity evaluation of a novel nattokinase-tauroursodeoxycholate complex显示文摘Nattokinase(NK), which has been identified as a potent fibrinolytic protease, has remarkable potential in treatment of thrombolysis, and even has the ability to ameliorate chronic vein thrombosis. To reduce the hemorrhagic risk from an intravenous injection of NK,nattokinase-tauroursodeoxycholate(NK-TUDCA) complex was prepared at different pH values and with different ratios of NK and TUDCA. When assessing survival time, survival state,tail injury, and the body weight of mice, it was found that the NK-TUDCA complex(NK: 10 k IU/ml; TUDCA: 10 mg/ml; pH 5.0) had a lower toxicity when administered at an NK dosage of 130 kIU/kg in the acute toxicity test and 13 kIU/kg in the repeated low-dose challenge. From the results of the in vitro thrombolytic test and characterization of NKTUDCA, we speculated that the delayed release of NK-TUDCA might be the main cause of toxicity reduction by the complex. This study described the preparation of an NK complex with low toxicity following intravenous administration, which could be utilized for further clinical study of NK.Rui Feng Jing Li Jiepeng Chen Lili Duan XinRong Liu Donghua Di Yihui Deng Yanzhi Song 2018Asian Journal of Pharmaceutical Sciences2018,13,2:2
14Influences of 1-methylcyclopropene-containing papers on the metabolisms of membrane lipids in Anxi persimmons during storage显示文摘Objectives:The aim of this work was to analyse the effects of 1-methylcyclopropene(1-MCP)treatment on the metabolisms of membrane lipids in postharvest Anxi persimmons during storage.Materials and methods:Anxi persimmon(Diospyros kaki L.f.cv.Anxi)fruits were treated by paper containing 1-MCP with a concentration of 1.35μl/l.The cellular membrane permeability was analysed by the electric conductivity meter.The activities of lipoxygenase(LOX),phospholipase(PLD)and lipase were determined by spectrophotometry.The component and relative amounts of membrane fatty acids were determined using gas chromatograph(GC).Results:The 1-MCP-treated Anxi persimmons manifested a lower electrolyte leakage rate,lower LOX,PLD and lipase activities,higher levels of unsaturated fatty acids(USFAs),higher ratio of USFAs to saturated fatty acids(SFAs)(U/S),higher index of USFAs(IUFA),but lower levels of SFAs.Conclusions:The degradation and the metabolisms of membrane lipids could be suppressed by 1-MCP treatment,which might be accountable for the delaying softening of postharvest Anxi persimmons during storage.Hui Wang Guo Chen Lili Shi Hetong Lin Yihui Chen Yifen Lin Zhongqi Fan 2020Food Quality and Safety2020,4,3:2
15miR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2显示文摘Yihui Ma Shuangni Yu Wugan Zhao Zhaohui Lu Jie Chen 2010Cancer Letters2010,,2:2
16Kirigami-inspired multiscale patterning of metallic structures via predefined nanotrench templates显示文摘Reliable fabrication of multiscale metallic patterns with precise geometry and size at both the nanoscale and macroscale is of importance for various applications in electronic and optical devices.The existing fabrication processes,which usually involve film deposition in combination with electron-beam patterning,are either timeconsuming or offer limited precision.Inspired by the kirigami,an ancient handicraft art of paper cutting,this work demonstrates an electron-beam patterning process for multiscale metallic structures with significantly enhanced efficiency and precision.Similar to the kirigami,in which the final pattern is defined by cutting its contour in a paper and then removing the unwanted parts,we define the target multiscale structures by first creating nanotrench contours in a metallic film via an electron-beam-based process and then selectively peeling the separated film outside the contours.Compared with the conventional approach,which requires the exposure of the whole pattern,much less exposure area is needed for nanotrench contours,thus enabling reduced exposure time and enhanced geometric precision due to the mitigated proximity effect.A theoretical model based on interface mechanics allows a clear understanding of the nanotrench-assisted selective debonding behaviour in the peeling process.By using this fabrication process,multiscale metallic structures with sub-10-nm up to submillimetre features can be reliably achieved,having potential applications for anti-counterfeiting and gap-plasmon-enhanced spectroscopy.Mengjie Zheng Yiqin Chen Zhi Liu Yuan Liu Yasi Wang Peng Liu Qing Liu Kaixi Bi Zhiwen Shu Yihui Zhang Huigao Duan 2019Microsystems & Nanoengineering2019,5,1:2
17SRV constraint based FIB design for wideband linear array显示文摘Frequency-invariant beamformer (FIB) design is a key issue in wideband array signal processing. To use commonly wideband linear array with tapped delay line (TDL) structure and complex weights, the FIB design is provided according to the rule of minimizing the sidelobe level of the beampattern at the reference frequency while keeping the distortionless response constraint in the mainlobe direction at the reference frequency, the norm constraint of the weight vector and the amplitude constraint of the averaged spatial response variation (SRV). This kind of beamformer design problem can be solved with the interior-point method after being converted to the form of standard second order cone programming (SOCP). The computer simulations are presented which illustrate the effectiveness of our FIB design method for the wideband linear array with TDL structure and complex weights.Peng Chen Yihui Liang Chaohuan Hou Xiaochuan Ma Dapeng Liu 2010Journal of Systems Engineering and Electronics2010,21,6:2
18Individual aortic baroreceptors are sensitive to different ranges of blood pressures显示文摘Many receptors,including thermal receptors and mechanical receptors,are only activated by stimuli within a clearly defined range of intensities.Differences in the receptive ranges enable individual receptors and their sensory centers to precisely detect the intensity of the stimulus and changes in intensity.Baroreceptors are the sensory terminals of the baroreflex.It is well understood that an increasing number of baroreceptors are recruited to produce afferent action potentials as the blood pressure increases,indicating that individual baroreceptors have different pressure thresholds.The present study revealed that individual baroreceptors could stop their afferent signals when the blood pressure exceeds a certain level,indicating that individual baroreceptors are sensitive to a specific range of blood pressure.The receptive ranges of individual baroreceptors differ in terms of the total range,the lower threshold,and the upper threshold.Of 85 baroreceptors examined in this study,the upper thresholds for about half were within the physiological blood pressure range.These results indicate that supraphysiological blood pressure is unlikely to be encoded by the recruitment of more baroreceptors.Instead,supraphysiological blood pressure levels might be signaled by an increase in the frequency of action potentials or by other mechanisms.In conclusion,our results indicate that rabbit baroreceptors are activated by blood pressure levels within specific receptive ranges.These findings should encourage further studies to examine the role of population coding of blood pressure by baroreceptors in the baroreflex.CHEN MengJiao YANG MingHao HAN WenJuan AN ShuCheng LIU YiHui LIU ZhiQiang REN Wei 2014Science China(Life Sciences)2014,57,5:2
19Understanding human influence on climate change in China显示文摘China’s climate has been warming since the 1950s, with surface air temperature increasing at a rate higher than the global average. Changes in climate have exerted substantial impacts on water resources,agriculture, ecosystems and human health. Attributing past changes to causes provides a scientific foundation for national and international climate policies. Here, we review recent progress in attributing the observed climate changes over past decades in China. Anthropogenic forcings, dominated by greenhouse gas emissions, are the main drivers for observed increases in mean and extreme temperatures. Evidence of the effect of anthropogenic forcings on precipitation is emerging. Human influence has increased the probability of extreme heat events, and has likely changed the occurrence probabilities for some heavy precipitation events. The way a specific attribution question is posed and the conditions under which the question is addressed present persistent challenges for appropriately communicating attribution results to non-specialists.Ying Sun Xuebin Zhang Yihui Ding Deliang Chen Dahe Qin Panmao Zhai 2022National Science Review2022,9,3:2
20经济激励政策对绿色建筑发展的促进作用分析显示文摘在创建资源节约和环境友好型的社会过程中,大力发展绿色建筑是低碳城市发展的主要目标。本文首先总结了国内外主要绿色建筑评价体系,然后对我国现行绿色建筑激励经济政策进行介绍。文章选取全国104个绿色建筑项目,以及苏州和上海2个案例城市选取的绿色建筑展开研究,首先从国家和地方层面对比分析了绿色建筑经济补贴和增量成本差异,从结果看到目前我国绿色建筑的正外部性并没有通过经济激励补贴政策得到充分的矫正;另外通过研究也看出目前我国绿色建筑发展中另一个重要问题在于获得绿色运行标识的建筑项目数目远少于获得绿色设计标识的项目。基于研究成果,本文提出了促进我国未来绿色建筑发展的经济激励政策建议。何燕 胡晓 蒋平 徐西蒙 CHEN Yihui 2017环境与可持续发展2017,42,6:2
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