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| 1 | Finger or Light:Stimulation Sensitivity of Visual Startle in the Coma Recovery Scale-Revised for Disorders of Consciousness显示文摘Dear Editor,Coma,the vegetative state(VS),and the minimallyconscious state(MCS),often collectively referred to as disorders of consciousness(DOCs),typically occur after severe traumatic or non-traumatic brain injury^([1]).The boundary between awareness and unawareness remains elusive,making it difficult to correctly distinguish MCS from VS patients.It is possible to employ noninvasive neuroimaging techniques,such as functional MRI(f MRI)[2]to assess residual cognitive processing as well | Feng Zhou Hui Li Kai Wang Yanbin He Yan Chen Xiaoxiao Ni Yechun Guo Wei Lv Jiechun Zhang Qiuyou Xie Ronghao Yu | 2018 | Neuroscience Bulletin2018，34，4： | 3 |
| 2 | Multi-omics for COVID-19:driving development of therapeutics and vaccines显示文摘The ongoing COVID-19 pandemic caused by SARS-CoV-2 has raised global concern for public health and economy.The development of therapeutics and vaccines to combat this virus is continuously progressing.Multi-omics approaches,including genomics,transcriptomics,proteomics,metabolomics,epigenomics and metallomics,have helped understand the structural and molecular features of the virus,thereby assisting in the design of potential therapeutics and accelerating vaccine development for COVID-19.Here,we provide an up-to-date overview of the latest applications of multi-omics technologies in strategies addressing COVID-19,in order to provide suggestions towards the development of highly effective knowledge-based therapeutics and vaccines. | Mengyu Guo Muya Xiong Jinying Peng Tong Guan Haixia Su Yanyi Huang Cai-Guang Yang Yang Li Diana Boraschi Thanigaimalai Pillaiyar Guanbo Wang Chengqi Yi Yechun Xu Chunying Chen | 2023 | National Science Review2023，10，9： | 0 |
| 3 | Lunasin peptide promotes lysosome-mitochondrial mediated apoptosis and mitotic termination in MDA-MB-231 cells显示文摘Lunasin,a novel bioactive peptide,is well-known for its anti-proliferation activity.However,the mechanism of this effect is still poorly reported.Here,synthesized lunasin was used and its anti-proliferative function was observed at the concentration of 0.25 mg/m L in human breast cancer cell MDA-MB-231.Conjoint analysis of transcriptome and proteome of MDA-MB-231 cells was further performed.The results demonstrated that cysteinyl aspartate specific proteinase(CASP)3,CASP 7,and CASP 14 were significantly up-regulated after lunasin exposure,together with an increased Bax/Bcl-2 ratio from 22.9 to 210.6,which indicated that caspase-mediated mitochondria intrinsic apoptosis was highly activated.Moreover,lysosomal pathway was signifi cantly suppressed under lunasin exposure,suggesting that lysosome may cooperate with mitochondria to participate in apoptosis.In addition,lunasin also down-regulated genes involved in DNA replication in MDA-MB-231 cells.Overall,our study reveals that the anti-proliferation effect of lunasin peptide might be triggered via the inhibition of DNA replication and cell mitosis,as well as the promotion of lysosome-mitochondrial mediated cell apoptosis. | Yuqiong Hao Huimin Guo Yechun Hong Xin Fan Yumei Su Xiushi Yang Guixing Ren | 2022 | Food Science and Human Wellness2022，11，6： | 0 |
| 4 | An alternative splicing variant of mineralocorticoid receptor discovered in preeclampsia tissues and its effect on endothelial dysfunction显示文摘The pathophysiology of preeclampsia(PE)remains unclear.PE spiral artery remodeling dysfunction and PE offspring cardiovascular future development has been a worldwide concern.We collected placental and umbilical artery samples from normotensive and PE pregnancies.Mineralocorticoid receptor(MR)and its alternative splicing variant(ASV)expression and their biological effects on PE were examined.An MR ASV was found to be highly expressed in all PE samples and slightly expressed in about half of the normotensive samples(umbilical artery,~57.58%;placenta,~36.84%).The MR ASV expression was positively associated with blood pressure in both groups.The MR ASV protein changed the aldosterone-induced expression pattern of MR target genes related to ion exchanges and cell signaling pathways.The MR ASV can also impair the proliferation,migration,and tube formation ability of endothelial cells.These findings indicate that MR ASV in PE placenta plays a pathogenic role in PE pathophysiology,especially in endothelial dysfunction,and the existence of the MR ASV in PE umbilical artery provides a new direction in the study of PE offspring with increased risk of cardiovascular diseases. | Mengxi Guo Chengliang Zhou Gufeng Xu Lin Tang Yechun Ruan Ying Yu Xianhua Lin Dandan Wu Hao Chen Priscilla Yu Luyang Jin Yinyu Wang Yimei Wu Kamran Ullah Tanzil Ur Rahman Xinmei Liu Jianzhong Sheng Hsiao-Chang Chan Hefeng Huang | 2020 | Science China(Life Sciences)2020，63，3： | 0 |
| 5 | Experimental investigation on separation characteristics of axial cyclone separator显示文摘Axial cyclone separator has been widely applied in chemical production as an efficient gas-liquid separation device.In this study,a new axial cyclone separator with integrated swirler and exhaust pipe is designed to achieve the development goal of compact structure for advanced engine,and the distribution characteristics of swirling flow patterns as well as the variation in separation characteristics are investigated under slug flow pattern.Based on flow visualizations and fluctuation characteristics of pressure signals,three typical flow patterns,namely,slug flow,swirling intermittent flow,and swirling annular flow,in the horizontal swirling separation flow are characterized.It is investigated how the inlet conditions affect the separation characteristic parameters.The separation purity and extreme points of the air separation efficiency are independent of the inlet liquid flow rate.The separation pressure drop is quadratically related to the inlet air flow rate.Based on the drift-flux model and other methods,the prediction methods for the air separation efficiency and pressure drop are proposed,and the prediction accuracy is within±20%,which may provide instructions for the practical application of axial cyclone separator. | WANG JinZhi WANG YeChun HAN JinZai XU Qiang XIE XiangDong PAN YingXiu GUO LieJin | 2023 | Science China(Technological Sciences)2023，66，11： | 0 |
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