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| 1 | Amorphous NiFeB nanoparticles realizing highly active and stable oxygen evolving reaction for water splitting显示文摘为发展反应(OER ) 的氧的高度有效、便宜的催化剂的发展为支持切开的水的全面效率是极其迫切的。此处,我们与改变 Fe 的原子比率到报导一系列非结晶的 NiFeB nanoparticles 的制造(Ni + Fe )( 由一个灵巧的化学减小的方法的 Fe ) 。非结晶的 NiFeB ( Fe = 0.20 ) nanoparticles ,联合优点在充实硼酸盐的 NiFeOOH 催化表面层,内在的非结晶的 nanostructures ,和 Fe 的优化的度的 situ 形成做,向在大量 pH 的 OER 的显示的高度活跃的 electrocatalytic 性能珍视(从对中立条件碱)。催化剂在 10 妈 / 厘米 2 在玻璃质的碳上与 43 mV/dec 的一个 Tafel 斜坡在 Ni 泡沫和 251 mV 上与 40 mV/dec 的一个 Tafel 斜坡展出了 216 mV 的相对低的过电位在 1 M KOH 溶液,比商业 RuO 2 的表明大得多的 OER 效率。NiFeB 的 OER 表演测试的长期的稳定性( Fe = 0.20 ) 由 chronoamperometry (过电位()= 320 mV ) 超过 200 h 没揭示降级的证据。灵巧的、可伸缩的合成和高度活跃的水氧化为 OER electrocatalysis 使 NiFeB nanoparticles 很吸引人。 | Guang Liu Dongying He Rui Yao Yong Zhao Jinping Li | 2018 | Nano Research2018，11，3： | 10 |
| 2 | Large-eddy simulation of shock-wave/turbulent boundary layer interaction with and without Spark Jet control显示文摘The efficiency and mechanism of an active control device ‘‘Spark Jet' and its application in shock-induced separation control are studied using large-eddy simulation in this paper.The base flow is the interaction of an oblique shock-wave generated by 8° wedge and a spatially-developing Ma = 2.3 turbulent boundary layer.The Reynolds number based on the incoming flow property and the boundary layer displacement thickness at the impinging point without shock-wave is20000.The detailed numerical approaches were presented.The inflow turbulence was generated using the digital filter method to avoid artificial temporal or streamwise periodicity.The numerical results including velocity profile,Reynolds stress profile,skin friction,and wall pressure were systematically validated against the available wind tunnel particle image velocimetry(PIV) measurements of the same flow condition.Further study on the control of flow separation due to the strong shock-viscous interaction using an active control actuator ‘‘Spark Jet' was conducted.The single-pulsed characteristic of the device was obtained and compared with the experiment.Both instantaneous and time-averaged flow fields have shown that the jet flow issuing from the actuator cavity enhances the flow mixing inside the boundary layer,making the boundary layer more resistant to flow separation.Skin friction coefficient distribution shows that the separation bubble length is reduced by about 35% with control exerted. | Yang Guang Yao Yufeng Fang Jian Gan Tian Li Qiushi Lu Lipeng | 2016 | Chinese Journal of Aeronautics2016，29，3： | 8 |
| 3 | Evaluation of the Sensitivity and Specificity of the New Clinical Diagnostic and Classification Criteria for Kashin-Beck Disease,an Endemic Osteoarthritis,in China显示文摘这研究试图评估敏感和特性新临床诊断并且为用六个临床的标记的 Kashin 山涧疾病(KBD ) 的分类标准:手指的远侧的部分的屈曲,使变形的手指,扩大手指关节,弄短的手指,蹲下来,并且侏儒症。在 Linyou 县的三分之一个张全部的人口被成层的随机的采样取样。调查包括了基线特征并且临床诊断,并且新标准的敏感和特性被评估。我们鉴别 3,459 个 KBD 病人, 69 早有上演 KBD, 1,952 有的舞台我, 1,132 有的阶段 II,和 306 有的阶段 III。分类的屏蔽测试作为舞台扩大了手指关节我 KBD 与 0.978 和 0.045 的敏感和特性,分别地。分别地,弄短的手指作为阶段 II KBD 被分类,与 0.969 和 0.844 的敏感和特性,侏儒症分别地与 0.951 和 0.992 的敏感和特性作为阶段 III KBD 被分类。连续屏蔽测试表明 KBD 的新临床的分类分类阶段与 0.949, 0.945,和 0.925 的敏感和 0.967, 0.970,和 0.993 的特性我, II,和 III KBD 分别地。屏蔽测试表明扩大手指关节,弄短的手指,和侏儒症是为有高敏感和特性的 KBD 的临床的诊断和分类的适当标记。 | YU Fang Fang PING Zhi Guang YAO Chong WANG Zhi Wen WANG Fu Qi GUO Xiong | 2017 | Biomedical and Environmental Sciences2017，30，2： | 6 |
| 4 | Effects of different ingredients of zedoary on gene expression of HSC-T6 cells显示文摘AIM: To investigate the effects of four different ingredients of zedoary (Curcuma aromatica oil, Curcumol,β-elemence, and Curcumin) on the gene expressions of hepatic stellate cells (HSCs), and to explore the molecular mechanism of zedoary against hepatic fibrosis at gene network level.METHODS: We detected the mRNA sequences of 50 liver fibrosis-related genes in GenBank and designed oligonucleotide probes. We synthesized oligonucleotides with PE8909 DNA synthesizing instrument, and carried out oligonucleotide microarray with OGR-04 dropping instrument and aldehyded glass chip. Cultured HSC-T6cells were treated with different concentrations of Colchicine,Curcuma aromatica oil, Curcumol, β-elemence, and Curcumin. According to the experiment of cell toxicity,we took the appropriate concentrations of medicines that resulted in over 50% of cell survival as experiment concentrations. We collected the cells at 1, 6, 12, and 24 h, and extracted total RNA with TRIzol reagent, then labeled cDNAs with Cy3-dUTP and Cy5-dUTP. These labeled cDNAs were hybridized to an oligonucleotide microarray which was washed several times and scanned by scanner GenePix 4000B. Different gene expressions of HSC-T6 cells were analyzed by ImaGene 4.2 software.RESULTS: After HSC-T6 cells were cultured in a medium containing 6.25 μg/mL Colchicine for 12 h, expression of TIMP-1 decreased 2.2-folds. After HSC-T6 cells were cultured in a medium containing 78.125 μg/mL of Curcuma aromatica oil for 24 h, the expression of TIMP-2and IL-6 decreased 2.3- and 2.2-folds, respectively.Moreover, after HSC-T6 cells were cultured in a medium containing 1.5625 μg/mL of Curcumol for 12 h, the expression of TGFβ1 and P450a decreased 2.3- and 2.1-folds, respectively.CONCLUSION: Our results may show the possible molecular mechanism of Curcuma aromatica oil and Curcumol against hepatic fibrosis. | Yuan Jiang Ze-Song Li Fu-Sheng Jiang Xin Deng Cong-Shun Yao Guang Nie | 2005 | World Journal of Gastroenterology2005，11，43： | 5 |
| 5 | Genetic Diversity and Population Structure for the Conservation of Giant Spiny Frog(Quasipaa spinosa)Using Microsatellite Loci and Mitochondrial DNA显示文摘The giant spiny frog(Quasipaa spinosa) is an endangered species with a relatively small distribution limited to southern China and Northern Vietnam. This species is becoming increasingly threatened because of over-exploitation and habitat degradation. This study provides data on the genetic diversity and population genetic structure of the giant spiny frog to facilitate the further development of effective conservation recommendations for this economically important but threatened species. We examined 10 species-specific microsatellite loci and Cyt b genes(562 bp) collected from 13 wild populations across the entire range of this species. Results of 10 microsatellite loci analysis showed a generally high level of genetic diversity. Moreover, the genetic differentiation among all 12 populations was moderate to large(overall F_(ST) = 0.1057). A total of 51 haplotypes were identified for Cyt b, which suggests high haplotype nucleotide diversities. Phylogeographic and population structure analyses using both DNA markers suggested that the wild giant spiny frog can be divided into four distinct major clades, i.e., Northern Vietnam, Western China, Central China, and Eastern China. The clades with significant genetic divergence are reproductively isolated, as evidenced by a high number of private alleles and strong incidence of failed amplification in microsatellite loci. Our research, coupled with other studies, suggests that Q. spinosa might be a species complex within which no detectable morphological variation has been revealed. The four phylogenetic clades and some subclades with distinct geographical distribution should be regarded as independent management units for conservation purposes. | Danna YU Rongquan ZHENG Qinfang LU Guang YANG Yao FU Yun ZHANG | 2016 | Asian Herpetological Research2016，7，2： | 5 |
| 6 | Exposure Effects of Terahertz Waves on Primary Neurons and Neuron-like Cells Under Nonthermal Conditions显示文摘Objective This study aimed to explore the potential effects of terahertz(THz) waves on primary cultured neurons from 4 rat brain regions(hippocampus, cerebral cortex, cerebellum, and brainstem)and 3 kinds of neuron-like cells(MN9 D, PC12, and HT22 cells) under nonthermal conditions.Methods THz waves with an output power of 50(0.16 THz) and 10(0.17 THz) m W with exposure times of 6 and 60 min were used in this study. Analysis of temperature change, neurite growth, cell membrane roughness, micromorphology, neurotransmitters and synaptic-related proteins(SYN and PSD95) was used to evaluate the potential effects.Results Temperature increase caused by the THz wave was negligible. THz waves induced significant neurotransmitter changes in primary hippocampal, cerebellar, and brainstem neurons and in MN9 D and PC12 cells. THz wave downregulated SYN expression in primary hippocampal neurons and downregulated PSD95 expression in primary cortical neurons.Conclusion Different types of cells responded differently after THz wave exposure, and primary hippocampal and cortical neurons and MN9 D cells were relatively sensitive to the THz waves. The biological effects were positively correlated with the exposure time of the THz waves. | TAN Sheng Zhi TAN Peng Cheng LUO Lan Qing CHI Yun Liang YANG Zi Long ZHAO Xue Long ZHAO Li DONG Ji ZHANG Jing YAO Bin Wei XU Xin Ping TIAN Guang CHEN Jian Kui WANG Hui PENG Rui Yun | 2019 | Biomedical and Environmental Sciences2019，32，10： | 5 |
| 7 | Extraction and characterization of bound extracellular polymeric substances from cultured pure cyanobacterium(Microcystis wesenbergii)显示文摘Preliminary characterization of bound extracellular polymeric substances(bEPS) of cyanobacteria is crucial to obtain a better understanding of the formation mechanism of cyanobacterial bloom. However,the characterization of bEPS can be affected by extraction methods. Five sets(including the control) of bEPS from Microcystis extracted by different methods were characterized using three-dimensional excitation and emission matrix(3DEEM) fluorescence spectroscopy combined chemical spectrophotometry; and the characterization results of bEPS samples were further compared. The agents used for extraction were NaOH,pure water and phosphate buffered saline(PBS) containing cationic exchange resins,and hot water. Extraction methods affected the fluorescence signals and intensities in the bEPS. Five fluorescence peaks were observed in the excitation and emission matrix fluorescence spectra of bEPS samples. Two peaks(peaks T1 and T2) present in all extractions were identified as protein-like fluorophores,two(peaks A and C) as humic-like fluorophores,and one(peak E) as a fulvic-like substance.Among these substances,the humic-like and fulvic-like fluorescences were only seen in the bEPS extracted with hot water. Also,NaOH solution extraction could result in strong fluorescence intensities compared to the other extraction methods. It was suggested that NaOH at pH 10.0 was the most appropriate method to extract bEPS from Microcystis. In addition,dialysis could affect the yields and characteristics of extracted bEPS during the determination process. These results will help us to explore the issues of cyanobacterial blooms. | Lizhen Liu Boqiang Qin Yunlin Zhang Guangwei Zhu Guang Gao Qi Huang Xin Yao | 2014 | Journal of Environmental Sciences2014，26，8： | 5 |
| 8 | Enhancing prime editing by Csy4-mediated processing of pegRNA显示文摘Dear Editor,The most advanced prime editor 3(PE3)system comprises the editor,a fusion protein of Cas9 H840A nickase and mutant reverse transcriptase(RTase)(hereafter termed NMRT),a prime editing guide RNA(pegRNA)and an alternative single-guide RNA(sgRNA).1 The pegRNA contains a primer binding site(PBS)and a reverse transcription(RT)template for introducing new genetic information1(Fig.1a;Supplementary information,Fig.S1a).We noted that the PBS,which is generally 10–16 nt at the 3′end of pegRNA,is complementary to part of the spacer at the 5′end of pegRNA,and their annealing is expected to cause pegRNA circularization,which can potentially hamper editing(Fig.1a;Supplementary information,Fig.S1b,c). | Yao Liu Guang Yang Shuhong Huang Xiangyang Li Xin Wang Guanglei Li Tian Chi Yulin Chen Xingxu Huang Xiaolong Wang | 2021 | Cell Research2021，31，10： | 5 |
| 9 | A New Method for Blood NT-proBNP Determination Based on a Near-infrared Point of Care Testing Device with High Sensitivity and Wide Scope显示文摘Objective To develop a rapid, highly sensitive, and quantitative method for the detection of NT-proBNP levels based on a near-infrared point-of-care diagnostic(POCT) device with wide scope. Methods The lateral flow assay(LFA) strip of NT-proBNP was first prepared to achieve rapid detection. Then, the antibody pairs for NT-proBNP were screened and labeled with the near-infrared fluorescent dye Dylight-800. The capture antibody was fixed on a nitrocellulose membrane by a scribing device. Serial dilutions of serum samples were prepared using NT-proBNP-free serum series. The prepared test strips, combined with a near-infrared POCT device, were validated by known concentrations of clinical samples. The POCT device gave the output of the ratio of the intensity of the fluorescence signal of the detection line to that of the quality control line. The relationship between the ratio value and the concentration of the specimen was plotted as a work curve. The results of 62 clinical specimens obtained from our method were compared in parallel with those obtained from the Roche E411 kit. Results Based on the log-log plot, the new method demonstrated that there was a good linear relationship between the ratio value and NT-proBNP concentrations ranging from 20 pg/mL to 10 ng/mL. The results of the 62 clinical specimens measured by our method showed a good linear correlation with those measured by the Roche E411 kit. Conclusion The new LFA detection method of NT-proBNP levels based on the near-infrared POCT device was rapid and highly sensitive with wide scope and was thus suitable for rapid and early clinical diagnosis of cardiac impairment. | ZHANG Xiao Guang SHU Yao Gen GAO Ju WANG Xuan LIU Li Peng WANG Meng CAO Yu Xi ZENG Yi | 2017 | Biomedical and Environmental Sciences2017，30，6： | 4 |
| 10 | Size,morphology,and composition of lunar samples returned by Chang'E-5 mission显示文摘This study focuses on the physical and chemical properties of surficial lunar regolith(LR)samples returned from the Moon by the Chang’E-5(CE-5)mission.Insights regarding the effect of a new sampling geological site on the surficial lunar sample CE5 C0400 were illustrated using nondestructive techniques such as laser diffractometry coupled with image analysis,X-ray computed tomography,and field emission scanning electron microscopy equipped with energy dispersive spectroscopy,and Xray diffraction combined with Rietveld refinement.From the characterization analyses,the CE-5 sampling site in the northeastern Oceanus Procellarum on the Moon yields a unique collection of relatively regular-shaped and fine basalt-dominated particles.The median grain size D_(50) is(55.24±0.96)μm,falling within the relatively low end of the range of the Apollo lunar returned samples.The coefficient of uniformity C_(u)of 15.1 and the coefficient of curvature C_(c)of 1.7 could classify CE5 C0400 to be well-graded.The minerals in CE5 C0400 comprise approximately 44.5%pyroxene,30.4%plagioclase,3.6%olivine,and6.0%ilmenite.There is a relatively low content of approximately 15.5%glass phase in the CE-5 lunar sample.From the results,we deduce that the CE-5 LR structure could have mainly resulted from micrometeoroid impacts to achieve such a high level of maturity. | Hui Zhang Xian Zhang Guang Zhang Keqi Dong Xiangjin Deng Xiaosong Gao Yaodong Yang Yuan Xiao Xiao Bai Kaixin Liang Yiwei Liu Wenbin Ma Shaofan Zhao Ce Zhang Xiaojing Zhang Jian Song Wei Yao Hong Chen Weihua Wang Zhigang Zou Mengfei Yang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，2： | 4 |
| 11 | Diagnosis and surgical treatment of multiple endocrine neoplasia显示文摘背景多重内分泌的瘤形成(人) 是相对稀罕的。但是更多的病人能被详细检查发现。我们讨论诊断和人的外科的治疗。95 个人盒子的临床的数据回顾地被分析的方法。有包括从 6 个家庭的 19 个盒子的 MEN1 的 30 个盒子。MEN1 基因变化在在 1997 以后承认的 81.48% 盒子中被检测。有主要甲状腺机能过盛(PHPT ) 的 22 个盒子,包括 insulinoma 的 9 个盒子的 enteropanceatic 肿瘤的 10 个盒子,垂体腺瘤的 15 个盒子,肾的腺瘤的 9 个盒子, thymic 的 2 个盒子良性肿瘤。二个病人把 4 腺深奥, 3 个病人把 3 腺深奥, 16 个病人把 2 腺深奥,并且 6 个病人把仅仅一腺深奥。三个病人有既不临床的症状也不生物化学的变化,并且被 MEN1 基因变化诊断。与 nephrolithasis 介绍的六个病人和 6 个病人损害了胰腺的内分泌的功能。有 MEN2a 的 60 个盒子和 MEN2b 的 5 个盒子。MEN2a 的 58 个盒子属于 19 个家族。所有 MEN2a 病人但是介绍的沤在 codon 的基因变化 634,并且所有 MEN2b 盒子在 codon 有变化 918。MEN2a 的 48 个盒子与提高的 calcitonin 层次有甲状腺群众。27 个病人包括多重 loci 和 5 恶意的 12 个盒子有 pheochromocytoma。与甲状腺机能过盛介绍的 13 个病人。5 个 MEN2b 病人与 Marfanoid 有髓的甲状腺癌和 mucosal ganglioneuromatosis。在他们之中, 3 个病人有双边的 pheochromocytoma。在 MEN1 的结果,小计 parathyroidectomy 与 PHPT 在 12 个病人被执行,一个病人收到了甲状旁腺的腺瘤 enucleation。Insulinomas 是在 4 个病人的 enucleated。二个病人经历了胸腺肿瘤根除。有地区性的淋巴节点的双边的解剖的全部的甲状腺切除与 MEN2a 在 16 个病人被执行,小瘤 enucleation 在 9 个病人被执行。22 个 MEN2a 病人在 10 种情况中包括双边的肾的切除术经历了 pheochromocytoma enucleation。5 个 MEN2b 病人与双边的淋巴节点解剖经历了全部的甲状腺切除。在他们之中, 3 个盒子经历了双边的肾的操作。结论人在症状变化。Germline 变化测试在建立诊断是有用的。外科的管理应该在 MEN2 在胎儿的肿瘤的 MEN1 和预防针对生活质量的改进。 | ZHOU Guang-wen WEI Yao CHEN Xi JIANG Xiao-hua LI Xiao-ying NING Guang LI Hong-wei | 2009 | Chinese Medical Journal2009，，13： | 4 |
| 12 | Effects of TiC on the microstructure and formation of acicular ferrite in ferritic stainless steel显示文摘The formation mechanism of acicular ferrite and its microstructural characteristics in 430 ferrite stainless steel with TiC additions were studied by theory and experiment.Using an'edge?to?edge matching'model,a 5.25 mismatch between TiC(FCC structure)and ferritic stainless steel(BCC structure)was identified,which met the mismatch requirement for the heterogeneous nucleation of 430 ferritic stainless steel.TiC was found to be an effective nucleation site for the formation of acicular ferrite in a smelting experiment,as analyzed by metallographic examination,Image-Pro Plus 6.0 analysis software,and SEM–EDS.Furthermore,small inclusions in the size of 2–4?m increased the probability of acicular ferrite nucleation,and the secondary acicular ferrite would grow sympathetically from the initial acicular ferrite to produce multi-dimensional acicular ferrites.Moreover,the addition of Ti C can increase the average microstrain and dislocation density of 430 ferrite stainless steel,as calculated by Williamson-Hall(WH)method,which could play some role in strengthening the dislocation. | Yang Li Peng-fei Du Zhou-hua Jiang Cong-lin Yao Lu Bai Qi Wang Guang Xu Chang-yong Chen Lei Zhang Hua-bing Li | 2019 | International Journal of Minerals,Metallurgy and Materials2019，26，11： | 4 |
| 13 | Research on the nanometric machining of a single crystal nickel via molecular dynamics simulation显示文摘Molecular dynamics simulations are employed to study the nanometric machining process of single crystal nickel. Atoms from different machining zones had different atomic crystal structures owing to the differences in the actions of the cutting tool. The stacking fault tetrahedral was formed by a series of dislocation reactions, and it maintained the stable structure after the dislocation reactions. In addition, evidence of crystal transition and recovery was found by analyzing the number variations in different types of atoms in the primary shear zone, amorphous region, and crystalline region. The effects of machining speed on the cutting force, chip and subsurface defects, and temperature of the contact zone between the tool and workpiece were investigated. The results suggest that higher the machining speed, larger is the cutting force. The degree of amorphousness of chip atoms and the depth and extent of subsurface defects increase with the machining speed. The average friction coefficient first decreases and then increases with the machining speed because of the temperature difference between the chip and machining surface. | GONG Ya Dong ZHU Zong Xiao ZHOU Yun Guang SUN Yao | 2016 | Science China(Technological Sciences)2016，59，12： | 4 |
| 14 | Additive Preservers of Idempotence and Jordan Homorphisms between Rings of Square Matrices显示文摘假定 R 是一枚 idempotence-diagonalizable 戒指。让的 n 和 m 是有 n ≥
的二个任意的积极整数3。我们由 M 表示 n (R) 在 R 上的所有 n × n 矩阵的戒指。让 〈
(R)〉
是 M 所有幂等矩阵 additively 产生的 n (R) 。让 =〈
(R)〉
或 M n (R) 。我们从到 M m (R) 当 2 是 R 的一个单位时。从而,我们也描绘约旦(分别地,包围并且响反 --) 从 M n (R) 到 M m (R) 当 2 是 R 的一个单位时。 | Hong Mei YAO Chong Guang CAO Xian ZHANG | 2009 | Acta Mathematica Sinica,English Series2009，25，4： | 3 |
| 15 | Primary dolostone related to the Cretaceous lacustrine hydrothermal sedimentation in Qingxi sag, Jiuquan Basin on the northern Tibetan Plateau: Discussion显示文摘Recently,a mechanism of hydrothermal sedimentation about a mantel-derived source was proposed to interpret the formation of lacustrine dolostone in the Cretaceous Xiagou Formation based on systematic petrological,mineralogical,and geochemical analyses(Wen et al.,2013).Similar to the texture found in classic hydrothermal sediments(Zhang, | LI Le YAO Guang Qing | 2016 | Science China Earth Sciences2016，59，4： | 3 |
| 16 | A new prenylated arylbenzofuran derivative from Morus alba L.显示文摘2-[3,5-Di-O-β-D-glucosyl-4-(3-methylbut-2-enyl)phenyl]benzofuran-6-ol,a new prenylated arylbenzofuran derivative was isolated from Morus alba L.Its structure was elucidated by various spectroscopic methods including MS,~1H NMR,^(13)C NMR,DEPT,~1H-~1HCOSY,HMQC and HMBC. | Tian, Hai Ying He, Xi Zeng, Guang Yao Tan, Jian Bin Shuang, Fu Liu, Guo Ru Tan, Gui Shan Zhou, Ying Jun | 2010 | Chinese Chemical Letters2010，21，3： | 3 |
| 17 | Impacts of climate change and human activities on water resources in the Ebinur Lake Basin, Northwest China显示文摘Changing climatic conditions and extensive human activities have influenced the global water cycle.In recent years,significant changes in climate and land use have degraded the watershed ecosystem of the Ebinur Lake Basin in Xinjiang,Northwest China.In this paper,variations of runoff,temperature,precipitation,reference evapotranspiration,lake area,socio-economic water usage,groundwater level and water quality in the Ebinur Lake Basin from 1961 to 2015 were systematically analyzed by the Mann-Kendall test methods(M-K)mutation test,the cumulative levelling method,the climate-sensitive method and land-use change index.In addition,we evaluated the effects of human activities on land use change and water quality.The results reveal that there was a significant increase in temperature and precipitation from 1961 to 2015,despite a decrease in reference evapotranspiration.The Wenquan station was not significantly affected by human activities as it is situated at a higher altitude.Runoff at this station increased significantly with climate warming.In contrast,runoff at the Jinghe station was severely affected by numerous human activities.Runoff decreased without obvious fluctuations.The contributions of climate change to runoff variation at the Jinghe and Wenquan stations were 46.87%and 58.94%,respectively;and the contributions of human activities were 53.13%and 41.06%,respectively.Land-use patterns in the basin have changed significantly between 1990 and 2015:urban and rural constructed lands,saline-alkali land,bare land,cultivated land,and forest land have expanded,while areas under grassland,lake,ice/snow and river/channel have declined.Human activities have dramatically intensified land degradation and desertification.From 1961 to 2015,both the inflow into the Ebinur Lake and the area of the lake have declined year by year;groundwater levels have dropped significantly,and the water quality has deteriorated during the study period.In the oasis irrigation area below the runoff pass,human activities mainly influenced the utilization mode and quantity of water resources.Changes in the hydrology and quantity of water resources were driven primarily by the continuous expansion of cultivated land and oasis,as well as the growth of population and the construction of hydraulic engineering projects.After 2015,the effects of some ecological protection projects were observed.However,there was no obvious sign of ecological improvement in the basin,and some environmental problems continue to persist.On this basis,this study recommends that the expansion of oasis should be limited according to the carrying capacity of the local water bodies.Moreover,in order to ensure the ecological security of the basin,it is necessary to determine the optimal oasis area for sustainable development and improve the efficiency of water resources exploitation and utilization. | WANG Yuejian GU Xinchen YANG Guang YAO Junqiang LIAO Na | 2021 | Journal of Arid Land2021，13，6： | 3 |
| 18 | Efficacy of polyphenolic ingredients of Chinese herbs in treating dyslipidemia of metabolic syndromes显示文摘There is an increasing interest and popularity of Chinese herbal medicine worldwide, which is accompanied by increasing concerns about its effectiveness and potential toxicity.Several ingredients, such as polyphenolic compounds berberine, flavonoids, and curcumin, have been studied extensively by using various animal models.Effectiveness of treatment and amelioration of metabolic syndromes, including insulin resistance and dyslipidemia, has been demonstrated.This review summarizes the major checkpoints and contributing factors in regulation of exogenous and endogenous lipid metabolism, with particular emphasis centered on triglyceride-rich and cholesterol-rich lipoproteins.Available experimental evidence demonstrating the lipid-lowering effect of berberine, fl avonoids and curcumin in cell culture and animal models is compiled, and the strengths and shortcomings of experimental designs in these studies are discussed. | Zemin Yao Li Zhang Guang Ji | 2014 | Journal of Integrative Medicine2014，12，3： | 3 |
| 19 | Joint Association of Metabolic Health and Obesity with Ten-Year Risk of Cardiovascular Disease among Chinese Adults显示文摘Objective This study aims to investigate the association of metabolic phenotypes that are jointly determined by body mass index(BMI)or fat mass percentage and metabolic health status with the tenyear risk of cardiovascular disease(CVD)among Chinese adults.Methods Data were obtained from a cross-sectional study.BMI and body fat mass percentage(FMP)combined with the metabolic status were used to define metabolic phenotypes.Multiple linear regression and logistic regression were used to examine the effects of metabolic phenotypes on CVD risk.Results A total of 13,239 adults aged 34-75 years were included in this study.Compared with the metabolically healthy non-obese(MHNO)phenotype,the metabolically unhealthy non-obese(MUNO)and metabolically unhealthy obese(MUO)phenotypes defined by BMI showed a higher CVD risk[odds ratio,OR(95% confidence interval,CI):2.34(1.89-2.89),3.45(2.50-4.75),respectively],after adjusting for the covariates.The MUNO and MUO phenotypes defined by FMP showed a higher CVD risk[OR(95%CI):2.31(1.85-2.88),2.63(1.98-3.48),respectively]than the MHNO phenotype.The metabolically healthy obese phenotype,regardless of being defined by BMI or FMP,showed no CVD risk compared with the MHNO phenotype.Conclusion General obesity without central obesity does not increase CVD risk in metabolically healthy individuals.FMP might be a more meaningful factor for the evaluation of the association of obesity with CVD risk.Obesity and metabolic status have a synergistic effect on CVD risk. | LIU Jun Ting YAO Hong Yan YU Shi Cheng LIU Jian Jun ZHU Guang Jin HAN Shao Mei XU Tao | 2022 | Biomedical and Environmental Sciences2022，35，1： | 3 |
| 20 | Synthesis of N-methylene phosphonic chitosan(NMPCS)and its potential as gene carder显示文摘N-Methylene phosphoulc chitosan (NMPCS),an amphiphilic macromolecule with powerful chelating ability of Ca^(2+) ions,was synthesized and characterized.The physicochemical properties of NMPCS and the interactions between NMPCS and plasmid DNA were investigated by FTIR,^(13)C NMR,X-ray,agarose gel electrophorcsis retardation assay,atomic force microscopy (AFM) and circular dichroism (CD).The results suggest that at charge ratio 2:1 or above,DNA could be completely entrapped and spherical complexes with mean size of 80-210 nm were formed.Taking HeLa as host cell,luciferase expression mediated by NMPCS improved about 100 times compared to the expression mediated by chitosan. | Dun Wan Zhu Jin Gen Bo Hai Ling Zhang Wen Guang Liu Xi Gang Leng Cun Xian Song Yu Ji Yin Li Ping Song Lan Xia Liu Lin Mei Xiu Lan Li Yang Zhang Kang De Yao | 2007 | Chinese Chemical Letters2007，18，11： | 3 |
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