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| 1 | Discrimination of abiogenic and biogenic alkane gases显示文摘We have combined the analytical data of the carbon isotope distribution pattern, R/Ra and CH4/3He values of abiogenic and biogenic (referring to the thermogenic and bacterial or microbial) alkane gases in China with those of alkane gases from USA, Russia, Germany, Australia and other countries. Four discrimination criteria are derived from this comparative study: 1) Carbon isotopic composition is generally greater than -30‰ for abiogenic methane and less than -30‰ for biogenic methane; 2) Abiogenic alkane gases have a carbon isotopic reversal trend (δ 13C1> δ 13C2> δ 13C3> δ 13C4) with δ 13C1>-30‰ in general; 3) Gases with R/Ra >0.5 and δ 13C11 δ 13C2>0 are of abiogenic origin; 4) Gases (meth- ane) with CH4/3He≤106 are of abiogenic origin, whereas gases with CH4/3He≥1011 are of biogenic origin. | DAI JinXing ZOU CaiNeng ZHANG ShuiChang LI Jian NI YunYan HU GuoYi LUO Xia TAO ShiZhen ZHU GuangYou MI JingKui LI ZhiSheng HU AnPing YANG Chun ZHOU QingHua SHUAI YanHua ZHANG Ying MA ChengHua | 2008 | Science China Earth Sciences2008，51，12： | 17 |
| 2 | TGIF2 promotes the progression of lung adenocarcinoma by bridging EGFR/RAS/ERK signaling to cancer cell stemness显示文摘TGF-β-induced factor homeobox 2(TGIF2)is a transcription regulator that plays essential roles in the regulation of development and cell fate decisions.Aberrant expression of TGIF family proteins has been observed in several cancers,including ovarian,esophageal,and colorectal cancers.Here,we report that TGIF2 mediates the EGFR–RAS–ERK signaling pathway to enhance the stemness of lung adenocarcinoma(LUAD)cells and,therefore,promote the progression and metastasis of LUAD.We found that high TGIF2 expression was closely correlated with tumor growth,lymph node metastasis,and survival of patients with LUAD.Mice bearing TGIF2-silenced H1299 xenografts developed smaller tumors and fewer lung metastases.Importantly,silencing TGIF2 decreased the cancer stem cell(CSC)-like properties in A549 and H1299 cells.Furthermore,we identified that TGIF2 binding to the OCT4 promoter promotes its expression.In both LUAD cells and in vivo LUAD mouse models,we revealed that EGFR–RAS–ERK signaling phosphorylated TGIF2 and increased its stability,which was important for TGIF2-promoted LUAD stemness since phosphorylation-deficient TGIF2 mutants lost these functions.Thus,our study revealed that an important factor,TGIF2,bridges EGFR signaling to the CSC characteristics of LUAD cells,which can be utilized as an effective target for LUAD therapy. | Renle Du Wenzhi Shen Yi Liu Wenjuan Gao Wei Zhou Jun Li Shuangtao Zhao Chong Chen Yanan Chen Yanhua Liu Peiqing Sun Rong Xiang Yi Shi Yunping Luo | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 7 |
| 3 | Combinatorial effects of conception and governor vessel electroacu-puncture and human umbilical cord blood-derived mesenchymal stem cells on pathomorphologic lesion and cellular apoptosis in rats with cerebral ischemia/reperfusion显示文摘OBJECTIVE: To investigate the combinatorial effects of conception and governor vessel electroacupuncture(EA) and human umbilical cord blood-derived mesenchymal stem cells(HUCB-MSCs) on pathomorphologic lesion and cellular apoptosis in rats with cerebral ischemia/reperfusion. METHODS: With the HUCB-MSCs isolated, cultured and identified and the models of cerebral ischemia-reperfusion established, the HUCB-MSCs of passage three were intracranially transplanted and the EA at conception and governor vessels was applied. The pathomorphologic lesion by hematoxylin-eosin staining and the cellular apoptosis by terminal deoxynucleotidyl transferase-mediated nick-end labeling method around the ischemic focus were observed. RESULTS: The cultured adherent HUCB-MSCs exhibited a spindle shape and expressed MSC-specific markers, with the cell purity and proliferation rate significantly increasing after the primary passage. HE staining showed that there were no pathological changes observed in the sham surgery group. However, in the PBS transplantation group, degeneration and necrosis of a great number of nerve cells were seen. In both the HUCB-MSCs transplantation group and the HUCB-MSCs transplantation + EA group, reparative changes of the pathomorphism of the tissue were found. Both combination treatment and simple MSCs treatment were able to improve the pathomorphorlogic lesion following cerebral ischemia and reduce the abnormal TUNEL-positive numbers, with former better than latter. CONCLUSION: HUCB-MSCs improve pathological lesions and inhibit the cellular apoptosis around the cerebral ischemic area. EA at conception and governor vessels also improve pathological lesion and inhibit the cellular apoptosis in rats treated with HUCB-MSCs transplantation, which effects were superior to that of simple HUCB-MSCs transplantation. | Zhuoxin Yang Pengdian Chen Haibo Yu Wenshu Luo Min Pi Yonggang Wu Ling Wang Fuxia Yang Yanhua Gou | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 5 |
| 4 | Comparison of effect of granules and herbs of Bu-Shen-Yi-Qi-Tang on airway inflammation in asthmatic mice显示文摘 | Wei Ying Lyu Yubao Li Mihui Luo Qingli Sun Jing Liu Feng Lin Yanhua Chen Meixia Mammat Nurahmat Muhammadian Abduwaki Dong Jingcheng | 2014 | Chinese Medical Journal2014，，22： | 3 |
| 5 | Experimental evidence for formation water promoting crude oil cracking to gas显示文摘Crude oil cracking to gas is the key to determining the exploration potential and strategy for deep hydrocarbon resources.Identifying the factors that affect the threshold and potential of crude oil cracking to gas as well as other possible influencing factors will provide the scientific basis for deep hydrocarbon exploration.A comparison of pyrolysis simulation experiments of crude oil,hydrous crude oil,and various water media under a constant temperature(350℃) and pressure(50 MPa) shows that water plays a large role in crude oil cracking to gas.(1) When water is added,the gas yields increase significantly,including those of alkane gases and non-hydrocarbon gases:the yield of alkane gases increases 1.8-3 times;the yields of H2 and CO2 also increase significantly.This means that water takes part in the process of crude oil cracking to gas,and supplies hydrogen.Therefore,the presence of water will dramatically enhance the potential of crude oil cracking to gas.(2) Mg2+ ions in the formation water promote the crude oil + water reaction to some extent and increase the total yield of alkane gases and the yields of both H2 and CO2 ;more interestingly,the i-C4/n-C4 and i-C5/n-C5 ratios increase significantly.This indicates that Mg2+ ions in formation water act as a catalyst,and a disproportionation reaction is involved in the crude oil + water reaction.This study helps us to understand the factors influencing crude oil cracked gas and to evaluate the hydrocarbon resources in deep sedimentary basins. | SHUAI YanHua ZHANG ShuiChang LUO Pan LIU JinZhong HU GuoYi | 2012 | Chinese Science Bulletin2012，57，35： | 3 |
| 6 | Hepatitis B virus hijacks CTHRC1 to evade host immunity and maintain replication显示文摘HepatitisBvirus(HBV)infection causes acuteand chronic liver diseases,but is not directly cytopathic.Liver injury results fromrepeated attempts of the cellular immune response system to control the viral infection.Here,we investigate the roles of cellular factors and signaling pathways involved in the regulation of HBV replication to reveal the mechanism underlying HBV infection and pathogenesis.Weshowthat collagen triple helix repeat containing 1(CTHRC1)expression is elevated in HBV-infected patients andin HBV-transfected cells through epigenetic modification and transcriptional regulation.CTHRC1 facilitates HBV replication in cultured cells and BALB/c mice by activating the PKCa/ERK/JNK/c-Jun cascade to repress the IFN/JAK/STAT pathway.HBV-activated CTHRC1 downregulates the activityof typeI interferon(IFN),theproductionof IFN-stimulatedgenes(ISGs),andthephosphorylationofsignal transducerandactivator of transcription 1/2(STAT1/2),whereas it upregulates the phosphorylation and ubiquitination of type I IFN receptors(IFNARa/b).Thus,our results showthat HBV uses a novelmechanismto hijack cellular factors and signal cascades in order to evade host antiviral immunity and maintain persistent infection.We also demonstrate that CTHRC1 has a novel role in viral infection. | Lan Bai Wei Zhang Li Tan Hongchuan Yang Maolin Ge Chengliang Zhu Rui Zhang Yanhua Cao Junbo Chen Zhen Luo Wenzhe Ho Fang Liu Kailang Wu Jianguo Wu | 2015 | Journal of Molecular Cell Biology2015，7，6： | 2 |
| 7 | Development of Bi/Er co-doped optical fibers for ultra-broadband photonic applications显示文摘 | Yanhua LUO Binbin YAN Jianzhong ZHANG Jianxiang WEN Jun HE Gang-Ding PENG | 2018 | Frontiers of Optoelectronics2018，11，1： | 2 |
| 8 | Structure formation dynamics in drawing silica photonic crystal fibres显示文摘 | Wenyu WANG Ghazal Fallah TAFTI Mingjie DING Yanhua LUO Yuan TIAN Shuai WANG Tomasz KARPISZ John CANNING Kevin COOK Gang-Ding PENG | 2018 | Frontiers of Optoelectronics2018，11，1： | 2 |
| 9 | Cloning,Expression and Activity Analysis of a Bacterial Serine Protease显示文摘In the study,a serine protease gene from Pantoea ananatis was cloned and expressed in prokaryotic cells. The activity of recombinant serine protease was analyzed. The results showed that the recombinant serine protease gene was 1 062 bp,encoding 352 amino acids; the optimal reaction temperature for recombinant serine protease was 50 ℃,and the optimal p H was 5. 0. The serine protease could be developed into a new tool enzyme in biological engineering and food processing. | Jinhui HOU Jishuang CHEN Bosong LUO Aijun DING Yanhua HU | 2015 | Agricultural Biotechnology2015，4，1： | 2 |
| 10 | Feasibility of Booster Vaccination in High-Risk Populations for Controlling Coronavirus Variants—China,2021显示文摘Introduction:Vaccination booster shots are completely necessary for controlling breakthrough infections of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in China.The study aims to estimate effectiveness of booster vaccines for high-risk populations(HRPs).Methods:A vaccinated Susceptible-Exposed-Symptomatic-Asymptomatic-Recovered/Removed(SEIAR)model was developed to simulate scenarios of effective reproduction number(Reff)from 4 to 6.Total number of infectious and asymptomatic cases were used to evaluated vaccination effectiveness.Results:Our model showed that we could not prevent outbreaks when covering 80%of HRPs with booster unless Reff=4.0 or the booster vaccine had efficacy against infectivity and susceptibility of more than 90%.The results were consistent when the outcome index was confirmed cases or asymptomatic cases.Conclusions:An ideal coronavirus disease 2019(COVID-19)booster vaccination strategy for HRPs would be expected to reach the initial goal to control the transmission of the Delta variant in China.Accordingly,the recommendation for the COVID-19 booster vaccine should be implemented in HRPs who are already vaccinated and could prevent transmission to other groups. | Kangguo Li Zeyu Zhao Hongjie Wei Jia Rui Jiefeng Huang Xiaohao Guo Yichao Guo Shiting Yang Guzainuer Abudurusuli Li Luo Xingchun Liu Yao Wang Jingwen Xu Yuanzhao Zhu Meng Yang TianlongYang Weikang Liu Bin Deng Chan Liu Zhuoyang Li Peihua Li Shanshan Yu Zimei Yang Yanhua Su Benhua Zhao Yan Niu Tianmu Chen | 2021 | China CDC weekly2021，3，50： | 2 |
| 11 | Endogenic Au-Ag polymetallic ore deposits and ore-bearing potentiality of strata显示文摘The problem of ore-bearing potentiality of the strata involves metallogenic theory and ore-search orientation.Studies of the spatial distribution of endogenic Au-Ag polymetallic ore deposits in North Hebei indicated that the strata in which ore deposits occurred range in age from Paleozoic,Proterozoic to Mesozoic.In addition the ore deposits are characterized as being strata-bound in nature.The arise and establishment of 'extracting' viewpoint may be attributed to the following three reasons:1) influence by the idea of 'ore-source bed';2) limitation of analytical techniques in the 1980s'(especially gold element);and 3) a small number of samples(sampling locations were mostly disturbed by mineralization).Studies have shown that ore-forming materials would most probably come from the deep interior of the Earth.Deep-seated ore-bearing materials including Au-Ag polymetals were brought to the shallow levels by way of mantle plume-mantle sub-plume-mantle branch structure multi-stage evolution,finally leading to the formation of ore deposits. | WANG Baode NIU Shuyin SUN Aiqun XIE Yan LUO Yi LIU Hailong WANG Yanhua | 2010 | Chinese Journal Of Geochemistry2010，29，4： | 1 |
| 12 | Regulation of the differentiation of mesenchymal stem cells in vitro and osteogenesis in vivo by microenvironmental modification of titanium alloy surfaces显示文摘 | Yan Hu Kaiyong Cai Zhong Luo Yuan Zhang Liqi Li Min Lai Yanhua Hou Yuran Huang Jinghua Li Xingwei Ding Bin Zhang K.L. Paul Sung | 2012 | Biomaterials2012，，13： | 1 |
| 13 | Reduced order modeling of the upper tropical pacific ocean model using proper orthogonal decomposition显示文摘 | Cao Yanhua Zhu Jiang Luo Zhendong | 2006 | Comput Math2006，52，89： | 1 |
| 14 | Constructions of ROS-responsive titanium-hydroxyapatite implant for mesenchymal stem cell recruitment in peri-implant space and bone formation in osteoporosis microenvironment显示文摘To solve the issue of unsatisfactory recruitment of mesenchymal stem cells(MSCs)around implant in osteoporotic fractures,we fabricated a ROS-responsive system on titanium surface through hydroxyapatite coating and biomolecule grafting.The porous hydroxyapatite and phosphorylated osteogenic growth peptides(p-OGP)were introduced onto titanium surface to synergistically improve osteogenic differentiation of MSCs.After the p-OGPpromoted expression of osteogenic related proteins,the calcium and phosphate ions were released through the degradation of hydroxyapatite and integrated into bone tissues to boost the mineralization of bone matrix.The ROS-triggered release of DNA aptamer(Apt)19S in the osteoporotic microenvironment guides MSC migration to implant site due to its high affinity with alkaline phosphatase on the membrane of MSCs.Once MSCs reached the implant interface,their osteogenic differentiation potential was enhanced by p-OGP and hydroxyapatite to promote bone regeneration.The study here provided a simple and novel strategy to prepare functional titanium implants for osteoporotic bone fracture repair. | Maohua Chen Yuting Sun Yanhua Hou Zhong Luo Menghuan Li Yujia Wei Maowen Chen Lu Tan Kaiyong Cai Yan Hu | 2022 | Bioactive Materials2022，7，12： | 1 |
| 15 | Modelling the Emerging COVID-19 Epidemic and Estimating Intervention Effectiveness—Taiwan,China,2021显示文摘Introduction:The coronavirus disease 2019(COVID-19)pandemic recently affected Taiwan,China.This study aimed to calculate the transmissibility of COVID-19 to predict trends and evaluate the effects of interventions.Methods:The data of reported COVID-19 cases was collected from April 20 to May 26,2021,which included daily reported data(Scenario I)and reported data after adjustment(Scenario II).A susceptibleexposed-symptomatic-asymptomatic-recovered model was developed to fit the data.The effective reproductive number(Reff)was used to estimate the transmissibility of COVID-19.Results:A total of 4,854 cases were collected for the modelling.In Scenario I,the intervention has already taken some effects from May 17 to May 26(the Reff reduced to 2.1).When the Reff was set as 0.1,the epidemic was projected to end on July 4,and a total of 1,997 cases and 855 asymptomatic individuals would have been reported.In Scenario II,the interventions were projected as having been effective from May 24 to May 26(the Reff reduced to 0.4).When the Reff was set as 0.1,the epidemic was projected to end on July 1,and a total of 1,482 cases and 635 asymptomatic individuals would have been reported.Conclusion:The epidemic of COVID-19 was projected to end after at least one month,even if the most effective interventions were applied in Taiwan,China.Although there were some positive effects of intervention in Taiwan,China. | Weikang Liu Wenjing Ye Zeyu Zhao Chan Liu Bin Deng Li Luo Jiefeng Huang Yao Wang Jia Rui Benhua Zhao Yanhua Su Shenggen Wu Kun Chen Jianming Ou Tianmu Chen | 2021 | China CDC weekly2021，3，34： | 1 |
| 16 | Simultaneous measurement of temperature and strain using a single Bragg grating in a few-mode polymer optical fiber显示文摘 | Qiu Weiwei Cheng Xusheng Luo Yanhua | 2013 | Journal of Lightwave Technology2013，31，14： | 1 |
| 17 | Sphingolipid synthesis inhibitor fumonisin B1 causes verticillium wilt in cotton显示文摘Verticillium wilt caused by Verticillium dahliae is a major disease of cotton. Acidic protein–lipopolysaccharide complexes are thought to be the toxins responsible for its symptoms. Here,we determined that the sphingolipid biosynthesis inhibitor fumonisin B1(FB1) acts as a toxin and phenocopies the symptoms induced by V. dahliae. Knocking out genes required for FB1 biosynthesis reduced V. dahliae pathogenicity. Moreover, we showed that overexpression of a FB1 and V. dahliae both downregulated gene, Gh IQD10, enhanced verticillium wilt resistance by promoting the expression of brassinosteroid and anti-pathogen genes. Our results provide a new strategy for preventing verticillium wilt in cotton. | Fan Xu Li Huang Junyao Wang Caixia Ma Yingqing Tan Fanlong Wang Yanhua Fan Ming Luo | 2022 | Journal of Integrative Plant Biology2022，64，4： | 1 |
| 18 | Spin effect on a single-mode single-polarization optical fiber显示文摘The spin effect on a single-mode single-polarization optical fiber is investigated theoretically and numerically. To get a practical single elliptically polarized fiber the normalized spin rate must be in the range of 0.2–0.35. A single elliptically polarized fiber with a normalized spin rate around 0.224 is demonstrated. It has a broad band from1.530 to 1.558 μm, in which the low-leakage elliptically polarized eigenmode loss is kept within 1.2 d B while the high-leakage elliptically polarized eigenmode loss is greater than 20 d B. This fiber can be used as an elliptical polarizer or applied in current sensing. | 季敏宁 Gang-Ding Peng Yanhua Luo | 2015 | Chinese Optics Letters2015，13，2： | 1 |
| 19 | Construction of a high-density mutant population of Chinese cabbage facilitates the genetic dissection of agronomic traits显示文摘Chinese cabbage(Brassica rapa ssp.pekinensis)is an economically important vegetable crop throughout the world,especially in Asia.High-quality genome sequences are available for Chinese cabbage,but gene functional studies remain challenging.To promote functional genomic studies of Chinese cabbage,we generated an ethyl methane sulfonate(EMS)mutant population of~8000 M_(2) plants using the double haploid inbred line A03 as the parent.The genome of A03 was sequenced and used as a reference for high-throughput functional characterization of gene mutations at the whole-genome level.A total of 300 M_(2) to M_(5) EMS mutants were phenotypically screened and then sequenced,revealing 750629 SNPs and 46272 InDel mutations that cover 98.27%of all predicted genes in the A03 genome.A forward-genetics approach was successfully used to identify two genes with chloroplast-related functions that are responsible for the yellow leaf mutant trait.A reverse-genetics approach was also used to identify associations between mutations in five genes of the glucosinolate biosynthetic pathway and variations in glucosinolate content of the mutant plants.In addition,we built the Chinese cabbage EMS mutation database(CCEMD,www.bioinformaticslab.cn/EMSmutation/home)to increase the usability of this mutant population resource.In summary,we performed large-scale screening of a heading Chinese cabbage EMS mutant collection at the phenotypic and genotypic levels,which will facilitate gene mining of Chinese cabbage and might also be useful for the study of other Brassica crops. | Xiaoxue Sun Xing Li Yin Lu Shan Wang Xiaomeng Zhang Kang Zhang Xiangjie Su Mengyang Liu Daling Feng Shuangxia Luo Aixia Gu Yu Fu Xueping Chen Shuxin Xuan Yanhua Wang Donghui Xu Shumin Chen Wei Ma Shuxing Shen Feng Cheng Jianjun Zhao | 2022 | Molecular Plant2022，15，5： | 1 |
| 20 | Building a Harmonious World and Developing Global Human Rights显示文摘<正>Retween September 2005 and April 2006,China's national leaders made four significant proposals to the international community on building a harmonious world.~1 This shows that China,as a responsible country,is bringing to the international community its own concepts and ideas on how to cope with internation- al conflicts.This action is a great effort and endeavor on China's part in resolving cur- rent international conflicts. | LUO YANHUA | 2008 | The Journal of Human Rights2008，7，2： | 0 |
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