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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Effects of preoperative oral melatonin medication on postoperative analgesia, sleep quality, and sedation in patients undergoing elective prostatectomy: a ran- domized clinical trial显示文摘 | Borazan I1 Tuncer S Yalcin N | 2010 | J Anesth2010，24，2： | 1 |
| 3 | Comparison of the biodiesel quality produced from refined sunflower (Helianthus annuus L) oil and waste cooking oil 显示文摘 | Abdurrahman S Aylin B K Yalcin T | 2010 | Energy Exploration & Exploitation2010，28，6： | 1 |
| 4 | A technique for atraumatic extrac- tion of teeth before immediate implant placement 显示文摘 | Yalcin S Aktas I Emes Y | 2009 | Implant Dent2009，18，6： | 1 |
| 5 | Bilateral oroantralfistulas following devitalization of teeth by arsenic trioxide: acase report 显示文摘 | Yalcin S Aybar B Haznedarolu F | 2003 | J Endod2003，293，： | 1 |
| 6 | Cerebral palsy:orthopedic as-pects and rehabilitation显示文摘 | Berker A N Yalcin M S | 2008 | Pediatr Clin N Am2008，55，5： | 1 |
| 7 | L-Carnitine ameliorates glyc- erol-induced myoglobinuric acute renal failure in rats 显示文摘 | Ustundag S Sen S Yalcin O | 2009 | Ren Fail2009，31，2： | 1 |
| 8 | Ultimate pile capacity for eccentric inclined load显示文摘 | Meyerhof G G Yalcin A S Mathur S K | 1983 | Journal of the Geotechnical Engineering Division ASCE1983，109，3： | 1 |
| 9 | Time course of hemorbeotogical alterations after heavy anaerobic exercise in untrained human sub- jects显示文摘 | Yalcin O Erman A Muratli S | 2003 | J Appl Physiol2003，94，3： | 1 |
| 10 | A technique for atraumatic extraction of teeth before immediate implant placement using implant drills 显示文摘 | Yalcin S Aktas I Emes Y | 2009 | Implant Dent2009，18，6： | 1 |
| 11 | Bonding to enamel and dentin using self-etching adhesive systems 显示文摘 | Kiremitei A Yalcin F Gokalp S | 2004 | Quintessence Int2004，35，5： | 1 |
| 12 | A single stage posterior approach and rigid fixation for preventing kyphosis in the treatment of spinal tuberculosis显示文摘 | Guven O Kumano K Yalcin S | 1994 | Spine1994，19，： | 1 |
| 13 | A single stage posterior approach and rigid fixation for preventing kyphosis in the treatment of spinal tuberculosis 显示文摘 | Guven O Kumano K Yalcin S | 1997 | Spine1997，19，9： | 1 |
| 14 | Pile capacity for eccentric inclined load in clay显示文摘 | Meyerhof G G Yalcin A S | 1984 | Canadian Geotechnical Journal1984，21，3： | 1 |
| 15 | Fracture resistances of cast metal and ceramic dowel and core restorations: a pilot study 显示文摘 | Yalcin E Cehreli MC Canay S | 2005 | J Prosthodont2005，14，2： | 1 |
| 16 | Effects of sevoflurane and des- flurane on oxidative stress during general anesthesia for elective ce- sarean section显示文摘 | Yalcin S Aydoan H Yuce HH | 2013 | Wien Klin Wochenschr2013，125，1516： | 1 |
| 17 | Preoperative serum vascular endothelial growth factor (VEGF) in ovarian masses显示文摘 | TANIR HM OZALP S YALCIN OT | 2003 | Eur J Gynaecol Oncol2003，24，： | 1 |
| 18 | Influence of dietary energy on bird performance, carcass parts yields and nutrient composition of breast meat of natural optimum and summer temperature显示文摘 | Yalcins S Ozkans S Acikgoz Z | 1998 | Bri Bouh Sci1998，39，5： | 1 |
| 19 | Isolated torsion of fallopian tube during pregnancy:Report of two cases显示文摘 | Yalcin OT Hassa H Zeytinoglu S | | 0，，： | 1 |
| 20 | Concomitant rotator cufl tear and brachial plexus injury in association with anterior shoulder dislocation: unhappy triad of the shoulder显示文摘 | Giiven O Akbar Z Yalcin S | 1994 | J Orthop Trauma1994，8，： | 1 |
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