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| 1 | Community structure of ammonia-oxidizing bacteria under long-term application of mineral fertilizer and organic manure in a sandy loam soil显示文摘 | Chu HY Fujii T Morimoto S Lin XG Yagi K Hu JL Zhang JB | 2007 | 中国生物学文摘2007，21，6： | 77 |
| 2 | 蛋白酶激活受体2在载脂蛋白E缺陷小鼠的血管炎症和动脉粥样硬化中发挥关键作用显示文摘凝血系统与血管炎症密切相关,尽管其潜在机制仍不清楚。最近的研究结果表明,蛋白酶激活受体(protease-activated receptor,PAR)2——活化因子X(activated factor X,FXa)的主要受体之一——在血管细胞和白细胞中均有表达,这提示PAR-2可能参与炎症性疾病的发病机制。 | Hara T Phuong PT Fukuda D Yamaguchi K Murata C Nishimoto S Yagi S Kusunose K Yamada H Soeki T Wakatsuki T Imoto I Shimabukuro M Sata M 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，6： | 11 |
| 3 | Antifibrotic effect of aloe vera in viral infection-induced hepatic periportal fibrosis显示文摘AIM:To investigate the anti-oxidative and anti-fibrotic effects of aloe vera in patients with liver fibrosis.METHODS:Aloe vera high molecular weight fractions(AHM) were processed by patented hyper-dry system in combination of freeze-dry technique with microwave and far infrared-ray radiation.Fifteen healthy volunteers as the control group and 40 patients were included.The patients were randomly subdivided into two equal groups:the conventional group was treated with placebo(starch),and AHM group was treated with 0.15 gm/d AHM,both for 12 consecutive weeks.The patients were investigated before and after treatment.Serum activity of aspartate aminotransferase(AST),alanine aminotransferase(ALT),alkaline phosphatase(ALP),hyaluronic acid(HA),transforming growth factor-β(TGF-β) and matrixmetalloproteinase-2(MMP-2) were determined.The reduced glutathione(GSH) and malondialdehyde(MDA) levels in liver were assayed and the expression of hepatic α-smooth muscle actin(α-SMA) was identified by immunohistochemistry.RESULTS:At the start of the study,the hematoxylin and eosin staining revealed fibro-proliferated bile ductules,thick fibrous septa and dense inflammatory cellular infiltration in the patients before treatment.The use of AHM for 12 wk significantly ameliorated the fibrosis,inhibited the inflammation,and resulted in minimal infiltration and minimal fibrosis compared to the conventional group.The enzyme activities of the liver(ALT,AST and ALP) were attenuated after treatment in both groups,and the decrease in the AHM group was more significant as compared with the conventional group.Similar to the AST,the MDA levels were significantly higher before treatment,and were attenuated after treatment in both groups.In contrast,the hepatic glutathione content in the patients were decreased significantly in the AHM group compared to the controls.The serum levels of the fibrosis markers(HA,TGF-β and MMP-2) were also reduced significantly after treatment.The expression of α-SMA was modified in patients before and after treatment as compared with the normal controls.In the conventional group,there was only thin and incomplete parenchymal α-SMA positive septum joining the thickened centrilobular veins,while in the AHM group,few α-SMA positive cells were present in sinusoid and lobule after treatment.CONCLUSION:Oral supplementation with AHM could be helpful in alleviating the fibrosis and inflammation of hepatic fibrosis patients. | Sahar K Hegazy Mohamed El-Bedewy Akira Yagi | 2012 | World Journal of Gastroenterology2012，18，17： | 7 |
| 4 | 步行6min负荷超声心动图预测结缔组织病患者远期显性肺高血压显示文摘肺高血压是结缔组织病(connective tissue disease,CTD)的主要死因。运动负荷试验已用于筛查早期肺高血压[1],但由于缺乏相关证据,最新的指南已停止其作为发现肺高血压的方法。近期研究发现平均肺动脉压(mean pulmonary arterial pressure,mPAP)升高导致心输出量异常可用于评估肺高血压进展及肺功能分级[2]。该研究将步行6min后的超声心动图参数作为非侵入性负荷试验。 | Kusunose K Yamada H Hotchi J Bando M Nishio S Hirata Y Ise T Yamaguchi K Yagi S Soeki T Wakatsuki T Kishi J Sata M 曲浥晨 | 2015 | 中华高血压杂志2015，23，10： | 3 |
| 5 | Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts显示文摘 | T Komori H Yagi S Nomura A Yamaguchi K Sasaki K Deguchi Y Shimizu R.T Bronson Y.-H Gao M Inada M Sato R Okamoto Y Kitamura S Yoshiki T Kishimoto | 1997 | Cell1997，，5： | 2 |
| 6 | Inhibition of I kappaB-alpha phosphory-lation at serine and tyrosine acts independently on sensitization to DNA damaging agents in human glioma cells显示文摘 | Miyakoshi J Yagi K | 2000 | Br J Cancer2000，82，1： | 1 |
| 7 | Effects of nitrogen fertiliser and wheat straw application on CH4 and N20 emissions from a paddy rice field显示文摘 | Ma J Li XL Xu H Han Y Cai ZC Yagi K | 2007 | Australian Journal of Soil Research2007，45，： | 1 |
| 8 | miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation显示文摘 | Mizuno Y Yagi K Tokuzawa Y | 2008 | Biochem Biophys Res Commu2008，368，2： | 1 |
| 9 | Kinetic analysis of cell proliferation using bromodeoxyuridine labeling and in situ detection of dying cell in the tympanic membrane and middle ear cholesteatoma显示文摘 | Koba K Yagi M Tabe H | 1996 | Arch Histol Cytol1996，59，： | 1 |
| 10 | Relationship between EMG signals and force in human vastus lateralis muscle using multiple bipolar wire electrodes显示文摘 | Onishi H Yagi R Akasaka K | 2000 | J Electromyogr Kinesiol2000，10，1： | 1 |
| 11 | Inhibition of the renin?angiotensin system prevents re-hospitalization of heart failure patients with preserved ejection fraction显示文摘 | Komukai K Yagi H OgawaT et sl | 2008 | Circ J2008，72，12： | 1 |
| 12 | Postoperative out- come after modified unilateral-approach microendoscopic midline decompression for degenerative spinal stenosis 显示文摘 | Yagi M Okada E Ninomiya K | 2009 | J Neurosurg Spine2009，10，4： | 1 |
| 13 | Effects of elevated atmospheric C02 concentrations on CH4 and N20 emission from rice soil:An experiment in controlled-environment chambers显示文摘 | Cheng W G Yagi K Sakai H | 2006 | Biogeochemistry2006，77，3： | 1 |
| 14 | Pterygium and dry eye显示文摘 | Ishioka M Shimmura S Yagi Y Tsubota K | | 0，，： | 1 |
| 15 | Effect of water management on methane emission from a Japanese rice paddy field : Automated methane monitoring显示文摘 | Yagi K Tsuruta H Kanda K | 1996 | Global Biogeochem Cycle1996，10，： | 1 |
| 16 | Comparison between magnifying endoscopy and histological culture and urease testings from the gastric mucoca of the cnrpus显示文摘 | Yagi K Nakamura A Sekine A | 2002 | Endoscopy2002，34，4： | 1 |
| 17 | Amorphous Wire MI Micro Sensor Using C-MOS IC Multivibrator显示文摘 | Kanno T Mohri K Yagi T | 1997 | IEEE Trans Magn1997，33，5： | 1 |
| 18 | Clinical features of immunocompromised and nonimmunocompromised patients with pulmonary tuberculosis显示文摘 | Kobashi Y Mouri K Yagi S | 2007 | J Infect Chemother2007，13，6： | 1 |
| 19 | Biomechanical rationale for a single implant-retained mandibular overdenture: an in vitro study 显示文摘 | Maeda Y Horisaka M Yagi K | 2008 | Clin Oral Implants Res2008，19，3： | 1 |
| 20 | Single-neuron diversity generated by Protocadherin-β cluster in mouse central andperipheral nervous systems显示文摘 | Hirano K Kaneko R Izawa T Kawaguchi M Kitsukawa T Yagi T | 2012 | Front Mol Neurosci2012，5，： | 1 |
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