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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Effect of carbon coating on electrochemical performance of treated natural graphite as lithium-ion battery anode material显示文摘 | YOSHIO M WANG H FUKUDA K | 2000 | J Electrochem Soc2000，147，4： | 1 |
| 3 | Expansion of potato cells in response to jasmonic acid显示文摘 | KIYOSHI T KAIEN F YOSHIO K | 1994 | Plant Science1994，100，1： | 1 |
| 4 | Tin-based amorphous ox-ide:A high capacity lithium-ion atorage material显示文摘 | Yoshio I Tadahiko K Akihiro M | 1997 | Science1997，276，： | 1 |
| 5 | Synthesis and activity of 1-N-iminosugar inhibitors,siastatin B analogues for α-N-acetylgalaetosaminidase and β-N-aeetylglueosaminidase 显示文摘 | Yoshio N Takahiko S Toshiaki K | 1996 | Bioorganie & Medicinal Chemistry1996，4，1： | 1 |
| 6 | Deposition of Silver Nanoparticles on Silica Spheres by Pretreatment Steps in Electroless Plating显示文摘 | Yoshio K | 2001 | Chem Mater2001，13，： | 1 |
| 7 | Novel functional graphite anode for Li-ion bat teries 显示文摘 | Yoshio M Fukuda K | 2000 | Powder Science & Engineering2000，32，12： | 1 |
| 8 | Study on a Regenerative Fuel Reformer for a Zero Mission Vehicle System显示文摘 | Yukitaka K Keiko A Yoshio Y | | 0，，07： | 1 |
| 9 | Expansion of potato cells in response to jasmonic cid显示文摘 | Kiyoshi T Kaien F Yoshio K | 1994 | Plant Science1994，100，1： | 1 |
| 10 | Ultra high speed optical beam steering by optical phased array antenna 显示文摘 | Keizo I Yoshio K | 1996 | SPIE1996，2699，： | 1 |
| 11 | Layered ionic liquids: anisotropic ion conduction in new self-organized liquidcrystalline materials 显示文摘 | YOSHIO M MUKAI T KANIE K | 2002 | Adv Mater2002，24，5： | 1 |
| 12 | Study on a novel catalytic reaction and its mecha- nism for CF31 synthesis显示文摘 | NORITAKA N YOSHIO M KOSUKE K | 2004 | Catalysis Today2004，88，34： | 1 |
| 13 | Expansion of potato cells in response to jasmonic acid显示文摘 | KIYOSHI T KAIEN F YOSHIO K | 1994 | Plant Science1994，100，1： | 1 |
| 14 | Identification and functional characterization of the trigeminal ventral cervical reflex pathway in the swine 显示文摘 | Seiya K Nicholas P Yoshio C | 2003 | Clinical Neurophysiology2003，114，： | 1 |
| 15 | Tin-based amorphous oxide:a highcapacity lithium-ion storage material 显示文摘 | Yoshio I Tadahiko K | 1997 | Sci1997，27，6： | 1 |
| 16 | Improvement of commercial activated carbon and its application in electric double layer capacitors显示文摘 | Yang H Yoshio M Isono K | 2002 | Electrochem Solid-State Lett2002，5，6： | 1 |
| 17 | Lymphatic drainage imaging of breast cancer in mice by micro-magnetic resonance lymphangiography using a nanosize paramagnetic contrast agent 显示文摘 | Hisataka K Satomi K Yoshio S | 2004 | Natl Cancer Ins2004，96，9： | 1 |
| 18 | Side-slip control to stabilize vehicle lateral motion by direct yaw moment显示文摘 | MASATO A YOSHIO K KAZUASA S | 2001 | JSAE2001，22，1： | 1 |
| 19 | In situ XAFS analysis of Li(Mn, M)2O4 (M Cr, Co, Ni) 5V cathode materials for lithium-ion secondary batteries 显示文摘 | TERADA Y YASAKA K NISHIKAWA F KONISHI T YOSHIO M NAKAI I | 2001 | Journal of Solid State Chemistry2001，156，： | 1 |
| 20 | Association of IgG anti-NR2 glutamate receptor antibodies in cerebrospinal fluid with neuropsychistric systemic lupus erythematosus显示文摘 | Onda K Nara H | 2006 | Arthritis Rheum2006，54，2： | 1 |
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