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您的检索式：作者名="Y. Furusawa"
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| 1 | Unraveling the mystery of enhanced cell-killing effect around the Bragg peak region of a double irradiation source^(9)C-ion beam显示文摘An enhanced cell-killing effect at the penetra- tion depths around the Bragg peak of a β-delayed particle decay 9C-ion beam has been observed in our preceding ra- diobiological experiments in comparison with a therapeutic 12C beam under the same conditions, and RBE values of the 9C beam were revealed to be higher than those of the comparative 12C beam by a factor of up to 2. This study is aimed at investigating the biophysical mechanisms underlying the important experimental phenomenon. First of all, a model for calculating the stopping probability density of the experimentally applied 9C beam is worked out, where all determinants such as the initial momentum spread of the 9C beam, the fluence attenuation with penetration depth due to the projectile-target nuclear reaction and the energy strag- gling effect are taken into account. On the basis of the calcu- lated 9C-ion stopping distribution, it has been found that the area corresponding to the enhanced cell-killing effect of the 9C beam appears at the stopping region of the incident 9C ions. The stopping 9C-ion density in depth, then, is derived from the calculated probability density. Moreover, taking entrance dose 1 Gy for the 9C beam as an example, the aver- age stopping 9C-ion numbers per cell at various depths are deduced. Meanwhile, the mean lethal damage events induced by the 9C and comparative 12C beams at the depths with al- most equal dose-averaged LETs are derived from the meas- ured cell surviving fractions at these depths for the 9C and 12C beams. Under the condition of the same absorbed doses, there are indeed good agreements between the average stop- ping 9C-ion number pre cell and the difference of the mean lethal damage events between the 9C and 12C beams at the depths of similar dose-averaged LETs. It can be inferred that if a 9C ion comes to rest in a cell, the cell would undergo dy- ing. In view of the decay property of 9C nuclide, clustered damage would be caused in the cell by the emitted low-energy particles. Therefore, the results achieved in this work can be taken as indirect evidence supporting that damage cluster is more efficient in leading to cell lethality. | LI Qiang Y. Furusawa M. Kanazawa A. Kitagawa | 2005 | Chinese Science Bulletin2005，50，22： | 2 |
| 2 | Enhanced Efficiency in Cell Killing at Penetration Depths around Bragg Peak of a Radioactive 9C-ion Beam显示文摘A β-delayed particle decay beam like 9C has been recognized as a double irradiation source, i.e. the external beam radiation itself and the delayed low-energy particles emitted internally. A radioactive 9C-ion beam, therefore, is considered to be very useful in cancer radiation therapy. To explore the potential importance of radioactive 9C-ion beams in cancer therapy, radiobiological experiments using a 9C beam supplied by the secondary beam line (SBL) at the Heavy Ion Medical Accelerator in Chiba (HIMAC), Japan were carried out. | Y. Furusawa M. Kanazawa T. Kanai A. Kitagawa M. Aoki E. Urakabe S. Sato | 2004 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2004，，1： | 0 |
| 3 | Clonogenic Surviving Effect of HSG Cells Exposed to High-LET Carbon Beams at Low Dose Rate显示文摘It is generally believed that there is no dose-rate sparing effect for mammalian cells exposed to high-LET heavy ion beams. To clarify this ambiguity, human salivary gland (HSG) cells were irradiated with carbon ion beams supplied by the Heavy Ion Medical Accelerator in Chiba (HIMAC), Japan at a low dose rate of 0. | Y. Furusawa M. Kanazawa M. Aoki E. Urakabe S. Sato | 2004 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2004，，1： | 0 |
| 4 | Unraveling Mystery of Enhanced Cell-killing Effect around Bragg Peak Region of a Double Radiation Source 9C-ion Beam显示文摘An enhanced cell-killing effect at the penetration depths around the Bragg peak of a β-delayed particle decay 9C -ion beam has been observed in our preceding radiobiological experiments in comparison with a therapeutic 12C beam under the same conditions, and RBE values of the 9C beam were revealed to be higher than those of the comparative 12C beam by a factor of up to 2. This study was aimed at investigating the biophysical mechanisms underlying the important experimental phenomenon. | Y. Furusawa M. Kanazawa T. Kanai A. Kitagawa | 2004 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2004，，1： | 0 |
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